DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and ABCA3

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_190358.3	Gene:	ABCA3 / 823928	AraportID:	AT3G47740	Length:	932	Species:	Arabidopsis thaliana

Alignment Length:	1003	Identity:	239/1003 - (23%)
Similarity:	428/1003 - (42%)	Gaps:	266/1003 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 WDKLKLLMWKNWILQWNQKMQIVFALVLPVLFLCLILVLRIIVLPEKMDE--------------- 68
            |.:...::.||...|.......|..:::| .:||::||....:...:::.
plant    10 WTRANAILRKNLTYQKRNIWSNVRLIMIP-FYLCIVLVFIQALFDSQVNNSLDNQCGCQCIDKLG 73

  Fly    69 ---------IRYPTVSISDLNLYMRMVPLGNRILHENGSLNIPR--------NF----------- 105
                     :.|.|..........:..|....||       |||        ||
plant    74 DGKCQMTCGLEYSTRDQGFFCAIPKPQPWPPLIL-------IPRPEYRALDANFTNDSCRRKNSC 131

  Fly   106 ---LCYTPNNPINSAIVGATAIRLRLLGTRAYDTALHMEQDMVLHNFLAGVQFEDNENVNTNDAG 167
               :.:|.||....|::....:| |.....:.|....:..:::...|....       .|..|||
plant   132 PVTILFTGNNHSLGAVLSRNLLR-RPFAMNSSDLLFSLANNVLATTFKGSA-------TNYLDAG 188

  Fly   168 Y-------------PLNLNYS-------LRFPSELRTMQGPIIDTWRTSRLFLSYDTSGSRNRLD 212
            .             |.|.|:|       |.|..::|.:||  ::.||.:.:.::.:.....::.:
plant   189 IVSDGSIYNIQPRCPPNSNFSISIGQSPLNFTKDMRCVQG--LNLWRNNSIEVNLELFEGYHKGN 251

  Fly   213 NDGGVPVGYIREGFLPIQHALTMSWLALASGVTDTGIPAIHL------------QRFPYR----- 260
            :|     |.|.|             :..|..:.||.:...::            :..||:
plant   252 SD-----GMINE-------------IVAAYDLFDTNMTNFNVNIWFNATYKDEARNQPYKVVRVP 298

  Fly   261 ------AYTYDQLLSGLRQ------------------------------------LLPFVILLSF 283
                  :..|.|.|.|.|.                                    ||| |||.|.
plant   299 RLVNWVSNAYLQYLQGPRTKMLFEFVKEMPKPETKLRLDIASLIGPIFFTWVILLLLP-VILNSL 362

  Fly   284 IYPASTVTKYVTSEKELQLKEIMKLIGVHNWLHWV---AWF--VKSYIMLMLVVFLIMSLIMVKF 343
            :|           ||:.:|:.|||:.|:.:..:|:   |:|  :.::.::.|::|  .|:|.:||
plant   363 VY-----------EKQQRLRIIMKMHGLGDGPYWIISYAYFLALSTFYIIFLMIF--GSVIGLKF 414

  Fly   344 Y-ASVAVLTFSSWVPVLLFLHTYVVTSVCLCFMLAVLFSKASTASAVAAIFWFLTYIPYSFGY-Y 406
            : .:...|.||       |...|:...:.:.|:|:..|||..|||..|.::.|.:.:...|.: :
plant   415 FLLNDFSLQFS-------FYFVYINLQISIAFLLSSAFSKVETASVAAYLYVFGSGLLGMFLFQF 472

  Fly   407 YYERLSLMSK-LLISLIFSNSALGFGIHVIVM--WEGT---GEGITWRNMFHPVSTDDSLTLFYI 465
            ..|.||...: :.:..::...:|..|::....  ::|.   .:|:.|: .|...:.|:   :|||
plant   473 LLEGLSFPRRWIFVMELYPGFSLYRGLYEFSQNAYQGNLNGKDGMKWK-YFSDNAIDE---VFYI 533

  Fly   466 IMTMSFGSIMFISICLYVEQVFPGEYGVPRRWNFMCHKNYWR------QYVPSLNIVPSFQTILH 524
            |:...|.:::   ...|::::  ...|....: |:.::|.::      :.|.::::......::|
plant   534 IIVEWFVALI---ATYYIDKM--SSSGKDLLF-FLKNQNPFKISHSLQKQVSAISVEMEKLDVIH 592

  Fly   525 GSAK------------AKSCRRAREVGIQLFNLQKNYGKLKAVKGISLKMHRNEITVLLGHNGAG 577
            .|.|            |..|.:.|:|    :..:......|||:.:||.:...|...:||.||||
plant   593 ESEKVAQLMLESSTSHAIVCDKLRKV----YPGRDGNPPKKAVRVLSLAVPSGECFGMLGPNGAG 653

  Fly   578 KTTTINMITGIVKPTSGTAIVNGYDIRTHLAKARESLGICPQNNILFKEMSVRDHIIFFSKLKGI 642
            ||:.|||:||:||||||.|.|.|.||...:.:...|:|:|||:::|::.::.|:|::|:.:||.:
plant   654 KTSFINMMTGLVKPTSGAAFVQGLDICKDMDRVYTSMGVCPQHDLLWETLTGREHLLFYGRLKNL 718

  Fly   643 RG---TKAVENEV---------------GKYMTMLKLQDKSYVAAKNLSGGMKRKLSLCCALCGN 689
            :|   .:|||..:               |||                 ||||||:||:..:|.||
plant   719 KGVDLNQAVEESLRSVNLFHGGVADKPAGKY-----------------SGGMKRRLSVAISLIGN 766

  Fly   690 AKVVLCDEPSSGIDAAGRRSLWDLLQSEKDGRTILLTTHYMDEADVLGDRIAILSEGKLQCQGTS 754
            .|||..||||:|:|.|.|::||.::::.|....|:||||.|:||:.|.||:.|..:|:|||.|..
plant   767 PKVVYMDEPSTGLDPASRKNLWTVIKNAKRHTAIILTTHSMEEAEFLCDRLGIFVDGRLQCIGNP 831

  Fly   755 FYLKKRFGTGYLLVCIMQSGCDVGAVTQLIRKYVPPIKP-ERVLGTELTYRLPTEYSKKFAELLQ 818
            ..||.|:|..|:|.....|..:.. |..|:::..|.:|. ..:.||: .:.:|.: ..:.:|:.|
plant   832 KELKGRYGGSYVLTMTTSSEHEKD-VEMLVQEVSPNVKKIYHIAGTQ-KFEIPKD-EVRISEVFQ 893

  Fly   819 DLDEKCAQLQLVGYGLSGATLEDVFMAV 846
            .:::..:..::..:||:..||||||:.|
plant   894 VVEKAKSNFKVFAWGLADTTLEDVFIKV 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324	7/32 (22%)
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	212/827 (26%)
ABCA3	NP_190358.3	ABC2_membrane_3	<360..511	CDD:289468	40/170 (24%)
		CcmA	609..892	CDD:224054	109/306 (36%)
		ABC_subfamily_A	614..835	CDD:213230	92/241 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810