DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7460 and Maoa

DIOPT Version :9

Sequence 1:	NP_001261998.1	Gene:	CG7460 / 39973	FlyBaseID:	FBgn0036749	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_387502.1	Gene:	Maoa / 29253	RGDID:	61898	Length:	526	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	119/512 - (23%)
Similarity:	199/512 - (38%)	Gaps:	122/512 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 IVIVGAGSAGIAAATRLLDLGFRNVLLLEAEDRIGGRVHTIPFADNV--VDLGAQWCHGEKGNVV 80
            :|::|.|.:|:||| :||.....|||:|||.||:|||.:|:. .::|  ||:|..:. |...|.:
  Rat    16 VVVIGGGISGLAAA-KLLSEYKINVLVLEARDRVGGRTYTVR-NEHVKWVDVGGAYV-GPTQNRI 77

  Fly    81 YDKVKDLNLLEVTEPHYETFRCVRSNKEVLPDDLADQLKTIADMSIPDRQAELLDFEGSLG---- 141
            ....|:|.:        ||:: |..|:.:        ::.:...:.|        |.|:..
  Rat    78 LRLSKELGI--------ETYK-VNVNERL--------VQYVKGKTYP--------FRGAFPPVWN 117

  Fly   142 -----DYINMKYWK---ELAKLPPID-------------------------RTIAEEFLEVFHKF 173
                 ||.|:  |:   |:.|..|:|                         ...|.||..:|
  Rat   118 PLAYLDYNNL--WRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLF--- 177

  Fly   174 EASVEAADHLFEVSGKGHLEY-WLCEGEL-LLNWKDKGYKRFLKLLMKAPEDQSEDLGILKDHVR 236
             .::.......|||....|.| ..|.|.. :.:..:.|.:|  |.:..:.:...:.:|:|.|.|:
  Rat   178 -VNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQER--KFVGGSGQVSEQIMGLLGDKVK 239

  Fly   237 LNRRIAEINWKGADELTVRCWNGEVITADHVICTVSLGVLKEQHPKLFVPALPAAKVRAIEGLKL 301
            |:..:..|: :..|.:.|...|.|.....:||..:...:..:.|   |.|.||..:.:.|:.|.:
  Rat   240 LSSPVTYID-QTDDNIIVETLNHEHYECKYVISAIPPILTAKIH---FKPELPPERNQLIQRLPM 300

  Fly   302 GTVDKFFLEFENPPLPGDWPGFNCLWLKED------LEELRASELFWLESVFGFYPVSRQPRILQ 360
            |.|.|..:.::           ...|.|:|      :|:..|.....|:..   .|....|.|:
  Rat   301 GAVIKCMVYYK-----------EAFWKKKDYCGCMIIEDEEAPIAITLDDT---KPDGSLPAIM- 350

  Fly   361 GWIIGPHARHMETLTEERVLEGLLWLFRKFLPFETA-HPVRMLRTQWHANPNFRGSYT------F 418
            |:|:...|..:..|.::.....:..|:.|.|..:.| :||......|.......|.||      .
  Rat   351 GFILARKADRLAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGI 415

  Fly   419 RSTYTDALRTGAWDLEAPLQDVCGRPRLQFAGESTHKHFYSTVHGAVETGWREAERL 475
            .:.|...:|          |.|   .|:.|||..|...:...:.||||.|.|.|..:
  Rat   416 MTQYGRVIR----------QPV---GRIYFAGTETATQWSGYMEGAVEAGERAAREV 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7460	NP_001261998.1	Amino_oxidase	32..476	CDD:279874	112/498 (22%)
CG7460	NP_001261998.1	NAD_binding_8	33..>74	CDD:290186	18/42 (43%)
Maoa	NP_387502.1	YobN	15..463	CDD:224152	119/512 (23%)
		NAD_binding_8	18..84	CDD:290186	27/68 (40%)
		Interaction with membrane phospholipid headgroups. /evidence=ECO:0000250	520..522
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343406
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840