Protein Alignment CG7460 and KDM1B

DIOPT Version :10

• Sequence 1: NP_649004.1
• Gene: CG7460 / 39973
• FlyBaseID: FBgn0036749
• Length: 486
• Species: Drosophila melanogaster
• Sequence 2: NP_001426046.1
• Gene: KDM1B / 221656
• HGNCID: 21577
• Length: 832
• Species: Homo sapiens
• Alignment Length: 526
• Identity: 138/526 - (26%)
• Similarity: 215/526 - (40%)
• Gaps: 138/526 - (26%)

  Fly     8 LLSKTRQTARIVIVGAGSAGIAAATRLLDLGFRNVLLLEAEDRIGGRV-HTIPFADNVVDLGAQW 71
            ||.|......::|:|||.||:|||.:|.:.|.: |.:|||:||||||| ....|....|..|||.
Human   384 LLPKDYHNKSVIIIGAGPAGLAAARQLHNFGIK-VTVLEAKDRIGGRVWDDKSFKGVTVGRGAQI 447

  Fly    72 CHGEKGNVVYDKVKDLNLLEVTEPHYETFRCVRSNKEVLPDDLADQLKTIADMSIPDRQAELLDF 136
            .:|...|.|....:.|.:    ..|....||          ||..:...|.|.:|..|    :||
Human   448 VNGCINNPVALMCEQLGI----SMHKFGERC----------DLIQEGGRITDPTIDKR----MDF 494

  Fly   137 E-GSLGDYINMKYWKELAKLP--PIDRTIAE-----------EFLEV------FHKFEASVEAAD 181
            . .:|.|.:: ::.|:..:|.  |:...|.|           :|.|:      ||..........
Human   495 HFNALLDVVS-EWRKDKTQLQDVPLGEKIEEIYKAFIKESGIQFSELEGQVLQFHLSNLEYACGS 558

  Fly   182 HLFEVSGKG--HLEYW--LCEGELLLNWKDKGYKRFLKLL-------MKAPEDQSEDLGILKDHV 235
            :|.:||.:.  |.|::  ......||.   .||...::.|       :|:|:.|.
Human   559 NLHQVSARSWDHNEFFAQFAGDHTLLT---PGYSVIIEKLAEGLDIQLKSPQVQC---------- 610

  Fly   236 RLNRRIAEINWKGADELTVRCWNGEVITADHVICTVSLGVLKEQHPKLFVPALPAAKVRAIEGLK 300
                    |::.| ||:.|...:|...:|..|:.||.|.:|::...: |.|.|...|::||..|.
Human   611 --------IDYSG-DEVQVTTTDGTGYSAQKVLVTVPLALLQKGAIQ-FNPPLSEKKMKAINSLG 665

  Fly   301 LGTVDKFFLEFENPPLPGDWPGFNCLWLKEDLEELRASELFWLESV-----FGFYPVSRQPR--- 357
            .|.::|..|:|                          ...||...|     ||..|.|...|
Human   666 AGIIEKIALQF--------------------------PYRFWDSKVQGADFFGHVPPSASKRGLF 704

  Fly   358 -------------ILQGWIIGPHARHMETLTEERVLEGLLWLFRK-FLPFETAHPVRMLRTQWHA 408
                         :|...|.|.....:.||.:::||:..:...|: |...|...|.:...|:|..
Human   705 AVFYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKEQEVPDPTKYFVTRWST 769

  Fly   409 NPNFRGSYTFRSTYTDALRTG----AWDLEAPLQDVCGRPRLQFAGESTHKHFYSTVHGAVETGW 469
            :|..:.:|:|       ::||    |:|:.|  :|:.|  .:.||||:|::||..||.||..:|.
Human   770 DPWIQMAYSF-------VKTGGSGEAYDIIA--EDIQG--TVFFAGEATNRHFPQTVTGAYLSGV 823

  Fly   470 REAERL 475
            |||.::
Human   824 REASKI 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7460	NP_649004.1	Amino_oxidase	32..476	CDD:396255	126/502 (25%)
KDM1B	NP_001426046.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47
		GLYR1-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS, ECO:0007744|PDB:4GUT, ECO:0007744|PDB:4GUU	282..301
		Histone H3-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23266887, ECO:0007744|PDB:4FWF, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS	447..476		7/42 (17%)
		Histone H3-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23266887, ECO:0007744|PDB:4FWF, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS	496..507		2/11 (18%)
		Histone H3-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23266887, ECO:0007744|PDB:4FWF, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS	547..581		7/33 (21%)
		GLYR1-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS, ECO:0007744|PDB:4GUT, ECO:0007744|PDB:4GUU	573..575		0/1 (0%)
		GLYR1-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS, ECO:0007744|PDB:4GUT, ECO:0007744|PDB:4GUU	808..824		7/15 (47%)