DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and Abca6

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_671751.2	Gene:	Abca6 / 76184	MGIID:	1923434	Length:	1624	Species:	Mus musculus

Alignment Length:	1844	Identity:	423/1844 - (22%)
Similarity:	797/1844 - (43%)	Gaps:	404/1844 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 KLLMWKNWILQWNQKMQIVFALVLPV-------LFLCLILVLRIIVLPEKMDEIRYPTVSISDLN 80
            :.|:.|..:.:|.:|.:.:....:|:       ||..|...::::.:|.:         .:..||
Mouse    13 RALLHKILLKKWRRKRESLLEWSIPIIIGLHMGLFSYLARNIQVLEVPPQ---------DLGSLN 68

  Fly    81 LYMRMVPLGNRILHENGSLNIPRNFLCYTPNNPINSAIVGATAIRLRLLGTRAYDT-ALHMEQDM 144
            .:             |||..:    :.|||.:.|...|:..|.....:.|||.... ::....::
Mouse    69 EF-------------NGSSLV----VVYTPISNITQQIMNKTTFAPTMKGTRIIGVPSIEDLDEV 116

  Fly   145 VLHNF--LAGVQFEDNENVNTNDAGYPLNLNYSLRFPSELRTMQGPII------DTWRT-SRLFL 200
            :|||.  ..||.|.|             :.:|.|:.   ||....|.:      ..|.| |:.|.
Mouse   117 LLHNIPDALGVIFND-------------SFSYQLKV---LRMYGNPFLKEDLLAHCWDTHSQAFC 165

  Fly   201 SYDTSGSRNRLDNDGGVPVGYIREGFLPIQHALTMSWLALASGVTDT-----------GIPAIHL 254
            |...                |...||:.:|.|:.       :|:.:.           .|..|::
Mouse   166 SLSK----------------YWERGFVALQTAIN-------AGIIEVTTNHSVMEELMSIDGINM 207

  Fly   255 QRFPYRAYTYDQLLSGLRQLLPFVILL--SFIYPASTVTKYVTSEKELQLKEIMKLIGVHNWLHW 317
            :..|:    ..:.||.....:.|.:|.  ||||.||:   .||.|:: |.||:||::|:.:...|
Mouse   208 KTLPF----IPRDLSDYEIFILFCLLYFSSFIYFASS---NVTKERK-QCKEVMKVMGLQDSAFW 264

  Fly   318 VAWFVKSYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCFMLAVLFSK 382
            ::|.: .|:..:.::.:.:::|:    .|..::..:.::.:......|.::.:.:.|::|||..|
Mouse   265 LSWGL-IYVGFIFIISIFIAIII----TSTQIIMMTGFLVIFTLFFLYGLSLIAVTFLMAVLLQK 324

  Fly   383 ASTASAVA---AIFWFLTYIPYSFGYYYYERLSLMSKLLISLIFSNSALGFGIHVIVMWEGTGEG 444
            |...:.:.   .:||...      |:....:....|...:..|||..|...|:..::..:....|
Mouse   325 AVLTNLIVLFFTLFWGCV------GFTVLHKELPPSLEWVLSIFSPFAFTSGMAKVIFQDYNLNG 383

  Fly   445 ITWRNMFHPVSTDDSLTLFYIIMTMSFGSIMFISICLYVEQVFPGEYGVPRR------------W 497
            :.:     |..:.:|..:..:...::|.|::::.:.||.:::.  .||...|            :
Mouse   384 VVF-----PDPSGESYVMIAVFFILAFDSLLYLVLALYFDKIL--LYGAEHRSAPLFFLNPTSCF 441

  Fly   498 NFMCHKN--YWRQYVPSL-------NIVPSFQTILHGSAKAKSCRRAREVGIQLFNLQKNY---- 549
            ....::|  ..|...|.|       .:.|.:|              .:| .|::.|::|.|
Mouse   442 RKTANRNKVIERDLDPELPSDEYFEPVDPEYQ--------------GKE-AIRIRNIKKEYKGKS 491

  Fly   550 GKLKAVKGISLKMHRNEITVLLGHNGAGKTTTINMITGIVKPTSGTAIV---NGYDIRTHLAKAR 611
            ||:||:||:.|.::.::||.:|||:||||::.:|:::|:..||:|:..|   |..|:: .|.:.|
Mouse   492 GKVKALKGLFLDIYESQITAILGHSGAGKSSLLNILSGLYVPTAGSVTVYNKNLSDMQ-DLKEIR 555

  Fly   612 ESLGICPQNNILFKEMSVRDHIIFFSKLKGIRGTKAVENEVGKYMTMLKLQDKSYVAAKNLSGGM 676
            :::|:|||:|:.|..::|::::..|:|:|||. .:.||.||.:.::.|.:|:.....|::||.|.
Mouse   556 KAIGVCPQHNVQFDALTVKENLTLFAKIKGIL-PQDVEQEVQQILSELDMQNIRDDLAEHLSEGQ 619

  Fly   677 KRKLSLCCALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQSEKDGRTILLTTHYMDEADVLGDRIA 741
            ||||:...|..|:.:::|.|||:.|:|...|:.:|..|:..:....||.:|.:|||||:|.||..
Mouse   620 KRKLTFGIATVGDPQILLLDEPTVGLDPFSRQRIWGFLKERRADHVILFSTQFMDEADILADRKV 684

  Fly   742 ILSEGKLQCQGTSFYLKKRFGTGYLLVCIMQSGCDVGAVTQLIRKYVPPIKPERVLGTELTYRLP 806
            :::.|.|:|.|:|.:||:::|.||.|...|...||...:|..|..::|..|.:.....:|.|.||
Mouse   685 LIANGALKCTGSSVFLKRKWGLGYHLSLFMDETCDSERLTSFINHHIPYAKLKAKTKEKLVYILP 749

  Fly   807 TEYSKKFAELLQDLDEKCAQLQLVGYGLSGATLEDVFMAVNTDKRVQGGAEGPPVDGSIDF--KE 869
            .|.:.:|.|...|||:...| .|:.|.:|.:||.|||:          ..||.| ....||  :|
Mouse   750 LERTSEFPEFFSDLDKYSGQ-GLMSYEVSMSTLNDVFL----------NLEGEP-STKQDFEKRE 802

  Fly   870 LVFDSKTREKRRIRRCFMFWQALFLKKFYTTTRNYWLLGIQLVLPIAVMALTILNSRGGR----- 929
            ...||::.....:.     :.:|...:...:|.:.|.:.:     .|:..|.||..:..|
Mouse   803 TATDSESLNDMEVA-----YPSLSQVQETVSTMSLWRMQV-----CAIARLRILKLKRERKAFLI 857

  Fly   930 --IYYELPAMPISINQYSSAYVVLEDNTTDKTSSLADAY---------------------SKHLE 971
              :...:..:|:.|...::|.:.:::|...||    |.|                     ..::|
Mouse   858 ILLLLGIALLPLVIEYVANALLEVKNNWEFKT----DLYFLSPGQLPQGLRTSLLVINNTESNIE 918

  Fly   972 HYARRCTLLRTGDLKFEDYILSHD--VNHSRRIDFHFLAGLTVS----ENNFIVWLNNKPLHTAP 1030
            .:.:        .||.::.:|..|  .|.:......:...:.||    :..|....|.|.||..|
Mouse   919 DFLQ--------SLKHQNIVLEVDDFENRNATNSLSYNGAIIVSGRQKDYRFSAVCNTKRLHCFP 975

  Fly  1031 LTLNLLHNALAIKLLGQDASTYVTNEPLPYSDDTRTLRLNKGQVLG----------AEISINLSL 1085
            :.:|::.|.:                 |...:.|:.:|: |..:..          .|..:.:..
Mouse   976 ILMNVISNGI-----------------LHMLNHTQYIRI-KEDIFSPFIVLVWTGIQETCLFILC 1022

  Fly  1086 TMCFITAFYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVWDYLVFVLSALSSILTIAAFKEIG 1150
            .:|.::...|:..:.:.:.:|....::||:...|||....|.|..:|....|:|..|....|
Mouse  1023 VICSLSPHIAMSSVSDYKKKADSQLWISGLYPSAYWCGQAVVDISLFSGMLLTSYFTSYTSK--- 1084

  Fly  1151 YITPLDLSR---YFYMLLIFGFPG--IMLSYAASGCFSDAATGFTRISIINTLMGTGLFLMFMTL 1210
             :..:|::.   :..::|..|...  :.|:|..|..|.......|..||        .||:.:.:
Mouse  1085 -LLNIDMTSEIVFSVIVLALGCAASLVFLTYVISFVFGKRKKNSTLWSI--------CFLLVIAI 1140

  Fly  1211 NFEAFQLKDVAEKLA-WYFRLSPHYS-------LASSTHSIHIGY-NIRRGCSIGGIRKLPKQLR 1266
            .||........|.|. ....|.|.::       |....:..:|.: .|:.|.|...:
Mouse  1141 TFEKVANGPFNEALVISATMLVPSFALNGLLVVLEMRAYQYYIEFEEIKHGLSAVDL-------- 1197

  Fly  1267 CRNVPICCDIPGYYGWRKPGVLVEITYMIMLGSTLFLLI-----------VMHDAKVCNLIAEKL 1320
                 :.|.||                  .:.:.||:.:           |:....:..:..:.|
Mouse  1198 -----LLCLIP------------------YIHTLLFIFVLRCLELKYGKNVVRRDPIFRIAPQSL 1239

  Fly  1321 GNCFSKRKRVEGGTSIENDSVVAEQRVVREMINSGRKD-VPLLV-------------YKISKRYR 1371
            ....:..:.::     |:::|.||:....:.:::...| .|:::             :..|:|.|
Mouse  1240 KAQPNPEEPID-----EDENVQAERLRTSDALSTPNLDEKPVIIASCLHKEYAGQKKHCCSRRTR 1299

  Fly  1372 SKLAVKAISFHVPHAECFGLLGINGAGKTSTFKMLAGDEKITSGEAYIDGTNISTHKVYR----- 1431
            : :||:.:||.|...|..||||.:||||:|:.:|:||..|.|:|:  ::...:|:...::
Mouse  1300 N-MAVRNVSFCVNKGEILGLLGPDGAGKSSSIRMIAGITKPTAGQ--VELKRLSSAVGHQGDSRA 1361

  Fly  1432 KIGYCPQFDALFEDLTGRETLNIYCLLRGVQRRHVTPICWGLAISFGFAKHMDKQTKHYSGGNRR 1496
            :.|||||.:.|:.:||.:|.|.:|..::|:::.........|..:......::.|.::...|..|
Mouse  1362 EFGYCPQENGLWPNLTVKEHLELYAAVKGLRKEDAVVAISRLVNALKLHDQLNVQVQNLVAGATR 1426

  Fly  1497 KLSTAISVLGNPSVLYLDEPTSGMDPAARRQLWQII-GLIRTAGKSIVLTSHSMDECEALCSRLA 1560
            ||...:|:|||..||.||||::|:|.:.:.|:||.| .:::...|.::|::|.:.|.||||.|.|
Mouse  1427 KLCFVLSILGNSPVLILDEPSTGLDVSGKHQVWQAIQAVVKDNEKGVLLSTHDLAEAEALCDRAA 1491

  Fly  1561 IMVDGEFKCLGSVQSLKNQFSKGLILKVKVKHKKKTFQRVVEDSSSSNDKKSISETDLKFLQMAS 1625
            |||.|..:|:|.:|.||.:|.:..:|:::|                    |.:|:..|
Mouse  1492 IMVSGRLRCIGPIQHLKRKFGQDYVLELRV--------------------KDVSQEPL------- 1529

  Fly  1626 VMESSQADRILKVNRFISKEIPDAELKEEYNGLITYYIPHSKT--LSKIFQLLETNSHKLNIEDY 1688
                        |:|.|.|..|.|..::....|:||.:|.:..  ||:.|..||...|..::|||
Mouse  1530 ------------VHREILKLFPQAARQDRCFSLLTYKLPVTDVHPLSQAFHKLEAVKHGFDLEDY 1582

  Fly  1689 LIMQTRLEEIFLDFASKRDSSDIF 1712
            .:.|..|:.:.|:.:.:::...::
Mouse  1583 SLSQCTLDRVILELSKEQELGTVY 1606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324	7/37 (19%)
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	397/1705 (23%)
Abca6	NP_671751.2	rim_protein	<169..1600	CDD:130324	383/1638 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838446
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.750