DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and SNQ2

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_010294.1	Gene:	SNQ2 / 851574	SGDID:	S000002418	Length:	1501	Species:	Saccharomyces cerevisiae

Alignment Length:	1276	Identity:	257/1276 - (20%)
Similarity:	418/1276 - (32%)	Gaps:	476/1276 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   552 LKAVKGISLKMHR---------------NEITVLLGHNGAGKTTTINMITG-------------- 587
            |...|||..|.|:               .|:.::||..|||.::.:.:..|
Yeast   158 LTIFKGIKAKRHQKMRQIISNVNALAEAGEMILVLGRPGAGCSSFLKVTAGEIDQFAGGVSGEVA 222

  Fly   588 --------IVKPTSGTAIVNG-YDIRTHLAKARESLGI---CPQ-----NNILFKE--MSVRDHI 633
                    ::|......|.|| .|:.......:::|..   |..     ||:..||  .|.||
Yeast   223 YDGIPQEEMMKRYKADVIYNGELDVHFPYLTVKQTLDFAIACKTPALRVNNVSKKEYIASRRD-- 285

  Fly   634 IFFSKLKGIRGTKAVENEVGKYMTMLKLQDKSYVAAKNLSGGMKRKLSLCCALCGNAKVVLCDEP 698
             .::.:.|:|.|  ...:||          ..:|  :.:|||.::::|:..||.....:...|..
Yeast   286 -LYATIFGLRHT--YNTKVG----------NDFV--RGVSGGERKRVSIAEALAAKGSIYCWDNA 335

  Fly   699 SSGIDAA-------GRRSLWDLLQSEKDGRTILLTTHYMDEADVLG--DRIAILSEGKLQCQGTS 754
            :.|:||:       ..|.:.:||:|     |..:|.:...| ::..  |::.:|..||....|..
Yeast   336 TRGLDASTALEYAKAIRIMTNLLKS-----TAFVTIYQASE-NIYETFDKVTVLYSGKQIYFGLI 394

  Fly   755 FYLKKRFG-TGYLLVCIMQSGCDVGAVTQLIRKYVPP-----IKP---ERVLGTELTYRLPTEYS 810
            ...|..|. .|||  |..:.     |..:.:.....|     |||   .:|..|...:......|
Yeast   395 HEAKPYFAKMGYL--CPPRQ-----ATAEFLTALTDPNGFHLIKPGYENKVPRTAEEFETYWLNS 452

  Fly   811 KKFAELLQDL---DEKCAQLQLVGYGLSGATLEDVFMAVNTDKRVQGGAEGPPVDGSIDFKELVF 872
            .:||::.:|:   .||                      |||:|.                ||:..
Yeast   453 PEFAQMKKDIAAYKEK----------------------VNTEKT----------------KEVYD 479

  Fly   873 DSKTREKRRIRRCFMFWQALFLKKFYTTTRNYW-------------LLGIQLVLPIAVMALTILN 924
            :|..:||.:..|          ||.|.|. :||             :.|.:....|.|.:..|.:
Yeast   480 ESMAQEKSKYTR----------KKSYYTV-SYWEQVKLCTQRGFQRIYGNKSYTVINVCSAIIQS 533

  Fly   925 SRGGRIYYELPAMPISINQYSSAYVVLEDNTTDKTSSLADAYSK------HLEHYARRCTLLRTG 983
            ...|.::|..|                        ||.:.|:|:      .|.:|    :|:...
Yeast   534 FITGSLFYNTP------------------------SSTSGAFSRGGVLYFALLYY----SLMGLA 570

  Fly   984 DLKFE---------DYILSH---DVNHSRRIDFHF-LAGLTVSENNFIVWLNNKPLHTAPLTLNL 1035
            ::.||         .|.|.|   :...|....|.| :.|||..   ||:......||
Yeast   571 NISFEHRPILQKHKGYSLYHPSAEAIGSTLASFPFRMIGLTCF---FIILFFLSGLH-------- 624

  Fly  1036 LHNALAIKLLGQDASTYVTNEPLPYSDDTRTLRLNKGQVLGAEISINLSLTMCFITAFYAIPIIR 1100
                                                 :..|:..:|.|.||||
Yeast   625 -------------------------------------RTAGSFFTIYLFLTMC------------ 640

  Fly  1101 ERETRAKLLQFLSGV-DVCAYWTSHIVWDYLVFVLSALSSILTIAA-----FKEIGYITPLDLSR 1159
             .|....|.:.:|.| |..:...|  :...|:..:|..|:.:....     ||.|.|:.|:   |
Yeast   641 -SEAINGLFEMVSSVCDTLSQANS--ISGILMMSISMYSTYMIQLPSMHPWFKWISYVLPI---R 699

  Fly  1160 YFYMLLIFGFPGIMLSYAASGCFSDAATGFTRISIINTLMGTGLFLMFMTLNFEAFQLKDVAEKL 1224
            |.:        ..||:....|...|.|         |||:.:|
Yeast   700 YAF--------ESMLNAEFHGRHMDCA---------NTLVPSG---------------------- 725

  Fly  1225 AWYFRLSPHYSLASSTHSIHIGYNIRRGCS-IGGIRKLPKQLRCRNVPICCDIPGY---YGWRKP 1285
            ..|..||..|.:.:...|       :.|.| :.|...|..|.:            |   :.||..
Yeast   726 GDYDNLSDDYKVCAFVGS-------KPGQSYVLGDDYLKNQFQ------------YVYKHTWRNF 771

  Fly  1286 GVLVEITYMIMLGSTLFLLIVMHDAKVCNLIAEKLGNCFSKRKR-VEGG---------------- 1333
            |:|    :..:||..:..:|                  |::.|| |:||
Yeast   772 GIL----WCFLLGYVVLKVI------------------FTEYKRPVKGGGDALIFKKGSKRFIAH 814

  Fly  1334 ---------------TSIENDSVVAEQRVVREMINSG---RKDVPLLV-YKISKRYRSKLAVKAI 1379
                           ....::|..|...|..::...|   .|||...: |:..||    :.:..:
Yeast   815 ADEESPDNVNDIDAKEQFSSESSGANDEVFDDLEAKGVFIWKDVCFTIPYEGGKR----MLLDNV 875

  Fly  1380 SFHVPHAECFGLLGINGAGKTSTFKMLA-GDEKITSGEAYIDGTNISTHKVYRKIGYCPQFDALF 1443
            |.:........|:|.:|||||:....|| .:..|.:|:..::|..|.. ...|:.||..|.|...
Yeast   876 SGYCIPGTMTALMGESGAGKTTLLNTLAQRNVGIITGDMLVNGRPIDA-SFERRTGYVQQQDIHI 939

  Fly  1444 EDLTGRETLNIYCLLRGVQR-------RHVTPICWGLAISFGFAKHMDKQTKHYSGG----NRRK 1497
            .:||.||:|.....:|..|.       .:|..|...|    |..::.:........|    .|:|
Yeast   940 AELTVRESLQFSARMRRPQHLPDSEKMDYVEKIIRVL----GMEEYAEALVGEVGCGLNVEQRKK 1000

  Fly  1498 LSTAISVLGNPS-VLYLDEPTSGMDPAARRQLWQIIGLIR---TAGKSIVLTSHS-----MDECE 1553
            ||..:.::..|. :|:|||||||:|   .:..|.||.|:|   .||:||:.|.|.     .:|.:
Yeast  1001 LSIGVELVAKPDLLLFLDEPTSGLD---SQSSWAIIQLLRKLSKAGQSILCTIHQPSATLFEEFD 1062

  Fly  1554 ALCSRLAIM------------------------VDGEFKC---------------LGSVQSLKNQ 1579
                ||.::                        .:|..||               .|:..|:|..
Yeast  1063 ----RLLLLRKGGQTVYFGDIGKNSATILNYFERNGARKCDSSENPAEYILEAIGAGATASVKED 1123

  Fly  1580 FSKGLILKVKVKHKKKTFQRVVEDSSSSNDKKSISETDLKF 1620
            :.:..:..|:.:..|:..|.::.|.|....|..:.:...|:
Yeast  1124 WHEKWLNSVEFEQTKEKVQDLINDLSKQETKSEVGDKPSKY 1164

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	257/1276 (20%)
SNQ2	NP_010294.1	3a01205	103..1480	CDD:273362	257/1276 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	105	1.000	Inparanoid score	I1418
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050