DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7460 and Su(var)3-3

DIOPT Version :9

Sequence 1:	NP_001261998.1	Gene:	CG7460 / 39973	FlyBaseID:	FBgn0036749	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_649194.1	Gene:	Su(var)3-3 / 40217	FlyBaseID:	FBgn0260397	Length:	890	Species:	Drosophila melanogaster

Alignment Length:	608	Identity:	142/608 - (23%)
Similarity:	239/608 - (39%)	Gaps:	182/608 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 RQTARIVIVGAGSAGIAAATRLLDLGFRNVLLLEAEDRIGGRVHTIPFADNVVDLGAQWCHGEKG 77
            ::..:::::|||.:|:|.|.:|...|. :|::|||.||:|||:.|......:.|:||....|..|
  Fly   262 KKLGKVIVIGAGISGLAVAHQLQQFGM-DVIVLEARDRVGGRISTFRKNSYIADVGAMVVTGVYG 325

  Fly    78 N--VVYDKVKDLNLLEV--TEPHY-----------------ETFRCVRSNKEV-----------L 110
            |  .:..|...::|:.:  |.|.|                 |..|.:.|...:           .
  Fly   326 NPMTILSKQIGMDLVPIQQTCPLYGPDGKPVPKEKDDVIEREFNRLLESASYLSHRLDFNYAGDC 390

  Fly   111 PDDLADQLKTIADM---------------------SIPDRQAELLDFEGSLGDYIN--------- 145
            |..|.|.|:.|..|                     .|.:::..|.....::|...|
  Fly   391 PVSLGDALEWIISMQEMQVMHKRGQHMQEIIATQTKIIEQRRRLKTLRDTIGKLKNEHLAMINQR 455

  Fly   146 --------MKY-WKEL------AKLPPIDRTIAEEFLEVFHKFEASVE---AADHLFEVSGKGHL 192
                    :|| ::|.      .|:        ||.:..||...|..:   |..|..|.:....:
  Fly   456 KPKGTDGDLKYCYQEFNIRNTQIKM--------EETISTFHDLHAEEKQMLAKLHELEQNRPSDV 512

  Fly   193 EYWLCEGELLLNWKDKGYK-----RFLKLLMKAPEDQSEDLGILKDH------------------ 234
             |......|:|:|.....:     |...|.:| ..||.:|...:..|
  Fly   513 -YLSSRDRLILDWHFANLEFANATRLNNLSLK-HWDQDDDFEFIGHHTTVRNGYSCVPVALTENL 575

  Fly   235 -VRLNRRIAEINW--KGADEL--TVRCWNGEV-ITADHVICTVSLGVLK---------EQHPKLF 284
             :|:|..:.||.:  ||.:.:  .::..|.:: ..||.|:||::|||||         :.:...|
  Fly   576 DIRVNSAVKEIKYGTKGVEVVAENLKTSNSQMTYKADLVVCTLTLGVLKVAVAHKESQQSNTVKF 640

  Fly   285 VPALPAAKVRAIEGLKLGTVDKFFLEFENPPLPGDWPGFNCLWLKEDLEELRASELFW--LESVF 347
            .|.||..|.:||:.|..|.::|..|.|:                          .:||  ..::|
  Fly   641 DPPLPDWKQQAIKRLGFGNLNKVVLCFD--------------------------RIFWDPNANLF 679

  Fly   348 G--------------FYPVSRQPRILQGWIIGPHARHMETLTEERVLEGLLWLFRK-FLPFETAH 397
            |              |:.:|..| :|...:.|..|..:|::|::.::...:.:.:. |.......
  Fly   680 GHVGSTTASRGEMFLFWSISSSP-VLLALVAGMAANLVESVTDDIIIGRCMSVLKNIFGNTSVPQ 743

  Fly   398 PVRMLRTQWHANPNFRGSYTFRSTYTDALRTGAWD-LEAPL-----QDVCGRPRLQFAGESTHKH 456
            |...:.|:|.::|..||||::.|..:..   ..:| |.||:     :|..|.|||.||||.|.::
  Fly   744 PKETVVTRWRSDPWARGSYSYVSVGSSG---SDYDLLAAPVIPPSSKDAEGLPRLFFAGEHTIRN 805

  Fly   457 FYSTVHGAVETGWREAERLHLYY 479
            :.:|||||..:|.|||.|:..||
  Fly   806 YPATVHGAYLSGLREAGRIADYY 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7460	NP_001261998.1	Amino_oxidase	32..476	CDD:279874	134/584 (23%)
CG7460	NP_001261998.1	NAD_binding_8	33..>74	CDD:290186	15/40 (38%)
Su(var)3-3	NP_649194.1	SWIRM	165..250	CDD:282311
		NAD_binding_8	269..327	CDD:290186	23/58 (40%)
		Amino_oxidase	274..824	CDD:279874	136/590 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452796
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46708
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10742
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940