Protein Alignment CG6052 and abca1

DIOPT Version :9

• Sequence 1: NP_649002.3
• Gene: CG6052 / 39971
• FlyBaseID: FBgn0036747
• Length: 1725
• Species: Drosophila melanogaster
• Sequence 2: XP_004910916.1
• Gene: abca1 / 100491942
• XenbaseID: XB-GENE-1001143
• Length: 2311
• Species: Xenopus tropicalis
• Alignment Length: 1879
• Identity: 530/1879 - (28%)
• Similarity: 866/1879 - (46%)
• Gaps: 433/1879 - (23%)

  Fly   140 MEQDMVLHN---FLAGVQFEDNENVNTNDAGYPLNLNYSLRFPSELRTMQGPIIDTWRTSRLFLS 201
            :::.|.|.|   |.||:.|.|.....|.   .|.::.|.:|.         .|.:..||:::...
 Frog   524 IDKSMELLNERKFWAGIVFMDMPEEETE---LPHHVKYKIRM---------DIDNVERTNKIKDG 576

  Fly   202 YDTSGSRNRLDNDGGVPVGYIREGFLPIQHALTMSWLALASGVTD-TGIPAIHLQRFPYRAYTYD 265
            |...|.|    .|....:.||..||..:|..:..:.:.:.:||.. ||   |::|:.||..|..|
 Frog   577 YWDPGPR----ADPFEDMRYIWGGFSYLQDVVEQAIIRVQTGVEKRTG---IYVQQMPYPCYVDD 634

  Fly   266 QLLSGLRQLLPFVILLSFIYPASTVTKYVTSEKELQLKEIMKLIGVHNWLHWVAWFVKSYIMLML 330
            ..|..:.:.:|..:.|::||..:.:.|.:..|||.:|||.|:::|:.|.:.|::||:.|     |
 Frog   635 IFLRVMSRSMPLFMTLAWIYSVAVIIKGIVYEKEARLKETMRIMGLDNGILWLSWFISS-----L 694

  Fly   331 VVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYVVTSVCLCFMLAVLFSKASTASAVAAIFWF 395
            :..|:.:.::|....:..:|.:|....|.:||..:.|.::..||:::.:||:|:.|:|...|.:|
 Frog   695 IPLLMSAALLVLILKTGNLLPYSDPSVVFVFLSVFAVVTISQCFLISTIFSRANLAAACGGIIYF 759

  Fly   396 LTYIPYSFGYYYYERLSLMSKLLISLIFSNSALGFGIHVIVMWEGTGEGITWRNMFHPVSTDDSL 460
            ..|:||.....:.:.:....|:..|.: |..|.|||..|..:.|..|.|:.|.|:......::..
 Frog   760 TLYLPYVLCVAWQDYVGYTLKIFASFL-SPVAFGFGCEVFALLEEQGVGVQWDNLLESPLEENGY 823

  Fly   461 TLFYIIMTMSFGSIMFISICLYVEQVFPGEYGVPRRWNFMCHKNYW-----RQYVPSLNIVPSFQ 520
            .:......|.|.::::..:..|:|.||||:||:||.|.|...|:||     ::|...       .
 Frog   824 NITTSGFMMLFDTLLYGIMTWYIEAVFPGQYGIPRPWYFPFTKSYWCGEECKEYNQP-------H 881

  Fly   521 TILHGSAKAKSCRRAR----EVGIQLFNLQKNY--GKLKAVKGISLKMHRNEITVLLGHNGAGKT 579
            |:..||::.  |....    .:|:.:.||.|.|  ||..||.|::|..:..:||..|||||||||
 Frog   882 TVQKGSSEV--CMEEEPSHLPLGVSIQNLVKIYRNGKKVAVDGLTLNFYEGQITSFLGHNGAGKT 944

  Fly   580 TTINMITGIVKPTSGTAIVNGYDIRTHLAKARESLGICPQNNILFKEMSVRDHIIFFSKLKGIRG 644
            ||::::||:..||:|||.:...||||.|...|::||:|||:|:||..::|.:||.|:::|||:..
 Frog   945 TTMSILTGLFPPTTGTAYIMKKDIRTELNSIRQNLGVCPQHNVLFDALTVEEHIWFYARLKGLSE 1009

  Fly   645 TKAVENEVGKYMTMLKLQDKSYVAAKNLSGGMKRKLSLCCALCGNAKVVLCDEPSSGIDAAGRRS 709
            .| |:.|:.:.:..:.|..|.......|||||:||||:..|..|.:|||:.|||::|:|...||.
 Frog  1010 EK-VKAEMEQMVNDVGLPHKKKYKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRG 1073

  Fly   710 LWDLLQSEKDGRTILLTTHYMDEADVLGDRIAILSEGKLQCQGTSFYLKKRFGTGYLLVCI---- 770
            :|:||...:.||||:|:||:|||||:|||||||:|.|||.|.|:|.:||.:.||||.|..:
 Frog  1074 IWELLIKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKRDN 1138

  Fly   771 ----------------------MQSGC-------------------------------------- 775
                                  .|:.|
 Frog  1139 DSSLSSCRNSSSTMSYLKKESSKQTACKQHPSPMIAAPSASGTTAAVITKHSKHTAGQKKEAKDR 1203

  Fly   776 ---------------------------DVGAVTQLIRKYVPPIKPERVLGTELTYRLPTEYSKK- 812
                                       ||.|::.||.|:||..:....:|.||||.||.|.:|:
 Frog  1204 EDSVSQSSSDAGLGSDHESDTMTIGLTDVSAISNLINKHVPEARLVEDIGHELTYVLPYEAAKEG 1268

  Fly   813 -FAELLQDLDEKCAQLQLVGYGLSGATLEDVFMAVNTDKRVQGGAEGPPVDGSI----------- 865
             |.||..::|::.:.|.:..||::..|||::|:.|..|.    |.:....||::
 Frog  1269 AFVELFHEIDDRLSDLGISSYGIADTTLEEIFLKVADDT----GVDAETSDGTLPARRKRYAFGD 1329

  Fly   866 --------------DFKELVFDSKTREK-----------------RRIRRCF--MFWQALFLKKF 897
                          |..:...|.::||.                 ..:|:.|  :.|:.|...|
 Frog  1330 HQSCLRPFTEDDAFDTNDSDMDPESRETDYLSGIDGKGSYQLKSWNLMRQQFTALLWKRLLYAK- 1393

  Fly   898 YTTTRNYWLLGIQLVLPIAVMALTILNSRGGRIYYELPAMPISINQYSSAYVVLEDNTTDK---- 958
             .:.:.::   .|:|||...:.:.::.|.....:.:.|::.:....|...|....::..|.
 Frog  1394 -RSRKGFF---AQIVLPAVFVLIALVFSLIVPPFGKYPSLELEPWMYDEQYTFFSNDAPDDQGTQ 1454

  Fly   959 ---------------------------------------TSSLADAY------------------ 966
                                                   :.|:.|.:
 Frog  1455 ALLKALIDKPGFGTACMEGHSVMKVSCSGEEEEWSTQFVSQSVMDLFLNGNWTMENPSPSCECSS 1519

  Fly   967 -------------SKHLEHYARRCTLLRTGDL-------KFEDYILS------------------ 993
                         :..|..:.||   ..|.|:       ...||::.
 Frog  1520 DKRKKMLPICPPGAGGLPPFQRR---QNTSDILQNLTGRNISDYLVKTYSQIIEKSLKNKIWVNE 1581

  Fly   994 -----------------------HDVNH-SRRIDF--------------HFLAGLTVSENNFIVW 1020
                                   ..:|| .:|::.              .|:.||. :::|..||
 Frog  1582 FRYGGFSLGASNSPALPPNEEVVASINHIKKRLELPQNGAANRFLDSFGAFMKGLD-TKDNVKVW 1645

  Fly  1021 LNNKPLHTAPLTLNLLHNALAIKLL--GQDASTY-VT--NEPLPYSDDTRTLRLNKGQVLGAEIS 1080
            .|||..|.....||:::||:....|  |:|.::| :|  |.||..:.:    :|::..::...:.
 Frog  1646 FNNKGWHAVGAFLNVMNNAILRSKLREGEDPASYGITAFNHPLNLTKE----QLSEVALMTTSVD 1706

  Fly  1081 INLSL----TMCFITAFYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVWDYLVFVLSALSSIL 1141
            :.:|:    .|.|:.|.:.:.:|:||.::||.:|.:|||....||.::.|||...:|:.|...|:
 Frog  1707 VLVSICVIFAMSFVPASFVVFLIQERVSKAKHMQCISGVKPVIYWLANFVWDMCNYVVPATLVII 1771

  Fly  1142 TIAAFKEIGYITPLDLSRYFYMLLIFGFPGIMLSYAASGCFSDAATGFTRISIINTLMG-TGLFL 1205
            ....|::..|::..:|.....:||::|:....|.|.||..|...:|.:..::.:|..:| .|...
 Frog  1772 IFICFQQDSYVSSSNLPVLALLLLLYGWSITPLMYPASFIFKIPSTAYVVLTSVNLFIGINGSVA 1836

  Fly  1206 MFMTLNFEAFQLKDVAEKLAWYFRLSPHYSLASSTHSIHIGYNIRRGCSIGGIRKLPKQLRCRNV 1270
            .|:...|...:|.::.|.|.....:.||:.|......:     ::.......:.:..:.   |.|
 Frog  1837 TFVLELFTNNKLSNINEILKSVLLIFPHFCLGRGLIDM-----VKNQAMADALERFGEN---RFV 1893

  Fly  1271 -PICCDIPGYYGWRKPGVLVEITYMIMLGSTLFLLIVMHDAKVCNLIAEKLGNCFSKRKRVEGGT 1334
             |:..|:.|.          .:..|.:.|...|.:.:|...:.           |.|.:.|....
 Frog  1894 SPMSWDLVGR----------NLFAMAVEGVVFFAITLMIQYRF-----------FIKPRPVNAKL 1937

  Fly  1335 S--IENDSVVAEQRVVREMINSGRKDVPLLVYKISKRYRSKL--AVKAISFHVPHAECFGLLGIN 1395
            .  ::.|..||.:   |:.||.|.::..|.:..::|.||.|.  ||..:...:|..|||||||:|
 Frog  1938 PPVVDEDEDVARE---RQRINEGGRNDILELKGLTKIYRMKRKPAVDRLCVGIPPGECFGLLGVN 1999

  Fly  1396 GAGKTSTFKMLAGDEKITSGEAYIDGTNI--STHKVYRKIGYCPQFDALFEDLTGRETLNIYCLL 1458
            |||||:|||||.||..:|:|||::...:|  :.|:|::.:||||||||:.|.|||||.|.:|.||
 Frog  2000 GAGKTTTFKMLTGDTDVTAGEAFLKNHSILRNIHEVHQNMGYCPQFDAINELLTGREHLELYALL 2064

  Fly  1459 RGVQRRHVTPIC-WGLAISFGFAKHMDKQTKHYSGGNRRKLSTAISVLGNPSVLYLDEPTSGMDP 1522
            |||..:.|..:. |.:. ..|..|:.:|...:|||||:|||||||:::|.|.|::|||||:||||
 Frog  2065 RGVPEKEVCKVAEWAIR-KLGLVKYSEKHAGNYSGGNKRKLSTAIALIGGPPVVFLDEPTTGMDP 2128

  Fly  1523 AARRQLWQIIGLIRTAGKSIVLTSHSMDECEALCSRLAIMVDGEFKCLGSVQSLKNQFSKGLILK 1587
            .|||.||.....:...|:|:|||||||:||||||:|:||||:|.||||||||.|||:|..|..:.
 Frog  2129 KARRFLWNCALSVIKEGRSVVLTSHSMEECEALCTRMAIMVNGRFKCLGSVQHLKNRFGDGYTII 2193

  Fly  1588 VKVKHKKKTFQRVVEDSSSSNDKKSISETDLKFLQMASVMESSQADRILKVNRFISKEIPDAELK 1652
            |::             :.|:.|.|.:.|                         |.|...|.:.||
 Frog  2194 VRI-------------AGSNPDLKPVEE-------------------------FFSHAFPGSVLK 2220

  Fly  1653 EEYNGLITYYIPHSK-TLSKIFQLLETNSHKLNIEDYLIMQTRLEEIFLDFASKRDSSD 1710
            |::..::.|.:..|: :|::||.:|..|..:|:||||.:.||.|:::|::||  :|.||
 Frog  2221 EKHRSMLQYQLRSSQSSLARIFSILSKNKKRLHIEDYSVSQTTLDQVFVNFA--KDQSD 2277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324
		rim_protein	<149..1709	CDD:130324	525/1864 (28%)
abca1	XP_004910916.1	rim_protein	1..2272	CDD:130324	525/1870 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	160	1.000	Domainoid score	I3998
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010