DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and abt-5

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_001364572.1	Gene:	abt-5 / 173081	WormBaseID:	WBGene00000023	Length:	1582	Species:	Caenorhabditis elegans

Alignment Length:	1658	Identity:	436/1658 - (26%)
Similarity:	724/1658 - (43%)	Gaps:	416/1658 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 IPAIHLQRFPYRAYTY--DQLLSGLRQL-------------------------------LPFVIL 280
            :|||..:.:.:|:|.|  ::::.||.|.                               |.|.:.
Worm   142 LPAIGRRSYNFRSYNYYMNKIMFGLSQRANNTSSIIENFDIKLYSITNFEESGFGQNFGLLFAVC 206

  Fly   281 LSFIYPASTVTKYVTSEKELQLKEIMKLIGVHNWLHWVAWFVKSYIMLMLVVFLIMSLIMVKFYA 345
            :  :.|..:|.:.:..||. .:|..:..||:..|:.::..|:...|....::.|:.:|.:
Worm   207 M--LMPVISVARALVVEKS-SVKPYLTTIGLPLWMFYLEHFLFGVIKNTFLITLLSTLYI----- 263

  Fly   346 SVAVLTFS-----SWVPVLLFLHTYVVTSVCLCFMLAVL------FSKASTASAVAAIFWFLTYI 399
                  ||     ::|...:|::|      |.|...::|      |.|......|  |.|....|
Worm   264 ------FSMDNCPTYVLAGIFMYT------CHCVSFSILCTSILPFGKRIVEGMV--IIWITLII 314

  Fly   400 ------PYSFGYYYYERLSLMSKLLISLIFSNSALGFGIHVIVMWEGTGEGITWRNMFHPVSTDD 458
                  .:.|.:.::          :.|:..|.:|...:....:..|.....|.........|..
Worm   315 AMHLSLEFEFDWLFW----------VPLLNPNYSLKLFVDATFLASGPNGTPTSALFSSKKKTLQ 369

  Fly   459 SLTLFYIIMTMSFGSIMFISICLYVEQVFPGEYGVPRRWNFMCH---KNYWRQYVPSLNIVPSFQ 520
            |..::       ||.::..::.:.|..:|     :.:.:.|:.|   |.:||
Worm   370 SAAVY-------FGIMISCTVVMLVAAIF-----MEKLYTFVGHAIFKRFWR------------- 409

  Fly   521 TILHGSAKAK------------------SCRRARE------VGIQLFNLQKNY--GKLKAVKGIS 559
              :.|.:|.|                  .|:...|      ..|:|..|.|.|  |: |||.|:|
Worm   410 --ILGFSKGKRSKIEERGDGVEDRSTILQCKETVEGRGSAIADIELSGLVKVYQNGE-KAVNGLS 471

  Fly   560 LKMHRNEITVLLGHNGAGKTTTINMITGIVKPTSGTAIVNGYDIRTHLAKARESLGICPQNNILF 624
            |:..|.::::||||||.||:||..||||:.:.|.|..::.|.|...:.|:|||.:|.|||.|.::
Worm   472 LRAIRGQVSILLGHNGCGKSTTFGMITGMHQATEGKVMIGGIDANANRAEARELIGYCPQYNPIY 536

  Fly   625 KEMSVRDHIIFFSKLKGIRGTKAVENEVGKYMTMLKLQDKSYVAAKNLSGGMKRKLSLCCALCGN 689
            .|::|.:|:...:.|||..|....:.:....:..::|.||....||||||||||||.:|.|:.|.
Worm   537 DELTVWEHLRLVNALKGRSGGSDFKMDAESLLKQIELTDKRNTLAKNLSGGMKRKLCVCMAMIGG 601

  Fly   690 AKVVLCDEPSSGIDAAGRRSLWDLLQSEKDGRTILLTTHYMDEADVLGDRIAILSEGKLQCQGTS 754
            ::|:|.|||::|:|.:.|..:.::|...|..|||||||||||||:.|||.|.::|.||:...|:.
Worm   602 SRVILLDEPTAGMDPSARIDVQNMLALVKADRTILLTTHYMDEAEKLGDWIFVMSHGKMAASGSK 666

  Fly   755 FYLKKRFGTGYLLVCIMQS----------------GCDVGAVTQLIRKYVPPIKPER-------V 796
            .|||:::|.|.||..:.:|                .|.....|.|       :|.||       :
Worm   667 HYLKQKYGGGMLLTLVFKSVHDPMRPRKSYETAYDVCKTVCSTAL-------VKDERGQMIEISI 724

  Fly   797 LGTELTYRLPT-----------EYSK-KFAELLQDLDEKCAQLQLVGYGLSGATLEDVFMAV--N 847
            |.||.: ||||           :|:. :|..|..|:.|||..|:|...|:|.::||.||:.:  .
Worm   725 LETEKS-RLPTLLKILESVMEEDYNNPEFQALEPDIQEKCRTLELATIGVSMSSLEQVFIKIGDE 788

  Fly   848 TDKRVQGGAEGPPVDGSIDFKELVFDSKTREKRRIRRCFMFWQALFLKKFYTTTRNYWLLGIQLV 912
            .|..:.|.......:....|..||.....:.|:...:..|...||..|:.|...||...:.:|::
Worm   789 CDDIMNGTGVDKKTERQEKFSTLVQYKIQQPKQGFSKLMMVVWALLQKRAYYLYRNPVQITLQII 853

  Fly   913 LPIAVMALTILNSRGGRIYYELPAMPISI--------NQY--SSAYVVLEDNTTDKTSSLADAYS 967
            ||:..:.|..:.      :..|...|..:        :||  |:..:.||:...|:.::..:::|
Worm   854 LPLLTLWLFAVP------FLRLEPKPPKLSDIESFDPSQYPHSTVLLQLENENDDRLANYLNSFS 912

  Fly   968 K-------HLEHYA----RRCTLLRT----------GDLKFEDYILSH-DVNHSRRIDFHFLAGL 1010
            .       :.:||.    :...:.:|          ||.||  |.:|. |.|
Worm   913 NFEVVKVGYNDHYGYLVKKYSQVFKTLGFIVKVNKKGDSKF--YKISQGDKN------------- 962

  Fly  1011 TVSENNFIVWLNNKPLHTAPLTLNLLHNALAIKLLGQDASTYVTNEPLPYSDDTRTLRLNKGQV- 1074
                              |.:.:|::.:|:.::    |.|  ||.  ||:. .:|.:.:|..::
Worm   963 ------------------AAILMNIIASAMYLR----DPS--VTK--LPHV-TSRVIWMNDPKIK 1000

  Fly  1075 --------LGAEISINLSLTMCFITAFYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVWDYLV 1131
                    |...|...|.|...||.:  .:.:|.|:..:....|:|:|:...|||....:||:|:
Worm  1001 YEGLASFFLFENIFFLLVLAGIFIQS--TVYLIEEKICKFAHQQYLTGLSTIAYWGVVFLWDFLL 1063

  Fly  1132 FVLSALSSILTIAAFKEI-GYITPLDLSRYFYMLLIFGFPGIMLSYAASGCFSDAATGFTRISII 1195
            |....|.:|..:.:|..: |:|.  ::...||.||.:..|.:.|:.|                :|
Worm  1064 FTFFLLYTIGFLISFGVLQGHIH--EIVVIFYGLLFYFAPLVYLTSA----------------LI 1110

  Fly  1196 NT-LMGTGLFLMFMTLNFEAFQLKDVAEKLAWYFRLSPHYSLASSTHS----------IHIGYNI 1249
            || ..|..|..||..:.:.|                   ||:.|..|:          |..|:.|
Worm  1111 NTPTRGNFLLYMFCCIPWLA-------------------YSIVSELHNFPPIQKYSDEIEYGFRI 1156

  Fly  1250 RRGCSIG---GIRKL-----PKQLRCRNVPICCDIPGYYGWRKPGVLVEITYMIMLGSTLFLLIV 1306
            ... |||   |:.|:     ||....::.....::     |...|:..|:.::...|  :||.|:
Worm  1157 FNP-SIGFLAGLMKIAALNYPKSGLDKHFEHLTNL-----WTYEGIFFELMFLFFGG--IFLTIL 1213

  Fly  1307 MHDAKVCNLIAEKLGNCF---------SKRKRVEGGTSIENDSVVAEQRVVREMINSGRKDVPLL 1362
            :.    |..:......||         .:|||.:|..|.:  :|..|:::|:|:   .:.:..|:
Worm  1214 LG----CATLKPFRRACFRGTRRRSQPRERKRYKGIESCK--AVKEEEQLVQEV---DKNETVLV 1269

  Fly  1363 VYKISKRYRSKLAVKAISFHVPHAECFGLLGINGAGKTSTFKMLAGDEKITSGEAYIDGTNISTH 1427
            :..:.|.:....||..:|..|.|.||||:||.||||||:||.::.|....|.|.|.|||.:| |.
Worm  1270 IDGLVKDFGKFRAVNDLSISVGHEECFGMLGANGAGKTTTFDIITGLTMPTGGSATIDGHDI-TE 1333

  Fly  1428 KVYRKIGYCPQFDALFEDLTGRETLNIYCLLRGVQR-RHVTPI---CWGLAISFGFAKHMDKQTK 1488
            .::  |||||||||:.:.::.|:||.|...|:|... :.|..:   |.|:: .||:     |..|
Worm  1334 TIH--IGYCPQFDAMLQQISCRQTLRIMAKLQGYPNVKEVVELVLDCVGMS-DFGY-----KLVK 1390

  Fly  1489 HYSGGNRRKLSTAISVLGNPSVLYLDEPTSGMDPAARRQLWQIIGLIRTAGK-SIVLTSHSMDEC 1552
            :.|||.:||:|..|:::...:.:.|||||:|:||.|||::|.||..:|...| |||||||||:||
Worm  1391 NCSGGQKRKISVGIALMSRATCIILDEPTAGIDPRARREIWDIIHEMREQAKCSIVLTSHSMEEC 1455

  Fly  1553 EALCSRLAIMVDGEFKCLGSVQSLKNQFSKGLILKVKVKHKKKTFQRVVEDSSSSNDKKSISETD 1617
            ||||:|:.|:..||...||:.||||:|:....::.:.:              :|..|.:|:..
Worm  1456 EALCTRIGILRKGEMIALGTSQSLKSQYGNTYMMTLIL--------------NSLEDLESVCV-- 1504

  Fly  1618 LKFLQMASVMESSQADRILKVNRFISKEIPDAELKEEYNGL---ITYYIPHSKT--LSKIFQLLE 1677
                                   .:|:|:|||.||...:.|   |.:.:|.||:  .|:.:..:|
Worm  1505 -----------------------IVSEEMPDAVLKTPESSLTTSIVWELPKSKSDKWSEKYNQVE 1546

  Fly  1678 TNSHKLNIEDYLIMQTRLEEIFLDFASKRDSSD 1710
            ..:.|.|.:||::.|..||:.|:...:..:..:
Worm  1547 VLAKKANAKDYMLTQASLEDTFIRLITTEEEEE 1579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	436/1655 (26%)
abt-5	NP_001364572.1	rim_protein	<419..1569	CDD:130324	378/1310 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	1	1.100	-	-	O	PTHR19229
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.930