DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6034 and FMS1

DIOPT Version :9

Sequence 1:	NP_649005.1	Gene:	CG6034 / 39974	FlyBaseID:	FBgn0036750	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_013733.1	Gene:	FMS1 / 855034	SGDID:	S000004622	Length:	508	Species:	Saccharomyces cerevisiae

Alignment Length:	552	Identity:	132/552 - (23%)
Similarity:	218/552 - (39%)	Gaps:	138/552 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TFSKTKETAKIVIIGAGASGVAAATKLLEQGFKNVLLFEAEDRIGGRINTIL-FANSLIDLGAQW 72
            |.|..|:  |::|||||.:|:.||:.|.:.|.::.|:.||.||:|||:.|:. :.....|:||.|
Yeast     3 TVSPAKK--KVIIIGAGIAGLKAASTLHQNGIQDCLVLEARDRVGGRLQTVTGYQGRKYDIGASW 65

  Fly    73 CHGEEGNVVYEKVKDLDVLDRTGDYVV---HFIRSNKEILTDVHNKAL------TELTNAFEVPG 128
            .|....|.::.:...|.:.|....:|.   :||..::|.....|:|.|      .|::...|:..
Yeast    66 HHDTLTNPLFLEEAQLSLNDGRTRFVFDDDNFIYIDEERGRVDHDKELLLEIVDNEMSKFAELEF 130

  Fly   129 EHEGSVGDAFNAYWKENIHQLVPNDKTIAKEAQDCLKKVICSMDACDNLSELSYRNFRNFAIAGG 193
            .....|.|.       :..|||.  |.:.:..|......|..:.......||.:
Yeast   131 HQHLGVSDC-------SFFQLVM--KYLLQRRQFLTNDQIRYLPQLCRYLELWH----------- 175

  Fly   194 DQNLSWRQKGYWKFLSVLLNSSDNQPGDQGILKGHVHLN-----KRIAKI---NW---------- 240
              .|.|:          ||::.|...|.||  :....||     :|||:.   ||
Yeast   176 --GLDWK----------LLSAKDTYFGHQG--RNAFALNYDSVVQRIAQSFPQNWLKLSCEVKSI 226

  Fly   241 --EGDGELTLRCWNGQFVSADHVICTV-----SLGVLREKHHK---LFVPALPASKIRSIEGLKL 295
              |....:|:.|.:|...:||:||.||     :|.|..||:.:   .|.|.|......:.:.:..
Yeast   227 TREPSKNVTVNCEDGTVYNADYVIITVPQSVLNLSVQPEKNLRGRIEFQPPLKPVIQDAFDKIHF 291

  Fly   296 GTVNKFYLEFEE---------------------QPV--PENIREMAFLWLEEDLKELRSGKYFWL 337
            |.:.|...||||                     :.|  .||:.|:..: ||.:..:..:....|.
Yeast   292 GALGKVIFEFEECCWSNESSKIVTLANSTNEFVEIVRNAENLDELDSM-LEREDSQKHTSVTCWS 355

  Fly   338 ESVCYFH-----RVDCQPRLLQGWIIGAHSRYVETISE----------------------EQVLE 375
            :.:.:.:     .|.....|:|..:    :.::|:|.|                      |.|::
Yeast   356 QPLFFVNLSKSTGVASFMMLMQAPL----TNHIESIREDKERLFSFFQPVLNKIMKCLDSEDVID 416

  Fly   376 GIMWMFRKFLKFSVPYPKNFLRSQWQSNPNFRGSYSYYSTYADELRTGRTDLASPLVDVTGR-PR 439
            | |.........:.|..:|.:.|.|..:|..||:||......|.:     |:...:.:  |: .|
Yeast   417 G-MRPIENIANANKPVLRNIIVSNWTRDPYSRGAYSACFPGDDPV-----DMVVAMSN--GQDSR 473

  Fly   440 IQFAGEASSRNHFSTVHGAIESGWREAERLNE 471
            |:||||.:..:.....:||.|||.|||.|:::
Yeast   474 IRFAGEHTIMDGAGCAYGAWESGRREATRISD 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6034	NP_649005.1	Amino_oxidase	33..470	CDD:279874	120/525 (23%)
CG6034	NP_649005.1	NAD_binding_8	<35..88	CDD:290186	17/53 (32%)
FMS1	NP_013733.1	Amino_oxidase	18..503	CDD:396255	122/531 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000632
OrthoInspector	1	1.000	-	-		otm46708
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2622
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.900