DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and CG8908

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_611464.3	Gene:	CG8908 / 37293	FlyBaseID:	FBgn0034493	Length:	1626	Species:	Drosophila melanogaster

Alignment Length:	1800	Identity:	473/1800 - (26%)
Similarity:	839/1800 - (46%)	Gaps:	307/1800 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LMW----KNWILQWNQKMQIVFALVLPVLFLCLILVLRIIVLPEKMDEIRYPTVSISDLNLYMRM 85
            |:|    |....|::..:..|..:|.|::...:.....:...|::...::||.|:|
  Fly    16 LLWLVICKTARFQFSNTLTSVIIIVGPIVVFLVYAATALFREPQEETSVKYPPVNI--------- 71

  Fly    86 VPLGNRILHENGSLNIPRNFLCYTPNNPINSAIVGATAIRLRLLGTRAYDTALHMEQDMV---LH 147
                        :..:|  ::.|:|.|.:.:|::......|:.:|::|:.:|..:.:.::   .:
  Fly    72 ------------TTKVP--YIYYSPENLVLAAVIEDVVHDLKAVGSKAFASASELNKALIGKDTY 122

  Fly   148 NFLAGVQFEDN-ENVNTNDAGYPLNLNYSLRFPSELRTMQGPIIDTWRTSRLFLSYDTSGSRNRL 211
            .:: |::|:|: .::|.    .|:|:...||||..||.....:.|  .||.|        ..:::
  Fly   123 GYV-GIEFDDSFSDINE----LPINVTVGLRFPLHLRKNPKMVWD--NTSIL--------KHSKM 172

  Fly   212 DNDGGVPVGYIREGFLPIQHALTMSWL-ALASGVTDTGIPAIHLQRFPYRAYTYDQLLSGLRQLL 275
            |.|     .|..||||.:|..|:.:.: |....|.   :|.:.||.:|..| ..|:|.:  |..|
  Fly   173 DVD-----YYQVEGFLVVQAKLSEALIRAKNEAVV---LPEVILQHYPDVA-EVDRLDN--RVAL 226

  Fly   276 PFVILLSFIYPASTVTKYVTSEKELQLKEIMKLIGVHNWLHWVAWFVKSYIMLMLVVFLIMSLIM 340
            ..|:.|.....|:.:.:.:..|:...|:::::|:||..|::|::||:.::::|.:....::.|:.
  Fly   227 GGVLFLPVTISAAYLAQMIVMERRDHLRDMLELMGVRAWIYWLSWFLVAFLLLSIPTVFMVLLLK 291

  Fly   341 VKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCFMLAVLFSKASTASAVAAIFWFLTYIPYSFGY 405
            .::::    |:.||.  ||.||..|.:..:...||::..||..........|...:..:|:
  Fly   292 WRYFS----LSDSSL--VLFFLLVYNLEVLTSAFMISSFFSDTVGVQVAIVIVHLIGCLPW---- 346

  Fly   406 YYYERLSLMS------KLLISLIFSNSALGFGIHVIVMWEGTGEGITWRNMFHPVSTDDSLTLFY 464
                ||.||.      :.:...:|.||:|..|:...:..|....|:.|..:|.....|:.:.|..
  Fly   347 ----RLLLMGYVPTLPRTIFVCLFLNSSLAMGLQQFIKSENLRLGLHWTYLFERTDWDEFVHLGP 407

  Fly   465 IIMTMSFGSIMFISICLYVEQVFPGEYGVPRRWNFMCHKNYWRQYVPSLNIVPSFQTILHGSAKA 529
            |::.|.||.::.|.:..|:||:...:   .|:|.|....::|
  Fly   408 ILLFMLFGCLLRILVLAYMEQLRSYQ---NRKWYFPVQPSFW----------------------- 446

  Fly   530 KSCR------------RAREVGI-------QLFNLQKNYGKLKAVKGISLKMHRNEITVLLGHNG 575
              ||            ..:|.||       :..|::|.:.:..|||.::|..:::||||.||||.
  Fly   447 --CRWNRRPRSDDFDVEGQETGIRGHPLIVRARNIEKVFNEWIAVKDLNLNFYQDEITVFLGHND 509

  Fly   576 AGKTTTINMITGIVKPTSGTAIVNGYDIRTHLAKARESLGICPQNNILFKEMSVRDHIIFFSKLK 640
            :||:|.:.::.|.::|::|...:||||:.|:..|||:|:.||||.|:||::::.|.|:.|:.:||
  Fly   510 SGKSTILMLLAGFLRPSAGEITINGYDLATNQRKARQSMCICPQPNVLFEKVNARWHLQFYCRLK 574

  Fly   641 GIRGTKAVENEVGKYMTMLKLQDKSYVAAKNLSGGMKRKLSLCCALCGNAKVVLCDEPSSGIDAA 705
            |:...:| ..|..||:.:.:|||.:....|||..|:||.|.|||.||||:|::|.|||.:.:|.|
  Fly   575 GLNRQEA-SAETDKYLEIGRLQDFANTKVKNLPSGIKRMLMLCCNLCGNSKILLLDEPGTSMDPA 638

  Fly   706 GRRSLWDLLQSEKDGRTILLTTHYMDEADVLGDRIAILSEGKLQCQGTSFYLKKRFGTG--YLLV 768
            .|.::||||:.|:.||.|::.||.|:||:|:.|:|.:|.:.::...||:.:|.:..|||  |||:
  Fly   639 MRSNMWDLLRRERKGRCIIMATHNMNEAEVVADQIVVLCDAQVIGYGTTGFLTQIAGTGSSYLLI 703

  Fly   769 CIMQSGCDVGAVTQLIRKYVPPIKPERVLGTELTYRLPTEYSKKFAELLQDLDEKCAQLQLVGYG 833
            |.....|.|..||..::...|.||........:||.|||:|.:::|.|..:|:|...:|.|....
  Fly   704 CTKMDTCIVAEVTNFLQIRFPDIKLHNEFSIYVTYELPTKYVQQYAALFLELEEALGELNLAEIS 768

  Fly   834 LSGATLEDVFMAVNTDKRVQGG--------AEGPPVDGSIDFKELVFDSKTREKRRIRRCFMFWQ 890
            :...||..||:.:..:.|....        :...|:   :....|:...:.||.....:|...|:
  Fly   769 VCAPTLGSVFLQMGEEMRQSWNRISSFDLLSSPSPM---LSLLNLLPTFEVREDDGRVKCCNQWR 830

  Fly   891 ALFLKKFYTTTRNYWLLGIQLVLPIAVMALTILNSRGGRIYY--------ELPAMPISINQYSSA 947
            |:..||...|.|:.....:.:..||.:..|.|..|    |:.        ||....:||  |..|
  Fly   831 AIVEKKRLFTLRHQKFYCMIIATPIIICLLIISFS----IFIFLVDHHLSELLVTDLSI--YPKA 889

  Fly   948 YVVLEDNTTDKTSSLADAYSKHLEHYARRC-----TLLRTGDLKFEDYILSHDVNHSRRIDFHFL 1007
            ..|::        |.|:. ::...||....     |:..|.....:||:|:...:...::...||
  Fly   890 VFVID--------SPAEG-NRFERHYMANVIGQGGTVRSTSGTPIDDYLLAEMESDQVKVQHTFL 945

  Fly  1008 AGLTV--SENNFIVWLNNKPLHTAPLTLNLLHNALAIKLLGQDASTYVTNEPLPYSDDTRTLRLN 1070
            ||.|.  :.|:.|.|.|||..|.:.|::.|::.|:..:|...|..  :.|:  ||.|..:  :..
  Fly   946 AGATFDSNANSIIAWSNNKLKHGSALSMGLVYAAIGQELAKLDIR--IVNK--PYQDTVQ--QAV 1004

  Fly  1071 KGQVLGAEISINLSLTMCFI--TAFYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVWDYLVFV 1133
            :|.:..:.|...:.:....:  ||.:|:..|.||.::.:..||.||:....||.||:.|||..::
  Fly  1005 RGLIYASTIEFAVLVFHYLVLGTAIFAVLPIVERRSKVQHQQFSSGMSRSTYWLSHLSWDYCFYI 1069

  Fly  1134 LSALSSILTIAAFKEIGYITPLDLSRYFYMLLIFGFPGIMLSYAASGCFSDAATGFTRISIINTL 1198
            ...|.  |.:.|...||.:.|:     ...||.|||..|..:|......:|....|:.|..||.:
  Fly  1070 AMILP--LIVVAGITIGSVLPV-----IVQLLAFGFSAISFTYLLCLMSNDFGKMFSIILYINMI 1127

  Fly  1199 MGTGLFLMFMTLNFEAFQLKDVAEKLAWYFRLSPHYSLASSTHSIHIGYNIRRGCSIGGIRKLPK 1263
               |:..:|:.......:...:...|.    :.|||||
  Fly  1128 ---GVLALFIHPKSPQTRYAVIESVLL----VHPHYSL--------------------------- 1158

  Fly  1264 QLRCRNVPICCDIPGYYGWRKPGV--LVEITYMIMLGSTLFLLIVMHDAKVCNLIAEKLGNCFSK 1326
                     ||   |.|...:...  |.::.|:|..|:....::|.      ..:..:|...|.
  Fly  1159 ---------CC---GMYEAIRMSTFSLKQLPYLIFSGAAYLTIVVF------AWVPRRLNYVFK- 1204

  Fly  1327 RKRVEGGTSIENDSVVAEQRVVREMINSGRKDV-----------PLLVYKISKRYRSKLAVKAIS 1380
                    ||.|:.:....:...:.::..|:.:           ||::..:||||.|.:||::::
  Fly  1205 --------SIRNEKIYPSYKDEDKEVDKMRRRLAYLTTAHYAFFPLILKNLSKRYGSFVAVRSLT 1261

  Fly  1381 FHVPHAECFGLLGINGAGKTSTFKMLAGDEKITSGEAYIDGTNISTH--KVYRKIGYCPQFDALF 1443
            ..:...||.||||.||:||:|.|:|:.|.|.||.|..:|.|.::.|.  ...|.:|:||:...|.
  Fly  1262 LDLNPFECVGLLGRNGSGKSSIFRMIVGMESITVGSIHIKGYSLKTRPKDASRHVGFCPRELMLL 1326

  Fly  1444 EDLTGRETLNIYCLLRGVQRRHVTPICWGLAISFGFAKHMDKQTKHYSGGNRRKLSTAISVLGNP 1508
            ..:||::.|...||:.|::|.::..:...||..|....||:|:...||.|.:|||..|:..|. |
  Fly  1327 SFMTGKDALRFCCLINGIRREYIKSLVASLAECFELVPHMNKRISTYSNGTKRKLMIAMGTLA-P 1390

  Fly  1509 SVLYLDEPTSGMDPAARRQLWQIIGLIRTAGKSIVLTSHSMDECEALCSRLAIMVDGEFKCLGSV 1573
            |::.|||||:|:|..|:.::|.|:..||..|:||:||:|:::|||.||:.:.||..|...|.||:
  Fly  1391 SLMCLDEPTAGVDMHAKYEIWSILDGIRQGGRSILLTTHNLEECEFLCTNVGIMDHGSLLCYGSL 1455

  Fly  1574 QSLKNQFSKGLILKVKVKHKKKTFQRVVEDSSSS---------NDKKSISETDLKFLQMASVM-- 1627
            ..||::|:.|:.:|||:..:.:     ::|...:         ||.:..|....:.:.:|.::
  Fly  1456 SRLKHRFNMGIFVKVKMGTRAE-----MDDERDNWMQITMMPPNDSEMGSTVGARRMMLAHLLRH 1515

  Fly  1628 --------ESSQADR-------------------ILKVNRFISKEIPDAELKEEYN--GLITYYI 1663
                    :.|:..|                   :.::.....|:.|.:.:.|:|:  |:||:.|
  Fly  1516 HNPPVEPVKKSRTSRAQPDTTNSELNMRKDYEALLQELEEVFKKDHPYSTVSEKYSYRGMITFCI 1580

  Fly  1664 PHSK-TLSKIFQLLETNSHKLNIEDYLIMQTRLEEIFLDFASKRD 1707
            |..: ..|.||:.:|....::.|..|.:..|..:::|:.|..|::
  Fly  1581 PRGQIKWSAIFEYMENLKDEMQILYYSVSHTTFQDVFMKFVRKQN 1625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324	7/32 (22%)
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	452/1668 (27%)
CG8908	NP_611464.3	ABC2_membrane_3	69..394	CDD:289468	87/387 (22%)
		LivG	471..686	CDD:223488	88/215 (41%)
		ABC_subfamily_A	474..691	CDD:213230	90/217 (41%)
		ABC2_membrane_3	845..1192	CDD:289468	96/420 (23%)
		NatA	1242..1461	CDD:226927	88/219 (40%)
		ABC_subfamily_A	1242..1459	CDD:213230	86/217 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451232
Domainoid	1	1.000	133	1.000	Domainoid score	I3135
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I138
Isobase	1	0.950	-	0	Normalized mean entropy	S3774
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		otm51427
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	P	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
	11	10.850