DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG6052 and Abca8a

DIOPT Version :9

Sequence 1:NP_649002.3 Gene:CG6052 / 39971 FlyBaseID:FBgn0036747 Length:1725 Species:Drosophila melanogaster
Sequence 2:XP_006533124.3 Gene:Abca8a / 217258 MGIID:2386846 Length:1653 Species:Mus musculus


Alignment Length:1858 Identity:462/1858 - (24%)
Similarity:792/1858 - (42%) Gaps:422/1858 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 LMWKNWILQWNQKMQIVFALVLPVLFLCLILVLRIIVLPEKMDEIRYPTVSISDLNLYMRMVPLG 89
            |:.||.:    :|.::.....|..|:..|||:..|:.|  ::.|: |...|:.|::|        
Mouse    49 LLCKNLL----RKKRLKRDTFLEFLYTALILLSLILFL--QLHEV-YDFSSLPDVDL-------- 98

  Fly    90 NRILHENGSLNIPRNFLCYTPNNPINSAIVGATAIRLRLLGTRAYDTALHMEQDMVLHNFLAGVQ 154
            .||    .|.|.....:.|||..|....|:...::...:.|.:.  .|...|::|   ..|..::
Mouse    99 GRI----DSFNDSTFMIVYTPITPTTQRIMDRVSLVSYMTGRKI--LASPNEENM---TELISMR 154

  Fly   155 FEDNENV-NTNDAGYPLNLNYSLRFPSELRTMQ---------GPII-----DTWRTSRLFLSYDT 204
            |.|...| .||...|.|......|.|: ::..|         |.||     :.|           
Mouse   155 FSDVVGVIFTNAYSYNLKFIKGARIPT-IKEHQDHTAHCHSYGEIIYCGLSEFW----------- 207

  Fly   205 SGSRNRLDNDGGVPVGYIREGFLPIQHA--------------------LTMSWLALASGVTDTGI 249
                              |:||:.:|.|                    ||..::.:.|.|...|.
Mouse   208 ------------------RDGFVALQAAINAAIIEVTTNHSVMEEMMSLTGKYIKIDSFVGQEGT 254

  Fly   250 PAIHLQRFPYRAYTYDQLLSGLRQLLPFVILLSFIYPASTVTKY----VTSEKELQLKEIMKLIG 310
                         |.|..|        |..::.|    |.:|.|    ||.|:: ::|.:|.::|
Mouse   255 -------------TTDCFL--------FFCIIRF----SPLTYYISAGVTRERK-KMKGLMAVMG 293

  Fly   311 VHNWLHWVAWFVKSYIMLMLVVFL---IMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCL 372
            :.:...|::|.:...:::.:|..|   |:.|:...|.....|: ||     |.|.  |.::.:.|
Mouse   294 LRDSAFWLSWGLLYGVIVFVVTLLSTTIVKLVQFVFLTGFMVI-FS-----LFFF--YGLSLISL 350

  Fly   373 CFMLAVLFSKASTASAVAAIFWFLTYIPYSFGY---YYYERLSLMSKLLISLIFSNSALGFGIHV 434
            .|:::||..|:.....|.   :.||....|.|:   |.|..:||  :.|:||:   |...|.:.:
Mouse   351 SFLMSVLLKKSFLTDLVV---FLLTVSCGSLGFTALYRYLPVSL--EWLLSLL---SPFAFMLGM 407

  Fly   435 IVM----WEGTGEGITWRNMFHPVSTDDSLTLFYIIMTMSFGSIMFISICLYVEQVFPGEYGVPR 495
            :.:    ::.........|....:.|         |..:.|..:.::.:..|.|:|.|.|||...
Mouse   408 VQLLRLDYDVNSNADPMGNPNEVIGT---------IFMLFFDGVFYLLLTFYFEKVLPSEYGRRH 463

  Fly   496 RWNFMCHKNYWRQYVPSLNIV-----------PSFQTI---LHGSAKAKSCRRAREVGIQLFNLQ 546
            ...|....::|....|:....           .||:.:   .||           :..|::.||.
Mouse   464 PPLFFLKSSFWSGQNPANRTALDNETDYEFSDDSFEPVSMEFHG-----------KEAIRIRNLT 517

  Fly   547 KNY----GKLKAVKGISLKMHRNEITVLLGHNGAGKTTTINMITGIVKPTSGTAIV--NGYDIRT 605
            |:|    .:.:|:|.::|.:::.:||.:|||:||||:|.:|:::|:..||.|...:  |.....|
Mouse   518 KDYIQKSKRTEALKDLTLDVYKGQITAILGHSGAGKSTLLNVLSGLCVPTKGWVTIHNNKLSEMT 582

  Fly   606 HLAKARESLGICPQNNILFKEMSVRDHIIFFSKLKGIRGTKAVENEVGKYMTMLKLQDKSYVAAK 670
            .|....:..|:|||.|:.|..::||:::..|:|:|||:..: |:|||.:.:..|.:::...:..:
Mouse   583 DLENISKLTGVCPQCNVQFDFLTVRENLRLFAKIKGIQAHE-VDNEVQRVLLELDMKNTQNILVQ 646

  Fly   671 NLSGGMKRKLSLCCALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQSEKDGRTILLTTHYMDEADV 735
            |||||.||||:...|:.|:.::.|.|||::|:|...|..:|:.|:..:..|.:|.:|.:|||||:
Mouse   647 NLSGGQKRKLTFGIAILGDPQIFLLDEPTAGLDPFSRHRVWNFLKERRADRVVLFSTQFMDEADI 711

  Fly   736 LGDRIAILSEGKLQCQGTSFYLKKRFGTGYLLVCIMQSGCDVGAVTQLIRKYVPPIKPERVLGTE 800
            |.||...:|:|||:|.|:|.:|||::|.||.|...:...|....:|.|:::::|..|.......:
Mouse   712 LADRKVFISKGKLKCAGSSLFLKKKWGIGYHLSLQLSETCVHERITSLVKQHIPDSKLSAESEGK 776

  Fly   801 LTYRLPTEYSKKFAELLQDLDEKCAQLQLVGYGLSGATLEDVFMAVN------------TDKRVQ 853
            |:|.||.|.:.||.:|.:|| |:...|.:..||:|..||.:||:.:.            |:....
Mouse   777 LSYILPLERTNKFPDLYRDL-ERSPDLGIENYGVSITTLTEVFLKLEGKSSIDQSDIGMTEDVQA 840

  Fly   854 GGAEGPPVDGSIDFKELVFDSKTREKRRIRRCFMFWQAL-------FLKKFYTTTRNYWLLGIQL 911
            |||..|.....::....:.:.:.:.|..:.   ::||.|       |||..:...        .:
Mouse   841 GGARSPERFAEVEQLVSLLNGRCKMKGGMA---LWWQQLCAVTRLRFLKLKHERK--------SI 894

  Fly   912 VLPIAVMALTILNSRGGRIY---------YEL------------PAMPISINQYSSAYVVLEDNT 955
            |:.|.|:.:.:|:.....||         :||            |..|:     ::..:|     
Mouse   895 VILILVLGIGLLHILSANIYRMVRQSDYCWELAPHMYFLTPGQQPQPPL-----TNLLIV----- 949

  Fly   956 TDKTSSLADAYSKHLEHYARRCTLLRTGDLKFEDYILSHDVNHSRR--IDFHFLAGLTVSEN--- 1015
             :||.:..|.:...||.               ::..|..|...:|.  .|..:...:.:|.:   
Mouse   950 -NKTGAKIDDFIHSLEQ---------------QNIALEVDAFGTRNGTEDSQYNGAIILSGDEKN 998

  Fly  1016 -NFIVWLNNKPLHTAPLTLNLLHNALAIKLLGQDASTYVTNEPLPYSDDTRTLRLNKGQVLGAEI 1079
             ||.:..|.|.|:..|:.::::.|.| :.|....|.........|..:|.|     |...| |..
Mouse   999 YNFTLACNTKRLNCFPVLVDIVSNGL-LGLFAPSAHIQTDRSTFPEENDHR-----KFDYL-AYF 1056

  Fly  1080 SINLSLTMCFITAFYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVWDYLVFVLSALSSILTIA 1144
            .:.:.|..| :..:.::..|.:.:.||:...::||:...|||....:::..|:....||  :.||
Mouse  1057 FLWVLLMAC-VPPYISMTSIDDYKNRAQFQLWISGLSPSAYWFGQALFEVPVYCALILS--IFIA 1118

  Fly  1145 AFKEIGYITPLDLSRYFYMLLIFGFPGIMLSYAASGCFSDAATGFTRISII--NTLMGTGLF-LM 1206
            .:......:...:...|..:|..|      .||.|..|....     ||.|  .....:||: |.
Mouse  1119 FYASAPPESKFTVGDLFIQILYVG------GYAMSVIFMTYV-----ISFIYRKGRKNSGLWSLC 1172

  Fly  1207 FMTLNF--EAFQLKDVAEKLAWYFRLSPHYSLASSTHSIHIGYNIRRGCSIGGIRKLPKQLRCRN 1269
            |..::|  ..|.|.|       |||....:.|.:......:|     ||::         |...|
Mouse  1173 FYIVSFFSMCFMLID-------YFRDISLFVLIALVPPATLG-----GCTL---------LHFEN 1216

  Fly  1270 VPICCDIPGYYGWRKPGVLV-----EITYMIMLGSTL-FLLIVMHDAKVCNLIAEKLG------- 1321
                         |:...::     |.:|:..|...| |.:.|:    :...:..|.|       
Mouse  1217 -------------REFSEIIFEPEREYSYLFFLAPLLHFAIFVV----ILRCMERKFGMKTMRTD 1264

  Fly  1322 ----------NCFSKRKRVEGGTSIENDSVVAEQRV--VREMINSGRKDVPLLV-------YKIS 1367
                      ..|:..:..:|     .|..|:::||  ...:.::..::.|.::       ||..
Mouse  1265 PVFRISPRSDRVFNNPEDPDG-----EDEDVSQERVWTANALTSADFQEKPAIIASCLRKEYKGK 1324

  Fly  1368 K-----RYRSKLAVKAISFHVPHAECFGLLGINGAGKTSTFKMLAGDEKITSGEAYIDGTNISTH 1427
            |     :.:.|:|.:.|||.|...|..||||.|||||:::.||:.|:.|.::|:..:.|:  ||.
Mouse  1325 KKCFVLKSKKKIATRNISFCVRKGEVVGLLGHNGAGKSTSIKMITGETKPSAGQVLLKGS--STG 1387

  Fly  1428 KVYRKIGYCPQFDALFEDLTGRETLNIYCLLRGVQRRHVTPICWGLAISFGFAKHMDKQTKHYSG 1492
            .....:|||||.:||:.:||.||.|.|:..::|:::.........||.:......:....|..|.
Mouse  1388 DTPGFLGYCPQENALWLNLTVREHLEIFAAIKGMRKSDANVAIERLADALKLQDQLKSPVKTLSE 1452

  Fly  1493 GNRRKLSTAISVLGNPSVLYLDEPTSGMDPAARRQLWQII-GLIRTAGKSIVLTSHSMDECEALC 1556
            |.:|||...:|:||||||:.||||::||||..::|:||.| .......:..:||:|.|.|.||:|
Mouse  1453 GVKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIQATFSNTERGALLTTHYMAEAEAVC 1517

  Fly  1557 SRLAIMVDGEFKCLGSVQSLKNQFSKGLILKVKVKHKKKTFQRVVEDSSSSNDKKSISETDLKFL 1621
            .|:||||.|..:|:||:|.||::|.|..:|::|||                              
Mouse  1518 DRVAIMVSGRLRCIGSIQHLKSKFGKEYLLEMKVK------------------------------ 1552

  Fly  1622 QMASVMESSQADRILKVNRFISKEIPDAELKEEYNGLITYYIPHS--KTLSKIFQLLETNSHKLN 1684
                  ..||.:   .:|..|.:..|.|..:|.|:.|:.|.:|..  :.||:.|..|||.....:
Mouse  1553 ------TPSQVE---PLNTEIMRLFPQAARQERYSSLMVYKLPREDVQPLSQAFFKLETVKQSFD 1608

  Fly  1685 IEDYLIMQTRLEEIFLDFASKRDSSDIFTKRI-YSCSW 1721
            :|:|.:.|:.||::||:. ||....|.|.:.: .|..|
Mouse  1609 LEEYSLSQSTLEQVFLEL-SKEQELDGFEEELDPSVKW 1645

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6052NP_649002.3 rim_protein 21..>54 CDD:130324 6/28 (21%)
rim_protein <149..1709 CDD:130324 429/1719 (25%)
Abca8aXP_006533124.3 rim_protein <258..1630 CDD:130324 402/1565 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838403
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D131191at2759
OrthoFinder 1 1.000 - - FOG0000051
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100045
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.750

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