DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7460 and Smox

DIOPT Version :9

Sequence 1:	NP_001261998.1	Gene:	CG7460 / 39973	FlyBaseID:	FBgn0036749	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	XP_006235125.1	Gene:	Smox / 308652	RGDID:	1306049	Length:	585	Species:	Rattus norvegicus

Alignment Length:	593	Identity:	180/593 - (30%)
Similarity:	248/593 - (41%)	Gaps:	157/593 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 KTRQTARIVIVGAGSAGIAAATRLLDLGFRNVLLLEAEDRIGGRVHTIPFADNVVDLGAQWCHGE 75
            :.|...|:|::|||.||:|||..||:.||.:|.:|||...|||||.::.......:|||.|.||.
  Rat    20 RRRGQPRVVVIGAGLAGLAAARALLEQGFTDVTVLEASSHIGGRVQSVKLGHATFELGATWIHGS 84

  Fly    76 KGNVVYDKVKDLNLLEVTEPH-----------------YETFRCVRSNKEVLPD--DLADQLKTI 121
            .||.:|...:...|||.|...                 |.|.|..|..|:|:.:  ||.:::..:
  Rat    85 HGNPIYQLAEANGLLEETTDGERSVGRISLYSKNGVACYLTNRGRRIPKDVVEEFSDLYNEVYNL 149

  Fly   122 ADMSIPDRQAELLDFEGSLGDYINMKYWKELAKLPPIDRTIA---------EEFLEV------FH 171
            ......:.:....:.:.|:|.:...|....:...|  |.|.|         :::|:|      .|
  Rat   150 TQEFFRNGKPVNAESQNSVGVFTREKVRNRIRDDP--DDTEATKRLKLAMIQQYLKVESCESSSH 212

  Fly   172 KF-EASVEAADHLFEVSGKGHLEYWLCEGELLLNWKDKGYKRFLKLLMKAPEDQSEDLGILKDHV 235
            .. |.|:.|.....|:.|..|:             ...|:.|.::||.|         ||....:
  Rat   213 SIDEVSLSAFGEWTEIPGAHHI-------------IPSGFMRVVELLAK---------GIPPHVI 255

  Fly   236 RLNRRIAEINWKGA--------------------------------------DE---LTVRCWNG 259
            :|.:.:..|:|..|                                      ||   :.|.|.:.
  Rat   256 QLGKPVRCIHWDQASARPRGPEIEPRGEGDHNHDAGEGGQSGENPQQGRWDEDEQWPVVVECEDC 320

  Fly   260 EVITADHVICTVSLGVLKEQHPKLFVPALPAAKVRAIEGLKLGTVDKFFLEFENPPLPGDW-PGF 323
            |||.|||||.||||||||.|:...|.|.||..||.||..|.:||.||.|||||.|    .| |..
  Rat   321 EVIPADHVIVTVSLGVLKRQYTSFFRPCLPTEKVAAIHRLGIGTTDKIFLEFEEP----FWGPEC 381

  Fly   324 NCL---WLKEDLEE---LRASELFWLESVFGF---YPVSRQPRILQGWIIGPHARHMETLTEERV 379
            |.|   |  ||..|   |......|...:.||   ||..|...:|.|||.|..|..||...:|.|
  Rat   382 NSLQFVW--EDEAESCTLTYPPELWYRKICGFDVLYPPERYGHVLSGWICGEEALVMERCDDEAV 444

  Fly   380 LEGLLWLFRKF-----LPFETAHPVRMLRTQWHANPNFRGSYTFRST---------------YTD 424
            .|....:.|:|     :|    .|.|:||:.|.:||.|||||::...               ||:
  Rat   445 AEICTEMLRQFTGNPNIP----KPRRILRSAWGSNPYFRGSYSYTQVGSSGADVEKLAKPLPYTE 505

  Fly   425 ALRT--GAWDLEAP---LQDVCGRPRLQ------------FAGESTHKHFYSTVHGAVETGWREA 472
            :.:|  |:...:.|   |...|....|.            |:||:||:.:|||.|||:.:|.|||
  Rat   506 SSKTAHGSSTKQQPGHLLSSKCPEQSLDPSRGSIKPMQVLFSGEATHRKYYSTTHGALLSGQREA 570

  Fly   473 ERLHLYYR 480
            .||...||
  Rat   571 ARLIEMYR 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7460	NP_001261998.1	Amino_oxidase	32..476	CDD:279874	166/566 (29%)
CG7460	NP_001261998.1	NAD_binding_8	33..>74	CDD:290186	17/40 (43%)
Smox	XP_006235125.1	NAD_binding_8	<45..88	CDD:290186	18/42 (43%)
Smox	XP_006235125.1	PLN02568	50..578	CDD:215308	163/561 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343428
Domainoid	1	1.000	138	1.000	Domainoid score	I4710
eggNOG	1	0.900	-	-		E1_KOG0685
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375579at33208
OrthoFinder	1	1.000	-	-		FOG0000632
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10742
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X429
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.850