DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and CG1494

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_001259763.1	Gene:	CG1494 / 33102	FlyBaseID:	FBgn0031169	Length:	1695	Species:	Drosophila melanogaster

Alignment Length:	1813	Identity:	430/1813 - (23%)
Similarity:	826/1813 - (45%)	Gaps:	279/1813 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KLKLLMWKNWILQWNQKMQIVFALVLPVLFLCLILVLRIIVLPEKMDEIRYPTVSISDLNLYMRM 85
            |..|:.|||..||....::::..|::|.||..:.:::|..:......:..|..:.:.  ..:|:|
  Fly     9 KFLLMNWKNHKLQLANPLELLVILLVPPLFTLVAVLMRFFIPVNHRSDTVYDPIDLD--RSWMQM 71

  Fly    86 VPLGNRILHENGSLNIPRNFLCYTPNNPIN---------SAIVGATAIRLRLLGTRAYDTALHME 141
            |....:......:.|:..|  .:||:..|.         .|::.....::..:.:..::....|.
  Fly    72 VEKLEKARQVADTYNVKGN--PFTPHLVIGWAPKRYGIFQAMMRRVQKQIEPMTSVGFEDCEEMR 134

  Fly   142 QDMVLHNFLAGVQFE----------DNENVNTNDAGYPLNLNYSLRFPSELRTMQGPI-IDTWRT 195
            :.::.:...||:.|:          :.:.:.:.....|: |||::..|||||.:.|.. :..|.|
  Fly   135 ESVIENGLFAGLCFDGSPFVEDQVFEEDTLESYSNIQPM-LNYTILLPSELRMLDGDFRMANWMT 198

  Fly   196 SRLFLSYDTSGSRNRLDN--DGGVPVGYIREGFLPIQHALTMSWLALASGVTDTGIPAIHLQRFP 258
              |:.....:....||:.  :||. |||:||||:.:|.:::.|:|.|.|   ...:|.|.::|||
  Fly   199 --LYNDDPNTFVLTRLNQPYEGGF-VGYVREGFIRLQKSVSESFLVLTS---HKSLPTIQIRRFP 257

  Fly   259 YRAYTYDQLLSGLRQLLPFVILLSFIYPASTVTKYVTSEKELQLKEIMKLIGVHNWLHWVAWFVK 323
            ......|.|:..|...:||:|::.|::||......|.|||:.|:::.:..:.:.|.:|:|:|::|
  Fly   258 ITGREQDPLMGNLNYGMPFIIIIGFLFPAQLFVWQVVSEKQSQVRQFLINMNIGNLIHFVSWYLK 322

  Fly   324 SYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCFMLAVLFSKASTASA 388
            ..|..|:...:|.:|:.:::.....|||.:.|..::|.|..|...:|....|:|..|..|..|..
  Fly   323 GLIYEMISSLIIAALLKIRWDQDHGVLTQTPWYILILVLFCYNCAAVAFAIMVAAFFRNALNAVR 387

  Fly   389 VAAIFWFLTYIP------------YSFGYYYYERLSLMSKLLISLIFSNSALGFGIHVIVMWEGT 441
            |..|.|.::|:|            ::..|..|...::::.|:|..:....::   :|
  Fly   388 VLTILWIMSYVPTFILSNNLEGNIHALRYVSYALPNVVATLVIEFLIERESI---VH-------- 441

  Fly   442 GEGITWRNMFHPVSTDDSLTLFYIIMTMS-----FGSIMFISICLYVEQVFPGEYGVPRRWNFMC 501
               |||.:..:.::.|..    :|.:|.|     ..::::.:|.|||:.
  Fly   442 ---ITWEDSGYRLNYDGG----HITVTASSWIFMLNALVYCAIGLYVDM---------------- 483

  Fly   502 HKNYWR------QYVPSLNIVPSFQTILHGSAKAKSCRRAREVGI---QLFNLQKNYGKLK---- 553
                ||      :.:...|...|.|...:.........:.:.:|:   :::.::.::.:.|
  Fly   484 ----WRGGDRSGKKMKKPNTNASVQEDPYHERGDSFTHQGQAIGVNSTKIYEVEPSHRRFKLKIK 544

  Fly   554 ------------AVKGISLKMHRNEITVLLGHNGAGKTTTINMITGIVKPTSGTAIVNGYDIRTH 606
                        |:...|..::.||:|||:||||.||:|.:.::.|:|:|:.||.:::.::|:|.
  Fly   545 KLCKRFATNDRPALNLFSWNVYENEVTVLMGHNGCGKSTLLKILAGLVEPSRGTVMISSHNIQTE 609

  Fly   607 LAKARESLGICPQNNILFKEMSVRDHIIFFSKLKGIRGTKAVENEVGKYMTMLKLQDKSYVAAKN 671
            ...|...|||...:::|....:|.|::.|..::||:.....::.:...::.:|::
  Fly   610 RKAASMELGIAFGHDMLLTGFTVIDYLRFICRVKGLHNNIEIDGQSNYFLNVLQI---------- 664

  Fly   672 LSGGMKRK------------LSLCCALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQSEKDGRTIL 724
              ||:|.|            :|:|||..||:.::|.|:..|.:|...:..:|:|:..||..|||:
  Fly   665 --GGLKTKRIRTLTDRDLCLVSICCAFVGNSPIILIDDVHSDLDKRTQSLVWNLINEEKSKRTII 727

  Fly   725 LTTHYMDEADVLGDRIAILSEGKLQCQGTSFYLKKRFGTGYLLVCIMQSGCDVGAVTQLIRKYVP 789
            |.::....|:.:.||:||:|.|:|:|.||..:||..:|.||.|.|:.........:..::..|:|
  Fly   728 LVSNSPALAENIADRMAIMSNGELKCTGTKPFLKNMYGHGYRLTCVKGKNYKRDELFGMMNSYMP 792

  Fly   790 PIKPERVLGTELTYRLPTEYSKKFAELLQDLDEKCAQLQLVGYGLSGATLEDVFMAVNTDKRVQG 854
            .:..||.:|.::|:.|..::..:|..|:.||:|...||.:|.:.:...::|::|:....:...|.
  Fly   793 NMSIERDIGYKVTFVLENKFEDQFPMLIDDLEENMQQLGVVSFRIRDTSMEEIFLRFGCEDNDQS 857

  Fly   855 GAEGPPVDGSIDFKELVFDSKTREKRRIRRC-----FMFWQALFLKKFYTTTRNYWLLGIQLVLP 914
            ||.....:..:..:| .:.:......:.||.     |:..:|:..|::....| :|::.|..||.
  Fly   858 GAFQSHENAQVLLEE-YYSTLAEANEKGRRTGWKLFFLHGRAVIYKRWIAAHR-HWIVLIFEVLA 920

  Fly   915 IAVMALTILNSRGGRIY---YELPAMPISINQYSS--AYVVL---EDNTTDKTSSLADAYSKHLE 971
            :|::|:...:|.  .||   |||..:..:::|..:  |:|.|   |::..|     ..||...|.
  Fly   921 MALVAVCTFSSI--FIYGKNYELEPLTFNLSQLHTVDAFVELFSEEEDVKD-----MHAYYTELL 978

  Fly   972 HY--ARRCTLLRTGDLKFEDYILSHDVNHSRRIDFHFLAGLTVSENNFIVWLNNKPLHTAPLTLN 1034
            ::  |...||.:.   :...|.|......:..::..::.|.|..:.....|.||.|||:||..||
  Fly   979 YWYDAHVATLTKN---RHNAYALLTQNQFTAHVNSRYIFGATFDQKIVTAWFNNIPLHSAPYALN 1040

  Fly  1035 LLHNALAIKLLGQDASTYVTNEPLPYSDDTRTLRLNKGQVLGAEISINLSLTMCFITAFYAIPII 1099
            ::|||:|..|..::|:..||..|||:.....|.. ......|..::..:...:.||...:||.:|
  Fly  1041 VVHNAVARHLFDEEATIDVTLAPLPFRTAINTFP-PSSHTFGGCLAFGICFVLTFIWPAFAIYMI 1104

  Fly  1100 RERETRAKLLQFLSGVDVCAYWTSHIVWDYLVFVLSALSSILTIAAFKEIGYITPLDLSRYFYM- 1163
            .||.:..|..|||:||.||:|||..:::|.|..::.....::.:|.::...:    |:..|.|:
  Fly  1105 TERGSLLKKQQFLAGVRVCSYWTFTVLYDLLFLLIFCACVVVMVALYENPNH----DVMLYGYIS 1165

  Fly  1164 --LLIFGFPGIMLSYAASGCFSDAATGFTRISIINTLMGTGLFLMFMTLNFEAFQLKDVAEKLAW 1226
              |::.||..|:|:|..:....:...||..:..||:: |...|..|...:.|:..|:.....:
  Fly  1166 VTLMLGGFWVILLAYLMASLCRNPCYGFLWLCGINSI-GLVCFSQFYRTHPESMLLEPTFMAM-- 1227

  Fly  1227 YFRLSPHYSLASSTHSIHIGYNIRRGCSIGGIRKLPKQL-RCRNVPICCDIPGYYGWRKPGVLVE 1290
                   |::|:....:.:.|..:..|....:.....:: :|.::|.|| |...||....|:..:
  Fly  1228 -------YTVATVICKLFMIYEFKLICMDPVVNFTSVEVFKCNSIPNCC-IKSNYGTFTAGIYHD 1284

  Fly  1291 ITYMIMLGSTLFLLIVMHDAKVCNLIAEK---LG--NCFSKRKRVEGGTSIENDSVVAEQRVVRE 1350
            :..:.:|...|.         .|..::|.   ||  :|     |::..|:...|| ..|.|....
  Fly  1285 LVILTLLDIILL---------ACLFVSEYHSILGFADC-----RLDTRTNESPDS-NQESRAFPG 1334

  Fly  1351 MINSGRKDVPLLVYK--------------------ISKRYRSKLAVKAISFHVPHAECFGLLGIN 1395
            ::::   |...||.|                    |..:||....::.:.|.:..:||..:.|.|
  Fly  1335 ILSN---DTAALVDKEHTSRLNEEERSKYAAVGIGIVSKYRRNRVLRDLDFTLAKSECLSITGAN 1396

  Fly  1396 GAGKTSTFKMLAGDEKITSGEAYIDGTNISTHKV--YRKIGYCPQFDALFEDLTGRETLNIYCLL 1458
            .:|||:..|::..:.|:.:|:.:|...:::||:|  ||.:|||||.|:|..:.|.||.|.|:.:|
  Fly  1397 NSGKTTLLKVVVNETKMNAGQLWIHDYSVNTHRVQCYRMVGYCPQKDSLPSEFTPRELLYIHAML 1461

  Fly  1459 RGVQRRH---------------VTPICWGLAISFGFAKHMDKQTKHYSGGNRRKLSTAISVLGNP 1508
            :|  .||               :|| ||            ::..:..:.|..|:|..|.:|||:|
  Fly  1462 QG--HRHRIGRELSEALLRLVGLTP-CW------------NRSVRMCTTGQIRRLYFAYAVLGSP 1511

  Fly  1509 SVLYLDEPTSGMDPAARRQLWQIIGLIRTAGKSIVLTSHSMDECEALCSRLAIMVDGEFKCLGSV 1573
            .::.:|...:|:||..:|.:..:...::..|.|.:.|..:..:.|.|..|..::::|:...:..:
  Fly  1512 DLICVDGVPAGLDPTGKRIILMMTSTMQAMGSSFLYTMLTGLDAERLSLRTPLLLEGQLWMIRPM 1576

  Fly  1574 QSLKNQFSKGLILKVKVKHKKKTFQRVVEDSSSSNDKKSISETDLKFLQMASVMESSQADRILKV 1638
            .:....:..|..|:|:.|.|             .|...|:|......:....:..:.      |.
  Fly  1577 DTETENYKSGYQLEVRFKRK-------------VNPNVSMSRATWNLINHFPMSPNK------KF 1622

  Fly  1639 NRFISKEIPDAELKEEYNGLITYYIP-HSKTLSKIFQLLETNSHKLNIEDYLIMQTRL 1695
            :.|:..:.|||.|..|.:..:.:.:| .:.|.|:||..|..::.::|||||.|.:..|
  Fly  1623 SAFMEIKFPDAVLTIERDDSMVFVLPLGTTTFSEIFLTLRKDAFEMNIEDYFITRNML 1680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324	11/32 (34%)
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	407/1676 (24%)
CG1494	NP_001259763.1	ABC2_membrane_3	<263..480	CDD:289468	54/234 (23%)
		CcmA	541..848	CDD:224054	89/318 (28%)
		ABC_subfamily_A	541..761	CDD:213230	65/231 (28%)
		ABC2_membrane_3	911..>1189	CDD:289468	81/292 (28%)
		ABC2_membrane	<1080..>1188	CDD:304374	31/111 (28%)
		ABC_subfamily_A	1370..1577	CDD:213230	59/221 (27%)
		PRK14255	1371..1586	CDD:172743	59/229 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450240
Domainoid	1	1.000	40	1.000	Domainoid score	I3722
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I138
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		otm51427
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
	9	9.000