DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6034 and KDM1B

DIOPT Version :9

Sequence 1:	NP_649005.1	Gene:	CG6034 / 39974	FlyBaseID:	FBgn0036750	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	XP_016865929.1	Gene:	KDM1B / 221656	HGNCID:	21577	Length:	832	Species:	Homo sapiens

Alignment Length:	525	Identity:	135/525 - (25%)
Similarity:	224/525 - (42%)	Gaps:	121/525 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSACSEPTTFSKTKETAKIVIIGAGASGVAAATKLLEQGFKNVLLFEAEDRIGGRI-NTILFANS 64
            :|..::.....|......::|||||.:|:|||.:|...|.| |.:.||:||||||: :...|...
Human   376 LSVGADQYLLPKDYHNKSVIIIGAGPAGLAAARQLHNFGIK-VTVLEAKDRIGGRVWDDKSFKGV 439

  Fly    65 LIDLGAQ------------WCH---------GEEGNVVYEKVKDLD-VLDRTGDYVVHFIRSNKE 107
            .:..|||            .|.         ||..:::.|..:..| .:|:..|:  ||     .
Human   440 TVGRGAQIVNGCINNPVALMCEQLGISMHKFGERCDLIQEGGRITDPTIDKRMDF--HF-----N 497

  Fly   108 ILTDVHNKALTELTNAFEVP-GEHEGSVGDAFNAYWKENIHQLVPNDKTIAKEAQDCLKKVICSM 171
            .|.||.::...:.|...:|| ||   .:.:.:.|:.||:..|....:..:       |:..:.::
Human   498 ALLDVVSEWRKDKTQLQDVPLGE---KIEEIYKAFIKESGIQFSELEGQV-------LQFHLSNL 552

  Fly   172 D-AC-DNLSELSYRNFRN---FAIAGGDQNLSWRQKGYWKFLSVLLNSSDNQPGDQGILKGHVHL 231
            : || .||.::|.|::.:   ||...||..|  ...||...:..|....|.|      ||
Human   553 EYACGSNLHQVSARSWDHNEFFAQFAGDHTL--LTPGYSVIIEKLAEGLDIQ------LK----- 604

  Fly   232 NKRIAKINWEGDGELTLRCWNGQFVSADHVICTVSLGVLREKHHKLFVPALPASKIRSIEGLKLG 296
            :.::..|::.|| |:.:...:|...||..|:.||.|.:| :|....|.|.|...|:::|..|..|
Human   605 SPQVQCIDYSGD-EVQVTTTDGTGYSAQKVLVTVPLALL-QKGAIQFNPPLSEKKMKAINSLGAG 667

  Fly   297 TVNKFYLEFEEQPVPENIREMAFLWLEEDLKELRSGKYFWLESV-------------------CY 342
            .:.|..|:|..:                          ||...|                   ..
Human   668 IIEKIALQFPYR--------------------------FWDSKVQGADFFGHVPPSASKRGLFAV 706

  Fly   343 FHRVDCQPR--LLQGWIIGAHSRYVETISEEQVLEGIMWMFRK-FLKFSVPYPKNFLRSQWQSNP 404
            |:.:|.|.:  :|...|.|.....|.|:.::|||:..|...|: |.:..||.|..:..::|.::|
Human   707 FYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKEQEVPDPTKYFVTRWSTDP 771

  Fly   405 NFRGSYSYYSTYADELRTGRTDLASPLV--DVTGRPRIQFAGEASSRNHFSTVHGAIESGWREAE 467
            ..:.:||:       ::||.:..|..::  |:.|  .:.|||||::|:...||.||..||.|||.
Human   772 WIQMAYSF-------VKTGGSGEAYDIIAEDIQG--TVFFAGEATNRHFPQTVTGAYLSGVREAS 827

  Fly   468 RLNEF 472
            ::..|
Human   828 KIAAF 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6034	NP_649005.1	Amino_oxidase	33..470	CDD:279874	123/489 (25%)
CG6034	NP_649005.1	NAD_binding_8	<35..88	CDD:290186	20/74 (27%)
KDM1B	XP_016865929.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6365
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2622
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.890