DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and abca1a

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_001296394.1	Gene:	abca1a / 558924	ZFINID:	ZDB-GENE-031006-12	Length:	2268	Species:	Danio rerio

Alignment Length:	1847	Identity:	561/1847 - (30%)
Similarity:	874/1847 - (47%)	Gaps:	403/1847 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 LRLLGTRAYDTALHMEQDMVLHNFLAGVQFEDNENVNTNDAGYPLNLNYSLRFPSELRTMQGPII 190
            :|||..|               .|.||:.|.|.:: ||:|  .|||:||.:|.         .|.
Zfish   528 MRLLDDR---------------KFWAGIVFPDMQS-NTSD--LPLNVNYKIRM---------DID 565

  Fly   191 DTWRTSRLFLSYDTSGSRNRLDNDGGVPVGYIREGFLPIQHALTMSWL-ALASGVTDTGIPAIHL 254
            :..||:::...|...|.|    .|....:.||..||..:|..:....: ||......||   :::
Zfish   566 NVERTNKIKDGYWDPGPR----ADPFEDLRYIWGGFTYLQDVIEHGIIRALTGSKEKTG---VYI 623

  Fly   255 QRFPYRAYTYDQLLSGLRQLLPFVILLSFIYPASTVTKYVTSEKELQLKEIMKLIGVHNWLHWVA 319
            |:.||..|..|..|..:.:.:|..:.|:::|..:.:.|.|..|||.:|||.|:::|:.|.:.|::
Zfish   624 QQMPYPCYVDDIFLRVMSRSMPLFMTLAWMYSVAIIIKGVVYEKEARLKETMRIMGLDNGILWLS 688

  Fly   320 WFVKSYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCFMLAVLFSKAS 384
            ||:.|     |:..||.:.::|.......:|.:|....:.|||.::.|.::..||:::.|||:|:
Zfish   689 WFISS-----LIPLLISAALLVLILKMGNLLPYSDPGVIYLFLSSFAVVTIMQCFLISTLFSRAN 748

  Fly   385 TASAVAAIFWFLTYIPYSFGYYYYERLSLMSKLLISLIFSNSALGFGIHVIVMWEGTGEGITWRN 449
            .|:|...|.:|..|:||.....:...:...:|:::||: |..|.|||.....::|..|.||.|.|
Zfish   749 LAAACGGIIYFTLYLPYVLCVAWQNYVGFGAKIVVSLL-SPVAFGFGCEYFALFEEQGVGIQWSN 812

  Fly   450 MFHPVSTDDSLTLFYIIMTMSFGSIMFISICLYVEQVFPGEYGVPRRWNFMCHKNY-------WR 507
            :......:||..|...|..|.|.|:::..:..|:|.||||:||:||.|.|...|:|       |.
Zfish   813 LLSSPMQEDSYNLTTSICLMLFDSVLYAVMTWYIEAVFPGQYGIPRPWYFPFTKSYWCGEKCGWT 877

  Fly   508 QYVPSLNIVPSFQTILHGSAKAKSCRRAREVGIQLFNLQKNY--GKLKAVKGISLKMHRNEITVL 570
            ..||| |...:.:.:......|..     :.|:.:.||.|.|  ||: ||.|::|..:..:||..
Zfish   878 TSVPS-NRKENAEAVCIEEEPAHI-----DPGVYIENLMKIYSNGKV-AVDGLTLGFYEGQITSF 935

  Fly   571 LGHNGAGKTTTINMITGIVKPTSGTAIVNGYDIRTHLAKARESLGICPQNNILFKEMSVRDHIIF 635
            |||||||||||::::||:..||||||.:.|.||||.|...|::||:|||:|:||..::|.:||.|
Zfish   936 LGHNGAGKTTTMSILTGLFPPTSGTAYIQGKDIRTDLNAIRQNLGVCPQHNVLFSMLTVEEHIWF 1000

  Fly   636 FSKLKGIRGTKAVENEVGKYMTMLKLQDKSYVAAKNLSGGMKRKLSLCCALCGNAKVVLCDEPSS 700
            :::|||:...| |::|:.:.:..|.|..|....:..|||||:||||:..|..|.:|||:.|||::
Zfish  1001 YARLKGLSAEK-VKSEMEQIVMDLGLPHKRTSRSNQLSGGMQRKLSVALAFVGGSKVVILDEPTA 1064

  Fly   701 GIDAAGRRSLWDLLQSEKDGRTILLTTHYMDEADVLGDRIAILSEGKLQCQGTSFYLKKRFGTGY 765
            |:|...||.:||||...:.||||:|:||:|||||:|||||||:|.|||.|.|:|.:||.:.||||
Zfish  1065 GVDPYARRGIWDLLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKTQLGTGY 1129

  Fly   766 LLVCIMQ------SGC----------------------------------------DVGAVTQLI 784
            .|..:.:      |.|                                        |:..::.:|
Zfish  1130 YLTLVKKDFDLSASSCRTSSSTVSYSKGSLKKDDSVSESSSDAGLGSDHESETTTIDISLISNVI 1194

  Fly   785 RKYVPPIKPERVLGTELTYRLPTEYSK--KFAELLQDLDEKCAQLQLVGYGLSGATLEDVFMAVN 847
            .|:||..:....||.|:||.||.|.:|  .|.||..::|::...|.:..||:|..|||::|:.|.
Zfish  1195 FKHVPTARLVEDLGHEITYVLPYESAKDGAFVELFHEIDDRLTDLSISSYGISDTTLEEIFLKVA 1259

  Fly   848 TD--------------KRVQGGAEG-------PPVDGSIDFKELVFDSKTREK------------ 879
            .|              :|.:..|.|       |..:...||.:...|.::||.
Zfish  1260 EDCGVDAETSDGTLPARRNRRHAFGDHQSCLKPFTEDDFDFNDSEGDPESRETDWLDGADGKGSY 1324

  Fly   880 -------RRIRRCFMFWQALFL-----KKFYTTTRNYWLLGIQLVLPIAVMALTILNSRGGRIYY 932
                   :|.:...:.|:.|..     |.|:.          |:|||...:.:.::.|.....:.
Zfish  1325 QVKGWSLKRQQFVALLWKRLLYARRSRKGFFA----------QIVLPAVFVCIALVFSLIVPPFG 1379

  Fly   933 ELPAMPISINQYSSAYVVLEDNTTD--KTSSLADAYSKHLEHYARRCT----------------- 978
            :.|::.:..:.|...:..:.::..:  .|:.|.||. |....|..:||
Zfish  1380 KYPSLALEPSMYEEQFTFISNDAPEDRHTNRLLDAL-KDSPAYTDQCTDGKNTASRSCPIKDGEW 1443

  Fly   979 -----------LLRTGDLKFE-------------------------------------------- 988
                       :...|:...|
Zfish  1444 LVPEVTESIEAIFLNGNWSMENPSPLCECSCEGRKKMLPECPPGAGGLPPPQIKVTHDETLQNLS 1508

  Fly   989 -----DYI-----------------------------------------LSHDVNHSR-RIDFH- 1005
                 ||:                                         |:..::|.| |....
Zfish  1509 GRNISDYLVKTYAQIIGKSLKNKLWVNEFRYGGFSLGARNTQALPPGDELTDAISHIRSRFSLES 1573

  Fly  1006 -------------FLAGLTVSENNFIVWLNNKPLHTAPLTLNLLHNALAIKLL--GQDASTY--- 1052
                         |:.||. :.||..:|.|||..|:....||:::||:....|  |.|.|.:
Zfish  1574 GTAADRFLGSLSTFIRGLD-TNNNVKIWFNNKGWHSIGSFLNVMNNAVLRANLPPGLDRSKFGIN 1637

  Fly  1053 VTNEPLPYSDDTRTLRLNKGQV---------LGAEISINLSLTMCFITAFYAIPIIRERETRAKL 1108
            ..|.|         |.|.|.|:         :...:||.:...|.|:.|.:.:.:|:||..:||.
Zfish  1638 AFNHP---------LNLTKEQLSHVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVNKAKH 1693

  Fly  1109 LQFLSGVDVCAYWTSHIVWDYLVFVLSALSSILTIAAFKEIGYITPLDLSRYFYMLLIFGFPGIM 1173
            :||:|||....||.::.|||...:::.|...|:....|::..|::..:|.....:||::|:....
Zfish  1694 MQFISGVQPFLYWLANFVWDMCNYIVPATLVIIIFVCFQQEAYVSSTNLPVLALLLLLYGWSITP 1758

  Fly  1174 LSYAASGCFSDAATGFTRISIINTLMG-TGLFLMFMTLNFEAFQLKDVAEKLAWYFRLSPHYSLA 1237
            |.|.||..|...:|.:..::.:|.|:| .|....|:...|.:.::..:.:.|...|.:.||:.|.
Zfish  1759 LMYPASFFFKIPSTAYVVLTSVNILIGINGSVSTFVLELFGSNEIGGINDILKNVFLIFPHFCLG 1823

  Fly  1238 SSTHSIHIGYNIRRGCSIGGIRKLPKQLRCRNVPICCDIPGYYGWRKPGVLVEITYMIMLGSTLF 1302
            .....:     ::.......:.:..:. |.|: |:..|:.|          ..:..|.:.|...|
Zfish  1824 RGLIDM-----VKNQAMADALERFGEN-RFRS-PLAWDMVG----------KNLFAMAIEGVIFF 1871

  Fly  1303 LLIVMHDAKVCNLIAEKLGNCFSKRKRVEGGTSIENDSVVAEQRVVREMINSGRKDVPLL--VYK 1365
            .:.|:...:.| :.|..|.   :|.|.:.     |.|..||.:| .|.:...|:.|:..|  :.|
Zfish  1872 SITVLIQYRFC-IKARSLS---TKLKPIG-----EEDEDVARER-QRILGGGGQTDILELRQLTK 1926

  Fly  1366 ISKRYRSKLAVKAISFHVPHAECFGLLGINGAGKTSTFKMLAGDEKITSGEAYIDGTNISTH--K 1428
            :.|| :.|.||..:...:|..|||||||:||||||||||||.||..:||||||:.|.::.|.  :
Zfish  1927 VYKR-KQKPAVDRLCVGIPPGECFGLLGVNGAGKTSTFKMLTGDSVVTSGEAYLAGNSVLTEIDE 1990

  Fly  1429 VYRKIGYCPQFDALFEDLTGRETLNIYCLLRGVQRRHVTPIC-WGLAISFGFAKHMDKQTKHYSG 1492
            |::.:||||||||:.:.|||||.|..|.:||||..:.|..:. ||:. ..|..|::||....|||
Zfish  1991 VHQNMGYCPQFDAINDLLTGREHLEFYAILRGVPEKEVCKVADWGIR-KLGLMKYVDKAAGSYSG 2054

  Fly  1493 GNRRKLSTAISVLGNPSVLYLDEPTSGMDPAARRQLWQIIGLIRTAGKSIVLTSHSMDECEALCS 1557
            ||.||||||::::|.|.|::|||||:||||.|||.||..|..|...|:|:|||||||:||||||:
Zfish  2055 GNMRKLSTAMALIGGPPVVFLDEPTTGMDPKARRALWNCILSIIKEGRSVVLTSHSMEECEALCT 2119

  Fly  1558 RLAIMVDGEFKCLGSVQSLKNQFSKG--LILKVKVKHKKKTFQRVVEDSSSSNDKKSISETDLKF 1620
            |:||||:|.|:||||||.|||:|..|  :||:|
Zfish  2120 RMAIMVNGRFRCLGSVQHLKNKFGDGYTIILRV-------------------------------- 2152

  Fly  1621 LQMASVMESSQAD-RILKVNRFISKEIPDAELKEEYNGLITYYIPHSKT-LSKIFQLLETNSHKL 1683
                     :.|| |:..|..||.:|:|.:.|||::..::.|.:..|.| |::||.:|..|..:|
Zfish  2153 ---------AGADPRLEPVMEFIERELPGSTLKEKHRNMLQYQLSSSLTSLARIFNILSKNKEQL 2208

  Fly  1684 NIEDYLIMQTRLEEIFLDFASKRDSSD 1710
            :||||.:.||.|:::|::||  :|.||
Zfish  2209 HIEDYSVSQTTLDQVFVNFA--KDQSD 2233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	555/1821 (30%)
abca1a	NP_001296394.1	rim_protein	1..2233	CDD:130324	559/1845 (30%)
		ABC_subfamily_A	904..1122	CDD:213230	110/219 (50%)
		ABC_subfamily_A	1919..2139	CDD:213230	122/221 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	168	1.000	Domainoid score	I3783
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.830