DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and LOC101883122

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	XP_021333309.1	Gene:	LOC101883122 / 101883122	-ID:	-	Length:	2391	Species:	Danio rerio

Alignment Length:	1970	Identity:	470/1970 - (23%)
Similarity:	750/1970 - (38%)	Gaps:	679/1970 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 LHNFLAGVQFEDNENVNTNDAGYPLNLNYSLRFPSELRTMQGPIIDTWRTSRLFLSYDTSGSRNR 210
            |..|.||:.|.|..  :.:|...|.::.|.:|.         .:.||.||.:|   .:.|.|...
Zfish   456 LDRFWAGLVFTDLG--DPSDPQPPTHIRYKIRM---------DVQDTERTDKL---KERSWSPTA 506

  Fly   211 LDNDGGVPVG---YIREGFLPIQHALTMSWLALASGVTDTGIPAIHLQRFPYRAYTYDQLLSGLR 272
            .||    |:.   |:|.||:.:|..:..:.:.|.:||..|  ..::.|:.||..|..|..:|.:.
Zfish   507 RDN----PLNDLRYVRGGFVYLQDMVDRAIIKLQTGVQQT--LGVYAQQMPYPCYMDDAFVSAIG 565

  Fly   273 QLLPFVILLSFIYPASTVTKYVTSEKELQLKEIMKLIGVHNWLHWVAWFVKSYIMLMLVVFLIMS 337
            .:||..::|:|.|..|.:.|.:..|||.:|||::::.||.|....:.||.::.|:||:...||.
Zfish   566 TMLPMFLVLAFNYSVSEIIKGLVLEKERRLKEVLRVSGVSNSTIRLCWFAENMILLMVPCALIS- 629

  Fly   338 LIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCFMLAVLFSKASTASAVAAIFWFLTYIPYS 402
             :|||:   ..||.:|....:.:||..:.:.:|..||.::|.||:|:.|:|...:.:||.|:|:.
Zfish   630 -VMVKY---GKVLRYSDPSVIFVFLLVFCLATVMQCFFISVFFSRANLAAACGGLLYFLLYLPHV 690

  Fly   403 FGYYYYERLSLMSKLLISLIFSNSALGFGIHVIVMWEGTGEGITWRNMFHPVSTDDSLTLFYIIM 467
            ..|.:.:.|...:|:..||: |..|.|:|......:|..|.||.|.|:......:|..:....|.
Zfish   691 LCYAWRDVLGFGAKIATSLL-SCVAFGYGCENFSTYEAQGVGIQWSNIRSSPQDNDRYSFIVSIF 754

  Fly   468 TMSFGSIMFISICLYVEQVFPGEYGVPRRWNFMCHKNYW-RQYVPSLNIVPSFQTILHGSAKAKS 531
            .|.|.::::.::..|:|.|:||:||:.:.|.|....:|| ...|.|.......|.:.:.|...:.
Zfish   755 MMLFDALIYWTLTWYIENVYPGQYGIAKPWYFPFTSSYWCGSRVGSDGHPDLLQDLENQSGFLEK 819

  Fly   532 CRRAREVGIQLFNLQKNY--GKLKAVKGISLKMHRNEITVLLGHNGAGKTTTINMITGIVKPTSG 594
            .....:.|:.:.||.|.|  |...||.|:||..:::.||..|||||||||||::::||:..||||
Zfish   820 PPSGLKPGVCIRNLVKVYKTGNKLAVDGLSLDFYQDHITSFLGHNGAGKTTTMSILTGLFAPTSG 884

  Fly   595 TAIVNGYDIRTHLAKARESLGICPQNNILFKEMSVRDHIIFFSKLKGIRGTKAVENEVGKYMTML 659
            ||.:|||||||.:...|:.||:|||:|:||.:::|.:||.|:::||| |.:|.|:.|:.:.:..:
Zfish   885 TAYINGYDIRTDMDCIRKQLGMCPQHNVLFDDLTVEEHIYFYARLKG-RSSKEVKKEIDQMIKDV 948

  Fly   660 KLQDKSYVAAKNLSGGMKRKLSLCCALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQSEKDGRTIL 724
            .|..|....||||||||:||||:..|..|.:.||:.|||::|:|...||.:|:||...|.||||:
Zfish   949 GLPHKRKDLAKNLSGGMQRKLSVAIAFVGGSNVVILDEPTAGVDPYARRGIWELLLKYKQGRTII 1013

  Fly   725 LTTHYMDEADVLGDRIAILSEGKLQCQGTSFYLKKRFGTGYLLV------------CI------- 770
            |:||:|||||:||||:||:|.|::||.|:|.:|||.:|.||.|.            |:
Zfish  1014 LSTHHMDEADILGDRVAIISHGRVQCCGSSLFLKKTYGRGYYLTIARANQERAPAQCVPSPEEFD 1078

  Fly   771 ---MQSG-C----------DVGAVTQLIRKYVPPIKPERVLGTELTYRLPTEYS----KKFAELL 817
               :..| |          ||..|::|:|::||..:....:|.||.|.||  ||    ..||.|.
Zfish  1079 QSSLDEGICSDSISSLDPPDVSDVSRLVRRHVPEAEFLEAVGQELVYVLP--YSGATNGSFATLF 1141

  Fly   818 QDLDEKCAQLQLVGYGLSGATLEDVFMAVNTDKRVQGGAEGPP---------VDG--SI------ 865
            ::||.:...|.:..||:|..:||::|:.|..|..|...:...|         :.|  ||
Zfish  1142 KELDLEKNTLGVTSYGISDTSLEEIFLKVAEDTGVDVESHDKPKQKPRSSSRISGKQSISSALEC 1206

  Fly   866 -DFKELVFDSKTREKRR-----------------------IRRCFMFWQALFLKKFYTTTRNYWL 906
             |.|.:..::|.|...|                       ||:.|:   |||:|:|:...|:...
Zfish  1207 RDAKTVKNEAKVRFASRVEDTHRPMCANGKGSDVINGWSLIRQQFL---ALFIKRFHHARRSRKG 1268

  Fly   907 LGIQLVLPIAVMAL-----------------------------------------------TILN 924
            :..|:|:|...:.|                                               .:||
Zfish  1269 IIAQVVMPAFFVCLALIFSLIVPPFNEYPSLELQPWMYGAPQNTFYSFDGPGVVQVEKVTNALLN 1333

  Fly   925 SRG-------------------GRIYYELPAMPISIN-----------------QYSSA--YVVL 951
            |.|                   |...:..||:..||:                 |.|:|  ..:|
Zfish  1334 SPGFGTRCMSTNPIPRLPCVSTGSTNWFTPAVDPSISDIFDKGNWTMQNPSPACQCSTAERSFML 1398

  Fly   952 ED---------------NTTDKTSSLADAYSKHLEHYARRCTLLRTGDLKFEDYIL--------- 992
            .|               ||||   :|.:...:::..:..: |..::|.:::..:.:
Zfish  1399 PDCPPGAGGLPPPQRTQNTTD---TLQNVTGRNMTDFLLK-TYQKSGKIRYGGFSVGGVNSQVRL 1459

  Fly   993 -----------------------SHDVNHSRRIDFHFLAGLTVSENNFIVWLNNKPLHTAPLTLN 1034
                                   |.|:..:.|:   ||..|. :.:|..||..|...|:....||
Zfish  1460 NESDITTLVSDLRSVFNVSQFKQSEDIFQAIRL---FLLELG-TRDNMKVWFYNPGWHSLVSFLN 1520

  Fly  1035 LLHN-ALAIKLLG----QDASTYVTNEPLPYSDD---TRTLRLNKGQVLGAEISINLSLTMCFIT 1091
            :..| ||...|..    :|......|.||..:.:   |..|..:...|:   ::|.:...|.||.
Zfish  1521 VASNGALRGNLPAGRRPEDYGITTFNHPLNLTREQLSTAALASSSTDVV---VAICVIFAMSFIP 1582

  Fly  1092 AFYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVWDYLVFVLSALSSILTIAAFKEIGYITPLD 1156
            |.:.:.:|:||.|:||.|||:|||:...||.::..||...:::..:..|:....|::..|::|.:
Zfish  1583 ASFVLFLIQERVTKAKHLQFVSGVNPTIYWLANFAWDMCNYIVPCVIVIIIFLCFQQKSYVSPPN 1647

  Fly  1157 LSRYFYMLLIFGFPGIMLSYAASGCFSDAATGFTRISIINTLMG----TGLFLMFMTLNFEAFQL 1217
            |.....:|.::|:....:.|..|..||..:|.:..::.||..:|    ...|:|.:..:....::
Zfish  1648 LPALILLLALYGWSITPMMYPFSFVFSVPSTAYVVLTCINLFIGINGSVATFVMELFDDPNITRI 1712

  Fly  1218 KDVAEKLAWYFRLSPHYSLASSTHSI-------------------------HIGYNI-------- 1249
            .|:.::....|   ||:.|......:                         .:|.|:
Zfish  1713 NDIVKQALLVF---PHFCLGRGLMDMAKNQAVATLYQNLGEDRFVNPLTWNMVGKNLFAMSIQGA 1774

  Fly  1250 -------------------------------------RRGCSIGGIRK-------LPKQL----- 1265
                                                 |.....||.:|       |.|.|
Zfish  1775 VMFAVTLLIQYKFFCKPRSVKSPFTSSAEEDEDVARERERVYNGGAQKDLLHICDLTKVLLKNPV 1839

  Fly  1266 --------------------------------------RCRNV---------------------- 1270
                                                  ..|||
Zfish  1840 LAVVLDQTLENTGFSSAVISNFLFNGPESERPAGMPSFDWRNVFNATSQSAQQLTQILKVCLHLL 1904

  Fly  1271 --------PICCDIP---------------------------------GYYGWRKP--------- 1285
                    |...|.|                                 |.|..:.|
Zfish  1905 KGVTKSWSPTARDNPLNDLRYVRGGFVYLQDMVDRAIIKLQTGVQQTLGVYAQQMPYPCYMDDAF 1969

  Fly  1286 -------------------------GVLVE----------------ITYMI--MLGSTL------ 1301
                                     ||:.|                .||.:  .:.|||
Zfish  1970 LRSLTRSLPLYMTLAWIFSVALIVKGVVQEKEARLKETVRMMGLKSSTYWLSWAISSTLPLAVSA 2034

  Fly  1302 -FLLIVMHDAKV---------------------------------CNLIAEKLG----------- 1321
             .|.:::...||                                 .||.|...|
Zfish  2035 ALLTLILKYGKVLRYSDPSVIFVFLLVFCLATVMQCFFISVFFSRANLAAACGGLLYFLLYLPHV 2099

  Fly  1322 NCFSKRKRVEGGTSI--------------ENDSVVAEQRV------------------------- 1347
            .|::.|..:..|..|              ||.|....|.|
Zfish  2100 LCYAWRDVLGFGAKIATSLLSCVAFGYGCENFSTYEAQGVGIQWSNIRSSPQDNDRYSFIVSIFM 2164

  Fly  1348 ---------------------------------------------------VREMIN-SGRKDVP 1360
                                                               ::::.| ||..:.|
Zfish  2165 MLFDALIYWTLTWYIENVYPGQYGIAKPWYFPFTSSYWCGSRVGSDGHPDLLQDLENQSGFLEKP 2229

  Fly  1361 -------LLVYKISKRYR--SKLAVKAIS--FHVPHAECFGLLGINGAGKTSTFKMLAGDEKITS 1414
                   :.:..:.|.|:  :||||..:|  |:..|...|  ||.||||||:|..:|.|....||
Zfish  2230 PSGLKPGVCIRNLVKVYKTGNKLAVDGLSLDFYQDHITSF--LGHNGAGKTTTMSILTGLFAPTS 2292

  Fly  1415 GEAYIDGTNISTHK--VYRKIGYCPQFDALFEDLTGRETLNIYCLLRGVQRRHVTPICWGLAISF 1477
            |.|||:|.:|.|..  :.:::|.|||.:.||:|||..|.:..|..|:|...:.|
Zfish  2293 GTAYINGYDIRTDMDCIRKQLGMCPQHNVLFDDLTVEEHIYFYARLKGRSSKEV----------- 2346

  Fly  1478 GFAKHMDKQTKHYSGGNRRK 1497
              .|.:|:..|.....::||
Zfish  2347 --KKEIDQMIKDVGLPHKRK 2364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	469/1967 (24%)
LOC101883122	XP_021333309.1	AAA	1..1833	CDD:333001	382/1422 (27%)
LOC101883122	XP_021333309.1	AAA	1835..>2372	CDD:333001	86/545 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010