DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and AUS1

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_014654.1	Gene:	AUS1 / 854175	SGDID:	S000005537	Length:	1394	Species:	Saccharomyces cerevisiae

Alignment Length:	1308	Identity:	244/1308 - (18%)
Similarity:	429/1308 - (32%)	Gaps:	425/1308 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   558 ISLKMHRNEITVLLGHNGA--------GKTTTINMITGIVKPTSGTAIVNGYDIRTHLAKARESL 614
            |:.:....|:.::||:..:        |||:......|.:|       ....:.::...|....:
Yeast    52 ITFQAEAGEMVLVLGYPTSTLFKTLFHGKTSLSYSPPGSIK-------FKNNEFKSFSEKCPHQI 109

  Fly   615 GICPQNNILFKEMSVRDHIIF-----FSKLKGIRGTKAVENEVGKYMTMLKLQDKSYVAA----- 669
            ....:.::.|..::|...|.|     |...||.|  ..:.||      :|:....|:|..
Yeast   110 IYNNEQDVHFPFLTVEQTIDFALSCKFDIPKGER--DQIRNE------LLREFGLSHVLKTIVGN 166

  Fly   670 ---KNLSGGMKRKLSLCCALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQS-EKDGRTILLT--TH 728
               :.:|||.::::|:......|..|.|.|..:.|:|:|......::|:. .|..|::.|.  :.
Yeast   167 DFFRGVSGGERKRISIIETFIANGSVYLWDNSTKGLDSATALDFLEILRKMAKATRSVNLVRISQ 231

  Fly   729 YMDEADVLGDRIAILSEGKLQCQGT----SFYLKKRFGTGYLLVCIMQSGCDVGAVTQLIRKYVP 789
            ..|:.....|:|.:||:......||    ..|.:...|                     |.|
Yeast   232 ASDKIVDKFDKILMLSDSYQLFYGTVDECLTYFRDTLG---------------------IEK--- 272

  Fly   790 PIKPERVLGTELTYRLPTEYSKKFAELLQDLDEKCAQLQLVGYGLSGATLEDVFMAVNTD----- 849
              .|...:...||..|..::..|....|.:......        |..||.|......|:|
Yeast   273 --DPNDCIIEYLTSILNFQFKNKNLGNLSNSSSASV--------LKTATGEVTKYTYNSDFDLYD 327

  Fly   850 ------------KRVQGGA------EGPPVDGSIDF-----KELVFDSKTREKRRIRRCFMFWQA 891
                        :::||.:      |..|.|.|..|     |:|:|.:|...:|.:.
Yeast   328 QWKHSSYYRNIKQQIQGSSIDDSIKEVDPSDVSPIFNIPLKKQLLFCTKRAFQRSLG-------- 384

  Fly   892 LFLKKFYTTTRNYWLLGIQLVLPIAVMALTILNSRGGRIYYELPAMPISINQYSSAYVVLEDNTT 956
               .|.|.|.:         .:.:.:.:|.|     |.::||:|...|.
Yeast   385 ---DKAYMTAQ---------FISVVIQSLVI-----GSLFYEIPLTTIG---------------- 416

  Fly   957 DKTSSLADAYSKHLEHYARRCTLLRTGDLKFEDYILSHDVNHSRRIDFHFLAGLTVSENNFIVWL 1021
                    :||:              |.|.|...:.           |.||:            |
Yeast   417 --------SYSR--------------GSLTFFSILF-----------FTFLS------------L 436

  Fly  1022 NNKPLHTAPLTLNLLHNALAIKLLGQDASTYVTNEPLPYSDDTRTLRLNKGQVLGAEISINLSLT 1086
            .:.|:
Yeast   437 ADMPI------------------------------------------------------------ 441

  Fly  1087 MCFITAFYAIPIIRERETRAKLLQFLSGVDVCAYWT---SHIVWDY-----LVFVLSALSSILTI 1143
                 ||...|:::::..    |.|.:.      |.   |..|:||     ||.|.|.:...|..
Yeast   442 -----AFQRQPVVKKQSQ----LHFYTN------WVETLSTTVFDYCFKLCLVIVFSIILYFLAH 491

  Fly  1144 AAFKEIGYITPLDLSRYFYMLLIFGFPGIMLSYAASGCFSDAATGFTRISIINTLMGTGLFLMFM 1208
            ..:|         .:|:|..||...|    .::.....|:........||:.|...|..|..:.|
Yeast   492 LQYK---------AARFFIFLLFLSF----YNFCMVSLFALTTLVAPTISVANLFAGILLLAIAM 543

  Fly  1209 TLNFEAFQLKDVAEKLAWYFRLSPHYSLASSTHSIHIGYNIRRGCSIGGIRKLPKQLRCRNVPI- 1272
            ..::..: ||::.....|...|:|......:..|..: ||::..||   ...:|:.....:||.
Yeast   544 YASYVIY-LKNMHPWFVWIAYLNPAMYAMEAILSNEL-YNLKLDCS---ETIVPRGPTYNDVPFS 603

  Fly  1273 --CCDIPG----------------------YYGWRKPGVLVEITYMIMLGSTLFLLIVMHDAKVC 1313
              .|...|                      ::.||..|:::        |..:|.:       .|
Yeast   604 HKACAWQGATLGNDYVRGRDYLKQGLSYTYHHVWRNFGIII--------GFLVFFI-------AC 653

  Fly  1314 NLIAEKLGNCFSKRKRVE----------------GGT--SIENDSVV-------------AEQRV 1347
            .|.|.:....:..:..:|                .||  |..|||..             :....
Yeast   654 TLFASQYIKPYFNKDEIERNNSRLTRWLPFLNKKRGTRSSARNDSKYVGIPKSHSVSSSSSSLSA 718

  Fly  1348 VREMINSGRKDVPLLVYK---ISKRYRSK---LAVKAISFHV------PHAECF------GLLGI 1394
            |...|:...|::.|..|.   |::...::   ::.|.|::.|      .:|..|      .|:|.
Yeast   719 VPYQISPSNKEMALNDYNEQPITETVETQKHIISWKNINYTVGTKKLINNASGFISSGLTALMGE 783

  Fly  1395 NGAGKTSTFKMLAG--DEKITSGEAYIDGTNISTHKVY-RKIGYCPQFDALFEDLTGRETLNIYC 1456
            :|||||:...:|:.  :..:.|||..|||..::....: |.||:..|.|...:.|:.:|:|.|.|
Yeast   784 SGAGKTTLLNVLSQRVETGVVSGEILIDGHPLTDEDAFKRSIGFVQQQDLHLDLLSVKESLEISC 848

  Fly  1457 LLRG-VQRRHVTPICWGLAISFGFAKHMDKQTKHYSGGNRRKLSTAISVLGNPS-VLYLDEPTSG 1519
            |||| ..|.::..:...|.:.      .|......:...|:.||..:.::..|| :|:|||||||
Yeast   849 LLRGDGDRAYLDTVSNLLKLP------SDILVADLNPTQRKLLSIGVELVTKPSLLLFLDEPTSG 907

  Fly  1520 MDPAARRQLWQIIGLIRTAGKSIVLTSH--SMDECEALCSRLAIMVDGEFKCLGSVQSLKNQFSK 1582
            :|..|...:.:.:..:...|::|..|.|  |........:...:...||....|.:......|..
Yeast   908 LDAEAALTIVKFLKQLSLQGQAIFCTIHQPSKSVISHFDNIFLLKRGGECVFFGPMDDACGYFMS 972

  Fly  1583 GLILKVKVKHKKKTFQRVVE---DSSSSNDKKSISET---DLKFLQMASVMESSQADRILKVNRF 1641
            .....|..|........|::   :|:||..|.:..|.   :.:.:..:::.|||...:::|
Yeast   973 HDNTLVYDKEHDNPADFVIDAVGNSNSSAGKDTAEEALTLNKEAIDWSALWESSVEKKLVK---- 1033

  Fly  1642 ISKEIPDAELKEEYNGLITYYIPHSKTLSKIFQLLETNSHKLNIEDYLIMQTRLEEIFLDFASKR 1706
              ||....|.....:|     :.::.:|.|....|:          .|.:.||.:.|    .:||
Yeast  1034 --KETARLEDDARASG-----VDYTTSLWKQPSYLQ----------QLALITRRQYI----CTKR 1077

  Fly  1707 DSSDIFTK 1714
            |.:.:..|
Yeast  1078 DMTYVMAK 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	243/1301 (19%)
AUS1	NP_014654.1	3a01205	56..1369	CDD:273362	243/1304 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	105	1.000	Inparanoid score	I1418
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050