Protein Alignment CG6052 and Abca8b

DIOPT Version :9

• Sequence 1: NP_649002.3
• Gene: CG6052 / 39971
• FlyBaseID: FBgn0036747
• Length: 1725
• Species: Drosophila melanogaster
• Sequence 2: NP_038879.2
• Gene: Abca8b / 27404
• MGIID: 1351668
• Length: 1620
• Species: Mus musculus
• Alignment Length: 1837
• Identity: 456/1837 - (24%)
• Similarity: 791/1837 - (43%)
• Gaps: 408/1837 - (22%)

  Fly    25 LMWKNWILQWNQKMQIVFALVLPVLFLCLILVLRIIVLPEKMDEIRYPTVSISDLNLYMRMVPLG 89
            |:.||.:.:|..|.:.:...|     ..|:|:|.:...|.........:|...||
Mouse    15 LLQKNLLKKWRLKRESLMEWV-----SSLLLLLFLYWYPHGHGATDLSSVPTKDL---------- 64

  Fly    90 NRI--LHENGSLNIPRNFLCYTPNNPINSAI---VGATAIRL--RLLGTRAYDTALHMEQDMVLH 147
            .|:  ..::|.:      :.|||...:...|   |.||....  ::||....:....:.:.   |
Mouse    65 GRVDSFRQSGFM------IGYTPVTSMTQQIMEKVAATPFMADKKVLGLLDEENIKELTES---H 120

  Fly   148 NFLAGVQFEDNENVNTNDAGYPLNLNYSLRFPSELRTMQGPIIDTWRTSRLFLSYDTSGSRNRLD 212
            ..:..|.|.|             ..:|.|:|..:.|      |.|.|..|     |.:...:.|.
Mouse   121 AEIIRVIFSD-------------TFSYHLKFQFDQR------IPTSRELR-----DHNAHCDGLY 161

  Fly   213 NDGGVPVG-YIREGFLPIQHALTMSWLALASGVTDTGIPAIHLQRFPYRAYTYDQLLS---GLRQ 273
            .|....:. :.:|||:.:|.|:.   .|:....|:..:              .::|||   ...:
Mouse   162 EDVNCLIAIFWKEGFVALQAAIN---AAIIETTTNHSV--------------MEELLSVSGKFMK 209

  Fly   274 LLPFV----ILLSF-----IYPASTVTKYVT---SEKELQLKEIMKLIGVHNWLHWVAW------ 320
            :.|||    ||..|     |...|.:|.||:   :.:..::|.:|.::|:.:...|::|
Mouse   210 IHPFVRQEGILTDFFIFTCIISFSPITYYVSINVARERKRMKGLMMMMGLRDPAFWLSWGLLYAG 274

  Fly   321 FVKSYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCFMLAVLFSKA-- 383
            ||  :||.:.:..:|.|   |:|:    :|| |..|...||| .|.::.:.|.|:::.|..|:
Mouse   275 FV--FIMALSLALVIKS---VQFF----ILT-SFMVVFSLFL-LYGLSMITLAFLMSALVRKSVL 328

  Fly   384 -STASAVAAIFWFLTYIPYSFGY-YYYERLSLMSKLLISLIFSNSALGFGIHVIVMWEGTGEGIT 446
             ..:..:..|||      .|.|: ..|..|....:..:|| ||..|...|:..::..:
Mouse   329 TGLSVFLLTIFW------GSLGFTSLYRYLPAPVEWTLSL-FSPFAFTLGMAQLLRVD------- 379

  Fly   447 WRNMFHPVSTDDSLTLFYIIMT---MSFGSIMFISICLYVEQVFPGEYGVPRRWNFMCHKNYWRQ 508
             .::......|.:.....||.|   :.|.:.:::::.:|.|:|.|.|||......|....::|.|
Mouse   380 -YDLNSNAPPDPASGSNLIIATNFMLVFDAFLYLALMMYFEKVLPNEYGHQHSPLFFLKSSFWLQ 443

  Fly   509 Y--------------VPSLNIVPSFQTI---LHGSAKAKSCRRAREVGIQLFNLQKNY----GKL 552
            .              |||..  .||:.:   .||           :..|::.|:.|.|    .|:
Mouse   444 TRKPAHVILEDGIDPVPSSG--DSFEPVSPEFHG-----------KESIRIRNISKEYKGKPNKI 495

  Fly   553 KAVKGISLKMHRNEITVLLGHNGAGKTTTINMITGIVKPTSGTAIV--NGYDIRTHLAKARESLG 615
            :|:|.::|.::..:||.:|||:||||:|.:|:::|:..||.|:..:  |.......|.......|
Mouse   496 EALKDLTLDIYEGQITAVLGHSGAGKSTLLNILSGLSVPTKGSVTIYNNNLSEMADLENILRIAG 560

  Fly   616 ICPQNNILFKEMSVRDHIIFFSKLKGIRGTKAVENEVGKYMTMLKLQDKSYVAAKNLSGGMKRKL 680
            :|||.|:.|..::||:::..|:|::|| ..:.||.||.:.:..|::::...:.|:|||||.||||
Mouse   561 VCPQANVQFDFLTVRENLRLFAKIRGI-PPQDVEKEVQRVLLELEMKNIQNILAQNLSGGQKRKL 624

  Fly   681 SLCCALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQSEKDGRTILLTTHYMDEADVLGDRIAILSE 745
            :...|:.|::::.|.|||::|:|...|..:|:||:..:..|.:|.:|.:|||||:|.||...:|.
Mouse   625 TFGIAILGDSQIFLLDEPTAGLDPFSRHRVWNLLKERRADRVVLFSTQFMDEADILADRKVFISN 689

  Fly   746 GKLQCQGTSFYLKKRFGTGYLLVCIMQSGCDVGAVTQLIRKYVPPIKPERVLGTELTYRLPTEYS 810
            |:|:|.|:|.:|||::|.||.|...::..|....:|.|:::::|..|.......:|.|.||.|.:
Mouse   690 GRLKCAGSSLFLKKKWGVGYHLSLQLKEVCVPENITSLVKQHIPAAKLSAEGEGKLLYTLPLETT 754

  Fly   811 KKFAELLQDLDEKCAQLQLVGYGLSGATLEDVFMAVNTDKRVQGGA--EGPPVDGSIDFKELVFD 873
            .:|.||.|.|| .|..|.:..||:|..||.:||:      :::|.|  :.|.||       :|.:
Mouse   755 YRFPELCQSLD-SCPGLGIENYGVSMTTLNEVFL------KLEGKASIDEPEVD-------IVGE 805

  Fly   874 SKTREKRRIRRCFMFWQAL-FLKKFYTTTRNYWLLGIQLVLPIAVMALTILNSRGGRIYYELPAM 937
            .:|.......|.....|.| .|::  |...:...|..|....||.:.|..|......:...|..:
Mouse   806 GQTERSGDTERLMEMEQTLSSLRE--TEKTDGMALWRQQTCAIAKVRLLKLKHERKTLLSVLLIL 868

  Fly   938 PISINQYSSAYVVLEDNTTDK--TSSLADAYSKHLEHYA---------RRCTLLRTGDLKFEDYI 991
            .:.|..:      |.:|.:.|  .||.....|.|....|         .:..::...:...:|:|
Mouse   869 VVGICPF------LFENISTKIRQSSYTWELSPHDYFLAPGQQPQGMLTQLLIINKTEASIDDFI 927

  Fly   992 ---------LSHDVNHSR--RIDFHFLAGLTVSEN----NFIVWLNNKPLHTAPLTLNLLHNALA 1041
                     |..|.:.:|  ..|..:...|.||.|    :|....|.|.|:..|:.:::|.|.
Mouse   928 HSVERQNIALEVDASGTRDGTDDPSYNGALIVSGNEKNHSFSFACNTKRLNCFPVLMDILSNG-- 990

  Fly  1042 IKLLGQ---------DASTYVTNEPL-PYSDDTRTLRLNKGQVLGAEISINLSLTMCFITAFYAI 1096
              |||.         |.|||:.:|.: |..|..:|             :..|.||.. ...:.|:
Mouse   991 --LLGMVKPSARIQTDRSTYLMDETIHPLEDLWKT-------------AFWLILTSA-CPPYIAM 1039

  Fly  1097 PIIRERETRAKLLQFLSGVDVCAYWTSHI---------------VWDYLV----FVLSALSSILT 1142
            ..:.:.:.||.....:||:...|||....               :.|||.    .:.|.:|.::.
Mouse  1040 SSVTDYKNRAWFQLRVSGLFPSAYWVGQAMVDIPLYCFVFLFMSLMDYLFRFPDTMFSIISHVIQ 1104

  Fly  1143 IAAFKEIGYITPLDLSRY-------------------FYMLLIFGFPGIMLSYAASGCFSDAATG 1188
            |..  .:||...|....|                   ||::.:|....|:|::...|      |.
Mouse  1105 IPC--SVGYAISLIFLTYVISFISRKGKKNSGIWSLSFYIITVFSVAVILLAFDVDG------TQ 1161

  Fly  1189 FTRISII--NTLMGTGLFLMFMTLNFEAFQLKDVAEKLAWYFRLSPHYSLASSTHSIHIGYNIRR 1251
            :..|.:|  :||:|..:..:.:.:. :.|:...|.|....:  |.|.         :|:...|
Mouse  1162 YYIIFLIPPSTLVGCLILSLHLFIG-QIFEEGQVIEPFLVF--LIPF---------LHVFIFI-- 1212

  Fly  1252 GCSIGGIRKLPKQLRCRNVPICCDIPGYYGWRKPGVLVEITYMIMLGSTLFLLIVMHDAKVCNLI 1316
                       ..|||..            |:       .....|....:|            .|
Mouse  1213 -----------FTLRCLE------------WK-------FGKKTMRKDPIF------------RI 1235

  Fly  1317 AEKLGNCFSKRKRVEGGTSIENDSVVAEQ-RVVREMINSGRKDVPLLVYK-ISKRY--------- 1370
            :.:..:.:...:..|.    |::.|..|: |....::::...:.|:::.. :.|.|
Mouse  1236 SPRNNDVYQNPEEPED----EDEDVQMERMRTANALVSTSFDEKPVIIASCLRKEYAGKQKHCLS 1296

  Fly  1371 --RSKLAVKAISFHVPHAECFGLLGINGAGKTSTFKMLAGDEKITSGEAYIDGTNISTHKVYRKI 1433
              ::|:|.:.:||.|...|..||||.|||||:::.||::||.|:|:|:..:.|:.......:  :
Mouse  1297 KKKAKIATRNVSFCVRKGEILGLLGHNGAGKSTSLKMISGDTKVTAGQVLLKGSREGDTPGF--L 1359

  Fly  1434 GYCPQFDALFEDLTGRETLNIYCLLRGVQRRHVTPICWGLAISFGFAKHMDKQTKHYSGGNRRKL 1498
            |||||.:||:.:||.:|.|.|:..:||:::.|.......||.:......:....|..|.|.:|||
Mouse  1360 GYCPQENALWPNLTVKEHLEIFAAVRGLRKSHAAVAITRLADALKLQDQLKSPVKTLSEGVKRKL 1424

  Fly  1499 STAISVLGNPSVLYLDEPTSGMDPAARRQLWQII-GLIRTAGKSIVLTSHSMDECEALCSRLAIM 1562
            ...:|:|||||:|.||||::|:||..::|:||.| .:|:...:..:||:|.|.|.||||.|:||:
Mouse  1425 CFVLSILGNPSILLLDEPSTGLDPEGQQQIWQAIRAIIKNTDRGALLTTHYMAEAEALCDRVAIL 1489

  Fly  1563 VDGEFKCLGSVQSLKNQFSKGLILKVKVKHKKKTFQRVVEDSSSSNDKKSISETDLKFLQMASVM 1627
            |.|..:|:||:|.||::|.|..:|::|||
Mouse  1490 VSGRLRCIGSIQHLKSKFGKDYLLEMKVK------------------------------------ 1518

  Fly  1628 ESSQADRILKVNRFISKEIPDAELKEEYNGLITYYIPHS--KTLSKIFQLLETNSHKLNIEDYLI 1690
               ..:::..:|..|.:..|.|..:|.|:.|:.|.:|..  :.||:.|..||......::|:|.:
Mouse  1519 ---TLEQVEPLNTEILRLFPQASRQERYSSLMAYKLPVEAVQPLSQAFFKLEKVKQTFDLEEYSL 1580

  Fly  1691 MQTRLEEIFLDFASKRD 1707
            .|:.||::||:.:.:::
Mouse  1581 SQSTLEQVFLELSKEQE 1597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324	6/28 (21%)
		rim_protein	<149..1709	CDD:130324	431/1706 (25%)
Abca8b	NP_038879.2	rim_protein	<265..1596	CDD:130324	393/1519 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838406
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750