DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7460 and lsd1

DIOPT Version :9

Sequence 1:	NP_001261998.1	Gene:	CG7460 / 39973	FlyBaseID:	FBgn0036749	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_595398.1	Gene:	lsd1 / 2539805	PomBaseID:	SPBC146.09c	Length:	1000	Species:	Schizosaccharomyces pombe

Alignment Length:	583	Identity:	117/583 - (20%)
Similarity:	202/583 - (34%)	Gaps:	200/583 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ASLRLLSKTRQTARIVIVGAGSAGIAAATRLLDLGFR-------------NVLLLEAEDRIGGRV 55
            :||:|.....|.. :.|:|||.|||:.|.:|.:|..:             .:::.||.:|:||.:
pombe   247 SSLKLDESLSQKT-VAIIGAGMAGISCARQLTNLFAQYEQDFLSRGEKPPRIVIYEASERLGGHI 310

  Fly    56 --HTIPFADNVVDLGAQWCHGEKG--------------NVVYDKVKDLNLLEVTEPHYETFRCVR 104
              |.:|.:||.|        .||.              |::.|.:..:..|: ::|.|     :.
pombe   311 YTHMVPLSDNEV--------SEKSSLATTVNATNECMVNLLTDSLIGMPTLD-SDPLY-----II 361

  Fly   105 SNKEVLPDDLADQLKTIADMSIPDRQAELLDFEGSLGDYINMK-----------YWKELAKLPPI 158
            |::::..|.:..:          :|:..|.|.|....|..:::           |:...|...|:
pombe   362 SSQQLSLDAVHTR----------NREFILHDIENGRIDTEHVQRIFRLFDALLFYFNASASKQPL 416

  Fly   159 DRTIA---EEFLEVFHK--FEASVEA-----ADHLFEVSGKG--------HLEY-------WLCE 198
            ...|.   :||::...:  :..|:||     .|.|.|..|..        ||..       |..|
pombe   417 HSLITPPEQEFIQKLDQIGWYISIEAFPLQIKDTLSEFLGNSANTLTSLLHLTVLDLKIFEWFKE 481

  Fly   199 -------------------------GELLLNWKDK-GYKRFLKLLMKAPE------DQSEDLGIL 231
                                     ||.:.::..| |....|..|...|.      ||......|
pombe   482 YLSQSLSVSLENVYPGSIPNLNLLLGENVASYSFKHGMADMLNSLASTPSPLPILFDQCVHTVKL 546

  Fly   232 KDHVRLNRRIAEINWKGADELTVRCWNGEVITADHVICTVSLGVLKEQHPKLFVPALPAAKVRAI 296
            :|:.        :|....:|.||        :.|.|:..:.:..| ..|...|.|.|...|::||
pombe   547 EDNT--------VNLSFVNETTV--------SVDKVVICIPMDKL-NTHLITFEPPLEEKKLKAI 594

  Fly   297 EGLKLGTVDKFFLEFENPPLPGDWPGFNCLWLKEDLEELRASELFWLE--SVFGFYPVSRQPRIL 359
            :......|.|..|.|:..                          ||..  |:||..|....
pombe   595 DRCHFTNVKKVILIFKTQ--------------------------FWEPNISIFGSLPQDSG---- 629

  Fly   360 QGWIIGPHARHME--TLT------------EERVLEGLLWLFRK-FLP-FETAHPVRMLRTQWHA 408
            :.:|.....|..|  ||:            ::.::.|::...:| :.| .|..:|:|.:.:.|..
pombe   630 RNFIFNDCTRFYEHPTLSVFVKVEGIDFMKDDDIVNGIVSQLKKVYKPKSEAINPIRTIISNWEN 694

  Fly   409 NPNFRGSYTFRSTYTDA---LRTGAWDLEAPLQDVCGRPRLQFAGESTHKHFYSTVHGAVETG 468
            |     |||..|:|..:   |......|..|:.:.     :.||.|:..:....::.||.::|
pombe   695 N-----SYTNHSSYQISNLFLEEDYAILSEPIDNT-----VFFASEAISQKNSGSIRGAFDSG 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7460	NP_001261998.1	Amino_oxidase	32..476	CDD:279874	105/555 (19%)
CG7460	NP_001261998.1	NAD_binding_8	33..>74	CDD:290186	12/55 (22%)
lsd1	NP_595398.1	SWIRM	157..240	CDD:282311
		NAD_binding_8	262..>316	CDD:290186	16/53 (30%)
		Amino_oxidase	267..755	CDD:279874	109/562 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870