DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and Abca4

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_001101191.1	Gene:	Abca4 / 310836	RGDID:	1309445	Length:	2290	Species:	Rattus norvegicus

Alignment Length:	1976	Identity:	566/1976 - (28%)
Similarity:	882/1976 - (44%)	Gaps:	484/1976 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 DEIRYPTVSISDLNLYMRMVPLGNRILHENGSLNIPRNFLCYTPNNP-INSA----------IVG 120
            |.:::|||.           ...||.|.|.|...  ...|.:.||.| .|.|          |..
  Rat   434 DTLQHPTVK-----------DFINRQLGEEGITT--EAILNFFPNGPRENQADDMTSFDWRDIFN 485

  Fly   121 ATAIRLRLLGT----------RAYDTALHMEQDMVL----HNFLAGVQFEDNENVNTNDAGYPLN 171
            .|...|||...          .:||..:.:.|..:.    :.|.|||.|.|   :....:..|.:
  Rat   486 ITDRFLRLANQYLECLVLDKFESYDDEVQLTQRALSLLEENRFWAGVVFPD---MYPWTSSLPPH 547

  Fly   172 LNYSLRFPSELRTMQGPIIDTWRTSRLFLSYDTSGSRNRLDNDGGVPV---GYIREGFLPIQHAL 233
            :.|.:|       |...:::  :|:::...|..||.|       ..||   .||..||..:|.
  Rat   548 VKYKIR-------MDIDVVE--KTNKIKDRYWDSGPR-------ADPVEDFRYIWGGFAYLQD-- 594

  Fly   234 TMSWLALASGVTDTGIPA-----IHLQRFPYRAYTYDQLLSGLRQLLPFVILLSFIYPASTVTKY 293
                 .:..|:..:..||     ::||:.||..:..|..:..|.:..|..::|::||..|...|.
  Rat   595 -----MVEQGIVRSQTPAEPPIGVYLQQMPYPCFVDDSFMIILNRCFPIFMVLAWIYSVSMTVKG 654

  Fly   294 VTSEKELQLKEIMKLIGVHNWLHWVAWFVKSYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPV 358
            :..||||:|||.:|..||.|.:.|..||:.|:.::.:.:||:...||     ...:|.:|....:
  Rat   655 IVLEKELRLKETLKNQGVSNAVIWCTWFLDSFSIMSMSIFLLTLFIM-----HGRILHYSDPFIL 714

  Fly   359 LLFLHTYVVTSVCLCFMLAVLFSKASTASAVAAIFWFLTYIPYSFGYYYYERLSLMSKLLISLIF 423
            .|||..:...::..||:.:..|||||.|:|.:.:.:|..|:|:...:.:.:|::...|..:||:
  Rat   715 FLFLLAFATATIMQCFLFSTFFSKASLAAACSGVIYFTLYLPHILCFAWQDRMTADLKTTVSLL- 778

  Fly   424 SNSALGFGIHVIVMWEGTGEGITWRNMFHPVSTDDSLTLFYIIMTMSFGSIMFISICLYVEQVFP 488
            |..|.|||...:|.:|..|.|:.|.|:.......|..:....:..|...:.::..:..|::||||
  Rat   779 SPVAFGFGTEYLVRFEEQGLGLQWSNIGKSPLEGDEFSFLLSMKMMLLDAALYGLLAWYLDQVFP 843

  Fly   489 GEYGVPRRWNFMCHKNYWRQYVPSLNIVPSFQTILHGSAKAKSCRRA------------------ 535
            |:||.|..|.|:..::||                |.|...:....||
  Rat   844 GDYGTPLPWYFLLQESYW----------------LGGEGCSTREERALEKTEPLTEEIEDPEYPE 892

  Fly   536 -----REV-----GIQLFNLQKNY--GKLKAVKGISLKMHRNEITVLLGHNGAGKTTTINMITGI 588
                 ||:     |:.:.||.|.:  |...||..:::..:.|:||..|||||||||||::::||:
  Rat   893 DSFFERELPGLVPGVCVKNLVKVFEPGSRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGL 957

  Fly   589 VKPTSGTAIVNGYDIRTHLAKARESLGICPQNNILFKEMSVRDHIIFFSKLKGIRGTKAVENEVG 653
            :.|||||.::.|.||...|...|:|||:|||:||||..::|.:||:|:::||| |..:....|:.
  Rat   958 LPPTSGTVLIGGKDIEISLDAVRQSLGMCPQHNILFHHLTVAEHILFYAQLKG-RSWEEARLEME 1021

  Fly   654 KYMTMLKLQDKSYVAAKNLSGGMKRKLSLCCALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQSEK 718
            ..:....|..|....|::|||||:||||:..|..|::|||:.|||:||:|...|||:||||...:
  Rat  1022 AMLEDTGLHHKRNEEAQDLSGGMQRKLSVAIAFVGDSKVVVLDEPTSGVDPYSRRSIWDLLLKYR 1086

  Fly   719 DGRTILLTTHYMDEADVLGDRIAILSEGKLQCQGTSFYLKKRFGTGYLLVCI-----MQS---GC 775
            .||||:::||:|||||:|||||||:|:|:|.|.||..:||..||||:.|..:     :||   ||
  Rat  1087 SGRTIIMSTHHMDEADLLGDRIAIISQGRLYCSGTPLFLKNCFGTGFYLTLVRKMKNIQSQRCGC 1151

  Fly   776 ------------------------------DVGAVTQLIRKYVPPIKPERVLGTELTYRLPTEYS 810
                                          ||..:|.|:..:||..|....:|.||.:.||.:..
  Rat  1152 EGACSCTSKGFSARCPARVDEITEEQVLDGDVKELTDLVYHHVPEAKLVECIGQELIFLLPNKNF 1216

  Fly   811 KK--FAELLQDLDEKCAQLQLVGYGLSGATLEDVFMAVNTD-------------KRVQGGAEGP- 859
            |:  :|.|.::|:|..|.|.|..:|:|...||::|:.|..|             ||...|...|
  Rat  1217 KQRAYASLFRELEETLADLGLSSFGISDTPLEEIFLKVTEDSESGSKFVGGTQQKREHTGLRHPC 1281

  Fly   860 --PVD--------------GSIDFKE-----------LVFDSKTREKRRIRRCFMFWQALFLKKF 897
              ||:              |.:|..:           :.|::..      |......|||.:|:|
  Rat  1282 SAPVEKHRQHAQASHTCSPGQVDPPKGQPSPEPEDPGIPFNTGA------RLILQHVQALLVKRF 1340

  Fly   898 YTTTRNYWLLGIQLVLPIAVMALTILNSRGGRIYYELPAMPISINQYSSAYV------------- 949
            :...|:......|:|||...:.|.::.|.....:.|.||:.:....|...:.
  Rat  1341 HHAVRSRKDFVAQIVLPATFVFLALMLSIIVPPFGEFPALTLHPWMYGHQFTFFSMDEPNNEHLE 1405

  Fly   950 VLED----------------------------------------------------------NTT 956
            ||.|                                                          :|.
  Rat  1406 VLADVLLNRPGFGNRCLKEEWLPEYPCGNATSWKTPSVSPNITHLFQKQKWTAAHPSPACKCSTR 1470

  Fly   957 DK-----------------------TSSLADAYSKHLEHYARRC--TLLRT-------------G 983
            :|                       |..|.|..::::..|..:.  .|:|:             |
  Rat  1471 EKLIMLPECPEGAGGLPPPQRIQRSTEVLQDLTNRNISDYLVKTYPALIRSSLKSKFWVNEQRYG 1535

  Fly   984 DL----KFEDYILSHD--------------------VNHSRRIDFHFLAGLTVSENNFIVWLNNK 1024
            .:    |..|..:|.:                    ...|.|....||..|. :::|..||.|||
  Rat  1536 GISIGGKLPDIPISGEALVGFLSDLGQMMNVSGGPVTRESSREMLDFLKHLE-TKDNIKVWFNNK 1599

  Fly  1025 PLHTAPLTLNLLHNALAIKLLGQDASTYVTNEPLPYSDD--TRTLRLNKGQV---------LGAE 1078
            ..|.....||:.|||:....|.:|      .:|..|...  ::.|.|.|.|:         :.|.
  Rat  1600 GWHALVSFLNVAHNAILRASLPKD------RDPEEYGITVISQPLNLTKEQLSEITVLTTSIDAV 1658

  Fly  1079 ISINLSLTMCFITAFYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVWDYLVFVLSALSSILTI 1143
            ::|.:...|.|:.|.:.:.:|:||.|:||.|||:|||....||.::.:||.:.:.:||...:...
  Rat  1659 VAICVIFAMSFVPASFVLYLIQERVTKAKHLQFISGVSPTTYWMTNFLWDIMNYAVSAGLVVGIF 1723

  Fly  1144 AAFKEIGYITPLDLSRYFYMLLIFGFPGIMLSYAASGCFSDAATGFTRISIINTLMG------TG 1202
            ..|::..|.:..:|.....:|:::|:..|.:.|.||..|...:|.:..:|..|..:|      |.
  Rat  1724 IGFQKKAYTSTDNLPALVTLLMLYGWAVIPMMYPASFLFDVPSTAYVALSCANLFIGINSSAITF 1788

  Fly  1203 LFLMF----MTLNFEAFQLKDVAEKLAWYFRLSPHYSLASSTHSIHIGYNIRRGCSIGGIRKLPK 1263
            :..:|    |.|.|.|     ...:|...|   ||:.|......:.:...:
  Rat  1789 VLELFENNRMLLRFSA-----TLRELLIVF---PHFCLGRGLIDLALSQAV-------------- 1831

  Fly  1264 QLRCRNVPICCDIPGYYG---------WRKPGVLVEITYMIMLGSTLFL--LIVMHDAKVCNLIA 1317
                      .||...:|         |...|  ..:..|.:.|...||  |::.|...:...||
  Rat  1832 ----------TDIYAQFGEEYSANPFQWDLIG--KNLVAMAIEGVVYFLLTLLIQHHFFLTRWIA 1884

  Fly  1318 EKLGNCFSKRKRVEGGTSIENDSVVAEQRVVREMINSGRKDVPLLVYKISKRY--RSKLAVKAIS 1380
            |      ..|:.|     .:.|..|||:|  :.:::.|.|...|.:.:::|.|  .|..||..:.
  Rat  1885 E------PAREPV-----FDEDDDVAEER--QRVMSGGSKSDILKLNELTKVYSGSSSPAVDRLC 1936

  Fly  1381 FHVPHAECFGLLGINGAGKTSTFKMLAGDEKITSGEAYIDGTNISTH--KVYRKIGYCPQFDALF 1443
            ..|...|||||||:||||||:|||||.||..:|||:|.|.|.:|.|:  .|::.:||||||||:.
  Rat  1937 VGVHPGECFGLLGVNGAGKTTTFKMLTGDTTVTSGDATIAGKSILTNISDVHQNMGYCPQFDAID 2001

  Fly  1444 EDLTGRETLNIYCLLRGVQRRHVTPIC-WGLAISFGFAKHMDKQTKHYSGGNRRKLSTAISVLGN 1507
            :.|||||.|.:|..||||..:.:..:. ||:. |.|.:.:.|:....|||||:|||||||::.|.
  Rat  2002 DLLTGREHLYLYARLRGVPSKEIEKVANWGIQ-SLGLSLYADRLAGTYSGGNKRKLSTAIALTGC 2065

  Fly  1508 PSVLYLDEPTSGMDPAARRQLWQ-IIGLIRTAGKSIVLTSHSMDECEALCSRLAIMVDGEFKCLG 1571
            |.:|.|||||:||||.|||.||. |:.:|| .|:::|||||||:||||||:||||||.|.|:|:|
  Rat  2066 PPLLLLDEPTTGMDPQARRMLWNTIVNIIR-QGRAVVLTSHSMEECEALCTRLAIMVKGTFQCMG 2129

  Fly  1572 SVQSLKNQFSKGLILKVKVKHKKKTFQRVVEDSSSSNDKKSISETDLKFLQMASVMESSQADRIL 1636
            ::|.||.:|..|.|:.:|:|..|                                      |.:|
  Rat  2130 TIQHLKYKFGDGYIVTMKIKSPK--------------------------------------DDLL 2156

  Fly  1637 ----KVNRFISKEIPDAELKEEYNGLITYYIPHSKTLSKIFQLLETNSHKLNIEDYLIMQTRLEE 1697
                .|.:|.....|.:..:|.::.::.:.:| |.:|::|||||.::...|.||:|.:.||.|::
  Rat  2157 PDLNPVEQFFQGNFPGSVQRERHHSMLQFQVP-SSSLARIFQLLISHKDSLLIEEYSVTQTTLDQ 2220

  Fly  1698 IFLDFASKR-DSSDI-FTKRIYSCSW 1721
            :|::||.:: ::.|: ...|....||
  Rat  2221 VFVNFAKQQTETYDLPLHPRAAGASW 2246

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	539/1854 (29%)
Abca4	NP_001101191.1	rim_protein	1..2249	CDD:130324	566/1976 (29%)
		ABC_subfamily_A	907..1126	CDD:213230	105/219 (48%)
		ABC_subfamily_A	1915..2135	CDD:213230	117/221 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342277
Domainoid	1	1.000	163	1.000	Domainoid score	I3872
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.760