DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and Abca2

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	XP_006497672.1	Gene:	Abca2 / 11305	MGIID:	99606	Length:	2464	Species:	Mus musculus

Alignment Length:	2014	Identity:	579/2014 - (28%)
Similarity:	902/2014 - (44%)	Gaps:	494/2014 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LQWNQKMQIVFALVLPVLFLCLILVLRIIVLPEKMDEIRYPTVSISDLNLYMRM---VPLGNRIL 93
            |||.|  |.|..|.|.               ||.|:      :|:.:|...:|.   :|.|..:|
Mouse   543 LQWLQ--QYVADLQLH---------------PEAMN------LSLEELPPALRQDFSLPNGTALL 584

  Fly    94 HENGSLNIPRNFLCYTPNNPINSAIVGATAIRLRLLGTRAYDTALHMEQDMVLHNFLAGVQFEDN 158
            .:               .:.|::|..|    .::.:...:.|.......:..:.|:.....::||
Mouse   585 QQ---------------LDTIDNAACG----WIQFMSKVSVDIFKGFPDEESIVNYTLNQAYQDN 630

  Fly   159 ENV-------NTNDAGYPLNLNYSLRFPSELRTMQGPIIDTWRTSRLFLSYDTSGSRNRLDNDGG 216
            ..|       ...|...|.:::|.:|..|..         |.:|:.:..:|...|     .|.||
Mouse   631 VTVFASVIFQTRKDGSLPPHVHYKIRQNSSF---------TEKTNEIRRAYWRPG-----PNTGG 681

  Fly   217 VPVGYIREGFLPIQHALTMSWLALASGVTDTGIPAIHLQRFPYRAYTYDQLLSGLRQLLPFVILL 281
              ..|...||:.||..:..:.:....| .|...|..::|.|||..||.|..|..:..::|..:::
Mouse   682 --RFYFLYGFVWIQDMMERAIINTFVG-HDVVEPGNYVQMFPYPCYTRDDFLFVIEHMMPLCMVI 743

  Fly   282 SFIYPASTVTKYVTSEKELQLKEIMKLIGVHNWLHWVAWFVKSYIMLMLVVFLIMSLIMVKFYAS 346
            |::|..:...:::.:|||.:|||:||.:|::|.:||||||:..::.|.:.|..:.:::.   |..
Mouse   744 SWVYSVAMTIQHIVAEKEHRLKEVMKTMGLNNAVHWVAWFITGFVQLSISVTALTAILK---YGQ 805

  Fly   347 VAVLTFSSWVPVLLFLHTYVVTSVCLCFMLAVLFSKASTASAVAAIFWFLTYIPYSF----GYYY 407
              ||..|..:.:.|||..|.|.::..||:::||:|||..|||...|.:||:|:||.:    ....
Mouse   806 --VLMHSHVLIIWLFLAVYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVA 868

  Fly   408 YERLSLMSKLLISLIFSNSALGFGIHVIVMWEGTGEGITWRNMFH-PVSTDDSLTLFYIIMTMSF 471
            :::::...|.:.||: |.:|.|.|.....::|..|.||.|..... ||..||...|..:.|.| .
Mouse   869 HDKITAFEKCIASLM-STTAFGLGSKYFALYEVAGVGIQWHTFSQSPVEGDDFNLLLAVTMLM-V 931

  Fly   472 GSIMFISICLYVEQVFPGEYGVPRRWNFMCHKNYWR--------------QYVPSLNIVPSFQTI 522
            .::::..:..|:|.|.||.||:||.|.|...|:||.              .:.|.|:::...|..
Mouse   932 DTVVYGVLTWYIEAVHPGMYGLPRPWYFPLQKSYWLGSGRTEAWEWSWPWAHTPRLSVMEEDQAC 996

  Fly   523 LHGSAKAKSCRRAREVGI---------QLFNLQKNYGKLKAVKGISLKMHRNEITVLLGHNGAGK 578
            ...|...:..|...|...         :|..:.||..|: |:..:||.::.|::...||||||||
Mouse   997 AMESRHFEETRGMEEEPTHLPLVVCVDKLTKVYKNDKKM-ALNKLSLNLYENQVVSFLGHNGAGK 1060

  Fly   579 TTTINMITGIVKPTSGTAIVNGYDIRTHLAKARESLGICPQNNILFKEMSVRDHIIFFSKLKGIR 643
            |||::::||:..||||:|.:.|:||||.:.:.|::||:|||:|:||..::|.:|:.|:|:||.:
Mouse  1061 TTTMSILTGLFPPTSGSATIYGHDIRTEMDEIRKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSM- 1124

  Fly   644 GTKAVENEVGKYMTMLKLQDKSYVAAKNLSGGMKRKLSLCCALCGNAKVVLCDEPSSGIDAAGRR 708
            ..:.:..|..|.:..|:|.:|.:...:.||||||||||:..|..|.::.::.|||::|:|...||
Mouse  1125 AQEEIRKETDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARR 1189

  Fly   709 SLWDLLQSEKDGRTILLTTHYMDEADVLGDRIAILSEGKLQCQGTSFYLKKRFGTGYLLVCIMQ- 772
            ::|||:...|.||||||:||:|||||:|||||||:|.|||:|.|:..:||..:|.||.|..:.|
Mouse  1190 AIWDLILKYKPGRTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGAYGDGYRLTLVKQP 1254

  Fly   773 ---------------------SGCDVGAVTQLIRKYVPPIKPERVLGTELTYRLPTEYSKK--FA 814
                                 |.|....|:|.|||:|..........|||:|.||:|..||  |.
Mouse  1255 AEPGTSQEPGLASSPSGCPRLSSCSEPQVSQFIRKHVASSLLVSDTSTELSYILPSEAVKKGAFE 1319

  Fly   815 ELLQDLDEKCAQLQLVGYGLSGATLEDVFMAVNTD---------------KRVQGGAEGPPV--- 861
            .|.|.|:.....|.|..:||...|||:||:.|:.:               |.|..||||...
Mouse  1320 RLFQQLEHSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEADVKESRKDVLPGAEGLTAVGG 1384

  Fly   862 ------------------------------------DGSIDFKELVFDS---------KTREKRR 881
                                                ||..|::.| ||:         :..|...
Mouse  1385 QAGNLARCSELAQSQASLQSASSVGSARGEEGTGYSDGYGDYRPL-FDNLQDPDNVSLQEAEMEA 1448

  Fly   882 I-------RRCFMFW------QALFLKKFYTTTRNYWLLGIQLVLP--IAVMALTILNS--RGGR 929
            :       |:...:|      ..|.:|:|:...||...|..|::||  ...:|:|:..|  ..|
Mouse  1449 LAQVGQGSRKLEGWWLKMRQFHGLLVKRFHCARRNSKALCSQILLPAFFVCVAMTVALSVPEIG- 1512

  Fly   930 IYYELPAMPISINQYSS-------------------------------------------AYVVL 951
               :||.:.:|.:||.:                                           |..||
Mouse  1513 ---DLPPLVLSPSQYHNYTQPRGNFIPYANEERQEYRLRLSPDASPQQLVSTFRLPSGVGATCVL 1574

  Fly   952 ED----------NTTDKTSSL----------ADAYSK---------------------------- 968
            :.          |.:...|.|          .:::::
Mouse  1575 KSPANGSLGPMLNLSSGESRLLAARFFDSMCLESFTQGLPLSNFVPPPPSPAPSDSPVSPDEDSL 1639

  Fly   969 -----------------------HLEHYARRCTL---------------------LRTGDLKFED 989
                                   .|.|...|||.                     :.|||:..:
Mouse  1640 QAWNMSLPPTAGPETWTSAPSLPRLVHEPVRCTCSAQGTGFSCPSSVGGHPPQMRVVTGDILTD- 1703

  Fly   990 YILSHDVNH-----SRRIDFHFLAGLT---------------------------VSENNFIVWLN 1022
             |..|:|:.     |.|...|....:|                           |::    |..|
Mouse  1704 -ITGHNVSEYLLFTSDRFRLHRYGAITFGNVQKSIPASFGARVPPMVRKIAVRRVAQ----VLYN 1763

  Fly  1023 NKPLHTAPLTLNLLHNAL----AIKLLGQDAS--TYVTNEPLPYSDDTRTL-RLNKGQVLGAEIS 1080
            ||..|:.|..||.|:||:    ..|..|..|:  ..|||.|:..:..:.:| .|.:|  ....|:
Mouse  1764 NKGYHSMPTYLNSLNNAILRANLPKSKGNPAAYGITVTNHPMNKTSASLSLDYLLQG--TDVVIA 1826

  Fly  1081 INLSLTMCFITAFYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVWDYLVFVLSALSSILTIAA 1145
            |.:.:.|.|:.|.:.:.::.|:.|:||.|||:||.:...||.::.|||.|.:::.|...::.:..
Mouse  1827 IFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPVIYWLANYVWDMLNYLVPATCCVIILFV 1891

  Fly  1146 FKEIGYITPLDLSRYFYMLLIFGFPGIMLSYAASGCFSDAATGFTRISIINTLMG-TGLFLMFMT 1209
            |....|.:|.:......:.|::|:....:.|.||..|...::.:..:.:||..:| |.....|:.
Mouse  1892 FDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSSAYVFLIVINLFIGITATVATFLL 1956

  Fly  1210 LNFEAFQ-LKDVAEKLAWYFRLSPHYSLASSTHSI-HIGYN---IRRGCSIGGIRKLPKQLRCRN 1269
            ..||..: ||.|...|...|.:.|:|:|.   |.: .:.||   ......||...|:..
Mouse  1957 QLFEHDKDLKVVNSYLKSCFLIFPNYNLG---HGLMEMAYNEYINEYYAKIGQFDKMKS------ 2012

  Fly  1270 VPICCDIPGYYGWRKPGVLVEITYMIMLGSTLFLLIVMHDAKVCNLIAEKLGNCFSKRKRVEGGT 1334
             |...||          |...:..|.:.|...|.|.:|     |..      |...:.:|:...|
Mouse  2013 -PFEWDI----------VTRGLVAMTVEGFVGFFLTIM-----CQY------NFLRQPQRLPVST 2055

  Fly  1335 S-IENDSVVA--EQRVVREMINSGRKDVPLL-VYKISKRYRSK-----LAVKAISFHVPHAECFG 1390
            . :|:|..||  .|||:|     |..|..:: :..::|.|:|:     |||..:...|...||||
Mouse  2056 KPVEDDVDVASERQRVLR-----GDADNDMVKIENLTKVYKSRKIGRILAVDRLCLGVRPGECFG 2115

  Fly  1391 LLGINGAGKTSTFKMLAGDEKITSGEAYIDGTNI--STHKVYRKIGYCPQFDALFEDLTGRETLN 1453
            |||:||||||||||||.|||..|.|||:::|.::  ...:|.:.:||||||||||::||.||.|.
Mouse  2116 LLGVNGAGKTSTFKMLTGDESTTGGEAFVNGHSVLKDLLQVQQSLGYCPQFDALFDELTAREHLQ 2180

  Fly  1454 IYCLLRGVQ-RRHVTPICWGLAISFGFAKHMDKQTKHYSGGNRRKLSTAISVLGNPSVLYLDEPT 1517
            :|..|||:. :.....:.|.|. .....|:.||....|||||:|||||||:::|.|:.::|||||
Mouse  2181 LYTRLRGIPWKDEAQVVKWALE-KLELTKYADKPAGTYSGGNKRKLSTAIALIGYPAFIFLDEPT 2244

  Fly  1518 SGMDPAARRQLWQ-IIGLIRTAGKSIVLTSHSMDECEALCSRLAIMVDGEFKCLGSVQSLKNQFS 1581
            :||||.|||.||. |:.||:| |:|:|||||||:||||||:||||||:|..:||||:|.|||:|.
Mouse  2245 TGMDPKARRFLWNLILDLIKT-GRSVVLTSHSMEECEALCTRLAIMVNGRLRCLGSIQHLKNRFG 2308

  Fly  1582 KGLILKVKVKHKKKTFQRVVEDSSSSNDKKSISETDLKFLQMASVMESSQADRILKVNRFISKEI 1646
            .|.::.|:.|             ||.|.|                          .|.||.::..
Mouse  2309 DGYMITVRTK-------------SSQNVK--------------------------DVVRFFNRNF 2334

  Fly  1647 PDAELKEEYNGLITYYIPHSK-TLSKIFQLLETNSHKLNIEDYLIMQTRLEEIFLDFASKRDSS 1709
            |:|.|||.::..:.|.:.... :|:::|..:|.....|.||||.:.||.|:.:|::||.|:..:
Mouse  2335 PEAMLKERHHTKVQYQLKSEHISLAQVFSKMEQVVGVLGIEDYSVSQTTLDNVFVNFAKKQSDN 2398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324	8/21 (38%)
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	557/1892 (29%)
Abca2	XP_006497672.1	rim_protein	58..2398	CDD:130324	579/2012 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838500
Domainoid	1	1.000	164	1.000	Domainoid score	I3920
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.760