DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6034 and lsd1

DIOPT Version :9

Sequence 1:	NP_649005.1	Gene:	CG6034 / 39974	FlyBaseID:	FBgn0036750	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_595398.1	Gene:	lsd1 / 2539805	PomBaseID:	SPBC146.09c	Length:	1000	Species:	Schizosaccharomyces pombe

Alignment Length:	552	Identity:	120/552 - (21%)
Similarity:	208/552 - (37%)	Gaps:	172/552 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 IVIIGAGASGVAAATKL------LEQGF-------KNVLLFEAEDRIGGRINTILFANSLIDLGA 70
            :.|||||.:|::.|.:|      .||.|       ..::::||.:|:||.|.|.:...|
pombe   260 VAIIGAGMAGISCARQLTNLFAQYEQDFLSRGEKPPRIVIYEASERLGGHIYTHMVPLS------ 318

  Fly    71 QWCHGEEGNVVYEKVKDLDVLDRTGDYVVH-----------------FIRSNKEILTD-VHNK-- 115
                   .|.|.||......::.|.:.:|:                 :|.|::::..| ||.:
pombe   319 -------DNEVSEKSSLATTVNATNECMVNLLTDSLIGMPTLDSDPLYIISSQQLSLDAVHTRNR 376

  Fly   116 --ALTELTNAFEVPGEHEGSVGDAFNA---YW-----KENIHQLV--PNDKTIAK---------- 158
              .|.::.|. .:..||...:...|:|   |:     |:.:|.|:  |..:.|.|
pombe   377 EFILHDIENG-RIDTEHVQRIFRLFDALLFYFNASASKQPLHSLITPPEQEFIQKLDQIGWYISI 440

  Fly   159 -----EAQDCLKKVI-CSMDACDNLSELSYRNFRNFAIAGGDQNLSWRQKGYWKFLSV------- 210
                 :.:|.|.:.: .|.:...:|..|:..:.:.|         .|.::...:.|||
pombe   441 EAFPLQIKDTLSEFLGNSANTLTSLLHLTVLDLKIF---------EWFKEYLSQSLSVSLENVYP 496

  Fly   211 -------------------------LLNSSDNQPGDQGILKGHVHLNKRIAKINWEGDGELTLRC 250
                                     :|||..:.|....||     .::.:..:..| |..:.|..
pombe   497 GSIPNLNLLLGENVASYSFKHGMADMLNSLASTPSPLPIL-----FDQCVHTVKLE-DNTVNLSF 555

  Fly   251 WNGQFVSADHVICTVSLGVLREKHHKLFVPALPASKIRSIEGLKLGTVNKFYLEFEEQPVPENIR 315
            .|...||.|.|:..:.:..| ..|...|.|.|...|:::|:......|.|..|.|:.|....||
pombe   556 VNETTVSVDKVVICIPMDKL-NTHLITFEPPLEEKKLKAIDRCHFTNVKKVILIFKTQFWEPNI- 618

  Fly   316 EMAFLWLEEDLKELRSGKYFWLESVCYFHRVDCQPRL-----LQGWIIGAHSRYVETISEEQVLE 375
             ..|..|.:|     ||:.|.......|:.   .|.|     ::|         ::.:.::.::.
pombe   619 -SIFGSLPQD-----SGRNFIFNDCTRFYE---HPTLSVFVKVEG---------IDFMKDDDIVN 665

  Fly   376 GIMWMFRKFLKFSVPYPK----NFLR---SQWQSNPNFRGSYSYYSTYADE---LRTGRTDLASP 430
            ||:...:|..|     ||    |.:|   |.|::|     ||:.:|:|...   |......|:.|
pombe   666 GIVSQLKKVYK-----PKSEAINPIRTIISNWENN-----SYTNHSSYQISNLFLEEDYAILSEP 720

  Fly   431 LVDVTGRPRIQFAGEASSRNHFSTVHGAIESG 462
             :|.|    :.||.||.|:.:..::.||.:||
pombe   721 -IDNT----VFFASEAISQKNSGSIRGAFDSG 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6034	NP_649005.1	Amino_oxidase	33..470	CDD:279874	113/538 (21%)
CG6034	NP_649005.1	NAD_binding_8	<35..88	CDD:290186	16/65 (25%)
lsd1	NP_595398.1	SWIRM	157..240	CDD:282311
		NAD_binding_8	262..>316	CDD:290186	18/53 (34%)
		Amino_oxidase	267..755	CDD:279874	115/545 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2622
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.900