DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and CG34120

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_001285513.1	Gene:	CG34120 / 318066	FlyBaseID:	FBgn0083956	Length:	1998	Species:	Drosophila melanogaster

Alignment Length:	1409	Identity:	347/1409 - (24%)
Similarity:	619/1409 - (43%)	Gaps:	240/1409 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 HLQRFPYRAYTYDQLLSG--LRQLLPFVILLSF-IYPASTVTKYVTSEKELQLKEIMKLIGVHNW 314
            :.::|||.|:..|....|  |.|.:....||.. ::.|.:|.:.:.. :|.:...:|:.:|:...
  Fly   609 YTKQFPYPAFLNDVFKRGLYLAQGVQVAYLLGLVVFVALSVRERIWM-RESRNSMLMRSMGLKAH 672

  Fly   315 LHWVAWFVKSYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCFMLAVL 379
            ...|||.:.|::.|.::..||..::.     |..:|.:::|..::.:..::.:..:..|:|....
  Fly   673 SELVAWALMSFLELCVIFALISGVLY-----SGGILGYTNWFFMMFYCLSFGLCLISFCYMCTNF 732

  Fly   380 FSKASTASAVAAIFWFLTYIPYSFGYYYYERLSLMSKLLISLIFSNS-ALGFGIHVIVMWEGTGE 443
            |:.|:..:..:|:.:|::..|:.....:..:||:....|:.|.|:.: |.|:|  .::..|...|
  Fly   733 FNSANIGAVASALLFFISLCPFIIVLMFDAKLSVFESFLVDLSFTTAFAKGWG--ELIRMELQQE 795

  Fly   444 GITWRNMFH--PVSTDDSLTLFYIIMTMSFGSIMFISICLYVEQVFPGEYGVPRRWNFMCHKNYW 506
            |:|.|::..  |..::.::.|...::.:...:::.::...|.:.                 .||
  Fly   796 GLTVRHLIQVGPARSECAMALLMFLLDLLLYAVIGLAYQRYKKT-----------------DNY- 842

  Fly   507 RQYVPSLNIVPSFQTILHGSAKAKSCRRAREVGIQLFNLQKNYGKLKAVKGISLKMHRNEITVLL 571
                       ||..:.......|       :|..|.|:.|.||...||..:||...||:::.||
  Fly   843 -----------SFVKVSRSQLDGK-------LGASLVNVSKLYGSKCAVSNLSLDFARNQVSCLL 889

  Fly   572 GHNGAGKTTTINMITGIVKPTSGTAIVNGYDIRTHLAKARESLGICPQNNILFKEMSVRDHIIFF 636
            |.|||||:|.|.::||.::.:||..::.|          ...:|:|.|:|||...::.|:|:..:
  Fly   890 GRNGAGKSTLIKLLTGQIRQSSGKVLLAG----------EHQVGVCWQDNILIPTLTAREHLQLY 944

  Fly   637 SKLK----GIRGTKAVENEVGKYMTMLKLQDKSYVAAKNLSGGMKRKLSLCCALCGNAKVVLCDE 697
            :::|    |..|.:.:.:||.:.:..|.........:..||||.:|:|.:..|...:..||:.||
  Fly   945 AQIKIPPGGSGGVEEIRSEVAQTLQSLNFGKHESYPSWQLSGGYRRRLCVAIAFIASPSVVILDE 1009

  Fly   698 PSSGIDAAGRRSLWDLLQSEKDGRTILLTTHYMDEADVLGDRIAILSEGKLQCQGTSFYLKKRFG 762
            |.:|:||..|:.:|.|::..:.||.::..||:||||..|.|.:.|:..|::..|.:...|::...
  Fly  1010 PCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAKYLSDSLVIMRNGRIIAQHSRDSLQRLCT 1074

  Fly   763 TGY--LLVCIMQSGCDVGAVTQLIRKYVPPIKPERVLGTELTYRLPTEY---------------- 809
            :.|  .|.|     .|...||.:|:| ...:.|:    |::|:....:|
  Fly  1075 SNYSIRLRC-----ADATGVTFVIQK-AQQLLPQ----TQVTHSGAADYPHSLTINASYAEHLTP 1129

  Fly   810 -SKKFAELLQDLDEKCAQLQLVGYGLS------GATLEDVFMAVNTDKRVQGGAEGPPVD--GSI 865
             :.:|.||||.        |:....:|      .::||..|..:|.:.. ..|...|..|  |.:
  Fly  1130 GAVEFLELLQS--------QVTAGSISDVELTTSSSLEQEFEQLNRNGE-DAGPRRPASDRSGVV 1185

  Fly   866 DFKELVFDSKTREKRRIRRCFMFWQALFLKKFYTTTRNYWLLGIQLVLPIAVMALTILNSRGGRI 930
            ....::.|......::.|       .|..|:....:|||.||...|:|| |:..|..:    ..:
  Fly  1186 AGPAMITDEPPTACKQFR-------LLMGKRLRHLSRNYRLLLYVLLLP-ALFELCAM----WFV 1238

  Fly   931 YYEL-----PAMPISINQY-SSAYVVLEDNTTDKTSSLADAYSKHLEHYARRCTLLRTGDLKFED 989
            .|.|     ..:|:|.:.| .:|..:..:..|..:..|........:|.. .|.:..|....: |
  Fly  1239 SYRLEDDFDTVLPLSRSLYPQTAQFLSHERATSFSEKLYPQLRTSCDHLG-ECRVFNTSQQSY-D 1301

  Fly   990 YILSHDVNHSRRIDFHFLAGLTVSENNFIVWLNNKPLHTAPLTLNLLHNALAIKLLGQDASTYVT 1054
            ::|:....:|.|    ...|..::.:...||.|||..|:....||.|::.|....:....|:.:|
  Fly  1302 WVLNSWGEYSER----RYGGYGLNGSGATVWYNNKGYHSMMAWLNDLNSELLRTTMNDSESSILT 1362

  Fly  1055 -NEP--LPYSD-DTRTLRLNKGQVLGAEISINLSLTMCFITAFYAIPIIRERETRAKLLQFLSGV 1115
             |||  |.::: .|.::....|.  |:.:.| |.:....:.|..::.::.||....||.|.|.||
  Fly  1363 LNEPWKLGFAELSTSSILRQAGD--GSMVFI-LLIAFGLVVASGSVYLVNERVNGEKLQQRLCGV 1424

  Fly  1116 DVCAYWTSHIVWDYLVFVLSALSSILTIAAFKEIGYITPLDLSRYFYMLLIFGFPGIMLSYAASG 1180
            ....||...:||||||.||..:..::.|..|....::....|.....:.|.|.|..:...:.|..
  Fly  1425 SAVTYWLVALVWDYLVMVLGLIVCLVVILMFGMPVFVDRQQLVGIIGLSLAFSFACVPSVHVAEK 1489

  Fly  1181 CFSDAATGFTRI---SIINTLMGTGLFLMFMTLNFEAFQLKDVAEKLAW---------YFRLSPH 1233
            .|||::.....|   ::|..|:..|:.|:          |..|.:..||         .|.:.|.
  Fly  1490 IFSDSSIAIVSIFCANLIVPLVTMGIILI----------LGVVGDGPAWDDWRHALNQAFLIFPI 1544

  Fly  1234 YSLASSTHSIHIGYNIRRGCSIGGIRKLPKQLRCRNV----------------PICCDIPGYYGW 1282
            ::|..                  |..:|     |:|.                |:..|:.|.:
  Fly  1545 HALGD------------------GFLEL-----CKNYMVALVFRRYDIDSYKHPLASDLLGRH-- 1584

  Fly  1283 RKPGVLVEITYMIMLGSTLFLLIVMHDAKVCNLI---AEKLGNCFSKRKRVEGGTSIENDSVVAE 1344
                    .|.::::|....::.|:.:..:...:   .|:|.:|..:|:..:.|..    .:|..
  Fly  1585 --------FTALLLVGVAALIINVLIEWHLLRRLWQRVERLLDCTYRRELDKLGQL----KLVNI 1637

  Fly  1345 QRVVREMINSG---RKDVPLLVYKISKRYRSKLAVKAISFHVPHAECFGLLGINGAGKTSTFKML 1406
            |.:.:..:::|   |.:...|.|:     |...||:.::|.|...|||||||.|||||::.||:|
  Fly  1638 QSIFKSCVDTGEAVRAENLWLAYR-----RGHYAVRNVNFSVQRGECFGLLGKNGAGKSTIFKLL 1697

  Fly  1407 AGDEKITSGEAYIDGTNISTHKVYRKIGYCPQFDALFEDLTGRETLNIYCLLRGVQRRHVTPICW 1471
            .|..:...|:.|.:...||         ||||.:.|...||..|.:..|..|||:  |.:.....
  Fly  1698 TGQLQPDVGQIYFEQPGIS---------YCPQSNPLDPLLTTTECIRFYGRLRGI--RDLDQFLD 1751

  Fly  1472 GLAISFGFAKHMDKQTKHYSGGNRRKLSTAISVLG-NPSVLYLDEPTSGMDPAARRQLWQIIGLI 1535
            .:..::....:.|.|.::.||||||||:.|::..| .|:|| :|||||.|||..|..::..|..:
  Fly  1752 RVLDTYELRPYKDVQVRNLSGGNRRKLTVAVTCCGCTPTVL-MDEPTSDMDPVTRDMVYATIEQL 1815

  Fly  1536 RTAGKSIVLTSHSMDECEALCSRLAIMVDGEFKCLGSVQSLKNQ 1579
            ..|.:::||||||:.|.|.||.|:|::..|:.....|.|.||::
  Fly  1816 LLARRAVVLTSHSVSEIEHLCQRVAVLRAGQVIASDSPQRLKSE 1859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	347/1409 (25%)
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468	28/144 (19%)
		ABC_subfamily_A	859..1073	CDD:213230	72/223 (32%)
		drrA	865..1162	CDD:130256	91/324 (28%)
		ABC2_membrane_3	1230..1601	CDD:289468	88/426 (21%)
		Mem_trans	1436..>1552	CDD:304621	30/143 (21%)
		ABC_subfamily_A	1651..1857	CDD:213230	82/222 (37%)
		drrA	1666..1945	CDD:130256	80/206 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451223
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	228	1.000	Inparanoid score	I138
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		otm46598
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	P	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.900