DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and ABCA11

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_001332171.1	Gene:	ABCA11 / 836291	AraportID:	AT5G61690	Length:	953	Species:	Arabidopsis thaliana

Alignment Length:	946	Identity:	228/946 - (24%)
Similarity:	404/946 - (42%)	Gaps:	201/946 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 WDKLKLLMWKNWILQWNQKMQIVFALVLPVLFLCLILVLRIIVLPEKMDEIRYPTVSISDLNLYM 83
            :.:...|..||.:|.|..|......:.....|:.||..:...:.........|..::...|.:..
plant    11 YQQFTALFGKNLLLSWRNKRATCLQIFSSFFFILLIFCIEEAMKASDASSSAYKNITDPTLLVSP 75

  Fly    84 RMVPLGNRILHENGSLNIPRNFLCYTPNN-----PINSAIVGATAIRLRLLGTRAYDTALHMEQD 143
            .::|..::..     :.:|.....::.||     .|.|||:
plant    76 PILPCEDKFF-----VKLPCYDFVWSGNNSRRVTDIVSAIM------------------------ 111

  Fly   144 MVLHNFLAGVQFEDNENVNTNDAGYPLNLN--YSLRFPSELRTMQGPIIDTWRTSRLFLSYDTSG 206
                               .|:.|.|:..|  .|.:.|.|        :|||..|.   .....|
plant   112 -------------------ANNPGRPIPTNKVQSFKEPDE--------VDTWLLSH---PLQVPG 146

  Fly   207 SRNRLDNDGGVPVGY---------IREG---------FLPIQHAL------------TMSWLALA 241
            :.:.::.:..| :.|         .:.|         .:|:|.|.            ...|   .
plant   147 ALHFVERNASV-ISYGVQTNSSSESKRGQTEDPTFKFLVPLQVAAEREIARSLLGDPNFGW---G 207

  Fly   242 SGVTDTGIPAIHLQRFPYRAYTYDQLLSGLRQLLPFVILLSFIYPASTVTKYVTSEKELQLKEIM 306
            .|..:...|||           ..:..|.|..:.|...|...::........:.:||||:|::.|
plant   208 LGFKEFARPAI-----------ITETTSALSVMGPVFFLAFSMFGFVLQLGALVTEKELKLRQAM 261

  Fly   307 KLIGVHN---WLHWVAWFVKSYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVT 368
            .::||::   ||.|:.|  :..:.|:..:||::..::.:|    .....:|:|.|.|....:...
plant   262 TMMGVYDSAYWLSWLTW--EGILTLVSSLFLVLFGMIFRF----DFFLKNSFVLVFLLFLLFQFN 320

  Fly   369 SVCLCFMLAVLFSKASTASAVAAIFWFLTYI---------PYSFGYYYYERLSLMSKLLISLIFS 424
            .:.|.|.|:.:.||:|:|:.|..:.:.:.:|         |||..|       .:|:.::..:|.
plant   321 MIGLAFALSSIISKSSSATTVGFLVFLIGFITQFVSATGFPYSSSY-------AVSRRVMWSLFP 378

  Fly   425 NSALGFGIHVIVMWEGT--GEGITWRNMFHPVSTDDSLTL---FYIIMTMSFGSIMF-ISICLYV 483
            .:....|:.:::....|  ..||:|.|  ..|......|.   ..||.....|:.:| ..:.:|.
plant   379 PNTFSAGLKLLLDATSTPKSSGISWSN--RAVCEGGQATCVISINIIYQWLLGTFLFWFVLAIYF 441

  Fly   484 EQVFPGEYGVPRRWNFMCHKNYWR-------------QYVPSLNIV----PSFQTILHGSAKAKS 531
            :.:.|...||.:...:.....||.             ..|.|:.:|    |:.:.:|....:.|
plant   442 DNIIPNASGVRKPIFYFLAPGYWTGKGGNKVEEGSIFSCVGSVPLVEHNTPNDKDVLEEETEVK- 505

  Fly   532 CRRARE------VGIQLFNLQKNY-GKLK-------------AVKGISLKMHRNEITVLLGHNGA 576
             ::|.:      :.:|:..|.|.| |..|             ||||:.:.:.::::..|||.|||
plant   506 -QQAMDGIADPNIAVQIHGLAKTYPGTTKLGCCKCTKTSPFHAVKGLWMNIAKDQLFCLLGPNGA 569

  Fly   577 GKTTTINMITGIVKPTSGTAIVNGYDIRTH--LAKARESLGICPQNNILFKEMSVRDHIIFFSKL 639
            ||||||:.:|||...|.|.|::.|..||:.  ::..|:.:|:|||.:||:..:|...|:..|:.:
plant   570 GKTTTISCLTGINPVTGGDALIYGDSIRSSVGISNIRKMIGVCPQFDILWDALSSEQHLHLFASI 634

  Fly   640 KGIRGTKAVENEVGKYMTMLKLQDKSYVAAKNLSGGMKRKLSLCCALCGNAKVVLCDEPSSGIDA 704
            ||: ...::::...|.:..:||...:.|.|.:.||||||:||:..||.|:.|:|..|||::|:|.
plant   635 KGL-PPASIKSTAEKLLADVKLTGAAKVRAGSYSGGMKRRLSVAVALIGDPKLVFLDEPTTGMDP 698

  Fly   705 AGRRSLWDLLQSEKDGRTILLTTHYMDEADVLGDRIAILSEGKLQCQGTSFYLKKRFGTGYL-LV 768
            ..||.:||::|..|.||.|:||||.|:|||:|.|||.|:::|:|:|.|||..||.|||||:: .|
plant   699 ITRRHVWDIIQESKKGRAIILTTHSMEEADILSDRIGIMAKGRLRCIGTSIRLKSRFGTGFVATV 763

  Fly   769 CIMQSGCD----VGAVTQLIRKY------VPPIKPERVLGTELTYRLPTEYSKKFAELLQDLDEK 823
            ..:::..|    |||..:.::|:      |.|.:..:..   :|:.:|.:.........::|..:
plant   764 SFIENKNDNNIGVGASHEPLKKFFKEHLKVEPTEENKAF---MTFVIPHDKENLLTGFFEELQNR 825

  Fly   824 CAQLQLVGYGLSGATLEDVFMAVNTDKRVQGG-AEG 858
            .::..:....|..||||:||:.:.....::.. |||
plant   826 ESEFGISDIQLGLATLEEVFLNIARQAELESATAEG 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324	7/32 (22%)
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	209/811 (26%)
ABCA11	NP_001332171.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2373
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920