DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and Abca7

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_001334010.1	Gene:	Abca7 / 27403	MGIID:	1351646	Length:	2167	Species:	Mus musculus

Alignment Length:	1892	Identity:	513/1892 - (27%)
Similarity:	834/1892 - (44%)	Gaps:	468/1892 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 PINSAIVGATAIRLRLLGTRAYDTALHMEQDMVLHNFLAGVQFEDNENVNTNDAGYPLNLNYSLR 177
            |...|:|...   |.|||.|               ...||:.|...|        :||:
Mouse   413 PSEEALVSRA---LELLGER---------------RLWAGIVFLSPE--------HPLD------ 445

  Fly   178 FPSELRT-----------MQGPIIDTWRTSRLFLSYDTSGSRNRLDNDGGVPVGYIREGFLPIQH 231
             ||||.:           ::..|.|..||:::...:...|.    ..|..:.:.|:..||:.:|.
Mouse   446 -PSELSSPALSPGHLRFKIRMDIDDVTRTNKIRDKFWDPGP----SADPFMDLRYVWGGFVYLQD 505

  Fly   232 ALTMSWL-ALASGVTDTGIPAIHLQRFPYRAYTYDQLLSGLRQLLPFVILLSFIYPASTVTKYVT 295
            .|..:.: .|..|.:.||   ::||:.|:..|..|..|..|.:.||..:.|::||..:...|.|.
Mouse   506 LLEQAAVRVLGGGNSRTG---LYLQQMPHPCYVDDVFLRVLSRSLPLFLTLAWIYSVALTVKAVV 567

  Fly   296 SEKELQLKEIMKLIGVHNWLHWVAWFVKSYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLL 360
            .|||.:|:|.|:.:|:...:.|:.||:.     .|..||:.:.::|.......:|.:|..|.:.|
Mouse   568 REKETRLRETMRAMGLSRAVLWLGWFLS-----CLGPFLVSAALLVLVLKLGNILPYSHPVVIFL 627

  Fly   361 FLHTYVVTSVCLCFMLAVLFSKASTASAVAAIFWFLTYIPYSFGYYYYERLSLMSKLLISLIFSN 425
            ||..:.|.:|...|:|:..||:|:.|:|...:.:|..|:||.....:.|||.|...|..||: |.
Mouse   628 FLAAFAVATVAQSFLLSAFFSRANLAAACGGLAYFALYLPYVLCVAWRERLHLGGLLAASLL-SP 691

  Fly   426 SALGFGIHVIVMWEGTGEGITWRNMFHPVSTDDSLTLFYIIMTMSF---GSIMFISICLYVEQVF 487
            .|.|||...:.:.|..|:|..|.|:    .|..:..:|.:....:|   .::::.....|:|.|.
Mouse   692 VAFGFGCESLALLEEQGDGAQWHNL----GTGPAEDVFSLAQVSAFLLLDAVIYGLALWYLEAVC 752

  Fly   488 PGEYGVPRRWNFMCHKNYW------RQYV--------------PSLNIVPSFQTILHGSAKAKSC 532
            ||:||:|..|||...::||      :..|              |.|.:||
Mouse   753 PGQYGIPEPWNFPFRRSYWCGPGPPKSSVLAPAPQDPKVLVEEPPLGLVP--------------- 802

  Fly   533 RRAREVGIQLFNLQKNYG--KLKAVKGISLKMHRNEITVLLGHNGAGKTTTINMITGIVKPTSGT 595
                  |:.:..|:|::.  ...|::|::|..:...||..|||||||||||:::::|:..|:||:
Mouse   803 ------GVSIRGLKKHFRGCPQPALQGLNLDFYEGHITAFLGHNGAGKTTTLSILSGLFPPSSGS 861

  Fly   596 AIVNGYDIRTHLAKARESLGICPQNNILFKEMSVRDHIIFFSKLKGIRGTKAVENEVGKYMTMLK 660
            |.:.|:|::|::|..|..||||||.|:||..::|.:|:.|:.:|||: ...|:..|..:.:..:.
Mouse   862 ASILGHDVQTNMAAIRPHLGICPQYNVLFDMLTVEEHVWFYGRLKGV-SAAAMGPERERLIRDVG 925

  Fly   661 LQDKSYVAAKNLSGGMKRKLSLCCALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQSEKDGRTILL 725
            |..|.....::|||||:||||:..|..|.::||:.|||::|:|.|.||.:|:||...::|||::|
Mouse   926 LTLKRDTQTRHLSGGMQRKLSVAIAFVGGSRVVIMDEPTAGVDPASRRGIWELLLKYREGRTLIL 990

  Fly   726 TTHYMDEADVLGDRIAILSEGKLQCQGTSFYLKKRFGTGYLLVCIMQSGCDV------------- 777
            :||::|||::||||:|:::.|.|.|.|:..:|::..|.||.|..:..|...|
Mouse   991 STHHLDEAELLGDRVAMVAGGSLCCCGSPLFLRRHLGCGYYLTLVKSSQSLVTHDAKGDSEDPRR 1055

  Fly   778 -----------------------------GAV---------TQLIRKYVPPIKPERVLGTELTYR 804
                                         |||         .:|::::||        |.:|...
Mouse  1056 EKKSDGNGRTSDTAFTRGTSDKSNQAPAPGAVPITPSTARILELVQQHVP--------GAQLVED 1112

  Fly   805 LPTE----------YSKKFAELLQDLDEKCAQLQLVGYGLSGATLEDVFMAVNTDKRVQGGAEGP 859
            ||.|          ....||.:.|:||::...|.|.|||:|...||::|:.|..|...:||...|
Mouse  1113 LPHELLLVLPYAGALDGSFAMVFQELDQQLELLGLTGYGISDTNLEEIFLKVVEDAHREGGDSRP 1177

  Fly   860 PV-------------DGSI----DFKELVFDSK---------------TREKRRIRRCFMFWQAL 892
            .:             :.|:    :..:||.|.:               |...:::|       ||
Mouse  1178 QLHLRTCTPQPPTGPEASVLENGELAKLVLDPQAPQGLAPNAAQVQGWTLTCQQLR-------AL 1235

  Fly   893 FLKKFYTTTRNYWLLGIQLVLPIAVMALTIL---------------------------------- 923
            ..|:|....|:...|..|:|||...:.|.:.
Mouse  1236 LHKRFLLARRSRRGLFAQVVLPALFVGLALFFSLIVPPFGQYPPLQLSPAMYGPQVSFFSEDAPG 1300

  Fly   924 -------------------------NSRGGR------IYYELPAMPISINQYSSAYVVLEDNTTD 957
                                     ::||..      .|:.:|.:|..:     |.::...|.|.
Mouse  1301 DPNRMKLLEALLGEAGLQEPSMQDKDARGSECTHSLACYFTVPEVPPDV-----ASILASGNWTP 1360

  Fly   958 KTSSLADAYSKHLEHYARR----C-------------------------------------TLLR 981
            ::.|.|...|   :..|||    |                                     :|:|
Mouse  1361 ESPSPACQCS---QPGARRLLPDCPAGAGGPPPPQAVAGLGEVVQNLTGRNVSDFLVKTYPSLVR 1422

  Fly   982 TGDLKFEDYI------------------LSHDV----------------NHSRRIDFHFLAGLTV 1012
            .| ||.:.::                  ..|:|                |...||    |..||.
Mouse  1423 RG-LKTKKWVDEVRYGGFSLGGRDPDLPTGHEVVRTLAEIRALLSPQPGNALDRI----LNNLTQ 1482

  Fly  1013 ------SENNFIVWLNNKPLHTAPLTLNLLHNALAIKLLG----QDASTYVT-NEPLPYSDDTRT 1066
                  :.|:..:|.|||..|.....:|..:|.|...||.    :.|.:..| |.||..:.:
Mouse  1483 WALGLDARNSLKIWFNNKGWHAMVAFVNRANNGLLHALLPSGPVRHAHSITTLNHPLNLTKE--- 1544

  Fly  1067 LRLNKGQVLGAEISINLSL----TMCFITAFYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVW 1127
             :|::..::.:.:.:.:|:    .|.|:.|.:.:.:|.||.||||.||.:||:....||..:.:|
Mouse  1545 -QLSEATLIASSVDVLVSICVVFAMSFVPASFTLVLIEERITRAKHLQLVSGLPQTLYWLGNFLW 1608

  Fly  1128 DYLVFVLSALSSILTIAAFKEIGYITPLDLSRYFYMLLIFGFPGIMLSYAASGCFSDAATGFTRI 1192
            |...::::....:....||::..|:.|.:|.....:||::|:....|.|.||..||..:|.:..:
Mouse  1609 DMCNYLVAVCIVVFIFLAFQQRAYVAPENLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVL 1673

  Fly  1193 SIINTLMGTGLFLMFMTLNFEAFQ-LKDVAEKLAWYFRLSPHYSLASSTHSIHIGYNIRRGCSIG 1256
            :.||..:|....:....|...:.| |::|:..|...|.:.||:.|......:     :|......
Mouse  1674 TCINLFIGINSSMATFVLELLSDQNLQEVSRILKQVFLIFPHFCLGRGLIDM-----VRNQAMAD 1733

  Fly  1257 GIRKL-PKQLRCRNVPICCDIPGYYGWRKPGVLVEITYMIMLGSTLFLLIVMHDAKVCNLIAEKL 1320
            ...:| .||.:.   |:..||.|           :....:|....|||||.:       |:..:.
Mouse  1734 AFERLGDKQFQS---PLRWDIIG-----------KNLLAMMAQGPLFLLITL-------LLQHRN 1777

  Fly  1321 GNCFSKRKRVEGGTSIENDSVVAEQRVVREMINSGRKDVPLLVYK-ISKRYRSKL--AVKAISFH 1382
            ......:.|:......|::.|..|    ||.:..|.....:||.: ::|.||.:.  ||..:...
Mouse  1778 RLLPQSKPRLLPPLGEEDEDVAQE----RERVTKGATQGDVLVLRDLTKVYRGQRNPAVDRLCLG 1838

  Fly  1383 VPHAECFGLLGINGAGKTSTFKMLAGDEKITSGEAYIDGTNISTHK--VYRKIGYCPQFDALFED 1445
            :|..|||||||:|||||||||:|:.||...:||||.:.|.|::..:  .:|.:|||||.||:|:.
Mouse  1839 IPPGECFGLLGVNGAGKTSTFRMVTGDTLPSSGEAVLAGHNVAQERSAAHRSMGYCPQSDAIFDL 1903

  Fly  1446 LTGRETLNIYCLLRGVQRRHVTPICWGLAISFGFAKHMDKQTKHYSGGNRRKLSTAISVLGNPSV 1510
            |||||.|.::..||||....|........:..|...:.|:....|||||:|||:||::::|:|:|
Mouse  1904 LTGREHLELFARLRGVPEAQVAQTALSGLVRLGLPSYADRPAGTYSGGNKRKLATALALVGDPAV 1968

  Fly  1511 LYLDEPTSGMDPAARRQLWQIIGLIRTAGKSIVLTSHSMDECEALCSRLAIMVDGEFKCLGSVQS 1575
            ::|||||:||||:|||.||..:..:...|:|:|||||||:||||||:||||||:|.|:||||.|.
Mouse  1969 VFLDEPTTGMDPSARRFLWNSLLSVVREGRSVVLTSHSMEECEALCTRLAIMVNGRFRCLGSSQH 2033

  Fly  1576 LKNQFSKGLILKVKVKHKKKTFQRVVEDSSSSNDKKSISETDLKFLQMASVMESSQADRILKVNR 1640
            ||.:|..|..|.::|...:                   .|..:.|:::.
Mouse  2034 LKGRFGAGHTLTLRVPPDQ-------------------PEPAIAFIRIT---------------- 2063

  Fly  1641 FISKEIPDAELKEEYNGLITYYIPHSK--TLSKIFQLLETNSHKLNIEDYLIMQTRLEEIFLDFA 1703
                 .|.|||:|.:...:.:.:|...  ||:::|:.|........:||:.:.||.|||:||.|:
Mouse  2064 -----FPGAELREVHGSRLRFQLPPGGRCTLTRVFRELAAQGRAHGVEDFSVSQTTLEEVFLYFS 2123

  Fly  1704 SKRDSSD 1710
            ..:...:
Mouse  2124 KDQGEEE 2130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	505/1853 (27%)
Abca7	NP_001334010.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1042..1088		3/45 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1172..1192		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2126..2167		0/5 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838430
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.760