DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and PDR5

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_014796.3	Gene:	PDR5 / 854324	SGDID:	S000005679	Length:	1511	Species:	Saccharomyces cerevisiae

Alignment Length:	1347	Identity:	261/1347 - (19%)
Similarity:	461/1347 - (34%)	Gaps:	467/1347 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   539 GIQLFNLQKNYGKLKAVKGISLKMHRNEITVLLGHNGAGKTTTINMITGIVKPTSG------TAI 597
            |::.|...|.....:.:|.:...::..|:.|:||..|:|.||   ::..|...|.|      |.|
Yeast   160 GLRKFQRSKETNTFQILKPMDGCLNPGELLVVLGRPGSGCTT---LLKSISSNTHGFDLGADTKI 221

  Fly   598 -VNGY---DIRTHLAKARESLGICPQNNILFKEMSVRDHIIFFSKLKGIRG-TKAVENE-VGKYM 656
             .:||   ||:.|.   |..:....:.::....::|.:.::..::||..:. .|.|:.| ...::
Yeast   222 SYSGYSGDDIKKHF---RGEVVYNAEADVHLPHLTVFETLVTVARLKTPQNRIKGVDRESYANHL 283

  Fly   657 TMLKLQDKSYVAAKN----------LSGGMKRKLSLC-CALCGNAKVVLCDEPSSGIDAAGRRSL 710
            ..:.:........:|          :|||.::::|:. .::|| :|....|..:.|:|:|.....
Yeast   284 AEVAMATYGLSHTRNTKVGNDIVRGVSGGERKRVSIAEVSICG-SKFQCWDNATRGLDSATALEF 347

  Fly   711 WDLLQSEKD----GRTILLTTHYMDEADVLGDRIAILSEGKLQCQGTSFYLKKRF-GTGYLLVC- 769
            ...|:::.|    ..|:.:.....|..| |.:::.:|.:|.....|.:...||.| ..||  ||
Yeast   348 IRALKTQADISNTSATVAIYQCSQDAYD-LFNKVCVLDDGYQIYYGPADKAKKYFEDMGY--VCP 409

  Fly   770 IMQSGCD-VGAVTQLIRKYVPPIKPERVLGTEL---------TYRLPTEY---SKKFAELLQDLD 821
            ..|:..| :.:||.         ..||.|..::         |.:...:|   |..:.||::::|
Yeast   410 SRQTTADFLTSVTS---------PSERTLNKDMLKKGIHIPQTPKEMNDYWVKSPNYKELMKEVD 465

  Fly   822 EKCAQLQLVGYGLSGATLEDVFMAVNTDKRVQGGAEGPPVDGSIDFKELVFDSK-TREKRRIRRC 885
            ::                     .:|.|:.               .:|.:.::. .::.:|.|..
Yeast   466 QR---------------------LLNDDEA---------------SREAIKEAHIAKQSKRARPS 494

  Fly   886 FMFWQALFLKKFYTTTRNYWLL----GIQL--VLPIAVMALTILNSRGGRI---------YYELP 935
            ..:..:..::..|...||.|.|    |..|  :|....||| ||.|...:|         |:...
Yeast   495 SPYTVSYMMQVKYLLIRNMWRLRNNIGFTLFMILGNCSMAL-ILGSMFFKIMKKGDTSTFYFRGS 558

  Fly   936 AM--PISINQYS------SAYVVLEDNTTDKTSSL----ADAYSKHLEHYARRCTLLRTGDLKFE 988
            ||  .|..|.:|      |.|.........:|.||    |||::..|.....:..:....::.|
Yeast   559 AMFFAILFNAFSSLLEIFSLYEARPITEKHRTYSLYHPSADAFASVLSEIPSKLIIAVCFNIIF- 622

  Fly   989 DYILSHDVNHSRRIDFHFLAGLTVSENNFIVWLNNKPLHTAPLTLNLLHNALAI-------KLLG 1046
             |.|         :||....|:      |..:              ||.|.:|:       :.:|
Yeast   623 -YFL---------VDFRRNGGV------FFFY--------------LLINIVAVFSMSHLFRCVG 657

  Fly  1047 QDASTYVTNEPLPYSDDTRTLRLNKGQVLGAEISINLSLTMCFITAFYAIPIIRERETRAKLLQF 1111
                             :.|..|::..|..:.:.:.||:    .|.| |||       :.|:|:
Yeast   658 -----------------SLTKTLSEAMVPASMLLLALSM----YTGF-AIP-------KKKILR- 692

  Fly  1112 LSGVDVCAYWTSHIVWDYLVFVLSALSSILTIAAFKEIGYITPLDLSRYFYMLLIFGFPGIMLSY 1176
                     |:                        |.|.||.|  |:..|..|||..|.||....
Yeast   693 ---------WS------------------------KWIWYINP--LAYLFESLLINEFHGIKFPC 722

  Fly  1177 AASGCFSDAATGFTRISIINTLMGTGLFLMFMTLNFEAFQLKDVAEKLAWYFRLSPHYSLASSTH 1241
            |.                                                |....|.|:..|||.
Yeast   723 AE------------------------------------------------YVPRGPAYANISSTE 739

  Fly  1242 SIHIGYNIRRGCSIGGIRKLPKQLRCRNVPICCDIPG---------------YY---GWRKPGVL 1288
            |:         |::.|.                 :||               ||   .||  |..
Yeast   740 SV---------CTVVGA-----------------VPGQDYVLGDDFIRGTYQYYHKDKWR--GFG 776

  Fly  1289 VEITYMIML-----------------GSTL-FLLIVMHDAKVCNLIAEKLGN----------CFS 1325
            :.:.|::..                 |..| |...::...|...::.||..|          ..|
Yeast   777 IGMAYVVFFFFVYLFLCEYNEGAKQKGEILVFPRSIVKRMKKRGVLTEKNANDPENVGERSDLSS 841

  Fly  1326 KRKRVEGGTSIENDSV----VAEQRVVREMINSGRKDVPLLVYKISKRYRSKLAVKAISFHVPHA 1386
            .||.::..:..|:|:.    :::...:....|        |.|::..:..::..:..:...|...
Yeast   842 DRKMLQESSEEESDTYGEIGLSKSEAIFHWRN--------LCYEVQIKAETRRILNNVDGWVKPG 898

  Fly  1387 ECFGLLGINGAGKTSTFKMLAGDEKIT----SGEAYIDGTNISTHKVY-RKIGYCPQFDALFEDL 1446
            ....|:|.:|||||:....||  |::|    :|:..::|  |...|.: |.||||.|.|...:..
Yeast   899 TLTALMGASGAGKTTLLDCLA--ERVTMGVITGDILVNG--IPRDKSFPRSIGYCQQQDLHLKTA 959

  Fly  1447 TGRETLNIYCLLR-------GVQRRHVTPICWGLAISFGFAKHMDKQTKHYSGG----NRRKLST 1500
            |.||:|.....||       ..:.|:|..:...|.:.    |:.|........|    .|::|:.
Yeast   960 TVRESLRFSAYLRQPAEVSIEEKNRYVEEVIKILEME----KYADAVVGVAGEGLNVEQRKRLTI 1020

  Fly  1501 AISVLGNPSVL-YLDEPTSGMDPAARRQLWQIIGLIRTAGKSIVLTSHS-----MDECEAL---- 1555
            .:.:...|.:| :|||||||:|......:.|::..:...|::|:.|.|.     |.|.:.|
Yeast  1021 GVELTAKPKLLVFLDEPTSGLDSQTAWSICQLMKKLANHGQAILCTIHQPSAILMQEFDRLLFMQ 1085

  Fly  1556 --------------CSRLAIMVD-----GEFKCLGSVQSLKNQFSKGLILKVKVKHKKKTFQRVV 1601
                          |.   .|:|     |..||.......  ::...::......|..:.:..|.
Yeast  1086 RGGKTVYFGDLGEGCK---TMIDYFESHGAHKCPADANPA--EWMLEVVGAAPGSHANQDYYEVW 1145

  Fly  1602 EDSSSSNDKKSI-SETDLKFLQMASVMESSQADRILKVNRFISKEIPD------AELKEEYNGLI 1659
            .   :|.:.::: ||.|                       ::.:|:|.      ||.|.|::..|
Yeast  1146 R---NSEEYRAVQSELD-----------------------WMERELPKKGSITAAEDKHEFSQSI 1184

  Fly  1660 TYYIPHSKTLS-KIFQLLETNSHKLNIEDYL---IMQTRLEEIFLDF 1702
            .|   .:|.:| ::||      ......|||   .:.|...::|:.|
Yeast  1185 IY---QTKLVSIRLFQ------QYWRSPDYLWSKFILTIFNQLFIGF 1222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	261/1347 (19%)
PDR5	NP_014796.3	ABC_trans_N	46..152	CDD:405234
PDR5	NP_014796.3	3a01205	100..1503	CDD:273362	261/1347 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	105	1.000	Inparanoid score	I1418
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050