DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and Eato

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_001036360.1	Gene:	Eato / 34783	FlyBaseID:	FBgn0028539	Length:	1597	Species:	Drosophila melanogaster

Alignment Length:	1768	Identity:	482/1768 - (27%)
Similarity:	800/1768 - (45%)	Gaps:	286/1768 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VLPVLFLC------LILVLRIIVLPEKMDEIRYPTVSISDLNLYMRMVPLGNRILHENGSLNIPR 103
            :||:|.:|      |...|...|.|           .:..:|.:...   ...:|.|   |..|.
  Fly    24 LLPLLLICSGFAGVLTAYLHWSVKP-----------VLHQINQFEAK---NEMVLRE---LYFPG 71

  Fly   104 N---FLCYTPNNPINSAIVGATAIRLRLLGTR------AYDTALHMEQDMVLHNFLAGVQFEDNE 159
            |   ::.|:|.:|....|:....:.|.::..|      :::..|.|||.  .......:.|....
  Fly    72 NELDYIYYSPISPNVEDIMDLLRVDLGIIPERLRPNNNSFEMQLEMEQQ--CRGSCFAIDFHRVP 134

  Fly   160 NVNTNDAGYPLNLNYSLRFPSELRTMQGPIIDTWRTSRLFLSYDTSGSRNRLDNDGGV-----PV 219
            |     .|......|||. .:::|.                     ..|.|..||..:     ..
  Fly   135 N-----RGSDRKFRYSLS-SNQMRI---------------------SPRKRFVNDEEIYHQIDDD 172

  Fly   220 GYIREGFLPIQHALTMSWLALAS-----GVTDTGIPAIHLQRFPYRAYTYDQLLSGLRQLLPFVI 279
            .|||.|||.:||.|...::....     .|..:.:|.:.:........||...|..:  |...|:
  Fly   173 DYIRSGFLSLQHILDKQYMKYQELGKDFEVVVSSMPNMEVISMDSHRLTYFGTLCSI--LFNVVL 235

  Fly   280 LLSFIYPASTVTKYVTSEKELQLKEIMKLIGVHNWLHWVAWFVKSYIMLMLVVFLIMSLIMVKFY 344
            |.||:.|       ...||:..|||.:.|:...::|:.:.:|:..::...|:  :|..|::...|
  Fly   236 LSSFVVP-------FVEEKQNGLKEFLNLVTPMSFLNGLTFFLIRFVCYTLL--MIFVLVVAYLY 291

  Fly   345 ASVAVLTFSSWVPVLLFLHTYVVTSVCLCFMLAVLFSKASTASAVAAIFW------FLTYIPYSF 403
            .::..:.| ::|.||..|  |:::::...:::::.|.         ::|:      .:..|||:|
  Fly   292 KALGSICF-AYVAVLFLL--YILSTMSYAYLISICFH---------SVFYAKIGGLAMLIIPYAF 344

  Fly   404 GYYYYERLSLMSKLLISLIFSNSALGFGIHVIVMWEGTGEGITWR--NMFHPVSTDDSLTLFYII 466
            .:     :...:..|..:.||.:....|:.:...:....:...:.  ::|..:.::.| |:|.:.
  Fly   345 SF-----VRSWATSLAFVCFSTNTFLEGLDIFQTFSNKRKNREFGAVDVFRVIKSNSS-TMFSVY 403

  Fly   467 MTMSFGSIMFISICLYVEQVFPGEYGVPR-RWNFMCHKNYWRQYVPSLNIVPSFQTILHGSAKAK 530
            :.:.|.|.::..:..|:..||||..|:.| .:.|:..|.|.::........|..   .|.....:
  Fly   404 VVLVFQSFLYAMLYNYLGCVFPGPGGLKRPMFFFLDPKTYMKRQRNEYTTTPRG---THAIIITE 465

  Fly   531 SCRRAREVGIQLFNLQKNYGKLKAVKGISLKMHRNEITVLLGHNGAGKTTTINMITGIVKPTSGT 595
            .|::        |...|....:.  ..:::.::..|||||||||||||||.:|||.|:|...||.
  Fly   466 LCKK--------FQTSKRDTLIS--DNLNMTINNKEITVLLGHNGAGKTTMMNMIMGLVPKDSGK 520

  Fly   596 AIVNGYDIRTHLAKARESLGICPQNNILFKEMSVRDHIIFFSKLKGIRGTKAVENEVGKYMTMLK 660
            .||..   ...:|..|..:|.|||:::....|:...|:.||::|:|...:.| .:...:.:..|.
  Fly   521 IIVCS---ERDVASYRHLIGFCPQHSVFMSYMTCHQHLEFFAQLRGACRSDA-RDWADEKLKKLG 581

  Fly   661 LQDKSYVAAKNLSGGMKRKLSLCCALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQSEKDGRTILL 725
            |.||.....|||||||||:|||..|:.||.|:|:.||||||:|...||.|||:|.:.:..:.:|:
  Fly   582 LSDKRNEFGKNLSGGMKRRLSLGIAIAGNTKIVILDEPSSGLDINSRRELWDILLNLRKEKAVLV 646

  Fly   726 TTHYMDEADVLGDRIAILSEGKLQCQGTSFYLKKRFGTGYLLVCIMQ--SGCDVGAVTQLIRKYV 788
            |||||:||:||||.|.||:.||||..|:...||::.|.||.|...:.  :..:| .:.::|..:|
  Fly   647 TTHYMEEAEVLGDTICILANGKLQSIGSPLELKRKSGIGYRLKLEINDFTSREV-EIMEIIHHFV 710

  Fly   789 PPIKPERVLGTELTYRLPTEYSKKFAELLQDLDEKCAQLQLVGYGLSGATLEDVFMAVNTDKRVQ 853
            |..:...|:...:...||..|...||::|..|:.:..:|.:....::..:|||||:....:   |
  Fly   711 PTARVLNVVNPTVYICLPYAYKNCFAQMLYRLETESKELGIHTISMTDTSLEDVFLRCAGE---Q 772

  Fly   854 GGAEGPPVDGS-IDFKELVFDSKTREKRRIRRCFMFWQALFLKKFYTTTRNYWLLG-IQLVLPIA 916
            ...:.|  ||| .|...|....:.::....|..|..|.|:|.|| :|...|.||.. |.|.:|..
  Fly   773 DQVDTP--DGSRNDAPLLAHYKRLQDHPPHRGLFQLWMAVFYKK-WTFISNEWLYTLIMLCIPFV 834

  Fly   917 VMALTILNSRGGRIYYELPAMPISINQYSSAYVVLEDNTTDKTSSLADAYSKHLEHY-------- 973
            .:...||......:.....|:|:.::|..|..:.:.:.|         .:..|||..
  Fly   835 CVFGAILVMHAMSLVENEEALPLKLSQMGSGVIYVHNPT---------GHHAHLEQQLRQQIELN 890

  Fly   974 ---ARRCTLLRTGDLKFEDYILSHDVNHSRRIDF---------HFLAGLTVSENNFI-VWLNNKP 1025
               |:...|..:.|:|.|    |.|:......||         .:..|...|:...| ::.:...
  Fly   891 GITAKTMHLRGSNDVKNE----SLDLQRDNLADFLEQVIGIIDMYGGGRGTSDTPTIEIFYSGNR 951

  Fly  1026 LHTAPLTLNLLHNALAIKLLGQDASTYVTNEPL-PYSDDTRTLRLNKGQVLGAEISINLSLTMCF 1089
            .|::...:||:.:|: :||...::....|..|: .:..|....||....|:   :.|.:     |
  Fly   952 YHSSVELINLVDSAM-LKLGRPESEIDTTYVPIRRFVSDISPSRLEYYAVI---VPIGM-----F 1007

  Fly  1090 ITAFYAIPI-IRERETRAKLLQFLSGVDVCAYWTSHIVWD--YLVFVLSALSSILTIAAFKEIGY 1151
            ...||.|.: .||.....|.||.:|..   .||.:|..:|  .|:||..||.|:.::....|: |
  Fly  1008 FFMFYFISLPFREYANGFKQLQTMSRF---TYWFAHFTFDMLILIFVCVALFSLQSLMMPSEL-Y 1068

  Fly  1152 ITP----LDLSRYFYMLLIFGFPGIMLSYAASGCFSDAATGFTRISIINTLMGTGLFLMFMTLNF 1212
            .|.    :.||.:||     |...:.:.||....|...:|..|.:.::  |:.:.:..:..:.|.
  Fly  1069 TTAELKVIVLSIFFY-----GCSYLPILYALGNNFKSISTISTYLLLM--LIVSAIAPLITSSNA 1126

  Fly  1213 EAFQLKDVAEKLAWYFRLSPHYSLASSTHSIHIGYNIRRGCSIGGIRKLPKQLRCRNVPICCDIP 1277
            .|.:|.:.  |:|:...| |.::|......|:..:..||..::  |:.|..|            .
  Fly  1127 AAMKLHET--KIAFLCFL-PDFNLNHQFRIINENFITRRHPAL--IKGLISQ------------D 1174

  Fly  1278 GYYGWRKP-GVLVEITYMIMLGSTLFLLIVMHDAKVCNLIAEKLGNCFSKRKRVEGGT-----SI 1336
            .::.:... ||:|...:.|:| ...:|...:||.     |.|.   .|.::|....||     ..
  Fly  1175 TFFAYATAVGVMVMAFFTIVL-EHKYLRRRIHDG-----IWEW---AFQRKKYNSTGTLPSTPIS 1230

  Fly  1337 ENDSVVAEQRVVREMINSGRKDVPLLVYKISKRYRSKLAVKAISFHVPHAECFGLLGINGAGKTS 1401
            |.|....|::.|.::|.....|..|:|:.:.|||..||||..:||.....|||||||:|||||||
  Fly  1231 EIDDCAREEKRVTDLIKDPLNDHSLIVHNLRKRYGDKLAVDGVSFAAAQGECFGLLGVNGAGKTS 1295

  Fly  1402 TFKMLAGDEKITSGEAYIDGTNISTHKV-YRK-IGYCPQFDALFEDLTGRETLNIYCLLRGVQRR 1464
            ||:|:|.:..:..|...|.|.:|..|:: ||: .|||||:|||.:.:|..:.|....||||:.||
  Fly  1296 TFQMIAANLPLDGGTIRIKGADIREHELKYREYFGYCPQYDALNKFMTAEQCLYYMALLRGLSRR 1360

  Fly  1465 HVT-PICWGLAISFGFAK-HMDK----QTKHYSGGNRRKLSTAISVLGNPSVLYLDEPTSGMDPA 1523
            ... |......:.:...| |:.|    |.:|||||.:|||..|::::|.|:::.|||||:|:||.
  Fly  1361 RTDGPASCKEHVKYWLEKMHLTKYQKVQVRHYSGGTKRKLLAAMAMIGAPALVLLDEPTTGVDPI 1425

  Fly  1524 ARRQLWQIIGLIRTAGKSIVLTSHSMDECEALCSRLAIMVDGEFKCLGSVQSLKNQFSKGLILKV 1588
            :||.|||.|...:...:::|||||||||||.||:|||||..|:||||.::.:||.  ..|..:|:
  Fly  1426 SRRFLWQCIKDFQGKDRTVVLTSHSMDECEELCNRLAIMAHGKFKCLNNICALKR--LSGFTIKL 1488

  Fly  1589 KVKHKKKTFQRVVEDSSSSNDKKSISETDLKFLQMASVMESSQADRILKVNRFISKEIPDAELKE 1653
            |:                    |:.:||::....:...::|               |.|..||:|
  Fly  1489 KM--------------------KADTETEMNVSTITGTLKS---------------EFPGLELRE 1518

  Fly  1654 EYNGLITYYIPHSKTL---SKIFQLLETN-SHKLN--IEDYLIMQTRLEEIFLDF----ASKRDS 1708
            .:.|.:||::...:::   |.:|::.|.. ..:|:  :.||.:.:..||:|||.|    .|:..|
  Fly  1519 SHAGTLTYFVSTQESVVLWSSVFKIAEEYLGDRLSALVADYSVNECTLEDIFLKFEREAKSQSTS 1583

  Fly  1709 SDIFTKRIYSCSW 1721
            .....:|...||:
  Fly  1584 RQTSVQRRPECSY 1596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324	4/14 (29%)
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	454/1635 (28%)
Eato	NP_001036360.1	ABC2_membrane_3	<209..347	CDD:289468	33/165 (20%)
		CcmA	460..767	CDD:224054	118/321 (37%)
		ABC_subfamily_A	461..679	CDD:213230	94/231 (41%)
		ABC2_membrane_3	<937..1117	CDD:289468	49/199 (25%)
		ABC_subfamily_A	1255..1479	CDD:213230	105/223 (47%)
		drrA	1262..1573	CDD:130256	131/347 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451235
Domainoid	1	1.000	40	1.000	Domainoid score	I3722
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I138
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		otm51427
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	P	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
	10	9.900