DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and Abca9

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_671753.2	Gene:	Abca9 / 217262	MGIID:	2386796	Length:	1623	Species:	Mus musculus

Alignment Length:	1868	Identity:	458/1868 - (24%)
Similarity:	795/1868 - (42%)	Gaps:	436/1868 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 MW----KNWILQWNQKMQIVFALVLPVLFLCLILVLRIIVLPEKMDEIR-YPTVSISDLNLYMRM 85
            ||    |||:.::..:.:    .:|..|| .|:|:|.:..|...:.::. .|.:|:.||
Mouse    12 MWALLCKNWLRKFRMRRE----TLLEWLF-SLLLILFVYQLSSNLHQVHDAPEMSVVDL------ 65

  Fly    86 VPLGNRILHENGSLNIPRNF-LCYTPNNPINSAIVGATAIRLRLLGTRAYDTALHMEQDMVLHNF 149
                .|:.:.|.|     |: :.:.|.:.....|:...|..                      .|
Mouse    66 ----GRVDNFNDS-----NYMMVFAPESEATHEIMNKVASA----------------------PF 99

  Fly   150 LAG---VQFEDNENVNTNDAGYPLNLNYSLRFPSELRTMQGPIIDTWRTSRLFLSYDTSGSRNRL 211
            :.|   |...|.:::|      .|:||||:   ..:|.:   ..||: :..|..|:.....:.:.
Mouse   100 MKGRTIVACPDEKSMN------ELDLNYSI---DAVRVI---FKDTF-SYHLKFSWGQRIPKTKE 151

  Fly   212 DNDGGVPV------------GYIREGFLPIQHALTMSWLALASGVTDTGIPAIHLQRFPYRAYTY 264
            ..|...|.            .:..:||:..|.|:....:.:   :|:..:              .
Mouse   152 HKDHSAPCEPLNNKMICENSAFWEKGFVAFQAAINAGIIEM---ITNHSV--------------M 199

  Fly   265 DQLLS--GLRQLLP--------------FVILLSF---IYPASTVTKYVTSEKELQLKEIMKLIG 310
            ::|:|  |....:|              |..::||   ||..|.   .:|.|:: .:..:|.::|
Mouse   200 EELMSVIGSNMKMPPFIAQGGVATDFFIFFCVISFSSLIYYLSV---NITQERQ-YMTTLMAMMG 260

  Fly   311 VHNWLHWVAWFVKSYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCFM 375
            :.....|::|.: .|...:|||.::||||:..  |.|.||| ...|..||||. |.::.:.|.|:
Mouse   261 LRESAFWLSWSL-MYAGFILVVAVLMSLIVKS--AQVVVLT-GFMVVFLLFLF-YGLSLITLSFL 320

  Fly   376 LAVLFSK---ASTASAVAAIFWFLTYIPYSFGY-YYYERLSLMSKLLISLIFSNSALGFGIHVIV 436
            ::||..|   ...|..:..:||      .|.|: ..|:.|....:..:..: |..|...|:..::
Mouse   321 MSVLIKKPFLTGLAIFILTVFW------GSLGFTALYKHLPAFVEWTLCFL-SPFAFTTGMAQLI 378

  Fly   437 MWEGTGEGITWRNMFHPVSTDDSLTL---FYIIMTMSF----GSIMFISICLYVEQVFPGEYGVP 494
                        ::.:.|:::.:|..   .|:||...|    .:::::.:.||.:::...:||..
Mouse   379 ------------HLDYDVNSNVNLNSPNNSYLIMATLFMLVLDALLYLVLALYFDKITLSKYGHQ 431

  Fly   495 RRWNFMCHKNYW-----RQYV---------PSLN-----IVPSFQTILHGSAKAKSCRRAREVGI 540
            |...|....:||     ..:|         ||||     :.|.||              .:| .|
Mouse   432 RSPLFFLKSSYWFKRRGASHVVLENEIDSDPSLNDSLEPVSPEFQ--------------GKE-AI 481

  Fly   541 QLFNLQKNY----GKLKAVKGISLKMHRNEITVLLGHNGAGKTTTINMITGIVKPTSGTAIVNGY 601
            ::.||:|.|    ||::|::|:...::..:||.||||:||||||.||.::|:..||:|:..:...
Mouse   482 RIKNLKKEYSGKHGKVEALRGLGFDIYEGQITALLGHSGAGKTTLINTLSGLSPPTTGSVTIYNQ 546

  Fly   602 DIRTHLAKARES------LGICPQNNILFKEMSVRDHIIFFSKLKGIRGTKAVENEVGKYMTMLK 660
            .:    ::..:|      .|:|||:|:.|..::||:::..|:|:|||. ...||.||.:.:..|:
Mouse   547 TV----SEMDDSDAVLTITGVCPQSNVQFGFLTVRENLRLFAKIKGIL-PHEVEQEVQQVLQDLE 606

  Fly   661 LQDKSYVAAKNLSGGMKRKLSLCCALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQSEKDGRTILL 725
            :::...:.|:|||||.||||:|..|:.|:.:|:|.|||::|:|...|..:|:||:..:.||.|:.
Mouse   607 MENIQDILAQNLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPLSRHRIWNLLKERRAGRVIVF 671

  Fly   726 TTHYMDEADVLGDRIAILSEGKLQCQGTSFYLKKRFGTGYLLVCIMQSGCDVGAVTQLIRKYVPP 790
            :|.:|||||:|.||...:|.|:|:|.|:|.:|||::|.||.|...:...||...:|.|::|::..
Mouse   672 STQFMDEADILADRKVFISNGRLKCAGSSLFLKKKWGIGYHLSLHLNEACDPEGITSLVKKHISD 736

  Fly   791 IKPERVLGTELTYRLPTEYSKKFAELLQDLDEKCAQLQLVGYGLSGATLEDVF-------MAVNT 848
            .:........|.|.||.|.:.||.:|.:||| :|:...:..||:|..||.:||       ||..:
Mouse   737 ARLTTQSEERLVYILPLERTNKFPDLYRDLD-RCSNQGIEDYGVSMTTLNEVFLKLEGKSMADES 800

  Fly   849 DKRVQGGAEGPPVDGSIDFKELV-------FDSKTREKRRIRRCFMFWQALF----LKKFYTTTR 902
            |..:.|..:.   ||:.|.:.||       .||....   :....::.|.|.    ::.|.....
Mouse   801 DVGICGRLQS---DGARDMESLVELEQVLSLDSSGSS---VSGMALWRQQLCAVAKVRFFKLKNE 859

  Fly   903 NYWLLGIQLVLPIAVMALTILNSRGGRIYYELPAMPISINQY-SSAYVVLEDNTT-----DKTSS 961
            ...|:.:.|:..|:.:. .:|.....::|::..:..:|.:.| .|.....:|..|     ::|.|
Mouse   860 RKSLMTVLLLFGISFVP-QLLEHLVYKVYHKSYSWGLSPSMYFLSPGQPPQDPLTHLLVINRTGS 923

  Fly   962 LADAYSKHLEHYARRCTLLRTGDLKFEDYILSHDVNHSRRIDFHFLAGLTV----SENNFIVWLN 1022
            ..|.:...|........|...|.....:..|             :...:||    ....|.|..|
Mouse   924 SIDNFVHALRQQGIALDLDALGTRNGTEEAL-------------YNGAITVLGEEKALRFSVACN 975

  Fly  1023 NKPLHTAPLTLNLLHNAL-----AIKLLGQDASTYVTNEPLPYSDDTRTLRLNKGQVLGAEISIN 1082
            .|.|:..|:.::::.|.|     :.:.:..|.|| |..|.:.|         ..|.:..|...|.
Mouse   976 AKRLNCFPVLMDIISNGLLGIFNSSERIQTDRST-VFEEHMLY---------EYGFMSNAFFWIP 1030

  Fly  1083 LSLTMCFITAFYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVWD-----YLVFVLSALSSILT 1142
            ::.:   :|.:.|:..|.:.:.:.....:.||:...|||....:.|     .::|::..:.|:.:
Mouse  1031 VAAS---LTPYIAMGSISDHKKKVLSQLWTSGLYPSAYWCGQALVDIPIYFLILFLMQIMDSVFS 1092

  Fly  1143 IAAF------------KEIGYITPLDLSRY-----------------FYMLLIFGFPGIMLSYAA 1178
            ...|            ..|||.:.|....|                 |:.|::
Mouse  1093 SEEFISVMESLLIQIPCSIGYASSLIFMTYVISFIFRNGRKNSGIWSFFFLIV------------ 1145

  Fly  1179 SGCFSDAATGFTRISIINTLMGT---------GLFLMFMTLNFEAFQLKDVAE-KLAWYFRLSPH 1233
             ..|...||.......:..|:.|         |..|:|..:::::......:| :|.:...|.|:
Mouse  1146 -TIFFIIATDINEYGFLELLICTFLVPPFTLIGSLLIFSEVSYDSVDYLGTSESQLVFLALLIPY 1209

  Fly  1234 YSLASSTHSIHIGYNIRRGCSIGGIRKLPKQLRC----RNVPICCDIPGYYGWRKPGVLVEITYM 1294
                  .|.:...:.:|  |....:||  |.||.    |..|..|  |......:||...|...|
Mouse  1210 ------LHFLLFFFILR--CLERYLRK--KSLRVDPVFRISPRSC--PAVPNPEEPGEEDEDVQM 1262

  Fly  1295 IMLGSTLFLLIVMHDAK-----VCNLIAEKLG---NCFSKRKRVEGGTSIENDSVVAEQRVVREM 1351
            ..:.:|..:..:..|.|     .| |..|.:|   .||||.|:
Mouse  1263 ERVRTTGAMATLQTDEKPVIIASC-LRKEYIGRTKRCFSKMKK---------------------- 1304

  Fly  1352 INSGRKDVPLLVYKISKRYRSKLAVKAISFHVPHAECFGLLGINGAGKTSTFKMLAGDEKITSGE 1416
                                 |:|.:.|||.|...|..||||.|||||::|..|:.||...|:|:
Mouse  1305 ---------------------KIATRNISFCVKKGEVLGLLGHNGAGKSTTISMITGDTIPTAGQ 1348

  Fly  1417 AYIDGTNISTHKVYRKIGYCPQFDALFEDLTGRETLNIYCLLRGVQRRHVTPICWGLAISFGFAK 1481
            .::.|:.......:  :|||||.:.|:.:||.:|.|.:|..::|::::........|..:.....
Mouse  1349 VFLKGSGGGAALGF--LGYCPQENVLWPNLTVKEHLELYAAVKGLKKKDAVVTITRLVNALKLQD 1411

  Fly  1482 HMDKQTKHYSGGNRRKLSTAISVLGNPSVLYLDEPTSGMDPAARRQLWQII-GLIRTAGKSIVLT 1545
            |:....:..|.|.:|||...:|:||||.|:.||||::||||..::|:||.| .......:..:||
Mouse  1412 HLKALVRTLSEGVKRKLCFVLSILGNPPVVLLDEPSTGMDPEGQQQMWQAIRATFTNTERGALLT 1476

  Fly  1546 SHSMDECEALCSRLAIMVDGEFKCLGSVQSLKNQFSKGLILKVKVKHKKKTFQRVVEDSSSSNDK 1610
            :|.|.|.||:|.|:||||.|..:|:||:|.||::|.|..:|::|||
Mouse  1477 THYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKDYLLEMKVK------------------- 1522

  Fly  1611 KSISETDLKFLQMASVMESSQADRILKVNRFISKEIPDAELKEEYNGLITYYIP--HSKTLSKIF 1673
                             ..||.:   .:|..|.:..|.|..:|.|:.|:.|.:|  ..:.||:.|
Mouse  1523 -----------------TPSQVE---PLNTEIMRLFPQAARQERYSSLMVYKLPVEDVRPLSEAF 1567

  Fly  1674 QLLETNSHKLNIEDYLIMQTRLEEIFLDFASKRDSSDIFTKRIYSCSW 1721
            ..||......::|:|.:.|:.||::||:.:.:::..|...:...|..|
Mouse  1568 FKLERLKENFDLEEYSLSQSTLEQVFLELSKEQELDDFGEEANSSVKW 1615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324	8/31 (26%)
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	432/1725 (25%)
Abca9	NP_671753.2	rim_protein	<128..1600	CDD:130324	421/1684 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838506
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750