DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and ABCA2

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_997698.1	Gene:	ABCA2 / 20	HGNCID:	32	Length:	2466	Species:	Homo sapiens

Alignment Length:	1983	Identity:	575/1983 - (28%)
Similarity:	901/1983 - (45%)	Gaps:	465/1983 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LPEKMDEIR-YPTVSISDLNLYMRMVPLGNRILHENGSLNIPRNFLCYTPNNPINSAIVGATAIR 125
            |.:.:.|:| :|..    |||.:..:|...|  .:|.||  |.........:.|::|..|    .
Human   546 LQQYVAELRLHPEA----LNLSLDELPPALR--QDNFSL--PSGMALLQQLDTIDNAACG----W 598

  Fly   126 LRLLGTRAYDTALHMEQDMVLHNFLAGVQFEDNENV-------NTNDAGYPLNLNYSLRFPSELR 183
            ::.:...:.|.......:..:.|:.....::||..|       ...|...|.:::|.:|..|..
Human   599 IQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDNVTVFASVIFQTRKDGSLPPHVHYKIRQNSSF- 662

  Fly   184 TMQGPIIDTWRTSRLFLSYDTSGSRNRLDNDGGVPVGYIREGFLPIQHALTMSWLALASGVTDTG 248
                    |.:|:.:..:|...|     .|.||  ..|...||:.||..:..:       :.||.
Human   663 --------TEKTNEIRRAYWRPG-----PNTGG--RFYFLYGFVWIQDMMERA-------IIDTF 705

  Fly   249 I------PAIHLQRFPYRAYTYDQLLSGLRQLLPFVILLSFIYPASTVTKYVTSEKELQLKEIMK 307
            :      |..::|.|||..||.|..|..:..::|..:::|::|..:...:::.:|||.:|||:||
Human   706 VGHDVVEPGSYVQMFPYPCYTRDDFLFVIEHMMPLCMVISWVYSVAMTIQHIVAEKEHRLKEVMK 770

  Fly   308 LIGVHNWLHWVAWFVKSYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCL 372
            .:|::|.:||||||:..::.|.:.|..:.:::.   |..  ||..|..|.:.|||..|.|.::..
Human   771 TMGLNNAVHWVAWFITGFVQLSISVTALTAILK---YGQ--VLMHSHVVIIWLFLAVYAVATIMF 830

  Fly   373 CFMLAVLFSKASTASAVAAIFWFLTYIPYSF----GYYYYERLSLMSKLLISLIFSNSALGFGIH 433
            ||:::||:|||..|||...|.:||:|:||.:    ....:::::...|.:.||: |.:|.|.|..
Human   831 CFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAHDKITAFEKCIASLM-STTAFGLGSK 894

  Fly   434 VIVMWEGTGEGITWRNMFH-PVSTDDSLTLFYIIMTMSFGSIMFISICLYVEQVFPGEYGVPRRW 497
            ...::|..|.||.|..... ||..||...|..:.|.| ..::::..:..|:|.|.||.||:||.|
Human   895 YFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLM-VDAVVYGILTWYIEAVHPGMYGLPRPW 958

  Fly   498 NFMCHKNYWR--------------QYVPSLNIVPSFQTILHGSAKAKSCRRARE------VGIQL 542
            .|...|:||.              ...|.|:::...|.....|.:.:..|...|      :.:.:
Human   959 YFPLQKSYWLGSGRTEAWEWSWPWARTPRLSVMEEDQACAMESRRFEETRGMEEEPTHLPLVVCV 1023

  Fly   543 FNLQKNY--GKLKAVKGISLKMHRNEITVLLGHNGAGKTTTINMITGIVKPTSGTAIVNGYDIRT 605
            ..|.|.|  .|..|:..:||.::.|::...|||||||||||::::||:..||||:|.:.|:||||
Human  1024 DKLTKVYKDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTSGSATIYGHDIRT 1088

  Fly   606 HLAKARESLGICPQNNILFKEMSVRDHIIFFSKLKGIRGTKAVENEVGKYMTMLKLQDKSYVAAK 670
            .:.:.|::||:|||:|:||..::|.:|:.|:|:||.: ..:.:..|:.|.:..|:|.:|.:...:
Human  1089 EMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSM-AQEEIRREMDKMIEDLELSNKRHSLVQ 1152

  Fly   671 NLSGGMKRKLSLCCALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQSEKDGRTILLTTHYMDEADV 735
            .||||||||||:..|..|.::.::.|||::|:|...||::|||:...|.||||||:||:|||||:
Human  1153 TLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWDLILKYKPGRTILLSTHHMDEADL 1217

  Fly   736 LGDRIAILSEGKLQCQGTSFYLKKRFGTGYLLVCIMQ----------------------SGCDVG 778
            |||||||:|.|||:|.|:..:||..:|.||.|..:.:                      |.|...
Human  1218 LGDRIAIISHGKLKCCGSPLFLKGTYGDGYRLTLVKRPAEPGGPQEPGLASSPPGRAPLSSCSEL 1282

  Fly   779 AVTQLIRKYVPPIKPERVLGTELTYRLPTEYSKK--FAELLQDLDEKCAQLQLVGYGLSGATLED 841
            .|:|.|||:|..........|||:|.||:|.:||  |..|.|.|:.....|.|..:||...|||:
Human  1283 QVSQFIRKHVASCLLVSDTSTELSYILPSEAAKKGAFERLFQHLERSLDALHLSSFGLMDTTLEE 1347

  Fly   842 VFMAVNTD---------------KRVQGGAEGP-------------------------------- 859
            ||:.|:.:               |.|..|||||
Human  1348 VFLKVSEEDQSLENSEADVKESRKDVLPGAEGPASGEGHAGNLARCSELTQSQASLQSASSVGSA 1412

  Fly   860 ---------------------PVD-GSIDFKELVFDSKTREKRRIRRCFMFW------QALFLKK 896
                                 |.| .::..:|:..::.:|..:..|:....|      ..|.:|:
Human  1413 RGDEGAGYTDVYGDYRPLFDNPQDPDNVSLQEVEAEALSRVGQGSRKLDGGWLKVRQFHGLLVKR 1477

  Fly   897 FYTTTRNYWLLGIQLVLP--IAVMALTILNS--RGGRIYYELPAMPISINQYSS----------- 946
            |:...||...|..|::||  ...:|:|:..|  ..|    :||.:.:|.:||.:
Human  1478 FHCARRNSKALFSQILLPAFFVCVAMTVALSVPEIG----DLPPLVLSPSQYHNYTQPRGNFIPY 1538

  Fly   947 --------------------------------AYVVLED----------NTTDKTSSLADAY--- 966
                                            |..||:.          |.:...|.|..|.
Human  1539 ANEERREYRLRLSPDASPQQLVSTFRLPSGVGATCVLKSPANGSLGPTLNLSSGESRLLAARFFD 1603

  Fly   967 SKHLEHYAR-------------------------------------------------------- 975
            |..||.:.:
Human  1604 SMCLESFTQGLPLSNFVPPPPSPAPSDSPASPDEDLQAWNVSLPPTAGPEMWTSAPSLPRLVREP 1668

  Fly   976 -RCTL---------------------LRTGDLKFEDYILSHDVNH-----SRRIDFHFLAGLTVS 1013
             |||.                     :.|||:..:  |..|:|:.     |.|...|....:|.
Human  1669 VRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTD--ITGHNVSEYLLFTSDRFRLHRYGAITF- 1730

  Fly  1014 ENNFI-------------------------VWLNNKPLHTAPLTLNLLHNAL----AIKLLGQDA 1049
             .|.:                         |:.|||..|:.|..||.|:||:    ..|..|..|
Human  1731 -GNVLKSIPASFGTRAPPMVRKIAVRRAAQVFYNNKGYHSMPTYLNSLNNAILRANLPKSKGNPA 1794

  Fly  1050 S--TYVTNEPLPYSDDTRTL-RLNKGQVLGAEISINLSLTMCFITAFYAIPIIRERETRAKLLQF 1111
            :  ..|||.|:..:..:.:| .|.:|  ....|:|.:.:.|.|:.|.:.:.::.|:.|:||.|||
Human  1795 AYGITVTNHPMNKTSASLSLDYLLQG--TDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQF 1857

  Fly  1112 LSGVDVCAYWTSHIVWDYLVFVLSALSSILTIAAFKEIGYITPLDLSRYFYMLLIFGFPGIMLSY 1176
            :||.:...||.::.|||.|.:::.|...::.:..|....|.:|.:......:.|::|:....:.|
Human  1858 VSGCNPIIYWLANYVWDMLNYLVPATCCVIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMY 1922

  Fly  1177 AASGCFSDAATGFTRISIINTLMG-TGLFLMFMTLNFEAFQ-LKDVAEKLAWYFRLSPHYSLASS 1239
            .||..|...::.:..:.:||..:| |.....|:...||..: ||.|...|...|.:.|:|:|.
Human  1923 PASFWFEVPSSAYVFLIVINLFIGITATVATFLLQLFEHDKDLKVVNSYLKSCFLIFPNYNLG-- 1985

  Fly  1240 THSI-HIGYN---IRRGCSIGGIRKLPKQLRCRNVPICCDIPGYYGWRKPGVLVEITYMIMLGST 1300
             |.: .:.||   ......||...|:..       |...||          |...:..|.:.|..
Human  1986 -HGLMEMAYNEYINEYYAKIGQFDKMKS-------PFEWDI----------VTRGLVAMAVEGVV 2032

  Fly  1301 LFLLIVMHDAKVCNLIAEKLGNCFSKRKRVEGGTS-IENDSVVA--EQRVVREMINSGRKDVPLL 1362
            .|||.:|     |..      |...:.:|:...|. :|:|..||  .|||:|     |..|..::
Human  2033 GFLLTIM-----CQY------NFLRRPQRMPVSTKPVEDDVDVASERQRVLR-----GDADNDMV 2081

  Fly  1363 -VYKISKRYRSK-----LAVKAISFHVPHAECFGLLGINGAGKTSTFKMLAGDEKITSGEAYIDG 1421
             :..::|.|:|:     |||..:...|...|||||||:||||||||||||.|||..|.|||:::|
Human  2082 KIENLTKVYKSRKIGRILAVDRLCLGVRPGECFGLLGVNGAGKTSTFKMLTGDESTTGGEAFVNG 2146

  Fly  1422 TNISTH--KVYRKIGYCPQFDALFEDLTGRETLNIYCLLRGVQ-RRHVTPICWGLAISFGFAKHM 1483
            .::...  :|.:.:|||||.||||::||.||.|.:|..|||:. :.....:.|.|. .....|:.
Human  2147 HSVLKELLQVQQSLGYCPQCDALFDELTAREHLQLYTRLRGISWKDEARVVKWALE-KLELTKYA 2210

  Fly  1484 DKQTKHYSGGNRRKLSTAISVLGNPSVLYLDEPTSGMDPAARRQLWQ-IIGLIRTAGKSIVLTSH 1547
            ||....|||||:|||||||:::|.|:.::|||||:||||.|||.||. |:.||:| |:|:|||||
Human  2211 DKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPTTGMDPKARRFLWNLILDLIKT-GRSVVLTSH 2274

  Fly  1548 SMDECEALCSRLAIMVDGEFKCLGSVQSLKNQFSKGLILKVKVKHKKKTFQRVVEDSSSSNDKKS 1612
            ||:||||||:||||||:|..:||||:|.|||:|..|.::.|:.|
Human  2275 SMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFGDGYMITVRTK--------------------- 2318

  Fly  1613 ISETDLKFLQMASVMESSQADRILKVNRFISKEIPDAELKEEYNGLITYYIPHSK-TLSKIFQLL 1676
                            |||:  :..|.||.::..|:|.|||.::..:.|.:.... :|:::|..:
Human  2319 ----------------SSQS--VKDVVRFFNRNFPEAMLKERHHTKVQYQLKSEHISLAQVFSKM 2365

  Fly  1677 ETNSHKLNIEDYLIMQTRLEEIFLDFASKRDSS 1709
            |..|..|.||||.:.||.|:.:|::||.|:..:
Human  2366 EQVSGVLGIEDYSVSQTTLDNVFVNFAKKQSDN 2398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	557/1893 (29%)
ABCA2	NP_997698.1	rim_protein	58..2398	CDD:130324	575/1981 (29%)
		ABC_subfamily_A	1021..1240	CDD:213230	100/219 (46%)
		ABC_subfamily_A	2081..2304	CDD:213230	117/224 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148383
Domainoid	1	1.000	161	1.000	Domainoid score	I4008
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.760