DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and Abca15

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_001099763.2	Gene:	Abca15 / 293442	RGDID:	1305981	Length:	1668	Species:	Rattus norvegicus

Alignment Length:	1790	Identity:	571/1790 - (31%)
Similarity:	896/1790 - (50%)	Gaps:	237/1790 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KLKLLMWKNWILQWNQKMQIVFALVLPVLFLCLILVLRIIVLPEKMDEIRYPTVSISDLNLYMRM 85
            ||.||:|||:.|:..:...:|..::|.:.|..::|..|.::...||:.:.:|...:..:..:.|:
  Rat     8 KLLLLLWKNFTLKRRKFGALVTEIILMLAFSIVLLTTRHLLSINKMESLHFPDQPVGAVPFFFRV 72

  Fly    86 ------------VPLGNRILH---EN--GSLNIPRNFLCYTPNNPINSAIVGATAIRLRLLGTRA 133
                        ||....::|   ||  ..||.|             .|::|..:         .
  Rat    73 SANSSRPWELAYVPSNITVVHNIVENVKKDLNFP-------------MAVIGFPS---------E 115

  Fly   134 YDTALHMEQDMVLHNFLAGVQFEDNENVNTNDAGYPLNLNYSLRFPSELRTMQGPII---DTWRT 195
            .|...:....:...|.||.:.| |:...|:.|. .|..:.|:|||....:.:.|...   .||.|
  Rat   116 SDFEDYARSSVNSRNILAAIVF-DHNFANSRDP-LPKKIKYNLRFSDIKKNIHGMAYYQGHTWLT 178

  Fly   196 SRLFLSYDTSGSRNRLDNDGGVPVGYIREGFLPIQHALTMSWLALASGVTDTGI---PAIHLQRF 257
            ..||......|.||..:.|||.| |||.||||.:||||..:.:....|...|.:   .::.:|||
  Rat   179 KFLFPPLRIVGPRNPQEADGGSP-GYITEGFLAVQHALDKAIMLHHGGAAATALFNDVSLFIQRF 242

  Fly   258 PYRAYTYDQLLSGLRQLLPFVILLSFIYPASTVTKYVTSEKELQLKEIMKLIGVHNWLHWVAWFV 322
            ||.||.:|.........:|..:...|......:...:..|||.:|||...:||:.||:.|:|:|.
  Rat   243 PYPAYYHDHFYLFANTFVPLTVASIFFLNHLILVWSIVWEKENRLKEYQLMIGLRNWMFWIAYFF 307

  Fly   323 KSYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCFMLAVLFSKASTAS 387
             ::..|..:..:.|.:::........:..::..:.|.:.|..|.::|:...||::.||::.|.|.
  Rat   308 -TFFCLYFINIIFMCIVLFVKIDPAPIFQYNDPILVFILLLFYAISSIFFSFMISTLFNRVSFAV 371

  Fly   388 AVAAIFWFLTYIPYSFGYYYYERLSLMSKLLISLIFSNSALGFGIHVIVMWEGTGEGITWRNMFH 452
            ::.:..:||||:|.......:|.:....||:.|..| |..:.||...:|..|....|:.|.|:|.
  Rat   372 SLGSFLFFLTYLPAITMNQSFEHMPPRQKLIWSFDF-NVGMAFGFRFLVNAETRKTGMKWNNIFL 435

  Fly   453 PVSTDDSLTLFYIIMTMSFGSIMFISICLYVEQVFPGEYGVPRRWNFMCHKNYW----RQYVPSL 513
            |..: |||...|::..:...:.::..:..|:|.|||||||||:.|||....:||    ||..|.:
  Rat   436 PTDS-DSLLFTYVLGMLLVDAFIYGLVAWYIEAVFPGEYGVPKPWNFFLMHSYWFGESRQQKPEI 499

  Fly   514 NIVPSFQTILHGSAKAKSCRRARE-----------VGIQLFNLQK-----NYGKLKAVKGISLKM 562
                           .:.|:|...           .|||:.:|.|     |..|: |:..:||.:
  Rat   500 ---------------TQFCKRVESKYFEVEPTDLTAGIQIKHLHKVFQENNITKV-AINDLSLNV 548

  Fly   563 HRNEITVLLGHNGAGKTTTINMITGIVKPTSGTAIVNGYDIRTHLAKARESLGICPQNNILFKEM 627
            :..:||||||||||||:||:::::|:..||||.|.|:|.||..|:.:.|..||:|||.|:||..:
  Rat   549 YEGQITVLLGHNGAGKSTTLSILSGLYPPTSGEAYVHGEDISQHMDQIRNFLGLCPQQNLLFDHL 613

  Fly   628 SVRDHIIFFSKLKGIRGTKAVENEVGKYMTMLKLQDKSYVAAKNLSGGMKRKLSLCCALCGNAKV 692
            :|.:|:.|:.::||:.....:| |....::...|.:|....:|:|||||||||::..||.|.:||
  Rat   614 TVSEHLYFYCRVKGVPQNMCLE-ETNNMLSAFNLTEKRDAFSKSLSGGMKRKLAIIIALIGGSKV 677

  Fly   693 VLCDEPSSGIDAAGRRSLWDLLQSEKDGRTILLTTHYMDEADVLGDRIAILSEGKLQCQGTSFYL 757
            |:.|||:||:|.|.|||.||::|:.|..||||||||||||||:|||||||:.:|.|:|.|:|.:|
  Rat   678 VILDEPTSGMDPASRRSTWDVVQTYKQNRTILLTTHYMDEADMLGDRIAIMVQGTLRCCGSSVFL 742

  Fly   758 KKRFGTGYLLVCIMQSGCDVGAVTQLIRKYVPPIKPERVLGTELTYRLPTEYSKKFAELLQDLDE 822
            |:.:|.|..:|.:.:..|||..:::||..|:|....:..:|.||::.||.||:.||..||..|:|
  Rat   743 KRLYGVGSHIVMVKEPVCDVDEISKLIHYYIPTATLKTNVGNELSFILPKEYTHKFEALLTALEE 807

  Fly   823 KCAQLQLVGYGLSGATLEDVFMAVN--TDKRVQGGAEGPPVDGSIDFKELVFDSKTR-------E 878
            ....|.:..:|:|..|:|:||:.|:  .|.:....|...|..||...:....:|..|       |
  Rat   808 NQENLGISSFGMSITTMEEVFLRVSKMEDSKPDMEATQSPSAGSKGNRNRDVESSMRAGFPTQSE 872

  Fly   879 KRRI---RRCFMFWQ---ALFLKKFYTTTRNYWLLGIQLVLPIAVMALTILNS---RGGRIYYEL 934
            .:.|   ..|.::.|   |:|:|:.....||:.:|.:| :|.:.:....:|.|   |..||
  Rat   873 DQTIVFNTGCPLYLQQFHAMFMKRLMYNWRNWRVLSVQ-ILGLVISTFLLLKSHEFRHKRI---- 932

  Fly   935 PAMPISINQYSSAYVVL----EDNTTDKTSSLADAYSKHLEHYARRCTLLRTGDLKFEDY---IL 992
              ..::::.|....|..    :.|.|  ||.|.     |||:      :|:.|:.:.::.   :|
  Rat   933 --RQMNLDDYGQTIVPFSILGKSNLT--TSLLI-----HLEN------MLKPGNHQLKEVQGDLL 982

  Fly   993 SHDVNHSRRIDFHFLA---GLTVSENNFIVWLNNKPLHTAPLTLNLLHNALAIKLLGQDASTYVT 1054
            .:...:...|....:|   .:........|..||:..|:..|:|.:|.|.|.:.|.|.:||..|.
  Rat   983 KYLEGNEECIHLCIVALSIKVAAGRAKLTVLFNNEAYHSPSLSLAVLDNILFMSLSGANASITVF 1047

  Fly  1055 NEPLPYSDDTRTLRLNKGQVLGAEISINLSLTM---CFITAFYAIPIIRERETRAKLLQFLSGVD 1116
            ::|.|........|...|:::..:|.:.::|.:   |.:|       :.||.|:||.:|||||..
  Rat  1048 HKPQPRPTSKEWPRSTYGKIVAFKIQLGMALLVSGFCILT-------VTERITKAKHMQFLSGAS 1105

  Fly  1117 VCAYWTSHIVWDYLVFVLSALSSILTIAAFKEIGYITPLDLSRYFYMLLIFGFPGIMLSYAASGC 1181
            |..||.|.:|:|:::|.:|....::....:|...|:|...:.....:|::||:..|.|:|..|..
  Rat  1106 VLVYWLSALVFDFIIFFISCCFLLVMFKYYKIDIYVTDYHILETMLILILFGWSAIPLTYLMSFL 1170

  Fly  1182 FSDAATGFTRISIINTLMGTGLFLMFMTLNFEAFQLKDVAEKLAWYFRLS-----PHYSLASSTH 1241
            ||.:...:.::.:...|.||...|:...:  || .|..:.......|.||     |.|:|.....
  Rat  1171 FSKSIPAYIQLLVFYYLSGTSGLLIDTII--EA-GLSTIISNSTQTFLLSSLLFFPTYNLGKCIS 1232

  Fly  1242 SIHIGYNIRRGCSIGGIRKLPKQLRC------RNVPICCDIPGYYGWRKPGVLVEITYMIMLGST 1300
            ...:.|..:..|.  ..:.:.|.|.|      :|:         |..:||.:...:..|.:.|..
  Rat  1233 EYTVIYQRKILCI--QQKNVLKYLNCSKEYTKKNI---------YSLKKPMIGKYLIAMSIAGFV 1286

  Fly  1301 LFLLIVMHDA---KVCNLIAEKL--GNCFSKRKRVE------GGTSIENDSVVAEQRVVREMINS 1354
            ..|.|...:.   |:..||.:.:  |.|  |:.:.:      .|||.:||  |..:|  ||::..
  Rat  1287 YLLFIFFWENISWKLRMLIHQHIYFGVC--KKYKSDIISNELSGTSEDND--VENER--REILYQ 1345

  Fly  1355 GRK--DVPLLVYKISKRYRSK---LAVKAISFHVPHAECFGLLGINGAGKTSTFKMLAGDEKITS 1414
            ..|  :.|:|:.:::|.|...   ||||.||..:...|||||||.||||||:||::|.|:...|:
  Rat  1346 PEKFLNCPVLIKQLTKIYFKSPLILAVKNISLAIQERECFGLLGFNGAGKTTTFQILTGEITPTA 1410

  Fly  1415 GEAYIDGTNISTH--KVYRKIGYCPQFDALFEDLTGRETLNIYCLLRGVQRRHVTPICWGLAISF 1477
            |:.:|||.:|:..  ||..|||||||||||.|.|||.|.:.:|..:.|:..|.:.|.......|.
  Rat  1411 GDVFIDGISITKDVLKVRSKIGYCPQFDALLEYLTGWEIMVMYARIWGISERQIRPYVNTYLNSL 1475

  Fly  1478 GFAKHMDKQTKHYSGGNRRKLSTAISVLGNPSVLYLDEPTSGMDPAARRQLWQIIGLIRTAGKSI 1542
            ....|.:.....||.||:|:|||||:::|.|||::||||::||||.|||.||..:..||.:||:|
  Rat  1476 ELEPHANSLISTYSEGNKRRLSTAIAMMGKPSVIFLDEPSTGMDPRARRLLWDAVIKIRESGKAI 1540

  Fly  1543 VLTSHSMDECEALCSRLAIMVDGEFKCLGSVQSLKNQFSKGLILKVKVKHKKKTFQRVVEDSSSS 1607
            ::|||||:||||||:||:|||.|:..||||.|.|||:|....|||.|||
  Rat  1541 IITSHSMEECEALCTRLSIMVHGKLTCLGSPQYLKNKFGDIYILKTKVK---------------- 1589

  Fly  1608 NDKKSISETDLKFLQMASVMESSQADRILKVNRFISKEIPDAELKEEYNGLITYYIPHSKTLS-- 1670
                                   ..:.:.:...||:...|.:|||:|..|::.|||| ||..|
  Rat  1590 -----------------------SGETLKEFKNFITLTFPGSELKQENQGILNYYIP-SKDNSWG 1630

  Fly  1671 KIFQLLETNSHKLNIEDYLIMQTRLEEIFLDFASK 1705
            |:|.:||....:.::|||.|.|..|:::||.||.:
  Rat  1631 KVFGILEKAKEQYDLEDYSISQITLDQVFLAFADQ 1665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324	11/32 (34%)
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	542/1645 (33%)
Abca15	NP_001099763.2	ABC2_membrane_3	<255..464	CDD:289468	51/211 (24%)
		CcmA	522..834	CDD:224054	141/313 (45%)
		ABC_subfamily_A	522..743	CDD:213230	108/222 (49%)
		ABC2_membrane_3	<1007..1195	CDD:289468	55/194 (28%)
		ABC_subfamily_A	1354..1575	CDD:213230	110/220 (50%)
		drrA	1369..1662	CDD:130256	144/332 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342267
Domainoid	1	1.000	176	1.000	Domainoid score	I3511
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1134	1.000	Inparanoid score	I207
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		mtm8956
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.910