DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG6052 and Abca1

DIOPT Version :9

Sequence 1:NP_649002.3 Gene:CG6052 / 39971 FlyBaseID:FBgn0036747 Length:1725 Species:Drosophila melanogaster
Sequence 2:XP_038965774.1 Gene:Abca1 / 313210 RGDID:631344 Length:2263 Species:Rattus norvegicus


Alignment Length:1994 Identity:557/1994 - (27%)
Similarity:905/1994 - (45%) Gaps:479/1994 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 GDWDKLKLLMWKNWILQWNQKMQIVFALVLPVLFLCLILVLRIIV--------LPEKMDEIRYPT 73
            |.|::|...:|.  .::.:|:|.:|                |.::        ...|:|.:.:  
  Rat   414 GMWEELSPQIWT--FMESSQEMDLV----------------RTMLDSRGNDQFWERKLDGLDW-- 458

  Fly    74 VSISDLNLYMRMVPLGNRILHENGSL---------------NIPRNFLCYTPN--NPINSAIVGA 121
             :..|:..::...|  ..:...|||:               .|.|...|...|  .||      .
  Rat   459 -TAQDIMAFLAKNP--EDVQSPNGSVYTWREAFNETNQAIQTISRFMECVNLNKLEPI------P 514

  Fly   122 TAIRLRLLGTRAYDTALHMEQDMVL---HNFLAGVQFEDNENVNTNDAGYPLNLNYSLRFPSELR 183
            |.:||             :.:.|.|   ..|.||:.|   ..:..:....|.::.|.:|.     
  Rat   515 TEVRL-------------INKSMELLDERKFWAGIVF---TGITPDSVELPHHVKYKIRM----- 558

  Fly   184 TMQGPIIDTWRTSRLFLSYDTSGSRNRLDNDGGVPVGYIREGFLPIQHALTMSWLALASGV-TDT 247
                .|.:..||:::...|...|.|    .|....:.|:..||..:|..:..:.:.:.:|. ..|
  Rat   559 ----DIDNVERTNKIKDGYWDPGPR----ADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGTEKKT 615

  Fly   248 GIPAIHLQRFPYRAYTYDQLLSGLRQLLPFVILLSFIYPASTVTKYVTSEKELQLKEIMKLIGVH 312
            |   :::|:.||..|..|..|..:.:.:|..:.|::||..:.:.|.:..|||.:|||.|:::|:.
  Rat   616 G---VYVQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKSIVYEKEARLKETMRIMGLD 677

  Fly   313 NWLHWVAWFVKSYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCFMLA 377
            |.:.|.:||:.|.|.|::...|::.::.:.     .:|.:|....|.:||..:.|.::..||:::
  Rat   678 NGILWFSWFISSLIPLLVSAGLLVIILKLG-----DLLPYSDPSVVFVFLSVFAVVTILQCFLIS 737

  Fly   378 VLFSKASTASAVAAIFWFLTYIPYSFGYYYYERLSLMSKLLISLIFSNSALGFGIHVIVMWEGTG 442
            .|||:.:.|:|...|.:|..|:||.....:.:.:....|:..||: |..|.|||.....::|..|
  Rat   738 TLFSRTNLAAACGGIIYFTLYLPYVLCVAWQDYVGFSIKIFASLL-SPVAFGFGCEYFALFEEQG 801

  Fly   443 EGITWRNMFHPVSTDDSLTLFYIIMTMSFGSIMFISICLYVEQVFPGEYGVPRRWNFMCHKNYWR 507
            .|:.|.|:|.....:|...|...:..|.|.:.::..:..|:|.||||:||:||.|.|.|.|:|| 
  Rat   802 IGVQWDNLFKSPVEEDGFNLTTSVSMMLFDTFIYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYW- 865

  Fly   508 QYVPSLNIVPSF-QTILHGSAKAKSCRRAREV-----------GIQLFNLQKNY--GKLKAVKGI 558
                       | :.|...|....|.:.|.|:           |:.:.||.|.|  |...||.|:
  Rat   866 -----------FGEEIDEKSHPGSSQKGASEICMEEEPTHLKLGVSIQNLVKVYRDGMKVAVDGL 919

  Fly   559 SLKMHRNEITVLLGHNGAGKTTTINMITGIVKPTSGTAIVNGYDIRTHLAKARESLGICPQNNIL 623
            :|..:..:||..|||||||||||::::||:..||||||.:.|.|||:.:...|::||:|||:|:|
  Rat   920 ALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMNSIRQNLGVCPQHNVL 984

  Fly   624 FKEMSVRDHIIFFSKLKGIRGTKAVENEVGKY-----MTMLKLQDKSYVAAKNLSGGMKRKLSLC 683
            |..::|.:||.|:::|||: ..|.|:.|:.:.     :...||:.|:    ..|||||:||||:.
  Rat   985 FDMLTVEEHIWFYARLKGL-SEKHVKAEMEQMALDVGLPPSKLKSKT----SQLSGGMQRKLSVA 1044

  Fly   684 CALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQSEKDGRTILLTTHYMDEADVLGDRIAILSEGKL 748
            .|..|.:|||:.|||::|:|...||.:|:||...:.||||:|:||:|||||:|||||||:|.|||
  Rat  1045 LAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKL 1109

  Fly   749 QCQGTSFYLKKRFGTGYLLVCIMQ------SGC-------------------------------- 775
            .|.|:|.:||.:.||||.|..:.:      |.|                                
  Rat  1110 CCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSCLKKVVPELPAAGQSGGRGGEVQR 1174

  Fly   776 ------DVGAVTQLIRKYVPPIKPERVLGTELTYRLPTEYSKK--FAELLQDLDEKCAQLQLVGY 832
                  ||.|::.||||:|...:....:|.||||.||.|.:|:  |.||..::|::.:.|.:..|
  Rat  1175 LVALTQDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSY 1239

  Fly   833 GLSGATLEDVFMAVNTDKRVQGGAEGPPVDG-------------------------SIDFKELVF 872
            |:|..|||::|:.|    ..:.|.:....||                         ::|..:...
  Rat  1240 GISETTLEEIFLKV----AEESGVDAETSDGTLPARRNRRAFGDKQSCLHPFTEDDAVDPNDSDL 1300

  Fly   873 DSKTREK-----------------RRIRRCF--MFWQALFL-----KKFYTTTRNYWLLGIQLVL 913
            |.::||.                 :..::.|  :.|:.|.:     |.|:.          |:||
  Rat  1301 DPESRETDLLSGMDGKGSYQLKGWKLTQQQFVALLWKRLLIARRSRKGFFA----------QIVL 1355

  Fly   914 PIAVMALTILNSRGGRIYYELPAMPISINQYSSAYVVLEDNTTDK--TSSLADAYSKHLEHYARR 976
            |...:.:.::.|.....:.:.|.:.:....|:..|..:.::..:.  |..|.:|.:|. ..:..|
  Rat  1356 PAVFVCIALVFSLIVPPFGKYPNLELQPWMYNEQYTFVSNDAPEDMGTQELLNALTKD-PGFGTR 1419

  Fly   977 C-------------------------TLL------------------------------------ 980
            |                         ||:                                    
  Rat  1420 CMEGNPIPNTPCLVGEEDWTTGPVPQTLMDLFQNGNWTMKNPSPSCQCSSDKIKKMLPVCPPGAG 1484

  Fly   981 ---------RTGDL-------KFEDYIL------------------------------------- 992
                     :|.|:       ...||::                                     
  Rat  1485 GLPPPQRKQKTADILQNLTGRNISDYLVKTYVQIIAKSLKNKVWVNEFRYGGFSLGVSDSQALPP 1549

  Fly   993 SHDVNHS-----------------RRIDF--HFLAGLTVSENNFIVWLNNKPLHTAPLTLNLLHN 1038
            |.:||::                 |.:..  .|:.||. ::||..||.|||..|.....||:::|
  Rat  1550 SQEVNNAIKQMKKLLKLTKDSSADRFLSSLGRFMTGLD-TKNNVKVWFNNKGWHAISSFLNVINN 1613

  Fly  1039 ALAIKLL--GQDASTY-VT--NEPLPYSDDTRTLRLNKGQV---------LGAEISINLSLTMCF 1089
            |:....|  |::.|.| :|  |.|         |.|.|.|:         :...:||.:...|.|
  Rat  1614 AILRANLQKGENPSQYGITAFNHP---------LNLTKQQLSEVALMTTSVDVLVSICVIFAMSF 1669

  Fly  1090 ITAFYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVWDYLVFVLSALSSILTIAAFKEIGYITP 1154
            :.|.:.:.:|:||.::||.|||:.||....||.|:.|||...:|:.|...::....|::..|::.
  Rat  1670 VPASFVVFLIQERVSKAKHLQFICGVKPVIYWLSNFVWDMCNYVVPATLVVIIFICFQQKSYVSS 1734

  Fly  1155 LDLSRYFYMLLIFGFPGIMLSYAASGCFSDAATGFTRISIINTLMG-TGLFLMFMTLNFEAFQLK 1218
            .:|.....:||::|:....|.|.||..|...:|.:..::.:|..:| .|....|:...|...:..
  Rat  1735 TNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKFN 1799

  Fly  1219 DVAEKLAWYFRLSPHYSLASSTHSIHIGYNIRRGCSIGGIRKLPKQLRCRNV-PICCDIPGYYGW 1282
            |:.:.|...|.:.||:.|......:     ::.......:.:..:.   |.| |:..|:.|.   
  Rat  1800 DINDILKSVFLIFPHFCLGRGLIDM-----VKNQAMADALERFGEN---RFVSPLSWDLVGR--- 1853

  Fly  1283 RKPGVLVEITYMIMLGSTLFLLIVMHDAKVCNLIAEKLGNCFSKRKRVEGGTSIENDSVVAEQRV 1347
                   .:..|.:.|...||:.|:...:.           |.:.:.|:......||.....:|.
  Rat  1854 -------NLFAMAVEGVVFFLVTVLIQYRF-----------FIRPRPVKARLPPLNDEDEDVRRE 1900

  Fly  1348 VREMINSGRKDVPLLVYKISKRYRSKL--AVKAISFHVPHAECFGLLGINGAGKTSTFKMLAGDE 1410
            .:.::..|.::..|.:.:::|.||.|.  ||..|...:|..|||||||:||||||||||||.||.
  Rat  1901 RQRILEGGGQNDILEIKELTKIYRRKRKPAVDRICVGIPPGECFGLLGVNGAGKTSTFKMLTGDT 1965

  Fly  1411 KITSGEAYIDGTNI--STHKVYRKIGYCPQFDALFEDLTGRETLNIYCLLRGVQRRHVTPIC-WG 1472
            .:|.|:|.::..:|  :.|:|::.:||||||||:.|.|||||.|..:.|||||..:.|..:. |.
  Rat  1966 AVTRGDALLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHLEFFALLRGVPEKEVGKVGEWA 2030

  Fly  1473 LAISFGFAKHMDKQTKHYSGGNRRKLSTAISVLGNPSVLYLDEPTSGMDPAARRQLWQIIGLIRT 1537
            :. ..|..|:.:|...:|||||:|||||||:::|.|.|::|||||:||||.|||.||.....|..
  Rat  2031 IR-KLGLVKYGEKYASNYSGGNKRKLSTAIALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIIK 2094

  Fly  1538 AGKSIVLTSHSMDECEALCSRLAIMVDGEFKCLGSVQSLKNQFSKGLILKVKVKHKKKTFQRVVE 1602
            .|:|:|||||||:||||||:|:||||:|.|:||||||.|||:|..|..:.|::            
  Rat  2095 EGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRI------------ 2147

  Fly  1603 DSSSSNDKKSISETDLKFLQMASVMESSQADRILKVNRFISKEIPDAELKEEYNGLITYYIPHS- 1666
             :.|:.|.|.:.|                         |.....|.:.|||::..::.|.:|.| 
  Rat  2148 -AGSNPDLKPVQE-------------------------FFGLAFPGSVLKEKHRNMLQYQLPSSL 2186

  Fly  1667 KTLSKIFQLLETNSHKLNIEDYLIMQTRLEEIFLDFASKRDSSD 1710
            .:|::||.:|..:..:|:||||.:.||.|:::|::||  :|.||
  Rat  2187 SSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFA--KDQSD 2228

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6052NP_649002.3 rim_protein 21..>54 CDD:130324 5/32 (16%)
rim_protein <149..1709 CDD:130324 529/1831 (29%)
Abca1XP_038965774.1 rim_protein 1..2238 CDD:130324 557/1994 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 158 1.000 Domainoid score I4008
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53524
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.830

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