DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adgf-B and Ada

DIOPT Version :9

Sequence 1:	NP_649006.2	Gene:	Adgf-B / 39975	FlyBaseID:	FBgn0036751	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001258981.1	Gene:	Ada / 11486	MGIID:	87916	Length:	352	Species:	Mus musculus

Alignment Length:	313	Identity:	81/313 - (25%)
Similarity:	122/313 - (38%)	Gaps:	90/313 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 YNALKEFAEDGVQYLELR---SLLP-------PLYCIDGDMLTIRDTVAIYNSELERFRADHPDF 292
            |..::..|::||.|:|:|   .||.       |....:|| :|..|.|.:.|..|:.
Mouse    84 YEFVEMKAKEGVVYVEVRYSPHLLANSKVDPMPWNQTEGD-VTPDDVVDLVNQGLQE-------- 139

  Fly   293 IGSKLIYAPLRGV------EPSVVEQYVKTAVELNKEF-PNFMVGFDLVGQEELGRPLIDFVEPL 350
             |.:.....:|.:      :||    :....:||.|:: ...:|..||.|.|.        :|..
Mouse   140 -GEQAFGIKVRSILCCMRHQPS----WSLEVLELCKKYNQKTVVAMDLAGDET--------IEGS 191

  Fly   351 LKMPEHINFY-----------FHAGETNWFGSP-IDENLVDAILLGTKRIGHGY-AITKHPMMMR 402
            ...|.|:..|           .||||.   ||| :....||  :|.|:|:|||| .|....:..|
Mouse   192 SLFPGHVEAYEGAVKNGIHRTVHAGEV---GSPEVVREAVD--ILKTERVGHGYHTIEDEALYNR 251

  Fly   403 LAKLLGIAIEVCPVSN--------QVLQLGVDYRNHPAALLLAANVPIVISSDDPSFWHCAPLSH 459
            |.| ..:..||||.|:        :.....|.::|..|...|..:.|::..|         .|..
Mouse   252 LLK-ENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKS---------TLDT 306

  Fly   460 DFYFAFLGIAPMKADLRF----LKSLAINSIRYSALVGEEKRV----GYRKWQ 504
            |:...       |.|:.|    .|.|.||:.:.|.|..|||:.    .||::|
Mouse   307 DYQMT-------KKDMGFTEEEFKRLNINAAKSSFLPEEEKKELLERLYREYQ 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-B	NP_649006.2	A_deaminase_N	36..113	CDD:285627
		adm_rel	56..515	CDD:273620	81/313 (26%)
		ADGF	93..507	CDD:238646	81/313 (26%)
Ada	NP_001258981.1	ADA	8..336	CDD:238645	74/295 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810