DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6052 and Abca12

DIOPT Version :9

Sequence 1:NP_649002.3 Gene:CG6052 / 39971 FlyBaseID:FBgn0036747 Length:1725 Species:Drosophila melanogaster
Sequence 2:NP_780419.2 Gene:Abca12 / 74591 MGIID:2676312 Length:2595 Species:Mus musculus


Alignment Length:1850 Identity:510/1850 - (27%)
Similarity:855/1850 - (46%) Gaps:356/1850 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 LPVLFLCLILVLRIIVLPEKMDEIRYPTVSISDLNLYMRMVPLGNRILHENGSLNIPRNFLCYTP 110
            |.||.|.|:..:.||   ::::.:...||:||...||.|:                         
Mouse   891 LDVLRLKLVNNIDII---DQLNTLSSLTVNISSCVLYDRI------------------------- 927

  Fly   111 NNPINSAIVGATAIRLRLLGTRAYDTALHME---QDMVLHNFLAG-VQFE-----------DNEN 160
                                 :|.||...||   :.:...|.|.| |.|:           |.|.
Mouse   928 ---------------------QASDTVEEMETVAEQLYKSNELFGSVIFKLPSNGSLHRGFDPEK 971

  Fly   161 VNTNDAGYPLNLNYSLRFPSELRTMQGPIIDTWRTSRLFL---SYDTSGSRNRLDNDGGVPVGYI 222
            |:     .|..:.|::|.  .|:|.|     |.|:.|..:   ....|.|.|::         |.
Mouse   972 VS-----LPPIVRYTIRM--SLKTAQ-----TTRSIRTKIWAPGPHNSPSHNQI---------YG 1015

  Fly   223 REGFLPIQHALTMSWLALASGVTDTGIPAIHLQRFPYRAYTYDQLLSGLRQLLPFVILLSFIYPA 287
            | .|:.:|.::..:.:.|.:|.....: |:.:|..||..:..|..|:.:...||.|::::::...
Mouse  1016 R-AFIYLQDSIERAIIELQTGRNSQEV-AVQVQAVPYPCFMKDNFLTSVSYSLPIVLMVAWVVFI 1078

  Fly   288 STVTKYVTSEKELQLKEIMKLIGVHNWLHWVAWFVKSYIMLMLVVFLIMSLIMVKFYASVAVLTF 352
            :...|.:..||:|:|.|.||::||::..|:.||.::|      :.||::::.::     :.:|.|
Mouse  1079 AAFVKKLVYEKDLRLHEYMKMMGVNSCSHFFAWLIES------IGFLLVTIAIL-----IVILKF 1132

  Fly   353 SSWVP----VLLFLH--TYVVTSVCLCFMLAVLFSKASTASAVAAIFWFLTYIPYSFGYYYYERL 411
            .:.:|    .:|||:  .|..:.:.:.::::|.|:..:.|:.:.::.:.:.:.|:.......:.|
Mouse  1133 GNILPKTNGFILFLYFSDYSFSVIAMSYLISVFFNNTNIAALIGSLIYVIAFFPFIVLVTVEDEL 1197

  Fly   412 SLMSKLLISLIFSNSALGFGIHVIVMWEGTGEGITWRNMFHPVSTDDSLTLFYIIMTMSFGSIMF 476
            |.:.|:.:||: |.:|..:....|..:|..|.|:.|.||:.....||:.:..::...:...|.::
Mouse  1198 SYVIKVFMSLL-SPTAFSYASQYIARYEEQGVGLQWENMYKSPVQDDTTSFGWLCCLILADSFIY 1261

  Fly   477 ISICLYVEQVFPGEYGVPRRWNFMCHKNYWRQ------------------YVPSLNIVPSFQTIL 523
            ..|..||..||||.||:...|.|....:||::                  .:...|..||     
Mouse  1262 FFIAWYVRNVFPGTYGMAAPWYFPILPSYWKERFGCAEVKHEKSNGLMFTNIMMQNTNPS----- 1321

  Fly   524 HGSAKAKSCR---------RAREVGIQLFNLQKNYGKLKAVKGISLKMHRNEITVLLGHNGAGKT 579
             .|..:..|.         :..:||:.|..:.|.||...||:.::|..:...||.|||.||||||
Mouse  1322 -ASKTSPDCAFPSNIEPEPKDLQVGVALHGVTKIYGSKTAVENLNLNFYEGHITSLLGPNGAGKT 1385

  Fly   580 TTINMITGIVKPTSGTAIVNGYDIRTHLAKARESLGICPQNNILFKEMSVRDHIIFFSKLKGIRG 644
            |||:|:||:...|:||..|.|.||:|.|...|:::|:|.|:::||..::.::|::.:..:|....
Mouse  1386 TTISMLTGLFGATAGTIFVYGKDIKTDLNTVRKNMGVCMQHDVLFSYLTTKEHLLLYGSIKVPHW 1450

  Fly   645 TKA-VENEVGKYMTMLKLQDKSYVAAKNLSGGMKRKLSLCCALCGNAKVVLCDEPSSGIDAAGRR 708
            ||. :..||.:.:....|....:.....||||||||||:..||.|.::||:.||||:|:|...||
Mouse  1451 TKTQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLSISIALIGGSRVVILDEPSTGVDPCSRR 1515

  Fly   709 SLWDLLQSEKDGRTILLTTHYMDEADVLGDRIAILSEGKLQCQGTSFYLKKRFGTGYLLVCIMQS 773
            |:||::...|..|||:|:||::|||:||.||||.|.:|.|:|.|:.||||:.||.||.|....:.
Mouse  1516 SIWDVISKNKTARTIILSTHHLDEAEVLSDRIAFLEQGGLRCCGSPFYLKEAFGDGYHLTLTKKK 1580

  Fly   774 G--------CDVGAVTQLIRKYVPPIKPERVLGTELTYRLP---TEYSKKFAELLQDLDEKCAQL 827
            .        ||..|||.:|:.::|....:..:|.||.|.||   |:.|..:..||:.||:...:|
Mouse  1581 SPNLDTNAICDTVAVTAMIQSHLPEAYLKEDIGGELVYVLPPFSTKVSGAYLSLLRALDKGMGKL 1645

  Fly   828 QLVGYGLSGATLEDVFMAVNTDKR----------VQGGAEGPPVDGSIDFKELVFDSKT---REK 879
            .:..||:|..|:|:||:.:..|.:          .|.....|..:|:....:|...|..   |:.
Mouse  1646 NIGCYGISDTTVEEVFLNLTKDSQKSSNMSLEHLTQRKVGNPSANGTSTPDDLSVSSSNFTDRDD 1710

  Fly   880 RRIRR---------CFMFWQALFLKKFYTTTRNYWLLGIQLVLPIAVMAL-----TILNSRGGRI 930
            :.:.|         ......|:.:|:|:.|.||:..|..|::|||..:|.     |:.:|...  
Mouse  1711 KVLTRSEKLEGFGLLLKKIMAILIKRFHHTRRNWKGLIAQVILPIVFVATAMGLGTLRDSSNS-- 1773

  Fly   931 YYELPAMP--ISINQYSSAYVVLEDNTTDKTSSL------------------------------- 962
            |.|:...|  ...::.::.|...:.:|:...|:|                               
Mouse  1774 YPEIMISPSIYGTSEQTAFYANFDPSTSGLVSALWNFPGIDNVCLNTSDLQCLKKDDLGKWNTSG 1838

  Fly   963 -----------------ADAYSKHLEH---YARRCTLLRTGDLKFEDYILSHDVNH---SRRIDF 1004
                             ...::.|..|   |:.:.....||. ..|:|::: ..||   .|...:
Mouse  1839 EAIDNFGVCSCSDNVQECPKFNYHPPHRRTYSSQVIYNLTGK-HMENYLIT-TANHFVQKRYGGW 1901

  Fly  1005 HFLAGLT---------VSENNFI--VWLNNKPLHTAPLTLNLLHN-ALAIKLLGQDASTY---VT 1054
            .|...||         |.:|..:  ||.:.:..|:.|..||.|:| .|.:.:...||:.:   :.
Mouse  1902 SFGMKLTNDLRFDVTAVPDNRTLAKVWYDPEGYHSLPAYLNSLNNFLLRVNMSEYDAARHGIIMY 1966

  Fly  1055 NEPLPYSDDTRTLRLNKGQVLGAEISINLSLTMCF--ITAFYAIPIIRERETRAKLLQFLSGVDV 1117
            :.|.|...|.....::.    ..:|.:.||:.|.:  .||.:...|:||.:|:||.||.:||:.|
Mouse  1967 SHPYPGVQDQEQATISS----LIDILVALSILMGYSVTTASFVTYIVREHQTKAKQLQHISGIGV 2027

  Fly  1118 CAYWTSHIVWDYLVFVLSALSSILTIAAFKEIGYITPLDLSRYFYMLLIFGFPGIMLSYAASGCF 1182
            ..||.::.::|.:.:::....||..||.||...:.:..:|.....:||:||:......|..:|.|
Mouse  2028 TCYWVTNFIYDMVFYLVPVAFSIGVIAIFKLPAFYSGNNLGAVSLLLLLFGYATFSWMYLLAGLF 2092

  Fly  1183 SDAATGFTRISIINTLMGTGLFLMFMTLNFEAFQ------LKDVAEKLAWYFRLSPHYSLASSTH 1241
            .:....|.....:|...|....:....:.|.:.:      |:.::|.|...|.:.|.:.      
Mouse  2093 HETGMAFITYVCVNLFFGINSIVSLSVVYFLSKEKPNDPTLELISETLKRIFLIFPQFC------ 2151

  Fly  1242 SIHIGYNIRRGCSIGGIRKLPKQLRCRNVPICCDIPGYYGWRKPGVLVEI-------TYMIMLGS 1299
               .||         |:.:|.:|      ....|....||...|....|:       ..::..|:
Mouse  2152 ---FGY---------GLIELSQQ------QAVLDFLKAYGVEYPSETFEMDKLGAMFVALVSQGT 2198

  Fly  1300 TLFLLIVMHDAKVCNLIAEKLGNCFSKRKRVEGGTSIENDSVVAEQRVVREMINSGRKDVPLL-V 1363
            ..|||.::    :...:.:||...|.|........:::.|..|   |..|..:.||..:..|: :
Mouse  2199 MFFLLRLL----INEWLIKKLRLFFRKFTSSPIMETVDEDEDV---RAERFRVESGAAEFDLVQL 2256

  Fly  1364 YKISKRY----RSKLAVKAISFHVPHAECFGLLGINGAGKTSTFKMLAGDEKITSGEAYI---DG 1421
            ::::|.|    :..:||..||..:|..|||||||:||||||:.||||.||...:||...|   .|
Mouse  2257 HRLTKTYQLIHKKIIAVNNISLGIPAGECFGLLGVNGAGKTTIFKMLTGDIIPSSGNILIRNKSG 2321

  Fly  1422 T--NISTHKVYRKIGYCPQFDALFEDLTGRETLNIYCLLRGVQRRHVTPICWGLAISFGFAKHMD 1484
            :  ::.:|.  ..:|||||.|||.:.:|..|.|..|..:.|:..:.:......|........:.|
Mouse  2322 SLGHVDSHS--SLVGYCPQEDALDDLVTVEEHLYFYARVHGIPEKDIKDTVHKLLRRLHLMAYKD 2384

  Fly  1485 KQTKHYSGGNRRKLSTAISVLGNPSVLYLDEPTSGMDPAARRQLWQIIGLIRTAGKSIVLTSHSM 1549
            :.|...|.|.:||||||::::|.||:|.||||:|||||.::|.||:||........|::||||||
Mouse  2385 RSTSMCSYGTKRKLSTALALIGKPSILLLDEPSSGMDPKSKRHLWRIISEEVQNKCSVILTSHSM 2449

  Fly  1550 DECEALCSRLAIMVDGEFKCLGSVQSLKNQFSKGLILKVKVKHKKKTFQRVVEDSSSSNDKKSIS 1614
            :||||||:||||||:|.|:|:||:|.:|::|.:|..:||.:|                |:|.|: 
Mouse  2450 EECEALCTRLAIMVNGRFQCIGSLQHIKSRFGRGFTVKVHLK----------------NNKVSM- 2497

  Fly  1615 ETDLKFLQMASVMESSQADRILKVNRFISKEIPDAELKEEYNGLITYYIP-HSKTLSKIFQLLET 1678
            ||..||:|:                     ..|...||:::..::.|::| .:..::.||.||||
Mouse  2498 ETLTKFMQL---------------------HFPKTYLKDQHLSMLEYHVPVTAGGVANIFDLLET 2541

  Fly  1679 NSHKLNIEDYLIMQTRLEEIFLDFASKRDS 1708
            |...|||.::|:.||.|||:|::||..:.|
Mouse  2542 NKTALNITNFLVSQTTLEEVFINFAKDQKS 2571

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6052NP_649002.3 rim_protein 21..>54 CDD:130324 4/7 (57%)
rim_protein <149..1709 CDD:130324 489/1743 (28%)
Abca12NP_780419.2 ABC2_membrane_3 <1006..1267 CDD:289468 63/283 (22%)
NosY <1108..1269 CDD:224196 35/172 (20%)
ZnuC 1346..1570 CDD:224046 98/223 (44%)
ABC_subfamily_A 1350..1565 CDD:213230 94/214 (44%)
ABC2_membrane_3 <1913..2174 CDD:289468 66/288 (23%)
CcmA 2253..2567 CDD:224054 136/353 (39%)
ABC_subfamily_A 2254..2477 CDD:213230 98/224 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838438
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 1 1.100 - - O PTHR19229
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.840

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