DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and Abcg1

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_445954.2	Gene:	Abcg1 / 85264	RGDID:	620294	Length:	666	Species:	Rattus norvegicus

Alignment Length:	833	Identity:	168/833 - (20%)
Similarity:	291/833 - (34%)	Gaps:	282/833 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   478 SICLYVEQVFPGEYGVPRRWNFMCHKNYWRQYVPSLNIVPSFQTILHGSAKA-----------KS 531
            |:|:.|::|.                        |.|:......:|:|..|.           .|
  Rat    28 SVCVSVDEVV------------------------SSNVDELETDLLNGHLKKVDNNFTEAQRFSS 68

  Fly   532 CRRAREVGIQLFNL-----------QKNYGKLKAVKGISLKMHRNEITVLLGHNGAGKTTTINMI 585
            ..|...|.|:..:|           :|.|..|  :||||.|.:..|:..::|.:||||:|.:|::
  Rat    69 LPRRAAVNIEFKDLSYSVPEGPWWRKKGYKTL--LKGISGKFNSGELVAIMGPSGAGKSTLMNIL 131

  Fly   586 TGIVKP-TSGTAIVNGY--DIRTHLAKARESLGICPQNNILFKEMSVRDHIIFFSKLKGIRGTKA 647
            .|..:. ..|..::||.  |:|..    |:......|:::|...::|::.::..:.||.....:.
  Rat   132 AGYRETGMKGAVLINGMPRDLRCF----RKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEG 192

  Fly   648 VENEVGKYMTMLKLQDKSYVAAKNLSGGMKRKLSLCCALCGNAKVVLCDEPSSGIDAAGRRSLWD 712
            ....|.:.:|.|.|...:.....:||||.:::|::...|..|..|:..|||:||:|:|....:..
  Rat   193 RREMVKEILTALGLLPCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVS 257

  Fly   713 LLQS-EKDGRTILLTTHYMDEADV--LGDRIAILSEGKLQCQGTSFYLKKRFGTGYLLVCIMQSG 774
            |::. .:.||:|:.|.| ...|.:  |.|::.:||:|:                     |:.:
  Rat   258 LMKGLAQGGRSIVCTIH-QPSAKLFELFDQLYVLSQGQ---------------------CVYR-- 298

  Fly   775 CDVGAVTQLIRKYVPPIKPERVLGTEL-TYRLPTEYSKKFAELLQDLDEKCAQLQLVGYGLSGAT 838
               |.|:.|    ||.:   |.||... ||..|.::..:.|. .:..|:....::.|..|
  Rat   299 ---GKVSNL----VPYL---RDLGLNCPTYHNPADFVMEVAS-GEYGDQNSRLVRAVREG----- 347

  Fly   839 LEDVFMAVNTDKRVQGGAEGPPVDGSID----FKELVFDSKTREKRRIRRCFMF-------WQAL 892
                 |..:..||..||      ||.::    .:....||.:.|     .|..|       :..|
  Rat   348 -----MCDSDYKRELGG------DGDVNPFLWHRPAEEDSASME-----GCHSFSASCLTQFCIL 396

  Fly   893 FLKKFYTTTRNYWL--------LGIQLVLPIAVMALTILN------SRGGRIYYEL------PAM 937
            |.:.|.:..|:..|        :||.|:  |.::.|.|.|      |..|.:::.:      ..|
  Rat   397 FKRTFLSIMRDSVLTHLRITSHIGIGLL--IGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALM 459

  Fly   938 PISINQYSSAYVVLEDNTTDKTSSLADAYSKHLEHYARRCTLLRTGDLKFEDYILSHDVNHSRRI 1002
            |..:.......|.|.:               ||.::           ...:.|.|:..:     .
  Rat   460 PTVLTFPLEMSVFLRE---------------HLNYW-----------YSLKAYYLAKTM-----A 493

  Fly  1003 DFHFLAGLTVSENNFIVWLNNKPLHTAPLTL--------NLLHNALAIKLLGQDASTYVTNEPLP 1059
            |..|.....|:..:.:.|:.::|.......|        :|:..:|.: |:|. |||
  Rat   494 DVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGL-LIGA-AST-------- 548

  Fly  1060 YSDDTRTLRLNKGQVLGAEISINLSLTMCFITAFYAIPIIRERETRAKLLQFLSGVDVCAYWTSH 1124
                    .|.....:|...:|.:.|...|..:|..||...:                   |.|:
  Rat   549 --------SLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQ-------------------WMSY 586

  Fly  1125 IVWDYLVFVLSALSSILTIAAFKEIGYITPLDLSRYFYMLLIFGFPGIMLSY-----------AA 1178
                                    |.|:      ||       ||.|::||.           .|
  Rat   587 ------------------------ISYV------RY-------GFEGVILSIYGLDREDLHCDIA 614

  Fly  1179 SGC-FSDAATGFTRISIINTLMGTGLFLMFMTLNFEAFQLKDVAEKLAWYFRL 1230
            ..| |..:......:.:.|    ..|:|.|:.|......|:.:|     ||.|
  Rat   615 ETCHFQKSEAILRELDVEN----AKLYLDFIVLGIFFISLRLIA-----YFVL 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	168/833 (20%)
Abcg1	NP_445954.2	3a01204	60..666	CDD:273361	159/777 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000