DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and Abca17

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_001026807.1	Gene:	Abca17 / 287112	RGDID:	1560494	Length:	1773	Species:	Rattus norvegicus

Alignment Length:	1797	Identity:	554/1797 - (30%)
Similarity:	913/1797 - (50%)	Gaps:	237/1797 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KLKLLMWKNWILQWNQKMQIVFALVLPVLFLCLILVLRIIVLPEKMDEIRYPTVSISDLNLYMRM 85
            |||||:|||::|:..:.:..|...::||||..::|.||:..:|.......||.|.:|.|.:|...
  Rat     6 KLKLLLWKNFVLKKRKTLVTVLETLMPVLFSAIVLYLRLNSMPRNKANTNYPAVDVSLLPVYFHN 70

  Fly    86 VPLGNRILHENGSLNIPRNFLCYTPN-----NPINSAIVGATAIRLRLLGTRAYDTALHMEQDMV 145
            .||.::..            |.|.|:     ..:...:....|:...:||.    .::.:.::.:
  Rat    71 YPLKSKFQ------------LVYIPSKSETLKAVTEVVEQTFAVDFEVLGF----PSVSLFENYI 119

  Fly   146 LHN-----FLAGVQFEDNENVNTNDAGYPLNLNYSLRFPSELRTMQGP--------IIDTWRTSR 197
            :.:     .|.|:.|  :.:.|:::...||.:.|.|||....|....|        .|:.|.|:.
  Rat   120 IKDPKSFYVLVGIVF--HHDFNSSNEPLPLVVKYDLRFSYVQRNSISPPRHLFFQEDIEGWCTAF 182

  Fly   198 LFLSYDTSGSRNRLDNDGGVPVGYIREGFLPIQHALTMSWLALASGVTDTGIPAIH--------- 253
            |:....:...|.....|||.| ||.:||||.||||:            |..|...|
  Rat   183 LYPPNLSQAPREFSYADGGHP-GYNKEGFLAIQHAV------------DKAIMLHHAPKAALDMF 234

  Fly   254 ------LQRFPYRAYTYDQLLSGLRQLLPFVILLSFIYPASTVTKYVTSEKELQLKEIMKLIGVH 312
                  :||||..::..|..|..|:...|.:::||||.....:|..:..|||.:.||.|.|:|:.
  Rat   235 KNLQVSVQRFPSGSHIQDPFLVILQNEFPLLLMLSFICVELIITNSILLEKERKQKEYMYLMGLE 299

  Fly   313 NWLHWVAWFVKSYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCFMLA 377
            |||||||||: ::.:..||....|:::.......|||...|:...:.:||..:.:.::...||::
  Rat   300 NWLHWVAWFI-TFFLSALVTVSGMTVLFCTKMNGVAVFRNSNPTLIFIFLMCFAIATIFFAFMMS 363

  Fly   378 VLFSKASTASAVAAIFWFLTYIPYSFGYYYYERLSLMSKLLISLIFSNSALGFGIHVIVMWEGTG 442
            ..|.:|...:.:..|.:|.||:||.:..:.|.:.:...|:| |.:|||.|:..|:..|.::|..|
  Rat   364 TFFQRAHVGTVIGGIVFFFTYLPYMYITFSYHQRTYSQKIL-SCLFSNVAMAMGVRFISLFEAEG 427

  Fly   443 EGITWRNMFHPVSTDDSLTLFYIIMTMSFGSIMFISICLYVEQVFPGEYGVPRRWNFMCHKNYWR 507
            .||.|||| ..|..|.|.|  .:::.:...|.::..:...||.:||.:.|:|:.|........||
  Rat   428 TGIQWRNM-GSVWGDFSFT--QVLVMLLLDSFLYCLVAFLVESLFPRKIGMPKSWYIFAKCPLWR 489

  Fly   508 QYVPSLNIVPSFQTILHGSAKAKSCRRAREV-----GIQLFNLQKNY--GKLK--AVKGISLKMH 563
            :  .|..::|....|......:|......|.     .|::.:|.|.:  |:.|  |||.:|:.::
  Rat   490 K--KSFPVIPPLLVIGDPEKTSKGDFLQDEPAGHINAIEIQHLYKVFYTGRSKCIAVKDLSMNLY 552

  Fly   564 RNEITVLLGHNGAGKTTTINMITGIVKPTSGTAIVNGYDIRTHLAKARESLGICPQNNILFKEMS 628
            :.:||||||||||||||..:::||::.|:.|.|.::|.:|...:.:.|:::|.|||::|||...:
  Rat   553 KGQITVLLGHNGAGKTTVCSVLTGLIPPSKGHAYIHGCEISKDMVRIRKNVGWCPQHDILFDNFT 617

  Fly   629 VRDHIIFFSKLKGIRGTKAVENEVGKYMTMLKLQDKSYVAAKNLSGGMKRKLSLCCALCGNAKVV 693
            |.||:.|:.:|||:......| ::.:.:..|.|:||....:|.|||||||||::..||...:||:
  Rat   618 VTDHLYFYGQLKGLSHQDCHE-KIEEMLHTLGLEDKRNSRSKFLSGGMKRKLAIGIALIAGSKVL 681

  Fly   694 LCDEPSSGIDAAGRRSLWDLLQSEKDGRTILLTTHYMDEADVLGDRIAILSEGKLQCQGTSFYLK 758
            :.|||:||:|::.||::|||||.:|..||:|||||:|||||:||||||||::|:|||.||..:||
  Rat   682 ILDEPTSGMDSSSRRAIWDLLQQQKGDRTVLLTTHFMDEADLLGDRIAILAKGELQCCGTPSFLK 746

  Fly   759 KRFGTGYLLVCIMQSGCDVGAVTQLIRKYVPPIKPERVLGTELTYRLPTEYSKKFAELLQDLDEK 823
            :::|.||.:..|....||...:.::|..::|....|..:|.|:.:.||.:...:|..|..||:::
  Rat   747 QKYGAGYYMTIIKTPLCDTEKLAKVIYHHIPNAILESRIGEEMIFTLPKKAMPRFEALFADLEQR 811

  Fly   824 CAQLQLVGYGLSGATLEDVFMA----------VNTDKRVQGGAEGP-----------PVDGSIDF 867
            ..:|.:..:|.|..|:|:||:.          |.|:||       |           |||.....
  Rat   812 QTELGISTFGASVTTMEEVFIRVCKLADPSTNVLTEKR-------PSLRHLPRNHRVPVDRIKCL 869

  Fly   868 KELVFDSKTREKRRIRR-----CFMFWQALFLKKFYTTTRNYWL-LGIQLVLPIAV--MALTILN 924
            ...:|...:.:..|:..     |..|: |:.|||...:.||:.| |.:|::||:.:  ::|:..|
  Rat   870 HSRIFSLSSDQPIRLNTGFSLLCQQFY-AMLLKKVAFSRRNWMLVLSVQILLPLVIIMLSLSFFN 933

  Fly   925 SRGGRIYYELPAMP--ISINQYSSAYV---VLEDNTTDKTSSLADAYSKHL-------------- 970
            .:    ..:|..:|  :::..|....|   :.|::..|  ..|:|.:.|.|
  Rat   934 FK----LRKLDNVPLELTLQTYGQTIVPFFIAENSRLD--PQLSDNFVKMLVAAGQVPLRIQGSV 992

  Fly   971 EHYARRCTLLRTGDLKFED----YILS---HDVNHSRRIDFHFLAGLTVSENNFIVWLNNKPLHT 1028
            |::     ||:......||    |:::   .|||....:...|               ||:..|:
  Rat   993 ENF-----LLKKAKEAPEDFDKLYVVAASFEDVNDHTTVKALF---------------NNQAYHS 1037

  Fly  1029 APLTLNLLHNALAIKLLGQDASTYVTNEPLPYS----DDTRTLRLNKGQVLGAEISINLSLTMCF 1089
            ..|.|.|:.|.|...|.|.:||...||.|.|.:    .:|...:..||..|    .:|....:.|
  Rat  1038 PSLALALVDNVLFKLLSGANASITTTNYPQPQTAMELSETILYQGPKGHYL----VVNFLFGIAF 1098

  Fly  1090 ITAFYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVWDYLVFVLSALSSILTIAAFKEIGYITP 1154
            :::.::|..:.|:..::|.|||||||.:.|:|.|.::||.:.|::..|..:|....:||..:..|
  Rat  1099 LSSSFSILTVGEKSIKSKNLQFLSGVSMAAFWLSALLWDLISFLVPTLLLVLVFFWYKEEAFAHP 1163

  Fly  1155 LDLSRYFYMLLIFGFPGIMLSYAASGCFSDAATGFTRISIINTLMGTGLFLMFMTLNFEAFQLKD 1219
            ..:.....:::::|:..|.|.|..|..|....:|..::..:.|.:.....::....:.......:
  Rat  1164 QSIPAVVLIMMLYGWAIIPLVYTVSFSFKTPGSGCVKLVAMLTFLSISPVVLVTVTSEIDLGYTE 1228

  Fly  1220 VAEKLAWYFRLSPHYSLASSTHSIHIGYNIRRGCSIGGIRKLPKQLRCRNVPICCDIPGY----- 1279
            :::.|...|.:.|.:.|..:..:::..:.|::.|:...:    ..:.|.:|     :.||
  Rat  1229 LSDTLDHIFLIFPGHCLGMAFSNLYYNFEIKKFCNAKNL----SDIDCNDV-----LEGYVVQKN 1284

  Fly  1280 -YGWRKPGVLVEITYMIMLGSTLFLLIVMHDAKVCNLIAEKLGNCFSKRK--RVEGGTSIENDSV 1341
             |.|...|:...:|.:.:||.....|:.:.:|.....:..:|...|.|:|  .:...|..|::.|
  Rat  1285 IYAWESLGIGKYLTALAILGPVYITLLFLTEANAFCALKARLSGFFCKQKLRMLLNVTGAEDEDV 1349

  Fly  1342 VAEQRVVREMINSGRKDVPLLVYKISKRYRSK---LAVKAISFHVPHAECFGLLGINGAGKTSTF 1403
            :.|...::..:::..|..||:|.::||.|:.|   |||..:||.|...|||||||:|||||||.|
  Rat  1350 LEEAENIKYHLDTLIKKSPLVVKELSKVYKEKVPLLAVNKVSFVVKEKECFGLLGLNGAGKTSIF 1414

  Fly  1404 KMLAGDEKITSGEAYIDGTNISTH--KVYRKIGYCPQFDALFEDLTGRETLNIYCLLRGVQRRHV 1466
            .||..::.||||:|::.|.||.|.  ||.:.|||||:||||...:||||.|.::..:||:...|:
  Rat  1415 NMLTREQPITSGDAFVKGFNIRTDMAKVQQWIGYCPEFDALLNFMTGREMLVMHARIRGIPECHI 1479

  Fly  1467 TPICWGLAISFGFAKHMDKQTKHYSGGNRRKLSTAISVLGNPSVLYLDEPTSGMDPAARRQLWQI 1531
            ......:..:.....:.||..|.||.||:|.|||||::||.|:|:.||||::||||.|||.:|..
  Rat  1480 KTCVDMILENLLMCVYADKLVKTYSDGNKRVLSTAIALLGEPTVILLDEPSTGMDPVARRLVWDA 1544

  Fly  1532 IGLIRTAGKSIVLTSHSMDECEALCSRLAIMVDGEFKCLGSVQSLKNQFSKGLILKVKVKHKKKT 1596
            :|.:|.:||:||:|||||:||||||:||||||.|:||||||.|.||::|..|..|:.||:.|.:
  Rat  1545 VGRVRESGKTIVITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSRFGSGYSLQAKVRRKWQ- 1608

  Fly  1597 FQRVVEDSSSSNDKKSISETDLKFLQMASVMESSQADRILKVNRFISKEIPDAELKEEYNGLITY 1661
             |:::|:..:                                  |:....|.:.|::|:..::.|
  Rat  1609 -QQMLEEFKA----------------------------------FVDLTFPGSSLEDEHQSMVQY 1638

  Fly  1662 YIP-HSKTLSKIFQLLETNSHKLNIEDYLIMQTRLEEIFLDF 1702
            |:| .:.:.:|:|.::|.......:|||.|.|..||:|||.|
  Rat  1639 YLPGQNLSWAKVFGIMEQAKKDYVLEDYSISQLSLEDIFLSF 1680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324	14/32 (44%)
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	522/1659 (31%)
Abca17	NP_001026807.1	ABC2_membrane_3	<262..464	CDD:289468	65/206 (32%)
		ABC_subfamily_A	525..746	CDD:213230	104/221 (47%)
		drrA	543..834	CDD:130256	125/291 (43%)
		ABC2_membrane_3	913..1255	CDD:289468	81/371 (22%)
		CcmA	1369..1682	CDD:224054	148/348 (43%)
		ABC_subfamily_A	1369..1590	CDD:213230	117/220 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1690..1773
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342204
Domainoid	1	1.000	176	1.000	Domainoid score	I3511
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1134	1.000	Inparanoid score	I207
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		mtm8956
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910