DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and PDR18

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_014468.3	Gene:	PDR18 / 855807	SGDID:	S000005353	Length:	1333	Species:	Saccharomyces cerevisiae

Alignment Length:	1311	Identity:	260/1311 - (19%)
Similarity:	435/1311 - (33%)	Gaps:	489/1311 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   546 QKNYGKLKAV-KGISLKMHRNEITVLLGHNGAGKTTTINMITGIVKPTSG--------------- 594
            :||..|:|.: |.:||.....|:.::||..|||.|:.:....|.....:|
Yeast    36 RKNRNKMKIILKNVSLLAKSGEMVLVLGRPGAGCTSFLKSAAGETSQFAGGVTTGHISYDGIPQK 100

  Fly   595 --------TAIVNG-YDIRTHLAKARESLGI---CPQ-----NNILFKEMSVRDHIIFFSKLKGI 642
                    ..|.|| .|:.......:::|..   |..     ||:. ||..:..:..|::|:.|:
Yeast   101 EMMQHYKPDVIYNGEQDVHFPHLTVKQTLDFAISCKMPAKRVNNVT-KEEYITANREFYAKIFGL 164

  Fly   643 RGTKAVENEVGKYMTMLKLQDKSYVAAKNLSGGMKRKLSLCCALCGNAKVVLCDEPSSGID---- 703
              |...:.:||          ..:::  .:|||.::::|:..||.....:...|..:.|:|
Yeast   165 --THTFDTKVG----------NDFIS--GVSGGERKRVSIAEALAAKGSIYCWDNATRGLDSSTA 215

  Fly   704 ---AAGRRSLWDLLQSEKDGRTILLTTHYMDEADVLG--DRIAILSEGKLQCQGTSFYLKKRF-G 762
               |...|::.:||     |.|.|:|.:...| ::..  |::.:|..|:....|.:...|..| .
Yeast   216 LEFARAIRTMTNLL-----GTTALVTVYQASE-NIYETFDKVTVLYAGRQIFCGKTTEAKDYFEN 274

  Fly   763 TGYLLVCIMQSGCDVGAVTQLIRKYVPPIKPERVLGTELTYRLPTEYSKKFAELLQDLDEKCAQL 827
            .|||......:...:.|:|.  ...:..|||    |.|  |::| ..:.:|.:...|..|
Yeast   275 MGYLCPPRQSTAEYLTAITD--PNGLHEIKP----GFE--YQVP-HTADEFEKYWLDSPE----- 325

  Fly   828 QLVGYGLSGATLEDVFMAVNTD--KRVQGGAEGPPVDGSIDFKELVFDSKTREKRRIRRCFMFWQ 890
                |......::.....|||:  |:.              :.|.:...|::..|:
Yeast   326 ----YARLKGEIQKYKHEVNTEWTKKT--------------YNESMAQEKSKGTRK--------- 363

  Fly   891 ALFLKKFYTTTRNYW----LLGIQLVLPI-AVMALTILNSRG--------GRIYYELPAMPISIN 942
                |.:||.  :||    |..|:..|.| ...:.|::|:..        |.::|:.|
Yeast   364 ----KSYYTV--SYWEQIRLCTIRGFLRIYGDKSYTVINTCAAIAQAFITGSLFYQAP------- 415

  Fly   943 QYSSAYVVLEDNTTDKTSSLADAYSK------HLEHYARRCTLLRTGDLKFED---------YIL 992
                             ||...|:|:      .|.:|    :|:...::.||.         |.|
Yeast   416 -----------------SSTLGAFSRSGVLFFSLLYY----SLMGLANISFEHRPILQKHKVYSL 459

  Fly   993 SH---DVNHSRRIDFHF-LAGLTVSENNFIVWLNNKPLHTAPLTLNLLHNALAIKLLGQDASTYV 1053
            .|   :...|....|.| :.|||.    ||:.|         ..|..||.:
Yeast   460 YHPSAEALASTISSFPFRMIGLTF----FIIIL---------YFLAGLHRS-------------- 497

  Fly  1054 TNEPLPYSDDTRTLRLNKGQVLGAEISINLSLTMCFITAFYAIPIIRERETRAKLLQFLSGVDVC 1118
                                 .||..::.|.||||             .|....|.|.:|.
Yeast   498 ---------------------AGAFFTMYLLLTMC-------------SEAITSLFQMVSS---- 524

  Fly  1119 AYWTSHIVWDYLVFVLSALSSI-----LTIAA--------------FKEIGYITPLDLSRY-FYM 1163
                       |...||..:||     |:||.              ||.|.||.|:   || |..
Yeast   525 -----------LCDTLSQANSIAGVVMLSIAMYSTYMIQLPSMHPWFKWISYILPI---RYAFES 575

  Fly  1164 LLIFGFPGIMLSYAASGCFSDAATGFTRI-------SIINTLMGTGLFLMFMTLNFEAFQLKDVA 1221
            :|...|.|..:.  ..|....:..||..|       :.:.:..|            :::.|.|.
Yeast   576 MLNAEFHGRHMD--CGGTLVPSGPGFENILPENQVCAFVGSRPG------------QSWVLGDD- 625

  Fly  1222 EKLAWYFRLSPHYSLASSTHSIHIGYNIRRGCSIGGIRKLPKQLRCRNVPICCDIPGYYGWRKPG 1286
                 |.|....|...::..:..|                          :.|.:.||...|  .
Yeast   626 -----YLRAQYQYEYKNTWRNFGI--------------------------MWCFLIGYIVLR--A 657

  Fly  1287 VLVEITYMIMLGSTLFLLIVMHDAKVCNLIAEKLGNCFSKRKRVEGGTSIEND-----SVVAEQR 1346
            |..|....:..|.         ||    |:.:|     ..:..::...|.:||     :.:|.|.
Yeast   658 VFTEYKSPVKSGG---------DA----LVVKK-----GTKNAIQRSWSSKNDEENLNASIATQD 704

  Fly  1347 VVREMINS----------GRKDVPLLVYKISKRYRSKLAVKAISFHVPHAE------------CF 1389
             ::|:.:|          |.:...:.::            |.:||.:||:.            |.
Yeast   705 -MKEIASSNDDSTSADFEGLESTGVFIW------------KNVSFTIPHSSGQRKLLDSVSGYCV 756

  Fly  1390 -----GLLGINGAGKTSTFKMLAGDEKIT-SGEAYIDGTNISTHKVYRKIGYCPQFDALFEDLTG 1448
                 .|:|.:|||||:....||.....| :|:..:||..:.. ...|:.||..|.|....:||.
Yeast   757 PGTLTALIGESGAGKTTLLNTLAQRNVGTITGDMLVDGLPMDA-SFKRRTGYVQQQDLHVAELTV 820

  Fly  1449 RETLNIYCLLRGVQ-------RRHVTPI---------CWGLAISFGFAKHMDKQTKHYSGGNRRK 1497
            :|:|.....:|..|       ..:|..|         ...|....|:..::::         |:|
Yeast   821 KESLQFSARMRRPQSIPDAEKMEYVEKIISILEMQEFSEALVGEIGYGLNVEQ---------RKK 876

  Fly  1498 LSTAISVLGNPS-VLYLDEPTSGMDPAARRQLWQIIGLIR---TAGKSIVLTSHSMDECEALCSR 1558
            ||..:.::|.|. :|:|||||||:|   .:..|.::.:::   .||:||:.|.|...
Yeast   877 LSIGVELVGKPDLLLFLDEPTSGLD---SQSAWAVVKMLKRLALAGQSILCTIHQPS-------- 930

  Fly  1559 LAIMVDGEFKCLGSVQSLKNQFSKGLILKVKVKHKKKTFQRVVEDSSSSNDKKSISETDLKFLQM 1623
                           .:|..||.:.|:|       .|..|.:.......|     |.:.:|:.:.
Yeast   931 ---------------ATLFEQFDRLLLL-------GKGGQTIYFGEIGKN-----SSSVIKYFEK 968

  Fly  1624 ASVMESSQ----ADRILK-----VNRFISKEIPD--------AELKEEYNGLITYYIPHSKTLSK 1671
            ....:..|    |:.||:     ....:.:..||        |.:.|:.|.:|       |.||
Yeast   969 NGARKCQQNENPAEYILEAIGAGATASVQQNWPDIWQKSHEYANINEKINDMI-------KDLS- 1025

  Fly  1672 IFQLLETNSHK 1682
                 .|..||
Yeast  1026 -----STTLHK 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	260/1311 (20%)
PDR18	NP_014468.3	3a01205	1..1333	CDD:273362	260/1311 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	105	1.000	Inparanoid score	I1418
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050