DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and Abca5

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_671752.2	Gene:	Abca5 / 217265	MGIID:	2386607	Length:	1642	Species:	Mus musculus

Alignment Length:	1858	Identity:	467/1858 - (25%)
Similarity:	824/1858 - (44%)	Gaps:	386/1858 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VGDWDKLKLLMWKNWILQWNQKMQIVFALVLPVLFLCLILVLRIIVLPEKMDEIRYPTVSISDLN 80
            ||.|.:.:.|:.||::::...|...|..::.|:.||..::::.::...:|.:|       :||:.
Mouse     8 VGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILVSMMHPNKKYEE-------VSDIE 65

  Fly    81 LY-MRMVPLGNRILHENGSLNIPRNFLCYTPNNPINSAIVG--ATAIRLRLLGTRAYDTALHMEQ 142
            |. |....|.|.||.             |||...|.|:|:.  :|....:::.|..|..    |:
Mouse    66 LSPMDKFSLSNVILG-------------YTPVTNITSSIMQRVSTDHLPKVIVTEEYAN----EK 113

  Fly   143 DMVL------HNFLAGVQFEDNENVNTNDAGYPLNLNYSLRFPSELRTMQGPIIDTWRTSRLFLS 201
            ::|.      .||: ||.|:|             .::|.|||..|:.    |:...:..||
Mouse   114 ELVAASLSKSSNFV-GVVFKD-------------TMSYELRFFPEMI----PVSSIYMNSR---- 156

  Fly   202 YDTSGSRNRLDNDGGVPVGYIREGFLPIQHALTMSWLALASGV--------TDTGI----PAIHL 254
               .|.....|     ...|...||..:|.::..:.:.|.:.|        |...|    ..:.:
Mouse   157 ---EGCSKTCD-----AAQYWSLGFTVLQASIDAAIIQLKTNVSVWSELESTKAVIMGEAAVVEI 213

  Fly   255 QRFPYRAYTYDQLLSGLRQLLPFVILLSFIYPASTVTKYVTSEKELQLKEIMKLIGVHNWLHWVA 319
            ..||             |.::...::::|......:..::.:|||.:|||.:|::|:|:...|::
Mouse   214 DTFP-------------RGVILIYLVIAFSPFGYFLAIHIVAEKEKKLKEFLKIMGLHDTAFWLS 265

  Fly   320 WFVKSYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCFMLAVLFSKAS 384
            |     ::|...:..:|||:|.....:.::...||.:.:.|....|.::||....||..||.|
Mouse   266 W-----VLLYASLIFLMSLLMAVIATASSLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKK-- 323

  Fly   385 TASAVAAIFWFLTYIPYSFGYYYYERLSLMSKLLISL------IFS---NSALGFGIHVIVMWEG 440
             :..|..:.:|:|.:   ||:     :.|:..|:.|.      :||   ..|...||..::..|.
Mouse   324 -SKHVGVVEFFVTVV---FGF-----VGLLIVLIESFPRSLVWLFSPLCQCAFLIGIAQVMHLED 379

  Fly   441 TGEGITWRNMFHPVSTDDSLTLFYIIMTMSFGSIMFISICLYVEQVFPGEYGVPRRWNFMCHKNY 505
            ..||..:.|:     |:....|...|:.::..|:.::.:.:|::||.|||:|:.|...:....:|
Mouse   380 FNEGALFSNL-----TEGPYPLIITIIMLALDSVFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSY 439

  Fly   506 W----RQYVP----------SLN-IVPSFQTILHGSAKAKSCRRAREVGIQLFNLQKNYGK---- 551
            |    |.|..          ||| ||....:...|           :..|::..:||:|.|
Mouse   440 WSKNKRNYKELSEGNINGNISLNEIVEPVSSEFIG-----------KEAIRISGIQKSYRKKTEN 493

  Fly   552 LKAVKGISLKMHRNEITVLLGHNGAGKTTTINMITGIVKPTSGTAIVNGYDIR--THLAKARESL 614
            ::|::.:|..::..:||.||||:|.||:|.:|::.|:..|:.|.|.:.|:.:.  ..:.:||:.:
Mouse   494 VEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMI 558

  Fly   615 GICPQNNILFKEMSVRDHIIFFSKLKGIRGTKAVENEVGKYMTMLKLQDKSYVAAKNLSGGMKRK 679
            |||||::|.|..::|.:::...:.:|||.....:: ||.|.:..|.:|......||.||||.|||
Mouse   559 GICPQSDINFDVLTVEENLSILASIKGIPANNIIQ-EVQKVLLDLDMQAIKDNQAKKLSGGQKRK 622

  Fly   680 LSLCCALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQSEKDGRTILLTTHYMDEADVLGDRIAILS 744
            ||:..|:.||.|::|.|||::|:|...|..:|:||:..|..|..:.:||:|||||:|.||.|::|
Mouse   623 LSVGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVIS 687

  Fly   745 EGKLQCQGTSFYLKKRFGTGYLLVCIMQSGCDVGAVTQLIRKYVPPIKPERVLGTELTYRLPTEY 809
            :|.|:|.|:|.:||.::|.||.|...:...|...:::.|:|:::|.....:....:|.|.||.:.
Mouse   688 QGMLKCVGSSIFLKSKWGIGYRLSMYIDRYCATESLSSLVRQHIPAAALLQQNDQQLVYSLPFKD 752

  Fly   810 SKKFAELLQDLDEKCAQLQLVGYGLSGATLEDVFMAVNTDKRVQGGAEGPPVDGSIDFKEL-VFD 873
            ..||:.|...||.. :.|.::.||:|..||||||:.:.             |:..||..:. ||.
Mouse   753 MDKFSGLFSALDIH-SNLGVISYGVSMTTLEDVFLKLE-------------VEAEIDQADYSVFT 803

  Fly   874 SKTREKRRIRRCF--MFWQALFL---KKFYTTTRNYWLLGIQLVL------------PIAVMALT 921
            .:.||:....:.|  |....|.|   |....:|.:.|...:..:.            .:..:.|.
Mouse   804 QQPREEETDSKSFDEMEQSLLILSETKASSVSTMSLWKQQVSTIAKFHFLSLKRESKSVRAVLLL 868

  Fly   922 ILNSRGGRIY-------YELPAMPISI-------------NQYSSAYVVLEDNTTDKTSSLADAY 966
            :|.....:|:       ::...:||.:             ::|.:: ::|:::|....:.|
Mouse   869 LLIFFAVQIFMFFLHHSFKNAVVPIKLVPDLYFLKPGDKPHKYKTS-LLLQNSTDSDINGL---- 928

  Fly   967 SKHLEHYARRCTLLRTGDLKFEDYILSHDVNHSRRIDFHFLAGLTV--SENNFI--VWLNNKPLH 1027
               :|.:|.:..::..  ....||:.:  ..||        |.|.|  ||.:::  ...|:..::
Mouse   929 ---IEFFAHQNIMVAM--FNDSDYVSA--APHS--------AALNVVRSEKDYVFSAVFNSTMVY 978

  Fly  1028 TAPLTLNLLHNALAIKLLGQDA-STYVTNEPLPYSDDTRTLRLNKGQVLGAEISINLSLTMCFIT 1091
            ..|:.:|::.|.....|...:| .|:.|    |:..:...:      |...|:....:|....:|
Mouse   979 CLPVMMNIISNYYLYHLNVTEAIQTWST----PFIQEITDI------VFKIELYFQAALLGIIVT 1033

  Fly  1092 A---FYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVWDYLVFVLSALSSILTIAAFKEIGYIT 1153
            |   ::|:......:.:|.....|||:...|||....|.|..:|.:..:..:.::.||....|..
Mouse  1034 AMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWVGQAVVDIPLFFVVLILMLGSLFAFHHGLYFY 1098

  Fly  1154 PLDLSRYFYMLLIFGFPGIMLSYAASGCFSDAATGFTRISIINTLMGTGLFLMFMTLNFEAFQLK 1218
            |.......:.|:.:....|:.:|.||         ||...|:||       ..|.:..:....|.
Mouse  1099 PAKFLAVVFCLIAYVPSVILFTYIAS---------FTFKKILNT-------KEFWSFIYSVTALA 1147

  Fly  1219 DVAEKLAWYFRLSPHYSLASSTH---SIHIGYNIRRGCSI----GGIRKLPKQLRCRNVPICCDI 1276
            .||.....:|.   .|::.:..|   .|.|......||.|    |..:.:||.   .|.
Mouse  1148 CVAITETTFFL---QYAVTAVFHYTFCIAIPIYPLLGCLISFIKGSWKNMPKN---ENT------ 1200

  Fly  1277 PGYYGWRKPGVLVEITYMIMLGSTLFLLIVMHDAKVCNLIAEKLGNCFSKRKRVEGGTSI----- 1336
              |..|.:..|.|.:.|   |...|::.::.|                  .:::.||.||
Mouse  1201 --YNPWDRLLVAVIMPY---LQCILWIFLLQH------------------YEKIHGGRSIRKDPF 1242

  Fly  1337 ---------------------ENDSVVAEQRVVREMINSG--RKDVPLLVYKISKRY-------- 1370
                                 |::.|.||:..|:|::...  .:...::|..:.|.|
Mouse  1243 FRALSQKAKNKKFPEPPINEDEDEDVKAERLKVKELMGCQCCEEKPAIMVCNLHKEYDDKKDFLH 1307

  Fly  1371 ---RSKLAVKAISFHVPHAECFGLLGINGAGKTSTFKMLAGDEKITSGEAYID--GTNIS-THKV 1429
               .:|:|.|.|||.|...|..||||.|||||::....|.||.:.|||:.::.  |::.| ..:.
Mouse  1308 SRKTTKVATKYISFCVKKGEILGLLGPNGAGKSTVINTLVGDVEPTSGKIFLGDYGSHSSEDDES 1372

  Fly  1430 YRKIGYCPQFDALFEDLTGRETLNIYCLLRGVQRRHVTPICWGLAISFGFAKHMDKQTKHYSGGN 1494
            .:.:|||||.:.|:.|||.:|...||..::|:....:..:...:..:....:|:.|..|....|.
Mouse  1373 IKCMGYCPQTNPLWPDLTLQEHFEIYGAVKGMSPGDMKEVISRITKALDLKEHLQKTVKKLPAGI 1437

  Fly  1495 RRKLSTAISVLGNPSVLYLDEPTSGMDPAARRQLWQIIGLIRTAGK----SIVLTSHSMDECEAL 1555
            :|||..|:|:||||.|..||||::||||.|::.:|:   .||||.|    :.:||:|.|:|.||:
Mouse  1438 KRKLCFALSMLGNPQVTLLDEPSTGMDPRAKQHMWR---AIRTAFKNKKRAALLTTHYMEEAEAV 1499

  Fly  1556 CSRLAIMVDGEFKCLGSVQSLKNQFSKGLILKVKVKHKKKTFQRVVEDSSSSNDKKSISETDLKF 1620
            |.|:||||.|:.:|:|:||.||::|.||..|::|:|
Mouse  1500 CDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLK----------------------------- 1535

  Fly  1621 LQMASVMESSQADRILKVNRFISKEIPDAELKEEYNGLITYYIPHS--KTLSKIFQLLETNSHKL 1683
                ..:|:.:.||:.:..::|   .|:|..:|.::.::.:.||..  ::||:.|..||......
Mouse  1536 ----DWIENLEIDRLQREIQYI---FPNASRQESFSSILAFKIPKEDVQSLSQSFAKLEEAKRTF 1593

  Fly  1684 NIEDYLIMQTRLEEIFLDFASKRDSSDIFTKRIYSCSW 1721
            .||:|...|..||::|::...:::..|.....:.|..|
Mouse  1594 AIEEYSFSQATLEQVFVELTKEQEEEDNSCGTLASTLW 1631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324	8/32 (25%)
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	431/1702 (25%)
Abca5	NP_671752.2	rim_protein	<84..1618	CDD:130324	440/1747 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820