Protein Alignment Ccn and CCN2

DIOPT Version :10

• Sequence 1: NP_730294.1
• Gene: Ccn / 39972
• FlyBaseID: FBgn0052183
• Length: 470
• Species: Drosophila melanogaster
• Sequence 2: NP_001892.2
• Gene: CCN2 / 1490
• HGNCID: 2500
• Length: 349
• Species: Homo sapiens
• Alignment Length: 271
• Identity: 81/271 - (29%)
• Similarity: 113/271 - (41%)
• Gaps: 74/271 - (27%)

  Fly    21 ANLSLGFKAIKLPRHPNPANCSVGNTTFAHGVTFKLDCKTQCVCENGRHACSTLCPNE-QLPAPE 84
            ||..:|....|     :.|.|..|.|.:..|.:|:..||.||.|.:|...|..||..: :||:|:
Human    88 ANRKIGVCTAK-----DGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLCSMDVRLPSPD 147

  Fly    85 DTISCRSPRLVEVPGHCCKMWLCENPTAD----------------------VYATCHNSTTSGNW 127
                |..||.|::||.||:.|:|:.|...                      :.|.|...||  .|
Human   148 ----CPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALAAYRLEDTFGPDPTMIRANCLVQTT--EW 206

  Fly   128 TACSRSCGLGTATRHTTTHAGCHQLSNLRLCENRRCDKDDHEDNKWSRSRPLTHKRKQHRAHSHS 192
            :|||::||:|.:||.|..:|.|......|||..|.|:.|..|:
Human   207 SACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEADLEEN---------------------- 249

  Fly   193 HQRYHHHKEHEEPAHRIRKGHECRSIQRLG-PARIRLGECVSRKLYRPKLCGRCHRGVKCCAPAV 256
                            |:||.:|....::. |.:..|..|.|.|.||.|.||.|..| :||.|..
Human   250 ----------------IKKGKKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDG-RCCTPHR 297

  Fly   257 STTIQVELLCP 267
            :||:.||..||
Human   298 TTTLPVEFKCP 308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ccn	NP_730294.1	VWC	41..104	CDD:450195	25/63 (40%)
		TSP1_spondin	118..163	CDD:480609	19/44 (43%)
CCN2	NP_001892.2	IGFBP	29..82	CDD:459717
		VWC	103..163	CDD:278520	25/63 (40%)
		TSP1_CCN	199..242	CDD:465952	19/44 (43%)
		Heparin-binding. /evidence=ECO:0000269|PubMed:12553878	247..349		26/101 (26%)
		GHB_like	253..345	CDD:473907	23/57 (40%)