DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and Abca15

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_796187.2	Gene:	Abca15 / 320631	MGIID:	2388709	Length:	1668	Species:	Mus musculus

Alignment Length:	1774	Identity:	576/1774 - (32%)
Similarity:	902/1774 - (50%)	Gaps:	193/1774 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VGDWD--KLKLLMWKNWILQWNQKMQIVFALVLPVLFLCLILVLRIIVLPEKMDEIRYPTVSISD 78
            :..|:  ||.||:|||:.|:..:...:|..:||.:|...::|..|.::..:|::.:.:|...||.
Mouse     1 MASWESRKLLLLLWKNFTLKRRKFGTLVSEIVLVLLLSIVLLTTRHLLSIKKIEALYFPDQPIST 65

  Fly    79 LNLYMR------------MVPLGNRILHENGSLNIPRNFLCYTPNNPINSAIVGATAIRLRLLG- 130
            :..:.|            .|| .|.::.||...|:         .|.:|        :.::::|
Mouse    66 VPSFFRASVTSFYPWELAYVP-SNIMVVENIVKNV---------KNDLN--------LHMKVIGF 112

  Fly   131 TRAYDTALHMEQDMVLHNFLAGVQFEDNENVNTNDAGYPLNLNYSLRFPSELRT-------MQGP 188
            ....|...:....:...|.||.:.|..| ..|::|. .|..:.|.||| |:::.       .||
Mouse   113 PSESDFEDYARSTVNSRNILAAIVFGHN-FANSSDP-LPKKVKYYLRF-SDIKKNINSGAYYQG- 173

  Fly   189 IIDTWRTSRLFLSYDTSGSRNRLDNDGGVPVGYIREGFLPIQHALTMSWLALASGVTDTGI---- 249
              |||.|..||.|....|.||..:.|||.| |||.||||.:||||..: :.|..|..|...
Mouse   174 --DTWLTKFLFHSLRLVGPRNPYEADGGSP-GYITEGFLAVQHALDKA-IMLHHGGADAAALFND 234

  Fly   250 PAIHLQRFPYRAYTYDQLLSGLRQLLPFVILLSFIYPASTVTKYVTSEKELQLKEIMKLIGVHNW 314
            .::.:|||||.||.:|.........:|..:..:|.:....:...:..|||.:|||...:||:.||
Mouse   235 ISLFIQRFPYPAYYHDYFYLFATTFIPLTVACTFFFNHYVLVWSIVWEKENRLKEYQLMIGLRNW 299

  Fly   315 LHWVAWFVKSYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCFMLAVL 379
            :.|||:|. :::.|..:..::|.:::........:..::....|.:||..|.::|:...||::.|
Mouse   300 MFWVAYFF-TFLCLYFINIIVMCMVLFVKIEPAPIFQYNDPTLVFIFLLFYAISSIFFSFMVSTL 363

  Fly   380 FSKASTASAVAAIFWFLTYIPYSFGYYYYERLSLMSKLLISLIFSNSALGFGIHVIVMWEGTGEG 444
            |:|.|.|.::.:..:||||.|....:..:||:....||:.|..| |..:.||...:|..:....|
Mouse   364 FNKVSLAMSLGSFLFFLTYFPAVAMHQSFERMPSKQKLIWSFDF-NVGMAFGFRFLVNTDAKKTG 427

  Fly   445 ITWRNMFHPVSTD-DSLTLFYIIMTMSFGSIMFISICLYVEQVFPGEYGVPRRWNFMCHKNYWRQ 508
            :.|.|:|  :||| ||....|::..:...:.::..:..|:|.|||||||||:.|||....:||..
Mouse   428 MKWSNIF--LSTDSDSFLFAYVLGMLLADAFIYGLVAWYIEAVFPGEYGVPKPWNFFLMHSYWFG 490

  Fly   509 YVP--SLNIVPSFQTILHGSAKAKSCRRAREVGIQLFNL----QKNYGKLKAVKGISLKMHRNEI 567
            ..|  .|.|...::.:.....:|:.....  .|||:.:|    |||.....|:|.:||.::..::
Mouse   491 EPPQQKLEITQFYERVESKYFEAEPTDLT--AGIQIKHLHKVFQKNNTTKVAIKDLSLNLYEGQV 553

  Fly   568 TVLLGHNGAGKTTTINMITGIVKPTSGTAIVNGYDIRTHLAKARESLGICPQNNILFKEMSVRDH 632
            |||||||||||:||:::::|:..||||.|.|:|.||..|:.:.|.|||:|||.|:||..::|.:|
Mouse   554 TVLLGHNGAGKSTTLSILSGLYPPTSGEAYVHGEDISQHMDQVRNSLGLCPQQNLLFDHLTVSEH 618

  Fly   633 IIFFSKLKGIRGTKAVENEVGKYMTMLKLQDKSYVAAKNLSGGMKRKLSLCCALCGNAKVVLCDE 697
            :.|:.::||:.....:| |....::...|.:|....:|:|||||||||::..||.|.:||.:.||
Mouse   619 LYFYCRIKGVPQKMYLE-ETNNMLSAFNLMEKCDAFSKSLSGGMKRKLAIIIALIGGSKVAILDE 682

  Fly   698 PSSGIDAAGRRSLWDLLQSEKDGRTILLTTHYMDEADVLGDRIAILSEGKLQCQGTSFYLKKRFG 762
            |:||:|.|.|||.||:||:.|..||||||||||||||||||||||:..|.|:|.|:|.:||:.:|
Mouse   683 PTSGMDPASRRSTWDILQTYKQNRTILLTTHYMDEADVLGDRIAIMVRGTLRCCGSSVFLKRLYG 747

  Fly   763 TGYLLVCIMQSGCDVGAVTQLIRKYVPPIKPERVLGTELTYRLPTEYSKKFAELLQDLDEKCAQL 827
            .|..||.:.:..||:..:::||..|||....|..:|.||::.||.||:.:|..|...|:|....|
Mouse   748 VGSHLVMVKEPYCDIAEISKLIHSYVPTATLETNVGNELSFILPKEYTHRFEALFTALEENQENL 812

  Fly   828 QLVGYGLSGATLEDVFMAVNT--DKRVQGGAEGPPVDGSIDFKELVFDSKTR-------EKRRI- 882
            .:..:|:|..|:|:||:.|:.  |.:....|...|..||...|....:|..|       |.:.|
Mouse   813 GISSFGVSITTMEEVFLKVSNLEDSKTDIEATQSPSVGSKGNKNGDVESSGRVGFPTQSEDQNIV 877

  Fly   883 --RRCFMFWQ---ALFLKKFYTTTRNYWLLGIQLVLPIAVMALTILNSRGGRIYYELPAMPISIN 942
              ..|.::.|   |:|:|:.....||:..:.:| :|.:.:....:|.|...| |.::..|  :::
Mouse   878 FNTGCSLYLQQFRAMFMKRLMYNWRNWRGILVQ-ILGLIISTFLLLKSHEFR-YKKIRQM--NLD 938

  Fly   943 QYSSAYVVLED-NTTDKTSSLADAYSKHLEHYARRCTLLRTGDLKFEDY---ILSHDVNHSRRID 1003
            :|....|.... ..::.||||.    .|||:      :|:.|:.:.::.   :|.:...:...:.
Mouse   939 EYGQTIVPFSIWGKSNLTSSLL----THLEN------MLKPGNHQLKEVQGDLLKYLEGNDECVH 993

  Fly  1004 FHFLA-GLTVSEN--NFIVWLNNKPLHTAPLTLNLLHNALAIKLLGQDASTYVTNEPLPYSDDTR 1065
            ...:| .:.|..|  |..|..||:..|:..|:|.:|.|.|.:.|.|.|||..|.|:|.|......
Mouse   994 LCVIALSIKVVANRVNLTVLFNNEAYHSPSLSLTVLDNILFMSLSGSDASITVFNKPQPSPQRKE 1058

  Fly  1066 TLRLNKGQVLGAEISINLSLTMCFITAFYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVWDYL 1130
            .    .|...|..::..:.|.|..:.:.:.|..:.||..:.|.:||||||.:..||.|.:|:|.:
Mouse  1059 W----PGSTDGKIVAFKIQLGMALLVSGFCILTVTERHNKTKHMQFLSGVSILVYWLSALVFDLI 1119

  Fly  1131 VFVLSALSSILTIAAFKEIGYITPLDLSRYFYMLLIFGFPGIMLSYAASGCFSDAATGFTRISII 1195
            :|.:|....::.....|...|:|...:.....:|.:||:..|.|:|..|..||.:.:.:..:.:.
Mouse  1120 IFFISCCFLLVMFKYCKFDIYVTDYHILDTMLILTLFGWSAIPLTYLLSFLFSKSNSAYINLLVF 1184

  Fly  1196 NTLMGTGLFLM----------FMTLNFEAFQLKDVAEKLAWYFRLSPHYSLASSTHSIHIGYNIR 1250
            ..|.||...||          .|:.:.:.|.|..:.        |.|.|:|........:.|..:
Mouse  1185 CYLSGTLSLLMDTIIEARISTIMSNSTQTFLLNALL--------LFPMYNLGKCISEYTVIYRKK 1241

  Fly  1251 RGCSIGGIRKLPKQLRCRNVPICCDIPGYYGWRKPGVLVEITYMIMLGSTLFLLIVMHDA---KV 1312
            ..|.  ..:...|.|.|.|.....:|   |..:||.:...:..|.:.|....|||...:.   ||
Mouse  1242 MLCI--QQKNALKYLNCSNKHTKKNI---YSLKKPMLGKYLIAMSIAGFVFLLLIFFWENISWKV 1301

  Fly  1313 CNLIAEKL--GNCFSKRKRVE------GGTSIENDSVVAEQRVVREMINSGRK--DVPLLVYKIS 1367
            ...|.:.:  |.|  |:.:.:      .|||.:||  |..:|  ||::....|  :.|:|:.:::
Mouse  1302 KMFIHQHIYFGAC--KKYKPDIISKELSGTSEDND--VENER--REILYQPEKFLNCPVLIKELT 1360

  Fly  1368 KRYRSK---LAVKAISFHVPHAECFGLLGINGAGKTSTFKMLAGDEKITSGEAYIDGTNISTH-- 1427
            |.|...   ||||.||..:....||||||.||||||:||::|.|:...|:|:.:|||.:::.:
Mouse  1361 KIYFKSPLILAVKNISLAIQERACFGLLGFNGAGKTTTFQILTGENIPTAGDVFIDGISLTKNIV 1425

  Fly  1428 KVYRKIGYCPQFDALFEDLTGRETLNIYCLLRGVQRRHVTPICWGLAISFGFAKHMDKQTKHYSG 1492
            ||..|||||||||||.|.:||.|.:.:|..:.|:....:.|.......|.....|.:.....||.
Mouse  1426 KVRSKIGYCPQFDALLEYMTGWEIMIMYARIWGISEHQIQPYVKKYLNSLDLESHANSLISTYSE 1490

  Fly  1493 GNRRKLSTAISVLGNPSVLYLDEPTSGMDPAARRQLWQIIGLIRTAGKSIVLTSHSMDECEALCS 1557
            ||:|:|||||:.:|.|||::||||::||||.|||.||..:..||.:||:|::|||||:||||||:
Mouse  1491 GNKRRLSTAIATMGKPSVIFLDEPSTGMDPRARRLLWDTVIKIRESGKAIIITSHSMEECEALCT 1555

  Fly  1558 RLAIMVDGEFKCLGSVQSLKNQFSKGLILKVKVKHKKKTFQRVVEDSSSSNDKKSISETDLKFLQ 1622
            ||:|||.|...||||.|.|||:|....|||.|||
Mouse  1556 RLSIMVRGRLTCLGSPQYLKNKFGNIYILKAKVK------------------------------- 1589

  Fly  1623 MASVMESSQADRILKVNRFISKEIPDAELKEEYNGLITYYIPH-SKTLSKIFQLLETNSHKLNIE 1686
                    ..:.:.:...||:...|.:||::|..|::.|.||. :.:..|:|.:||....:.|:|
Mouse  1590 --------SGETLDEFKNFITLTFPGSELQQENQGILNYCIPRKNNSWGKVFGILEKAKEQYNLE 1646

  Fly  1687 DYLIMQTRLEEIFLDFASK 1705
            ||.|.|..|:::||.||.:
Mouse  1647 DYSISQITLDQVFLSFADQ 1665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324	12/32 (38%)
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	545/1626 (34%)
Abca15	NP_796187.2	ABC2_membrane_3	144..464	CDD:289468	100/330 (30%)
		ABC2_membrane	<267..383	CDD:304374	32/116 (28%)
		CcmA	522..831	CDD:224054	142/309 (46%)
		ABC_subfamily_A	522..743	CDD:213230	110/221 (50%)
		ABC2_membrane_3	<1009..1231	CDD:289468	64/233 (27%)
		CcmA	1354..1648	CDD:224054	132/332 (40%)
		ABC_subfamily_A	1354..1575	CDD:213230	106/220 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838477
Domainoid	1	1.000	208	1.000	Domainoid score	I2852
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1133	1.000	Inparanoid score	I220
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		mtm8719
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910