DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and Abca2

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	XP_006233707.2	Gene:	Abca2 / 79248	RGDID:	620238	Length:	2435	Species:	Rattus norvegicus

Alignment Length:	1979	Identity:	573/1979 - (28%)
Similarity:	889/1979 - (44%)	Gaps:	468/1979 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 PEKMDEIRYPTVSISDLNLYMRM----VPLGNRILHENGSLNIPRNFLCYTPNNPINSAIVGATA 123
            ||.|:      :|:.:|...:|:    :|.|..:|.:               .:.|::|..|
  Rat   527 PEAMN------LSLDELPPALRLDYFSLPNGTALLQQ---------------LDTIDNAACG--- 567

  Fly   124 IRLRLLGTRAYDTALHMEQDMVLHNFLAGVQFEDNENV-------NTNDAGYPLNLNYSLRFPSE 181
             .::.:...:.|.......:..:.|:.....::||..|       ...|...|.:::|.:|..|.
  Rat   568 -WIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPPHVHYKIRQNSS 631

  Fly   182 LRTMQGPIIDTWRTSRLFLSYDTSGSRNRLDNDGGVPVGYIREGFLPIQHALTMSWLALASGVTD 246
            .         |.:|:.:..:|...|     .|.||  ..|...||:.||..:..:.:....| .|
  Rat   632 F---------TEKTNEIRRAYWRPG-----PNTGG--RFYFLYGFVWIQDMIERAIINTFVG-HD 679

  Fly   247 TGIPAIHLQRFPYRAYTYDQLLSGLRQLLPFVILLSFIYPASTVTKYVTSEKELQLKEIMKLIGV 311
            ...|..::|.|||..||.|..|..:..::|..:::|::|..:...:::.:|||.:|||:||.:|:
  Rat   680 VVEPGNYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMKTMGL 744

  Fly   312 HNWLHWVAWFVKSYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCFML 376
            :|.:||||||:..::.|.:.|..:.:::.   |..  ||..|..:.:.|||..|.|.::..||::
  Rat   745 NNAVHWVAWFITGFVQLSISVTALTAILK---YGQ--VLMHSHVLIIWLFLAVYAVATIMFCFLV 804

  Fly   377 AVLFSKASTASAVAAIFWFLTYIPYSF----GYYYYERLSLMSKLLISLIFSNSALGFGIHVIVM 437
            :||:|||..|||...|.:||:|:||.:    ....:::::...|.:.||: |.:|.|.|.....:
  Rat   805 SVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLM-STTAFGLGSKYFAL 868

  Fly   438 WEGTGEGITWRNMFH-PVSTDDSLTLFYIIMTMSFGSIMFISICLYVEQVFPGEYGVPRRWNFMC 501
            :|..|.||.|..... ||..||...|..:.|.| ..::::..:..|:|.|.||.||:||.|.|..
  Rat   869 YEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLM-VDTVVYGVLTWYIEAVHPGMYGLPRPWYFPL 932

  Fly   502 HKNYWR--------------QYVPSLNIVPSFQTILHGSAKAKSCRRAREVGI---------QLF 543
            .|:||.              .:.|.|:::...|.....|...:..|...|...         :|.
  Rat   933 QKSYWLGSGRTETWEWSWPWAHAPRLSVMEEDQACAMESRHFEETRGMEEEPTHLPLVVCVDKLT 997

  Fly   544 NLQKNYGKLKAVKGISLKMHRNEITVLLGHNGAGKTTTINMITGIVKPTSGTAIVNGYDIRTHLA 608
            .:.||..|| |:..:||.::.|::...|||||||||||::::||:..||||:|.:.|:||||.:.
  Rat   998 KVYKNDKKL-ALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRTEMD 1061

  Fly   609 KARESLGICPQNNILFKEMSVRDHIIFFSKLKGIRGTKAVENEVGKYMTMLKLQDKSYVAAKNLS 673
            :.|::||:|||:|:||.:::|.:|:.|:|:||.: ..:.:..|:.|.:..|:|.:|.:...:.||
  Rat  1062 EIRKNLGMCPQHNVLFDQLTVEEHLWFYSRLKSM-AQEEIRKEMDKMIEDLELSNKRHSLVQTLS 1125

  Fly   674 GGMKRKLSLCCALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQSEKDGRTILLTTHYMDEADVLGD 738
            ||||||||:..|..|.::.::.|||::|:|...||::|||:...|.||||||:||:|||||:|||
  Rat  1126 GGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADLLGD 1190

  Fly   739 RIAILSEGKLQCQGTSFYLKKRFGTGYLLVCIMQ----------------------SGCDVGAVT 781
            ||||:|.|||:|.|:..:||..:|.||.|..:.:                      |.|....|:
  Rat  1191 RIAIISHGKLKCCGSPLFLKGAYGDGYRLTLVKRPAEPGTSQEPGMASSPSGRPQLSNCSEMQVS 1255

  Fly   782 QLIRKYVPPIKPERVLGTELTYRLPTEYSKK--FAELLQDLDEKCAQLQLVGYGLSGATLEDVFM 844
            |.|||:|..........|||:|.||:|..||  |..|.|.|:.....|.|..:||...|||:||:
  Rat  1256 QFIRKHVASSLLVSDTSTELSYILPSEAVKKGAFERLFQQLEHSLDALHLSSFGLMDTTLEEVFL 1320

  Fly   845 AVNTD---------------KRVQGGAEG------------------------------------ 858
            .|:.:               |....||||
  Rat  1321 KVSEEDQSLENSEADVKESRKDALPGAEGLTAVESQAGNLARCSELAQSQASLQSASSVGSARGD 1385

  Fly   859 -------------PPVDG-----SIDFKELVFDSKTREKRRIRRCFMFW------QALFLKKFYT 899
                         |..|.     |:..:|...::..|..:..|:...:|      ..|.:|:|:.
  Rat  1386 EGAGYTDGYGDYRPLFDNLQDPDSVSLQEAEMEALARVGQGSRKLEGWWLKMRQFHGLLVKRFHC 1450

  Fly   900 TTRNYWLLGIQLVLP--IAVMALTILNS-----------------------RGG--------RIY 931
            ..||...|..|::||  ...:|:|:..|                       ||.        |..
  Rat  1451 ARRNSKALCSQILLPAFFVCVAMTVALSVPEIGDLPPLVLSPSQYHNYTQPRGNFIPYANEERRE 1515

  Fly   932 YELPAMP-ISINQYSSAY-----------------------------------------VVLEDN 954
            |.|...| .|..|..|.:                                         :.||..
  Rat  1516 YRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPMLNLSSGESRLLAARFFDSMCLESF 1580

  Fly   955 T-----------------------TDKTSSLADAYS----------------KHLEHYARRCTL- 979
            |                       .|:.|.||...|                ..|.|...|||.
  Rat  1581 TQGLPLSNFVPPPPSPAPSDSPLSPDEDSLLAWNTSLPPTAGPETWTWAPSLPRLVHEPVRCTCS 1645

  Fly   980 --------------------LRTGDLKFEDYILSHDVNH-----SRRIDFHFLAGLT-------- 1011
                                :.|||:..:  |..|:|:.     |.|...|....:|
  Rat  1646 AQGTGFSCPSSVGGHPPQMRVVTGDILTD--ITGHNVSEYLLFTSDRFRLHRYGAITFGNIQKSI 1708

  Fly  1012 -------------------VSENNFIVWLNNKPLHTAPLTLNLLHNAL----AIKLLGQDAS--T 1051
                               |::    |..|||..|:.|..||.|:||:    ..|..|..|:  .
  Rat  1709 PAPIGTRTPLMVRKIAVRRVAQ----VLYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGI 1769

  Fly  1052 YVTNEPLPYSDDTRTL-RLNKGQVLGAEISINLSLTMCFITAFYAIPIIRERETRAKLLQFLSGV 1115
            .|||.|:..:..:.:| .|.:|  ....|:|.:.:.|.|:.|.:.:.::.|:.|:||.|||:||.
  Rat  1770 TVTNHPMNKTSASLSLDYLLQG--TDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGC 1832

  Fly  1116 DVCAYWTSHIVWDYLVFVLSALSSILTIAAFKEIGYITPLDLSRYFYMLLIFGFPGIMLSYAASG 1180
            :...||.::.|||.|.:::.|...|:.:..|....|.:|.:......:.|::|:....:.|.||.
  Rat  1833 NPVIYWLANYVWDMLNYLVPATCCIIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASF 1897

  Fly  1181 CFSDAATGFTRISIINTLMG-TGLFLMFMTLNFEAFQ-LKDVAEKLAWYFRLSPHYSLASSTHSI 1243
            .|...::.:..:.:||..:| |.....|:...||..: ||.|...|...|.:.|:|:|.   |.:
  Rat  1898 WFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLG---HGL 1959

  Fly  1244 -HIGYN---IRRGCSIGGIRKLPKQLRCRNVPICCDIPGYYGWRKPGVLVEITYMIMLGSTLFLL 1304
             .:.||   ......||...|:..       |...||          |...:..|.:.|...|.|
  Rat  1960 MEMAYNEYINEYYAKIGQFDKMKS-------PFEWDI----------VTRGLVAMTVEGFVGFFL 2007

  Fly  1305 IVMHDAKVCNLIAEKLGNCFSKRKRVEGGTS-IENDSVVA--EQRVVREMINSGRKDVPLL-VYK 1365
            .:|     |..      |...:.:|:...|. :|:|..||  .|||:|     |..|..:: :..
  Rat  2008 TIM-----CQY------NFLRQPQRLPVSTKPVEDDVDVASERQRVLR-----GDADNDMVKIEN 2056

  Fly  1366 ISKRYRSK-----LAVKAISFHVPHAECFGLLGINGAGKTSTFKMLAGDEKITSGEAYIDGTNI- 1424
            ::|.|:|:     |||..:...|...|||||||:||||||||||||.|||..|.|||:::|.::
  Rat  2057 LTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVL 2121

  Fly  1425 -STHKVYRKIGYCPQFDALFEDLTGRETLNIYCLLRGVQ-RRHVTPICWGLAISFGFAKHMDKQT 1487
             ...:|.:.:||||||||||::||.||.|.:|..|||:. :.....:.|.|. .....|..||..
  Rat  2122 KDLLQVQQSLGYCPQFDALFDELTAREHLQLYTRLRGIPWKDEAQVVRWALE-KLELTKCADKPA 2185

  Fly  1488 KHYSGGNRRKLSTAISVLGNPSVLYLDEPTSGMDPAARRQLWQ-IIGLIRTAGKSIVLTSHSMDE 1551
            ..|||||:|||||||:::|.|:.::|||||:||||.|||.||. |:.||:| |:|:|||||||:|
  Rat  2186 GSYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKT-GRSVVLTSHSMEE 2249

  Fly  1552 CEALCSRLAIMVDGEFKCLGSVQSLKNQFSKGLILKVKVKHKKKTFQRVVEDSSSSNDKKSISET 1616
            |||:|:||||||:|..:||||:|.|||:|..|.::.|:.|             ||.|.|
  Rat  2250 CEAVCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTK-------------SSQNVK------ 2295

  Fly  1617 DLKFLQMASVMESSQADRILKVNRFISKEIPDAELKEEYNGLITYYIPHSK-TLSKIFQLLETNS 1680
                                .|.||.::..|:|.|||.::..:.|.:.... :|:::|..:|...
  Rat  2296 --------------------DVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKMEHVV 2340

  Fly  1681 HKLNIEDYLIMQTRLEEIFLDFASKRDSS 1709
            ..|.||||.:.||.|:.:|::||.|:..:
  Rat  2341 GVLGIEDYSVSQTTLDNVFVNFAKKQSDN 2369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	559/1887 (30%)
Abca2	XP_006233707.2	rim_protein	1..2369	CDD:130324	573/1977 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342290
Domainoid	1	1.000	158	1.000	Domainoid score	I4008
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.760