DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and ABCA10

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_001364250.1	Gene:	ABCA10 / 10349	HGNCID:	30	Length:	1543	Species:	Homo sapiens

Alignment Length:	1732	Identity:	435/1732 - (25%)
Similarity:	758/1732 - (43%)	Gaps:	349/1732 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 LLGTRAYDTALHMEQDMVLHNFLAGVQFEDNENVNTNDAGYPLNLNYSLRFP-----SELR---- 183
            ::||...:| :.:|.....|. :.||.|.|.       ..|.|..|:..|.|     ||..
Human    15 VIGTPDEET-MDIELPKKYHE-MVGVIFSDT-------FSYRLKFNWGYRIPVIKEHSEYTEHCW 70

  Fly   184 TMQGPIIDTWRTSRLFLSYDTSGSRNRLDNDGGVPVGYIREGFLPIQHALTMSWLALAS--GVTD 246
            .|.|.|.       .:|:                  .|..:||:..|.|:..:.:.:.:  .|.:
Human    71 AMHGEIF-------CYLA------------------KYWLKGFVAFQAAINAAIIEVTTNHSVME 110

  Fly   247 --TGIPAIHLQRFPYRAYTYDQLLSGLRQLLPFVILLSFIYPASTVTKYVTSEKELQLKEIMKLI 309
              |.:..|:::..|:  .:..::::........|...||||.||.   .|..|:. :.|::|.::
Human   111 ELTSVIGINMKIPPF--ISKGEIMNEWFHFTCLVSFSSFIYFASL---NVARERG-KFKKLMTVM 169

  Fly   310 GVHNWLHWVAWFVKSYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCF 374
            |:.....|::|.: :||..:.::.:.|:|::    .|:.::..:.::.:......|.::.:.|.|
Human   170 GLRESAFWLSWGL-TYICFIFIMSIFMALVI----TSIPIVFHTGFMVIFTLYSLYGLSLIALAF 229

  Fly   375 MLAVLFSK---ASTASAVAAIFW-------FLTYIPYSFGYYYYERLSLMSKLLISLIFSNSALG 429
            :::||..|   |..|..:..:||       ....:|.|.|:.    |||:|..         |..
Human   230 LMSVLIRKPMLAGLAGFLFTVFWGCLGFTVLYRQLPLSLGWV----LSLLSPF---------AFT 281

  Fly   430 FGIHVIVMWEGTGEGITWRNMFHPVSTDDSLTLFYIIMTMSFGSIMFISICLYVEQVFPGEYGVP 494
            .|:..|...:....|:.:     |..:.||..:......::|.::.::...||.|:|.|.:.|..
Human   282 AGMAQITHLDNYLSGVIF-----PDPSGDSYKMIATFFILAFDTLFYLIFTLYFERVLPDKDGHG 341

  Fly   495 RRWNFMCHKNYWRQYV------------PSLNIVPSFQTI---LHGSAKAKSCRRAREVGIQLFN 544
            ....|....::|.::.            |..:...||:.:   .||           :..|::.|
Human   342 DSPLFFLKSSFWSKHQNTHHEIFENEINPEHSSDDSFEPVSPEFHG-----------KEAIRIRN 395

  Fly   545 LQKNY----GKLKAVKGISLKMHRNEITVLLGHNGAGKTTTINMITGIVKPTSGTAIVNGYDIR- 604
            :.|.|    ||::|::||...::..:||.:||||||||:|.:|:::|:...|.|:|.:....:.
Human   396 VIKEYNGKTGKVEALQGIFFDIYEGQITAILGHNGAGKSTLLNILSGLSVSTEGSATIYNTQLSE 460

  Fly   605 -THLAKARESLGICPQNNILFKEMSVRDHIIFFSKLKGIRGTKAVENEVGKYMTMLKLQDKSYVA 668
             |.:.:.|:::|.|||.|..|..::||:::..|:|:|||: .|.||.||.:.:..|.:|....:.
Human   461 ITDMEEIRKNIGFCPQFNFQFDFLTVRENLRVFAKIKGIQ-PKEVEQEVKRIIMELDMQSIQDII 524

  Fly   669 AKNLSGGMKRKLSLCCALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQSEKDGRTILLTTHYMDEA 733
            ||.||||.||||:|..|:.|:.:|:|.|||::|:|...|..:|.||:..|..|.||.:|.:||||
Human   525 AKKLSGGQKRKLTLGIAILGDPQVLLLDEPTAGLDPFSRHRVWSLLKEHKVDRLILFSTQFMDEA 589

  Fly   734 DVLGDRIAILSEGKLQCQGTSFYLKKRFGTGYLLVCIMQSGCDVGAVTQLIRKYVPPIKPERVLG 798
            |:|.||...||.|||:|.|:|.:||:::|.||.|.......||...:|.||::::|..|......
Human   590 DILADRKVFLSNGKLKCAGSSLFLKRKWGIGYHLSLHRNEMCDTEKITSLIKQHIPDAKLTTESE 654

  Fly   799 TELTYRLPTEYSKKFAELLQDLDEKCAQLQLVGYGLSGATLEDVFMAVNTDKRVQGGAEGPPVDG 863
            .:|.|.||.|.:.||.:|..||| ||:...:..|.:|..:|.:||:               .::|
Human   655 EKLVYSLPLEKTNKFPDLYSDLD-KCSDQGIRNYAVSVTSLNEVFL---------------NLEG 703

  Fly   864 SIDFKELVFDSKTREKRRIRR------------CFM-----------FWQ----ALFLKKFYTTT 901
            .....|..||...:||..:.|            |.:           .|:    |:...:|....
Human   704 KSAIDEPDFDIGKQEKIHVTRNTGDESEMEQVLCSLPETRKAVSSAALWRRQIYAVATLRFLKLR 768

  Fly   902 R-NYWLLGIQLVLPIAVMALTILNSRGGRIYYEL----------PAMP-ISINQYSS---AYVVL 951
            | ...||.:.|||.||.:.:.:     .:|.|::          |:|. :|:.|...   ..:::
Human   769 RERRALLCLLLVLGIAFIPIIL-----EKIMYKVTRETHCWEFSPSMYFLSLEQIPKTPLTSLLI 828

  Fly   952 EDNTTDKTSSLADAYSKHLEHYARRCTLLRTGDLKFEDYILSHD--VNHSRRIDFHFLAGLTVS- 1013
            .:||   .|::.|     |.|           .||.:|.:|..|  .|.:...|..:...:.||
Human   829 VNNT---GSNIED-----LVH-----------SLKCQDIVLEIDDFRNRNGSDDPSYNGAIIVSG 874

  Fly  1014 ---ENNFIVWLNNKPLHTAPLTLNLLHNALA-----IKLLGQDASTYVTNEPLPYSDDTRTLRLN 1070
               :..|.|..|.|.|:..|:.:.::.|||.     .:|:..:::::..::          :.|:
Human   875 DQKDYRFSVACNTKKLNCFPVLMGIVSNALMGIFNFTELIQMESTSFSRDD----------IVLD 929

  Fly  1071 KGQVLGAEISINLSLTMCFITAFYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVWDYLVFVLS 1135
            .|.:.|   ||.|.|....::.|..:..|.:.:...:...::||:...|||....:.|..::.|
Human   930 LGFIDG---SIFLLLITNCVSPFIGMSSISDYKKNVQSQLWISGLWPSAYWCGQALVDIPLYFL- 990

  Fly  1136 ALSSILTIAAFKEIGYITPLDLSRYFYMLLIFGFPG-----IMLSYAASGCFSDAATGFTRISII 1195
            .|.||..|..|..:|:    .||.....:|:....|     |.|:|..|..|......
Human   991 ILFSIHLIYYFIFLGF----QLSWELMFVLVVCIIGCAVSLIFLTYVLSFIFRKWRKN------- 1044

  Fly  1196 NTLMGTGLFLMFMTLNFEAFQLKDVAEKLAWYFRL--SPHYSLASSTHSIHIGYNIRRGCSIGGI 1258
            |.....|.|::.:.::  ...:....|||.....:  .|.::|        :|| :.....:..:
Human  1045 NGFWSFGFFIILICVS--TIMVSTQYEKLNLILCMIFIPSFTL--------LGY-VMLLIQLDFM 1098

  Fly  1259 RKLPK-QLRCRNVPICCDIPGYYGWRKPGVLVEITYMIMLGSTLFLLIVMHDAKVCNLIAEKLGN 1322
            |.|.. ..|...|            .|..:|.  |.:..|.|.:||.::       ..:..|.||
Human  1099 RNLDSLDNRINEV------------NKTILLT--TLIPYLQSVIFLFVI-------RCLEMKYGN 1142

  Fly  1323 ---------CFSKRKRVEGGT----SIENDSVVAEQ-RVVREMINSGRKDVPLLVYK-ISKRY-- 1370
                     ..|.|.|.....    ..|::.|.||: :....:.....::.|::... :.|.|
Human  1143 EIMNKDPVFRISPRSRETHPNPEEPEEEDEDVQAERVQAANALTAPNLEEEPVITASCLHKEYYE 1207

  Fly  1371 ---------RSKLAVKAISFHVPHAECFGLLGINGAGKTSTFKMLAGDEKITSGEAYIDGTNIST 1426
                     :.|:|::.:||.|...|..||||.|||||:::.||:.|..|.|:|...:.|:..|.
Human  1208 TKKSCFSTRKKKIAIRNVSFCVKKGEVLGLLGHNGAGKSTSIKMITGCTKPTAGVVVLQGSRASV 1272

  Fly  1427 HKVY----RKIGYCPQFDALFEDLTGRETLNIYCLLRGVQRRHVTPICWGLAISFGFAKHMDKQT 1487
            .:.:    :.:|||||.::|:..||.:|.|.:|..::|:.:.........|..:....:.:....
Human  1273 RQQHDNSLKFLGYCPQENSLWPKLTMKEHLELYAAVKGLGKEDAALSISRLVEALKLQEQLKAPV 1337

  Fly  1488 KHYSGGNRRKLSTAISVLGNPSVLYLDEPTSGMDPAARRQLWQII-GLIRTAGKSIVLTSHSMDE 1551
            |..|.|.:|||...:|:||||||:.||||.:||||..::|:|||: ..::...:..:||:|.|.|
Human  1338 KTLSEGIKRKLCFVLSILGNPSVVLLDEPFTGMDPEGQQQMWQILQATVKNKERGTLLTTHYMSE 1402

  Fly  1552 CEALCSRLAIMVDGEFKCLGSVQSLKNQFSKGLILKVKVKHKKKTFQRVVEDSSSSNDKKSISET 1616
            .||:|.|:|:||.|..:|:||:|.|||:|.:..:|::|:|
Human  1403 AEAVCDRMAMMVSGTLRCIGSIQHLKNKFGRDYLLEIKMK------------------------- 1442

  Fly  1617 DLKFLQMASVMESSQADRILKVNRFISKEIPDAELKEEYNGLITYYIPHSKT--LSKIFQLLETN 1679
                       |.:|.:.:   :..|.|..|.|..:|.|:.|:.|.:|....  ||:.|..||..
Human  1443 -----------EPTQVEAL---HTEILKLFPQAAWQERYSSLMAYKLPVEDVHPLSRAFFKLEAM 1493

  Fly  1680 SHKLNIEDYLIMQTRLEEIFLDFASKRDSSDIFTKRIYSCSW 1721
            ....|:|:|.:.|..||::||:...:::..::..|...:..|
Human  1494 KQTFNLEEYSLSQATLEQVFLELCKEQELGNVDDKIDTTVEW 1535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	428/1697 (25%)
ABCA10	NP_001364250.1	rim_protein	<37..1520	CDD:130324	428/1691 (25%)
ABCA10	NP_001364250.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1153..1177		5/23 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148342
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100045
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.750