Protein Alignment CG6052 and Abca1

DIOPT Version :9

• Sequence 1: NP_649002.3
• Gene: CG6052 / 39971
• FlyBaseID: FBgn0036747
• Length: 1725
• Species: Drosophila melanogaster
• Sequence 2: XP_006537617.1
• Gene: Abca1 / 11303
• MGIID: 99607
• Length: 2263
• Species: Mus musculus
• Alignment Length: 1994
• Identity: 557/1994 - (27%)
• Similarity: 912/1994 - (45%)
• Gaps: 479/1994 - (24%)

  Fly    17 GDWDKLKLLMWKNWILQWNQKMQIVFALVLPVLFLCLILVLRIIV--------LPEKMDEIRYPT 73
            |.|::|...:|.  .::.:|:|.:|                |.::        ..:|:|.:.:
Mouse   414 GMWEELSPQIWT--FMENSQEMDLV----------------RTLLDSRGNDQFWEQKLDGLDW-- 458

  Fly    74 VSISDLNLYMRMVPLGNRILHENGSL---------------NIPRNFLCYTPN--NPINSAIVGA 121
             :..|:..::...|  ..:...|||:               .|.|...|...|  .||      .
Mouse   459 -TAQDIMAFLAKNP--EDVQSPNGSVYTWREAFNETNQAIQTISRFMECVNLNKLEPI------P 514

  Fly   122 TAIRLRLLGTRAYDTALHMEQDMVL---HNFLAGVQFEDNENVNTNDAGYPLNLNYSLRFPSELR 183
            |.:||             :.:.|.|   ..|.||:.|   ..:..:....|.::.|.:|.
Mouse   515 TEVRL-------------INKSMELLDERKFWAGIVF---TGITPDSVELPHHVKYKIRM----- 558

  Fly   184 TMQGPIIDTWRTSRLFLSYDTSGSRNRLDNDGGVPVGYIREGFLPIQHALTMSWLALASG-VTDT 247
                .|.:..||:::...|...|.|    .|....:.|:..||..:|..:..:.:.:.:| ...|
Mouse   559 ----DIDNVERTNKIKDGYWDPGPR----ADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGSEKKT 615

  Fly   248 GIPAIHLQRFPYRAYTYDQLLSGLRQLLPFVILLSFIYPASTVTKYVTSEKELQLKEIMKLIGVH 312
            |   :::|:.||..|..|..|..:.:.:|..:.|::||..:.:.|.:..|||.:|||.|:::|:.
Mouse   616 G---VYVQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKSIVYEKEARLKETMRIMGLD 677

  Fly   313 NWLHWVAWFVKSYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCFMLA 377
            |.:.|.:|||.|.|.|::...|::.::.:.     .:|.:|....|.:||..:.:.::..||:::
Mouse   678 NGILWFSWFVSSLIPLLVSAGLLVVILKLG-----NLLPYSDPSVVFVFLSVFAMVTILQCFLIS 737

  Fly   378 VLFSKASTASAVAAIFWFLTYIPYSFGYYYYERLSLMSKLLISLIFSNSALGFGIHVIVMWEGTG 442
            .|||:|:.|:|...|.:|..|:||.....:.:.:....|:..||: |..|.|||.....::|..|
Mouse   738 TLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFSIKIFASLL-SPVAFGFGCEYFALFEEQG 801

  Fly   443 EGITWRNMFHPVSTDDSLTLFYIIMTMSFGSIMFISICLYVEQVFPGEYGVPRRWNFMCHKNYWR 507
            .|:.|.|:|.....:|...|...:..|.|.:.::..:..|:|.||||:||:||.|.|.|.|:||
Mouse   802 IGVQWDNLFESPVEEDGFNLTTAVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYW- 865

  Fly   508 QYVPSLNIVPSF-QTILHGSAKAKSCRRAREV-----------GIQLFNLQKNY--GKLKAVKGI 558
                       | :.|...|....|.:...|:           |:.:.||.|.|  |...||.|:
Mouse   866 -----------FGEEIDEKSHPGSSQKGVSEICMEEEPTHLRLGVSIQNLVKVYRDGMKVAVDGL 919

  Fly   559 SLKMHRNEITVLLGHNGAGKTTTINMITGIVKPTSGTAIVNGYDIRTHLAKARESLGICPQNNIL 623
            :|..:..:||..|||||||||||::::||:..||||||.:.|.|||:.::..|::||:|||:|:|
Mouse   920 ALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSSIRQNLGVCPQHNVL 984

  Fly   624 FKEMSVRDHIIFFSKLKGIRGTKAVENEVGKY-----MTMLKLQDKSYVAAKNLSGGMKRKLSLC 683
            |..::|.:||.|:::|||: ..|.|:.|:.:.     :...||:.|:    ..|||||:||||:.
Mouse   985 FDMLTVEEHIWFYARLKGL-SEKHVKAEMEQMALDVGLPPSKLKSKT----SQLSGGMQRKLSVA 1044

  Fly   684 CALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQSEKDGRTILLTTHYMDEADVLGDRIAILSEGKL 748
            .|..|.:|||:.|||::|:|...||.:|:||...:.||||:|:||:|||||:|||||||:|.|||
Mouse  1045 LAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKL 1109

  Fly   749 QCQGTSFYLKKRFGTGYLLVCIMQ------SGC-------------------------------- 775
            .|.|:|.:||.:.||||.|..:.:      |.|
Mouse  1110 CCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSCLKKVVPGLPAAGQSGGRGGEVQR 1174

  Fly   776 ------DVGAVTQLIRKYVPPIKPERVLGTELTYRLPTEYSKK--FAELLQDLDEKCAQLQLVGY 832
                  ||.|::.||||:|...:....:|.||||.||.|.:|:  |.||..::|::.:.|.:..|
Mouse  1175 LVALTQDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSY 1239

  Fly   833 GLSGATLEDVFMAVNTDKRVQGGAEGPPVDG-------------------------SIDFKELVF 872
            |:|..|||::|:.|    ..:.|.:....||                         ::|..:...
Mouse  1240 GISETTLEEIFLKV----AEESGVDAETSDGTLPARRNRRAFGDKQSCLHPFTEDDAVDPNDSDI 1300

  Fly   873 DSKTREK-----------------RRIRRCF--MFWQALFL-----KKFYTTTRNYWLLGIQLVL 913
            |.::||.                 :..::.|  :.|:.|.:     |.|:.          |:||
Mouse  1301 DPESRETDLLSGMDGKGSYQLKGWKLTQQQFVALLWKRLLIARRSRKGFFA----------QIVL 1355

  Fly   914 PIAVMALTILNSRGGRIYYELPAMPISINQYSSAYVVLEDNTTDK--TSSLADAYSKHLEHYARR 976
            |...:.:.::.|.....:.:.|::.:....|:..|..:.::..:.  |..|.:|.:|. ..:..|
Mouse  1356 PAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDMGTQELLNALTKD-PGFGTR 1419

  Fly   977 C------------------------------------TL-------------------------- 979
            |                                    |:
Mouse  1420 CMEGNPIPDTPCLAGEEDWTISPVPQSIVDLFQNGNWTMKNPSPACQCSSDKIKKMLPVCPPGAG 1484

  Fly   980 --------LRTGDL-------KFEDYIL------------------------------------- 992
                    .:|.|:       ...||::
Mouse  1485 GLPPPQRKQKTADILQNLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNSQALPP 1549

  Fly   993 SHDVNHS-----------------RRIDF--HFLAGLTVSENNFIVWLNNKPLHTAPLTLNLLHN 1038
            ||:||.:                 |.:..  .|:|||. ::||..||.|||..|.....||:::|
Mouse  1550 SHEVNDAIKQMKKLLKLTKDSSADRFLSSLGRFMAGLD-TKNNVKVWFNNKGWHAISSFLNVINN 1613

  Fly  1039 ALAIKLL--GQDASTY-VT--NEPLPYSDDTRTLRLNKGQV---------LGAEISINLSLTMCF 1089
            |:....|  |::.|.| :|  |.|         |.|.|.|:         :...:||.:...|.|
Mouse  1614 AILRANLQKGENPSQYGITAFNHP---------LNLTKQQLSEVALMTTSVDVLVSICVIFAMSF 1669

  Fly  1090 ITAFYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVWDYLVFVLSALSSILTIAAFKEIGYITP 1154
            :.|.:.:.:|:||.::||.|||:|||....||.|:.|||...:|:.|...|:....|::..|::.
Mouse  1670 VPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSS 1734

  Fly  1155 LDLSRYFYMLLIFGFPGIMLSYAASGCFSDAATGFTRISIINTLMG-TGLFLMFMTLNFEAFQLK 1218
            .:|.....:||::|:....|.|.||..|...:|.:..::.:|..:| .|....|:...|...:|.
Mouse  1735 TNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKLN 1799

  Fly  1219 DVAEKLAWYFRLSPHYSLASSTHSIHIGYNIRRGCSIGGIRKLPKQLRCRNV-PICCDIPGYYGW 1282
            |:.:.|...|.:.||:.|......:     ::.......:.:..:.   |.| |:..|:.|.
Mouse  1800 DINDILKSVFLIFPHFCLGRGLIDM-----VKNQAMADALERFGEN---RFVSPLSWDLVGR--- 1853

  Fly  1283 RKPGVLVEITYMIMLGSTLFLLIVMHDAKVCNLIAEKLGNCFSKRKRVEGGTSIENDSVVAEQRV 1347
                   .:..|.:.|...||:.|:...:.           |.:.:.|:......||.....:|.
Mouse  1854 -------NLFAMAVEGVVFFLITVLIQYRF-----------FIRPRPVKAKLPPLNDEDEDVRRE 1900

  Fly  1348 VREMINSGRKDVPLLVYKISKRYRSKL--AVKAISFHVPHAECFGLLGINGAGKTSTFKMLAGDE 1410
            .:.:::.|.::..|.:.:::|.||.|.  ||..|...:|..|||||||:|||||::|||||.||.
Mouse  1901 RQRILDGGGQNDILEIKELTKIYRRKRKPAVDRICIGIPPGECFGLLGVNGAGKSTTFKMLTGDT 1965

  Fly  1411 KITSGEAYIDGTNI--STHKVYRKIGYCPQFDALFEDLTGRETLNIYCLLRGVQRRHVTPIC-WG 1472
            .:|.|:|:::..:|  :.|:|::.:||||||||:.|.|||||.:..:.|||||..:.|..:. |.
Mouse  1966 PVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWA 2030

  Fly  1473 LAISFGFAKHMDKQTKHYSGGNRRKLSTAISVLGNPSVLYLDEPTSGMDPAARRQLWQIIGLIRT 1537
            :. ..|..|:.:|...:|||||:||||||::::|.|.|::|||||:||||.|||.||.....|..
Mouse  2031 IR-KLGLVKYGEKYASNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIVK 2094

  Fly  1538 AGKSIVLTSHSMDECEALCSRLAIMVDGEFKCLGSVQSLKNQFSKGLILKVKVKHKKKTFQRVVE 1602
            .|:|:|||||||:||||||:|:||||:|.|:||||||.|||:|..|..:.|::
Mouse  2095 EGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRI------------ 2147

  Fly  1603 DSSSSNDKKSISETDLKFLQMASVMESSQADRILKVNRFISKEIPDAELKEEYNGLITYYIPHS- 1666
             :.|:.|.|.:.|                         |.....|.:.|||::..::.|.:|.|
Mouse  2148 -AGSNPDLKPVQE-------------------------FFGLAFPGSVLKEKHRNMLQYQLPSSL 2186

  Fly  1667 KTLSKIFQLLETNSHKLNIEDYLIMQTRLEEIFLDFASKRDSSD 1710
            .:|::||.:|..:..:|:||||.:.||.|:::|::||  :|.||
Mouse  2187 SSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFA--KDQSD 2228

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324	5/32 (16%)
		rim_protein	<149..1709	CDD:130324	529/1831 (29%)
Abca1	XP_006537617.1	rim_protein	6..2238	CDD:130324	557/1994 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	159	1.000	Domainoid score	I4067
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53524
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.830