DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6034 and Maoa

DIOPT Version :9

Sequence 1:	NP_649005.1	Gene:	CG6034 / 39974	FlyBaseID:	FBgn0036750	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_387502.1	Gene:	Maoa / 29253	RGDID:	61898	Length:	526	Species:	Rattus norvegicus

Alignment Length:	508	Identity:	120/508 - (23%)
Similarity:	200/508 - (39%)	Gaps:	104/508 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 IVIIGAGASGVAAATKLLEQGFKNVLLFEAEDRIGGRINTILFANSLIDLGAQWCHGEEGNVVYE 83
            :|:||.|.||:||| |||.:...|||:.||.||:|||..|                     |..|
  Rat    16 VVVIGGGISGLAAA-KLLSEYKINVLVLEARDRVGGRTYT---------------------VRNE 58

  Fly    84 KVKDLDVLDRTGDYV----VHFIRSNKEILTDVH----NKALTELTNAFEVPGEHEGSVGDAFN- 139
            .||.:||   .|.||    ...:|.:||:..:.:    |:.|.:.......|  ..|:....:|
  Rat    59 HVKWVDV---GGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYP--FRGAFPPVWNP 118

  Fly   140 -AY------WK--ENIHQLVPNDKT-IAKEAQD----CLKKVICSMDACDNLSELSYRNFRNFAI 190
             ||      |:  :.:.:.:|.|.. .|:.||:    .:|.:|..:.......|.:|. |.|..:
  Rat   119 LAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYL-FVNINV 182

  Fly   191 AGGDQNLS-----W--RQKGYWKFLSVLLN--------SSDNQPGDQ--GILKGHVHLNKRIAKI 238
            ......:|     |  ||.|....:..:.|        ....|..:|  |:|...|.|:..:..|
  Rat   183 TSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYI 247

  Fly   239 NWEGDGELTLRCWNGQFVSADHVICTVSLGVLREKHHKLFVPALPASKIRSIEGLKLGTVNKFYL 303
            : :.|..:.:...|.:.....:||..:. .:|..|.|  |.|.||..:.:.|:.|.:|.|.|..:
  Rat   248 D-QTDDNIIVETLNHEHYECKYVISAIP-PILTAKIH--FKPELPPERNQLIQRLPMGAVIKCMV 308

  Fly   304 EFEEQPVPENIREMAFLWLEED------LKELRSGKYFWLESVCYFHRVDCQPRLLQGWIIGAHS 362
            .::|          || |.::|      :::..:.....|:..    :.|.....:.|:|:...:
  Rat   309 YYKE----------AF-WKKKDYCGCMIIEDEEAPIAITLDDT----KPDGSLPAIMGFILARKA 358

  Fly   363 RYVETISEEQVLEGIMWMFRKFL-KFSVPYPKNFLRSQWQSNPNFRGSYSYYSTYADELRTGRTD 426
            ..:..:.::.....|..::.|.| .....||.::....|.......|.|:.|.......:.||.
  Rat   359 DRLAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRV- 422

  Fly   427 LASPLVDVTGRPRIQFAGEASSRNHFSTVHGAIESGWREA-ERLNEFYEGRAA 478
            :..|:      .||.|||..::......:.||:|:|.|.| |.||..  |:.|
  Rat   423 IRQPV------GRIYFAGTETATQWSGYMEGAVEAGERAAREVLNAL--GKVA 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6034	NP_649005.1	Amino_oxidase	33..470	CDD:279874	107/484 (22%)
CG6034	NP_649005.1	NAD_binding_8	<35..88	CDD:290186	17/52 (33%)
Maoa	NP_387502.1	YobN	15..463	CDD:224152	118/500 (24%)
		NAD_binding_8	18..84	CDD:290186	33/90 (37%)
		Interaction with membrane phospholipid headgroups. /evidence=ECO:0000250	520..522
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343405
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840