DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and ABCA1

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_850354.2	Gene:	ABCA1 / 818768	AraportID:	AT2G41700	Length:	1882	Species:	Arabidopsis thaliana

Alignment Length:	1984	Identity:	537/1984 - (27%)
Similarity:	900/1984 - (45%)	Gaps:	410/1984 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KLKLLMWKNWILQWNQKMQIVFALVLPVLFLCLILVLRIIVLPEKMDEIRYPTVSISDLNLYMRM 85
            :.|.::.|||:|:..........::||.:.:.|::.:|     .::|...:|..|..|.:..:.
plant     7 QFKAMLRKNWLLKTRHPFVTSAEILLPTIVMLLLIAVR-----TRVDTTIHPAHSNIDKDTVVE- 65

  Fly    86 VPLGN--------RILHENGSLNIPRNFLCYTPNNPINSAIVGATAIR---LRLLGTRAYDTALH 139
            |..||        ::|...|      :||.:.|:....:.::...:::   |||: |:.:...:.
plant    66 VGKGNSPSFPEVLKLLLAEG------DFLAFAPDTDETNNMIDILSLKFPELRLV-TKIFKDDIE 123

  Fly   140 MEQDMVLHNFLAGVQFEDNENVNTNDAG-------------YPLNLNYSLRFP-----SELRTMQ 186
            :|..:...::  ||..|.....|....|             |.:.||::..|.     ..:....
plant   124 LETYITSAHY--GVCSEVRNCSNPKIKGAVVFHEQGPHLFDYSIRLNHTWAFAGFPNVKSIMDTN 186

  Fly   187 GPI-------IDTWRTSRLFLSYDTSG-------------SRNRLDNDGGVPVGYIREGFLPIQH 231
            ||.       |:|..|    :.|..||             ..::.:||            ||:.|
plant   187 GPYINDLEMGINTIPT----MQYSFSGFLTLQQVVDSFIIFASQQNND------------LPLSH 235

  Fly   232 A-------LTMSWLALASGVTDTGIPAIHLQRFPYRAYTYDQLLSGLRQLLPFVILLSFIYPAST 289
            :       ..:.|...:..|       |.:..||.|.||.|:..|.::.::..:.||.|::|.|.
plant   236 SNLSSALRFELPWTLFSPSV-------IRMVPFPTREYTDDEFQSIVKSVMGLLYLLGFLFPISR 293

  Fly   290 VTKYVTSEKELQLKEIMKLIGVHNWLHWVAWFVKSYIMLMLVVFLIMSLIMVKFYASVAVLTFSS 354
            :..|...|||.:::|.:.::|:.:.:..::||:...:...|...:|.:..|...:      .:|.
plant   294 LISYSVFEKEQKIREGLYMMGLKDEIFHLSWFITYALQFALCSGIITACTMGSLF------KYSD 352

  Fly   355 WVPVLLFLHTYVVTSVCLCFMLAVLFSKASTASAVAAIFWFLTYIPYSFGYYYY--ERLSLMSKL 417
            ...|..:...:.::::.|.||::..|::|.||.||..    ||::...|.||..  |.:|::.|:
plant   353 KTLVFTYFFLFGLSAIMLSFMISTFFTRAKTAVAVGT----LTFLGAFFPYYTVNDESVSMVLKV 413

  Fly   418 LISLIFSNSALGFGIHVIVMWEGTGEGITWRNMFHPVSTDDSLTLFYIIMTMSFGSIMFISICLY 482
            :.||: |.:|...|......:|....|:.|.|::...|   .::.|..::.|...||::.::.||
plant   414 VASLL-SPTAFALGSINFADYERAHVGLRWSNIWRASS---GVSFFVCLLMMLLDSILYCALGLY 474

  Fly   483 VEQVFPGEYGVPRRWNFMCHKNYWRQYVPSLNIVPSFQTILHGS---------------AKAKSC 532
            :::|.|.|.||...|||:..|.:.|:.....|.:|.|:|.:..:               :.:...
plant   475 LDKVLPRENGVRYPWNFIFSKYFGRKKNNLQNRIPGFETDMFPADIEVNQGEPFDPVFESISLEM 539

  Fly   533 RRAREVG--IQLFNLQKNY----GKLKAVKGISLKMHRNEITVLLGHNGAGKTTTINMITGIVKP 591
            |:....|  ||:.||.|.|    |...||..:.|.::.|:|..|||||||||:|||:|:.|::.|
plant   540 RQQELDGRCIQVRNLHKVYASRRGNCCAVNSLQLTLYENQILSLLGHNGAGKSTTISMLVGLLPP 604

  Fly   592 TSGTAIVNGYDIRTHLAKARESLGICPQNNILFKEMSVRDHIIFFSKLKGI-----RGTKA-VEN 650
            |||.|::.|..|.|::.:.|:.||:|||::|||.|::||:|:..|:.|||:     :.|.. :..
plant   605 TSGDALILGNSIITNMDEIRKELGVCPQHDILFPELTVREHLEMFAVLKGVEEGSLKSTVVDMAE 669

  Fly   651 EVGKYMTMLKLQDKSYVAAKNLSGGMKRKLSLCCALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQ 715
            |||       |.||.....:.|||||||||||..||.||:||::.|||:||:|....|..|.|::
plant   670 EVG-------LSDKINTLVRALSGGMKRKLSLGIALIGNSKVIILDEPTSGMDPYSMRLTWQLIK 727

  Fly   716 SEKDGRTILLTTHYMDEADVLGDRIAILSEGKLQCQGTSFYLKKRFGTGYLLVCIMQSGCDVGAV 780
            ..|.||.||||||.||||:.|||||.|::.|.|:|.|:|.:||..:|.||.|. ::::...|...
plant   728 KIKKGRIILLTTHSMDEAEELGDRIGIMANGSLKCCGSSIFLKHHYGVGYTLT-LVKTSPTVSVA 791

  Fly   781 TQLIRKYVPPIKPERVLGTELTYRLPTEYSKKFAELLQDLD---------EKCAQLQ------LV 830
            ..::.:::|.......:|.|::::||......|..:.::::         .|.::::      :.
plant   792 AHIVHRHIPSATCVSEVGNEISFKLPLASLPCFENMFREIESCMKNSVDRSKISEIEDSDYPGIQ 856

  Fly   831 GYGLSGATLEDVFMAV---NTDKRVQGGAE----GPPVDGSI--------------------DFK 868
            .||:|..|||:||:.|   |.|  ::...|    .|....|:                    |..
plant   857 SYGISVTTLEEVFLRVAGCNLD--IEDKQEDIFVSPDTKSSLVCIGSNQKSSMQPKLLASCNDGA 919

  Fly   869 ELVFDSKTREKR-------------RIRRC-------FMFW---QALFLKKFYTTTRNYWLLGIQ 910
            .::..|..:..|             .|:.|       .|||   :|||:|:..:..|:...:..|
plant   920 GVIITSVAKAFRLIVAAVWTLIGFISIQCCGCSIISRSMFWRHCKALFIKRARSACRDRKTVAFQ 984

  Fly   911 LVLPIAVMALTIL--------------------------NSRGGRIYYELPAMPIS--INQY-SS 946
            .::|...:...:|                          ...||.|.::| ::||:  :.|| ..
plant   985 FIIPAVFLLFGLLFLQLKPHPDQKSITLTTAYFNPLLSGKGGGGPIPFDL-SVPIAKEVAQYIEG 1048

  Fly   947 AYVVLEDNTTDK----TSSLADAYSKHLEHYARRCTLLRTGDLKFEDYIL-SHDVNHSRRIDFHF 1006
            .::....||:.|    ..:||||..      |...||..| .|...:::: |.|.::..|.....
plant  1049 GWIQPLRNTSYKFPNPKEALADAID------AAGPTLGPT-LLSMSEFLMSSFDQSYQSRYGSIL 1106

  Fly  1007 LAGLTVSEN-NFIVWLNNKPLHTAPLTLNLLHNALAIKLLGQDASTYVT-NEPLPYSDDTRTLRL 1069
            :.|.....: .:.|..|....|..|:.:|::|.|:.....|....|..| |.|||   .|:|.|:
plant  1107 MDGQHPDGSLGYTVLHNGTCQHAGPIYINVMHAAILRLATGNKNMTIQTRNHPLP---PTKTQRI 1168

  Fly  1070 NKGQVLGAEISINLSLTMCFITAFYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVWDYLVFVL 1134
            .:..:.....:|.:::...||.|.:|:||::|||.:||..|.:|||.|.:||.|..|||::.|:.
plant  1169 QRHDLDAFSAAIIVNIAFSFIPASFAVPIVKEREVKAKHQQLISGVSVLSYWLSTYVWDFISFLF 1233

  Fly  1135 SALSSILTIAAFK-----EIGYITPLDLSRYFYMLLIFGFPGIMLSYAASGCFSDAATGFTRISI 1194
            .:..:|:...||.     .||...|..|     |||.:|......:|..:..|::.:.....|.:
plant  1234 PSTFAIILFYAFGLEQFIGIGRFLPTVL-----MLLEYGLAIASSTYCLTFFFTEHSMAQNVILM 1293

  Fly  1195 INTLMGTGLFLMFMTLNFEAFQLKDVAEKLAW---YFRLSPHYSLASSTHSIHIGYNIRRGCSIG 1256
            ::...|    |:.|.::|....:...|...::   :|||||.:..:....|:.:   :|:|....
plant  1294 VHFFSG----LILMVISFVMGLIPATASANSYLKNFFRLSPGFCFSDGLASLAL---LRQGMKDK 1351

  Fly  1257 GIRKLPKQLRCRNVPICCDIPGYYGWRKPGVLVEITYMIMLGSTLFLLIV--MHDAKVCNLIAEK 1319
            ...                  |.:.|...|  ..|.| :.|.|..:.|:.  :....|..:::..
plant  1352 SSH------------------GVFEWNVTG--ASICY-LGLESIFYFLVTLGLELMPVQKVMSFS 1395

  Fly  1320 LGNCFSKRKRVEGG------------------TSIENDSVVAEQRVVREMINSGRKDVPLL---- 1362
            :|..:...|..:.|                  |.:|:|..|.|:   |:.:.||..|..:|
plant  1396 IGEWWQNLKAFKQGAGSSSTEPLLKDSTGAISTDMEDDIDVQEE---RDRVISGLSDNTMLYLQN 1457

  Fly  1363 ---VYKISKRYRSKLAVKAISFHVPHAECFGLLGINGAGKTSTFKMLAGDEKITSGEAYIDGTNI 1424
               ||...|.:..|:||::::|.|...||||.||.||||||:|..||:|:|..|||.|:|.|.:|
plant  1458 LRKVYPGDKHHGPKVAVQSLTFSVQAGECFGFLGTNGAGKTTTLSMLSGEETPTSGTAFIFGKDI 1522

  Fly  1425 --STHKVYRKIGYCPQFDALFEDLTGRETLNIYCLLRGVQRRHVTPICWGLAISFGFAKHMDKQT 1487
              |...:.:.||||||||||||.||.:|.|.:|..::||....:..:.....:.|...||..|.:
plant  1523 VASPKAIRQHIGYCPQFDALFEYLTVKEHLELYARIKGVVDHRIDNVVTEKLVEFDLLKHSHKPS 1587

  Fly  1488 KHYSGGNRRKLSTAISVLGNPSVLYLDEPTSGMDPAARRQLWQIIGLIRT-AGK-SIVLTSHSMD 1550
            ...||||:||||.||:::|:|.::.||||::||||.|:|.:|.:|..:.| :|| :::||:|||:
plant  1588 FTLSGGNKRKLSVAIAMIGDPPIVILDEPSTGMDPVAKRFMWDVISRLSTRSGKTAVILTTHSMN 1652

  Fly  1551 ECEALCSRLAIMVDGEFKCLGSVQSLKNQFSKGLILKVKVKH----KKKTFQRVVE--------- 1602
            |.:|||:|:.|||.|..:|:||.|.||.::...|.|:||...    :.:.|.::::
plant  1653 EAQALCTRIGIMVGGRLRCIGSPQHLKTRYGNHLELEVKPNEVSNVELENFCQIIQQWLFNVPTQ 1717

  Fly  1603 --------------DSSSSNDKKSISETDL---------KFL---QMASVM-----------ESS 1630
                          ..|.:.|..|.||..|         |||   |..|.:           :..
plant  1718 PRSLLGDLEVCIGVSDSITPDTASASEISLSPEMVQRIAKFLGNEQRVSTLVPPLPEEDVRFDDQ 1782

  Fly  1631 QADRILK---------------------VNRFISKEIPDAELKEEYNGL-ITYYIPHSK---TLS 1670
            .::::.:                     ::.||....|.|..| ..||| |.|.:|..:   :|:
plant  1783 LSEQLFRDGGIPLPIFAEWWLTKEKFSALDSFIQSSFPGATFK-SCNGLSIKYQLPFGEGGLSLA 1846

  Fly  1671 KIFQLLETNSHKLNIEDYLIMQTRLEEIFLDFAS 1704
            ..|..||.|.::|.|.:|.|.|:.||.||..||:
plant  1847 DAFGHLERNRNRLGIAEYSISQSTLETIFNHFAA 1880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324	7/32 (22%)
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	511/1845 (28%)
ABCA1	NP_850354.2	ABC2_membrane_3	<290..474	CDD:289468	46/197 (23%)
		ABC_subfamily_A	549..770	CDD:213230	108/227 (48%)
		drrA	556..874	CDD:130256	127/325 (39%)
		ABC2_membrane_3	<1118..1381	CDD:289468	76/298 (26%)
		Zinc_peptidase_like	<1215..1382	CDD:301362	43/199 (22%)
		EcfA2	1450..1676	CDD:224047	101/225 (45%)
		ABC_subfamily_A	1453..1679	CDD:213230	102/225 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	144	1.000	Domainoid score	I1483
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	716	1.000	Inparanoid score	I123
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		otm2678
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.980