Protein Alignment CG6052 and ABCA3

DIOPT Version :9

• Sequence 1: NP_649002.3
• Gene: CG6052 / 39971
• FlyBaseID: FBgn0036747
• Length: 1725
• Species: Drosophila melanogaster
• Sequence 2: NP_001080.2
• Gene: ABCA3 / 21
• HGNCID: 33
• Length: 1704
• Species: Homo sapiens
• Alignment Length: 1808
• Identity: 592/1808 - (32%)
• Similarity: 924/1808 - (51%)
• Gaps: 245/1808 - (13%)

  Fly    21 KLKLLMWKNWILQWNQKMQIVFALVLPVLFLCLILVLRIIVLPEKMDEIR-YPTVSISDLNLYMR 84
            :|.||:|||:.||..:.:..|..|.||:||..:::.||:.:..|.:.... ||..||.:|.|:..
Human     6 QLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIYPGQSIQELPLFFT 70

  Fly    85 MVPLGNRILHENGSLNIPRNFLCYTPNN-----PINSAIVGATAIRLRLLG-TRAYDTALHMEQD 143
            ..|.|:..            .|.|.|::     .:...:..|..|.:|:.| ....|...::..|
Human    71 FPPPGDTW------------ELAYIPSHSDAAKTVTETVRRALVINMRVRGFPSEKDFEDYIRYD 123

  Fly   144 MVLHNFLAGVQFEDNENVNTNDAGYPLNLNYSLRFPSELR----TMQGPII----DTWRTSRLFL 200
            ....:.||.|.||  ...|.:....||.:.|.|||....|    |..|...    :.|.|:.||.
Human   124 NCSSSVLAAVVFE--HPFNHSKEPLPLAVKYHLRFSYTRRNYMWTQTGSFFLKETEGWHTTSLFP 186

  Fly   201 SYDTSGSRNRLDNDGGVPVGYIREGFLPIQHALTMSWLALASGVTDTGIPAIH------------ 253
            .:...|.|.....|||.| ||||||||.:|||:            |..|...|
Human   187 LFPNPGPREPTSPDGGEP-GYIREGFLAVQHAV------------DRAIMEYHADAATRQLFQRL 238

  Fly   254 ---LQRFPYRAYTYDQLLSGLRQLLPFVILLSFIYPASTVTKYVTSEKELQLKEIMKLIGVHNWL 315
               ::||||..:..|..|..::..||.::||||.|.|.|:.:.|..|||.:|||.|:::|:.:||
Human   239 TVTIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWL 303

  Fly   316 HWVAWFVKSYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCFMLAVLF 380
            ||.|||:..::.|::....:..|..||...:||||:.|....||.||..:.::::...||::..|
Human   304 HWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFF 368

  Fly   381 SKASTASAVAAIFWFLTYIPYSFGYYYYERLSLMSKLLISLIFSNSALGFGIHVIVMWEGTGEGI 445
            |||:.|:|.....:|.|||||.|....|..::|..| |.|.:.||.|:..|..:|..:|..|.||
Human   369 SKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQK-LCSCLLSNVAMAMGAQLIGKFEAKGMGI 432

  Fly   446 TWRNMFHPVSTDDSLTLFYIIMTMSFGSIMFISICLYVEQVFPGEYGVPRRWNFMCHKNYWRQYV 510
            .||::..||:.||......::..:...|:::..:..|:|.||||::|||:.|.|....:||
Human   433 QWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYW---- 493

  Fly   511 PSLNIVPSFQTILHGSAKAKSCRRAREV----------------------------GIQLFNLQK 547
                                 |.:.|.|                            ||::.:|.|
Human   494 ---------------------CGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSK 537

  Fly   548 NY----GKLKAVKGISLKMHRNEITVLLGHNGAGKTTTINMITGIVKPTSGTAIVNGYDIRTHLA 608
            .:    ....||:.::|.::..:|||||||||||||||::|:||:..||||.|.::||:|...:.
Human   538 VFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMV 602

  Fly   609 KARESLGICPQNNILFKEMSVRDHIIFFSKLKGIRGTKAVENEVGKYMTMLKLQDKSYVAAKNLS 673
            :.|:|||:|||::|||..::|.:|:.|:::|||:...|..| ||.:.:.::.|:||....::.||
Human   603 QIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPE-EVKQMLHIIGLEDKWNSRSRFLS 666

  Fly   674 GGMKRKLSLCCALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQSEKDGRTILLTTHYMDEADVLGD 738
            |||:||||:..||...:||::.|||:||:||..||::|||||.:|..|||:||||:|||||:|||
Human   667 GGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGD 731

  Fly   739 RIAILSEGKLQCQGTSFYLKKRFGTGYLLVCIMQSGCDVGAVTQLIRKYVPPIKPERVLGTELTY 803
            ||||:::|:|||.|:|.:||:::|.||.:..:.:..|:...::||:..:||....|...|.||::
Human   732 RIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHHVPNATLESSAGAELSF 796

  Fly   804 RLPTEYSKKFAELLQDLDEKCAQLQLVGYGLSGATLEDVFMAVNT-------------------- 848
            .||.|.:.:|..|...|::|..:|.:..:|.|..|:|:||:.|..
Human   797 ILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGKLVDSSMDIQAIQLPALQYQH 861

  Fly   849 DKRVQGGAEGPPVDGSIDFKE----LVFDSKTREKRR---IRRCFMFWQALFLKKFYTTTRNYWL 906
            ::|....|....:.|::|..:    |:.:.:|..|..   ...|..|| |:||||...:.|.:.:
Human   862 ERRASDWAVDSNLCGAMDPSDGIGALIEEERTAVKLNTGLALHCQQFW-AMFLKKAAYSWREWKM 925

  Fly   907 LGIQLVLPIAVMALTILNSRGGRIYYELPAMPISINQYSSAYVVLEDNTTDKTSSLADAYSKHL- 970
            :..|:::|:..:.|.:|........::.|.:.:::.:|....|..   :...||.|....|:||
Human   926 VAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTLGEYGRTVVPF---SVPGTSQLGQQLSEHLK 987

  Fly   971 -----EHYARRCTLLRTGDLKFEDYILSHDVNHSRRIDFHFLAGLT---VSENNFI-VWLNNKPL 1026
                 |....|..|   |||  |::::..........:...|...:   |.|...: ...||:..
Human   988 DALQAEGQEPREVL---GDL--EEFLIFRASVEGGGFNERCLVAASFRDVGERTVVNALFNNQAY 1047

  Fly  1027 HTAPLTLNLLHNALAIKLLGQDASTYVTNEPLPYSDDTRTLRLNKGQV----LGAEISINLSLTM 1087
            |:....|.::.|.|...|.|..||..|:|.|.|.|    .|:..|.|.    .|.:|::||...|
Human  1048 HSPATALAVVDNLLFKLLCGPHASIVVSNFPQPRS----ALQAAKDQFNEGRKGFDIALNLLFAM 1108

  Fly  1088 CFITAFYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVWDYLVFVLSALSSILTIAAFKEIGYI 1152
            .|:.:.::|..:.||..:||.:||:|||.|.::|.|.::||.:.|::.:|..::...||....:.
Human  1109 AFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAFT 1173

  Fly  1153 TPLDLSRYFYMLLIFGFPGIMLSYAASGCFSDAATGFTRISIINTLMGTGLFLMFMTLNFEAFQL 1217
            ....::....:||::|:..|.|.|..:..|..|||.:||::|.|.|.|...|||...:...|.:|
Human  1174 RDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTRLTIFNILSGIATFLMVTIMRIPAVKL 1238

  Fly  1218 KDVAEKLAWYFRLSPHYSLASSTHSIHIGYNIRRGCSIGGI-----RKLPKQLRCRNVPICCDIP 1277
            :::::.|...|.:.|::.|..:..|.:..|..||.|:...:     :|...|.:          .
Human  1239 EELSKTLDHVFLVLPNHCLGMAVSSFYENYETRRYCTSSEVAAHYCKKYNIQYQ----------E 1293

  Fly  1278 GYYGWRKPGVLVEITYMIMLGSTLFLLIVMHDAKVCNLIAEKLG-NCFSKRKR--VEGGTS---I 1336
            .:|.|..|||...:..|...|....:|:.:.:.   ||:....| .|..:|:|  .|..|.   :
Human  1294 NFYAWSAPGVGRFVASMAASGCAYLILLFLIET---NLLQRLRGILCALRRRRTLTELYTRMPVL 1355

  Fly  1337 ENDSVVAEQRVVREMINSGRKD----VPLLVYKISKRYRSK---LAVKAISFHVPHAECFGLLGI 1394
            ..|..||::|.   .|.:...|    .||::.::||.|..:   |||..:|..|...|||||||.
Human  1356 PEDQDVADERT---RILAPSPDSLLHTPLIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGF 1417

  Fly  1395 NGAGKTSTFKMLAGDEKITSGEAYIDGTNISTH--KVYRKIGYCPQFDALFEDLTGRETLNIYCL 1457
            ||||||:|||||.|:|.:|||:|::.|..||:.  ||.::||||||||||.:.:||||.|.:|..
Human  1418 NGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYAR 1482

  Fly  1458 LRGVQRRHVTPICWGLAISFGFAKHMDKQTKHYSGGNRRKLSTAISVLGNPSVLYLDEPTSGMDP 1522
            |||:..||:...............|.:|..:.|||||:|||||.|:::|.|:|::||||::||||
Human  1483 LRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDP 1547

  Fly  1523 AARRQLWQIIGLIRTAGKSIVLTSHSMDECEALCSRLAIMVDGEFKCLGSVQSLKNQFSKGLILK 1587
            .|||.||..:...|.:||:|::|||||:||||||:||||||.|:||||||.|.||::|..|..|:
Human  1548 VARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLR 1612

  Fly  1588 VKVKHKKKTFQRVVEDSSSSNDKKSISETDLKFLQMASVMESSQADRILKVNRFISKEIPDAELK 1652
            .||:                                    ...|.:.:.:...|:....|.:.|:
Human  1613 AKVQ------------------------------------SEGQQEALEEFKAFVDLTFPGSVLE 1641

  Fly  1653 EEYNGLITYYIPHSKTLS--KIFQLLETNSHKLNIEDYLIMQTRLEEIFLDFA 1703
            :|:.|::.|::| .:.||  |:|.:||....|..::||.:.|..||::||.||
Human  1642 DEHQGMVHYHLP-GRDLSWAKVFGILEKAKEKYGVDDYSVSQISLEQVFLSFA 1693

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324	14/32 (44%)
		rim_protein	<149..1709	CDD:130324	558/1673 (33%)
ABCA3	NP_001080.2	ABC2_membrane_3	<271..469	CDD:289468	69/198 (35%)
		CcmA	530..839	CDD:224054	136/309 (44%)
		ABC_subfamily_A	530..751	CDD:213230	108/221 (49%)
		ABC2_membrane_3	923..1261	CDD:289468	91/349 (26%)
		ABC_subfamily_A	1381..1602	CDD:213230	117/220 (53%)
		drrA	1397..1692	CDD:130256	142/331 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148318
Domainoid	1	1.000	175	1.000	Domainoid score	I3651
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1130	1.000	Inparanoid score	I224
Isobase	1	0.950	-	0	Normalized mean entropy	S3774
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		otm40487
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.860