Protein Alignment CG6052 and Abca3

DIOPT Version :9

• Sequence 1: NP_649002.3
• Gene: CG6052 / 39971
• FlyBaseID: FBgn0036747
• Length: 1725
• Species: Drosophila melanogaster
• Sequence 2: NP_001034670.1
• Gene: Abca3 / 27410
• MGIID: 1351617
• Length: 1704
• Species: Mus musculus
• Alignment Length: 1804
• Identity: 602/1804 - (33%)
• Similarity: 945/1804 - (52%)
• Gaps: 237/1804 - (13%)

  Fly    21 KLKLLMWKNWILQWNQKMQIVFALVLPVLFLCLILVLRIIVLPEKMDEIR-YPTVSISDLNLYMR 84
            :|.||:|||:.|:..:.:..|..|.||:||..:::.||:.:..|.:.... ||..||.:|.|:..
Mouse     6 QLTLLLWKNYTLKKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATVYPDQSIQELPLFFS 70

  Fly    85 MVPLGNRILHENGSLNIPRNFLCYTPNN-----PINSAIVGATAIRLRLLG-TRAYDTALHMEQD 143
            ..|.|       |:..     |.|.|::     .|...:.....|::|:.| :...|...::..|
Mouse    71 FPPPG-------GTWE-----LAYVPSHSDAARTITETVKREFMIKMRVHGFSSEKDFEDYIRYD 123

  Fly   144 MVLHNFLAGVQFEDNENVNTNDAGYPLNLNYSLRFPSELR----TMQGPII----DTWRTSRLFL 200
            ....:.||.|.||  .:.|.:....||.:.|.|||....|    |..|.|.    :.|.|:.||.
Mouse   124 NHSSSVLAAVVFE--HSFNHSQDPLPLAVKYHLRFSYTRRNYMWTQTGNIFLKETEGWHTTSLFP 186

  Fly   201 SYDTSGSRNRLDNDGGVPVGYIREGFLPIQHALTMSWLALASGVTDTGIPAIH------------ 253
            .:.:.|.|.....|||.| ||||||||.:|||:            |..|...|
Mouse   187 LFPSPGPREPSSPDGGEP-GYIREGFLAMQHAV------------DKAIMRYHANTSAQQLFQKL 238

  Fly   254 ---LQRFPYRAYTYDQLLSGLRQLLPFVILLSFIYPASTVTKYVTSEKELQLKEIMKLIGVHNWL 315
               .:|||:..|..|..|..::..||.:::|||.|.:.|:.:.|..|||.:|||.|:::|:::||
Mouse   239 MVITKRFPFPPYISDPFLIAIQYQLPLLLMLSFTYTSLTIIRAVVQEKEKKLKEYMRMMGLNSWL 303

  Fly   316 HWVAWFVKSYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCFMLAVLF 380
            ||.|||:..::..::||..:..|..||....:|||:.|....||.||..:.::|:...||::..|
Mouse   304 HWSAWFLMFFLFFLIVVSFMTLLFCVKVKKDIAVLSNSDPSLVLAFLLCFAISSISFSFMVSTFF 368

  Fly   381 SKASTASAVAAIFWFLTYIPYSFGYYYYERLSLMSKLLISLIFSNSALGFGIHVIVMWEGTGEGI 445
            |||:.|:||....:|.||.||.|....|..::|..||| |.:.||.|:..|..:|..:|..|.||
Mouse   369 SKANIAAAVGGFLYFFTYTPYFFVAPRYNWMTLSQKLL-SCLLSNVAMAMGAQLIGKFEAKGTGI 432

  Fly   446 TWRNMFHPVSTDDSLTLFYIIMTMSFGSIMFISICLYVEQVFPGEYGVPRRWNFMCHKNYWRQYV 510
            .||::.:||:.||:.....::..:...|.::..:..|||.||||::|||:.|:|....:||
Mouse   433 QWRDLLNPVNVDDNFCFGQVLGMLLLDSALYGLVTWYVEAVFPGQFGVPQPWHFFLMPSYW---- 493

  Fly   511 PSLNIVPSFQTIL----HGSAKAKSCRRA--------REVGIQLFNLQK-----NYGKLKAVKGI 558
                 ..:.:|::    .||...|:.|..        ...||::.:|.|     |..|: .::.:
Mouse   494 -----CGNPRTVVGKEEEGSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFQVGNKDKM-GIRDL 552

  Fly   559 SLKMHRNEITVLLGHNGAGKTTTINMITGIVKPTSGTAIVNGYDIRTHLAKARESLGICPQNNIL 623
            :|.::..:|||||||||||||||::::||:..||||.|.::||:|...:|:.|:|||:|||:::|
Mouse   553 TLNLYEGQITVLLGHNGAGKTTTMSLLTGLFPPTSGHAYIHGYEISQDMAQIRKSLGLCPQHDVL 617

  Fly   624 FKEMSVRDHIIFFSKLKGIRGTKAVENEVGKYMTMLKLQDKSYVAAKNLSGGMKRKLSLCCALCG 688
            |..::|.:|:.|:::|||:...|..| ||.:.:.:|.|:||..:.:|.||||||||||:..||..
Mouse   618 FDNLTVAEHLYFYAQLKGLSLQKCPE-EVKQMLHILSLEDKRDLRSKFLSGGMKRKLSIGIALIA 681

  Fly   689 NAKVVLCDEPSSGIDAAGRRSLWDLLQSEKDGRTILLTTHYMDEADVLGDRIAILSEGKLQCQGT 753
            .:||::.|||:||:||..||::|||||.:|..||:|||||:|||||:||||||||::|:|||.|:
Mouse   682 GSKVLMLDEPTSGMDAVSRRAIWDLLQQQKSDRTVLLTTHFMDEADLLGDRIAILAKGELQCCGS 746

  Fly   754 SFYLKKRFGTGYLLVCIMQSGCDVGAVTQLIRKYVPPIKPERVLGTELTYRLPTEYSKKFAELLQ 818
            |.:||:::|.||.:..:.:..|:...::||:..:||....|...|.||::.||.|.:.:|..|..
Mouse   747 SLFLKQKYGAGYHMTLVKEPHCNPEGISQLVHHHVPNAMLESHAGAELSFILPKESTHRFESLFA 811

  Fly   819 DLDEKCAQLQLVGYGLSGATLEDVFMAVNTDKRVQGGAEGPPVDGSIDFKELVFDS-KTREKRRI 882
            .|::|..:|.:..:|.|..|:|:||:.|           |..||.|:|.:.:...: :.:.:||.
Mouse   812 KLEKKQKELGIASFGASVTTMEEVFLRV-----------GKLVDTSMDIQAIQLPALQYQHERRA 865

  Fly   883 R-------------------------------------RCFMFWQALFLKKFYTTTRNYWLLGIQ 910
            .                                     .|..|| |:||||...:.|.:.::..|
Mouse   866 SDWALDSNLCGVMDPTNGIGALIEEEEVLVKLNTGLALHCQQFW-AMFLKKAAYSWREWKMVAAQ 929

  Fly   911 LVLPIAVMALTILNSRGGRIYYELPAMPISINQYSSAYVVLEDNTTDKTSSLADAYSKHL----- 970
            :::|:..:.|.:|........::.|.:.:|:|:|....|..   :...||.||...|::|
Mouse   930 VLVPLTCLTLALLAIHYTSEIFDDPLLKLSLNEYGRTVVPF---SVPGTSRLAQQLSENLRDMLQ 991

  Fly   971 -EHYARRCTLLRTGDLK----FEDYILSHDVNHSRRI--DFHFLAGLTVSENNFIVWLNNKPLHT 1028
             |....|..|   |||:    |...:.....|....:  .|.....|||....|    ||:..|:
Mouse   992 AERQEPREVL---GDLEEFLVFRASVEGGGFNERCLVATSFKDRGELTVVTALF----NNQAYHS 1049

  Fly  1029 APLTLNLLHNALAIKLLGQDASTYVTNEPLPYSDDTRTLRL-----NKGQVLGAEISINLSLTMC 1088
            ....|.::.|.|...|.|..||..::|.|.|    ..||::     |:|: .|.:|::||.:.|.
Mouse  1050 PATALAIVDNLLFKLLCGPQASIEISNYPQP----RNTLQVAKDHFNEGR-KGFDIALNLLIAMA 1109

  Fly  1089 FITAFYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVWDYLVFVLSALSSILTIAAFKEIGYIT 1153
            |:.:.::|..:.||..:||.:||:|||.|..:|.|.::||.:.|::.:|..::...||....:..
Mouse  1110 FLASTFSILAVSERAVQAKHVQFVSGVHVATFWFSALLWDLISFLVPSLLLLVVFQAFNVHAFTR 1174

  Fly  1154 PLDLSRYFYMLLIFGFPGIMLSYAASGCFSDAATGFTRISIINTLMGTGLFLMFMTLNFEAFQLK 1218
            ...::....:|:::|:..|.|.|..|..||.|:|.:||::|.|.|.|...|:|...:...|.:|:
Mouse  1175 DGHMADLLLLLMLYGWAIIPLMYLMSFFFSAASTAYTRLTIFNILSGIATFIMVTIMRIPAVKLE 1239

  Fly  1219 DVAEKLAWYFRLSPHYSLASSTHSIHIGYNIRRGCSIGGI-----RKLPKQLRCRNVPICCDIPG 1278
            :::..|...|.:.|::.|..:..:.:..|..||.|:...:     :|...|.:          ..
Mouse  1240 ELSRTLDHVFLVLPNHCLGMAVSNFYENYETRRYCTSSELAAHYCKKYNIQYQ----------ES 1294

  Fly  1279 YYGWRKPGVLVEITYMIMLGSTLFLLIVMHDAKVCNLIAE-KLGNCFSKRK----RVEGGTSI-E 1337
            :|.|..|||...:|.|...|.....|:.:.:.   ||:.. :...|..:|:    .::..||: .
Mouse  1295 FYAWSTPGVGKFVTSMAASGGIYLTLLFLIET---NLLWRLRTFICAFRRRWTLAELQNRTSVLP 1356

  Fly  1338 NDSVVAEQRVVREMINS--GRKDVPLLVYKISKRYRSK---LAVKAISFHVPHAECFGLLGINGA 1397
            .|..|||:| .|.::.|  ...|.||::.::||.|..:   |||..||..|...|||||||.|||
Mouse  1357 EDQDVAEER-SRILVPSLDSMLDTPLIINELSKVYDQRAPLLAVDRISLAVQKGECFGLLGFNGA 1420

  Fly  1398 GKTSTFKMLAGDEKITSGEAYIDGTNISTH--KVYRKIGYCPQFDALFEDLTGRETLNIYCLLRG 1460
            |||:|||||.|:|.||||:|::.|.:||:.  ||.:::|||||||||.:.:||||.|.:|..|||
Mouse  1421 GKTTTFKMLTGEETITSGDAFVGGYSISSDIGKVRQRMGYCPQFDALLDHMTGREMLVMYARLRG 1485

  Fly  1461 VQRRHVTPICWGLAISFGFAKHMDKQTKHYSGGNRRKLSTAISVLGNPSVLYLDEPTSGMDPAAR 1525
            :..|.:...............|.:|..|.|||||:|||||.|:::|.|:|::||||::||||.||
Mouse  1486 IPERLINACVENTLRGLLLEPHANKLVKTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVAR 1550

  Fly  1526 RQLWQIIGLIRTAGKSIVLTSHSMDECEALCSRLAIMVDGEFKCLGSVQSLKNQFSKGLILKVKV 1590
            |.||..:...|.:||:||:|||||:||||||:||||||.|:||||||.|.||::|..|..|:.||
Mouse  1551 RLLWDTVARARESGKAIVITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLQAKV 1615

  Fly  1591 KHKKKTFQRVVEDSSSSNDKKSISETDLKFLQMASVMESSQADRILKVNRFISKEIPDAELKEEY 1655
            :.:.|                                    .|.:.:...|:....|.:.|::|:
Mouse  1616 RSEGK------------------------------------QDALEEFKAFVDLTFPGSILEDEH 1644

  Fly  1656 NGLITYYIPH-SKTLSKIFQLLETNSHKLNIEDYLIMQTRLEEIFLDFA 1703
            ..::.|::|. ..:.:|:|.:||....|..::||.:.|..||::||.||
Mouse  1645 QDMVHYHLPGCDLSWAKVFGILEKAKEKYGVDDYSVSQISLEQVFLSFA 1693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324	13/32 (41%)
		rim_protein	<149..1709	CDD:130324	568/1669 (34%)
Abca3	NP_001034670.1	rim_protein	1..>43	CDD:130324	13/36 (36%)
		rim_protein	<206..1699	CDD:130324	541/1589 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838422
Domainoid	1	1.000	208	1.000	Domainoid score	I2852
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1133	1.000	Inparanoid score	I220
Isobase	1	0.950	-	0	Normalized mean entropy	S3774
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		mtm8719
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.860