DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6052 and abcg4a

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	XP_687685.2	Gene:	abcg4a / 564842	ZFINID:	ZDB-GENE-050517-39	Length:	641	Species:	Danio rerio

Alignment Length:	733	Identity:	153/733 - (20%)
Similarity:	270/733 - (36%)	Gaps:	221/733 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   555 VKGISLKMHRNEITVLLGHNGAGKTTTINMITGIVKP-TSGTAIVNG--YDIRTHLAKARESLGI 616
            :|.:|.|....|:..::|.:||||:|.:|::.|..:. ..|..:|||  .|:||.    |:....
Zfish    79 LKCLSGKFCSRELIGIMGPSGAGKSTLMNILAGYRETGMKGQILVNGRPRDLRTF----RKMSCY 139

  Fly   617 CPQNNILFKEMSVRDHIIFFSKLKGIRGTKAVENEVGKYMTMLKLQDKSYVAAKNLSGGMKRKLS 681
            ..|:::|...::.|:.::..:.||.....:..:..|.:.:|.|.||:.:.....:||||..::|:
Zfish   140 IMQDDMLLPHLTTREAMMVSANLKLNENMEVKKELVNEILTALGLQECAQTRTISLSGGQCKRLA 204

  Fly   682 LCCALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQS-EKDGRTILLTTHYMDEADV--LGDRIAIL 743
            :...|..|..|:..|||:||:|:|....:..|::| .:.||||:.|.| ...|.:  :.|::.||
Zfish   205 IALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIH-QPSAKLFEMFDKLYIL 268

  Fly   744 SEGKLQCQGTSFYLKKRFGTGYLLVCIMQSGCDVGAVTQLIRKYVPPIKPERVLGTEL-TYRLPT 807
            |:|:...:||..||                              :|.:|.   ||... ||..|.
Zfish   269 SQGQCIYKGTVPYL------------------------------IPYLKN---LGLHCPTYHNPA 300

  Fly   808 EY-----SKKFAELLQDLDEKCAQLQLVGYGLSGATLEDVFMAVNTDKR---VQGGAEGPPVDGS 864
            ::     |.::.:|...|.|          .:.|....|.....::||.   ....::..|..|.
Zfish   301 DFIIEVASGEYGDLNPVLFE----------AVQGGLCSDDSKKNSSDKNDPTTSCPSQCYPDSGY 355

  Fly   865 IDFKELVFDSKTREKRRIRRCFMFWQALFLKKFYTTTRNYWLLGIQLVLPIAVMALTILNSRGGR 929
            |:.......:.|:           :..||.:.|.|..|:..|..::::..:.:..|.      |.
Zfish   356 IEKHTFATSTLTQ-----------FCILFKRTFITICRDVVLTHLRVMSHLCIGVLI------GL 403

  Fly   930 IYYELPAMPISINQYSSAYVVLEDNTTDKTSSLADAYSKHLEHYARRCTLLRTGDLKFEDYILSH 994
            :|..:.      |..|..:        :.|..|  .:|.....:|.....:.|..|:...:|..|
Zfish   404 LYLNIG------NDASKVF--------NNTGFL--FFSMLFLMFAALMPTVLTFPLEMGVFIREH 452

  Fly   995 DVNHSRRIDFHFLAGLTVSENNF-----------IVWLNNKPLHTAPLTLNLLHNALAIKLLGQD 1048
             :|:...:..::|| .|:::..|           :.|:..:|                     .:
Zfish   453 -LNYWYSLKAYYLA-KTMADIPFQVICPIMYCSIVYWMTEQP---------------------PE 494

  Fly  1049 ASTYVTNEPLPYSDDTRTLRLNKGQVLGAEISINLSLTMCFITAFYAIPIIR------ERETRAK 1107
            |..|:....|  |..|..:..:.|.::|| .|.:|.:. .|:....|||::.      ..:|..|
Zfish   495 AGRYLLFMAL--STSTALVAQSLGLLIGA-ASTSLQVA-TFVGPVSAIPVLLFSGFFVNFDTIPK 555

  Fly  1108 LLQFLSGVDVCAYWTSHIVWDYLVFVLSALSSILTIAAFKEIGYITPLDLSRYFYMLLIFGFPGI 1172
            .||          |:|:                        :.|:      ||       ||.|:
Zfish   556 YLQ----------WSSY------------------------VSYV------RY-------GFEGV 573

  Fly  1173 MLSYAASGCFSDAATGFTRISIINTLMGTGLFLMFMTLNFEAFQLKDVAE--------------- 1222
            :||          ..|..|    :.|...|:...|.... |..||.||.:
Zfish   574 ILS----------IYGMNR----SELECPGIVCKFQKPE-EVLQLLDVEDAKLYVDFMVLGVFFL 623

  Fly  1223 --KLAWYFRLSPHYSLAS 1238
              :||.||.|  .|.:.|
Zfish   624 VLRLATYFVL--RYKVKS 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	153/733 (21%)
abcg4a	XP_687685.2	3a01204	38..641	CDD:273361	153/733 (21%)
		ABCG_EPDR	53..277	CDD:213180	59/202 (29%)
		ABC2_membrane	372..574	CDD:279410	52/297 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000