Protein Alignment CG6034 and KDM1B

DIOPT Version :10

• Sequence 1: NP_649005.1
• Gene: CG6034 / 39974
• FlyBaseID: FBgn0036750
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_001426046.1
• Gene: KDM1B / 221656
• HGNCID: 21577
• Length: 832
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 135/525 - (25%)
• Similarity: 224/525 - (42%)
• Gaps: 121/525 - (23%)

  Fly     1 MSACSEPTTFSKTKETAKIVIIGAGASGVAAATKLLEQGFKNVLLFEAEDRIGGRI-NTILFANS 64
            :|..::.....|......::|||||.:|:|||.:|...|.| |.:.||:||||||: :...|...
Human   376 LSVGADQYLLPKDYHNKSVIIIGAGPAGLAAARQLHNFGIK-VTVLEAKDRIGGRVWDDKSFKGV 439

  Fly    65 LIDLGAQ------------WCH---------GEEGNVVYEKVKDLD-VLDRTGDYVVHFIRSNKE 107
            .:..|||            .|.         ||..:::.|..:..| .:|:..|:  ||     .
Human   440 TVGRGAQIVNGCINNPVALMCEQLGISMHKFGERCDLIQEGGRITDPTIDKRMDF--HF-----N 497

  Fly   108 ILTDVHNKALTELTNAFEVP-GEHEGSVGDAFNAYWKENIHQLVPNDKTIAKEAQDCLKKVICSM 171
            .|.||.::...:.|...:|| ||   .:.:.:.|:.||:..|....:..:       |:..:.::
Human   498 ALLDVVSEWRKDKTQLQDVPLGE---KIEEIYKAFIKESGIQFSELEGQV-------LQFHLSNL 552

  Fly   172 D-AC-DNLSELSYRNFRN---FAIAGGDQNLSWRQKGYWKFLSVLLNSSDNQPGDQGILKGHVHL 231
            : || .||.::|.|::.:   ||...||..|  ...||...:..|....|.|      ||
Human   553 EYACGSNLHQVSARSWDHNEFFAQFAGDHTL--LTPGYSVIIEKLAEGLDIQ------LK----- 604

  Fly   232 NKRIAKINWEGDGELTLRCWNGQFVSADHVICTVSLGVLREKHHKLFVPALPASKIRSIEGLKLG 296
            :.::..|::.|| |:.:...:|...||..|:.||.|.:| :|....|.|.|...|:::|..|..|
Human   605 SPQVQCIDYSGD-EVQVTTTDGTGYSAQKVLVTVPLALL-QKGAIQFNPPLSEKKMKAINSLGAG 667

  Fly   297 TVNKFYLEFEEQPVPENIREMAFLWLEEDLKELRSGKYFWLESV-------------------CY 342
            .:.|..|:|..:                          ||...|                   ..
Human   668 IIEKIALQFPYR--------------------------FWDSKVQGADFFGHVPPSASKRGLFAV 706

  Fly   343 FHRVDCQPR--LLQGWIIGAHSRYVETISEEQVLEGIMWMFRK-FLKFSVPYPKNFLRSQWQSNP 404
            |:.:|.|.:  :|...|.|.....|.|:.::|||:..|...|: |.:..||.|..:..::|.::|
Human   707 FYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKEQEVPDPTKYFVTRWSTDP 771

  Fly   405 NFRGSYSYYSTYADELRTGRTDLASPLV--DVTGRPRIQFAGEASSRNHFSTVHGAIESGWREAE 467
            ..:.:||:       ::||.:..|..::  |:.|  .:.|||||::|:...||.||..||.|||.
Human   772 WIQMAYSF-------VKTGGSGEAYDIIAEDIQG--TVFFAGEATNRHFPQTVTGAYLSGVREAS 827

  Fly   468 RLNEF 472
            ::..|
Human   828 KIAAF 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6034	NP_649005.1	Amino_oxidase	33..470	CDD:396255	123/489 (25%)
KDM1B	NP_001426046.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47
		GLYR1-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS, ECO:0007744|PDB:4GUT, ECO:0007744|PDB:4GUU	282..301
		Histone H3-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23266887, ECO:0007744|PDB:4FWF, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS	447..476		3/28 (11%)
		Histone H3-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23266887, ECO:0007744|PDB:4FWF, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS	496..507		4/15 (27%)
		Histone H3-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23266887, ECO:0007744|PDB:4FWF, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS	547..581		9/33 (27%)
		GLYR1-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS, ECO:0007744|PDB:4GUT, ECO:0007744|PDB:4GUU	573..575		0/1 (0%)
		GLYR1-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS, ECO:0007744|PDB:4GUT, ECO:0007744|PDB:4GUU	808..824		7/15 (47%)