DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6052 and abca3

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	XP_004918068.1	Gene:	abca3 / 100490925	XenbaseID:	XB-GENE-1010698	Length:	1720	Species:	Xenopus tropicalis

Alignment Length:	1818	Identity:	615/1818 - (33%)
Similarity:	937/1818 - (51%)	Gaps:	255/1818 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KLKLLMWKNWILQWNQKMQIVFALVLPVLFLCLILVLRIIVLPEKMDEIRYPTVSISDLNLYMRM 85
            :|.||:|||:|||..|.:..|..|.||:||..:::.||          .|.|:|:..:..|| |.
Frog    22 QLGLLLWKNYILQKRQVLVTVIELALPLLFSAILIALR----------HRVPSVTYPNATLY-RE 75

  Fly    86 VPLGNRILHENGSLNIPRNF-LCYTPNNPINSAIVGATAIRLRL-----------LGTRAYDTAL 138
            :|..|...     :..||.: |.|.|::.     ..|.:|.|.:           ...|.:.|..
Frog    76 MPFPNLPF-----IPGPRPWELAYVPSHS-----KAAHSIILDVGNHLFPYYFANQSARGFPTEE 130

  Fly   139 HMEQDMVLHN-----FLAGVQFEDNENVNTNDAGYPLNLNYSLRF-------PSELRTMQGPIID 191
            ..| |.:.||     .||.|.||.|.| ::.|. .||.:.|.|||       |...:|...|.:|
Frog   131 DFE-DYIRHNNHSSKILAAVVFEHNFN-HSGDP-LPLQVRYRLRFKYSPRNAPMSEQTGLNPNVD 192

  Fly   192 -TWRTSRLFLSYDTSGSRNRLDNDGGVPVGYIREGFLPIQHAL---TMSWLALASGVTDTGIPAI 252
             .|.|..|:..:...|.|...|..||.| ||.|||||.:||.:   .|.:.|..||........:
Frog   193 RNWHTRYLYPLFQMPGPREAGDKTGGTP-GYQREGFLAMQHEVDRAIMRYHANESGRLLLDNIDV 256

  Fly   253 HLQRFPYRAYTYDQLLSGLRQLLPFVILLSFIYPASTVTKYVTSEKELQLKEIMKLIGVHNWLHW 317
            .::||||..|..|..:..::..||.:::|||.|.:.::.:.:..|||.:|||.|:::|:.:|||.
Frog   257 AIRRFPYPPYVNDLFILAIQNQLPLLLMLSFTYTSLSIVRALVLEKERKLKEYMRVMGLSSWLHS 321

  Fly   318 VAWFVKSYIMLMLVVFLIMSLIMVKFYASVAVLTFSSWVPVLLFLHTYV--VTSVCLCFMLAVLF 380
            .|||:..:::|::.||.:..|:.::..:..||||.|.  |.|:|::..|  |:::...||::..|
Frog   322 TAWFIHFFLLLLVSVFFVTLLLCIQVSSEGAVLTRSD--PSLVFVYILVFSVSTISFSFMISSFF 384

  Fly   381 SKASTASAVAAIFWFLTYIPYSFGYYYYERLSLMSKLLISLIFSNSALGFGIHVIVMWEGTGEGI 445
            |:|:.|:|.....:||:||||.|...:|:.|:..:| :.|.:|||..:..|..:|.|:||.|.|.
Frog   385 SRANMAAAAGGFLYFLSYIPYFFISPWYDELNHGAK-VSSCLFSNVGMAMGAQLIGMFEGKGTGA 448

  Fly   446 TWRNMFHPVSTDDSLTLFYIIMTMSFGSIMFISICLYVEQVFPGEYGVPRRWNFMCHKNYW---- 506
            .|.|:|.|||.||:.||..::..:....:::..:..|||.|.||:||||:.|.|....:||
Frog   449 QWSNLFTPVSVDDNFTLGQVLQMLMLDCVLYFLVGWYVESVMPGDYGVPQPWYFCFLPSYWCGTP 513

  Fly   507 -------------------RQYV---PSLNIVPSFQTILHGSAKAKSCRRAREVGIQLFNLQKNY 549
                               .:|:   || ::||                     ||::.:|.|.|
Frog   514 RLVEGLEKEDDEDPEKALKGEYLEEEPS-DLVP---------------------GIRIKHLTKVY 556

  Fly   550 ---GKLK-AVKGISLKMHRNEITVLLGHNGAGKTTTINMITGIVKPTSGTAIVNGYDIRTHLAKA 610
               ||.: ||:.::|.|:..::|||||||||||:||::|:||:..|:||...:.||:|....|..
Frog   557 HASGKKRIAVRDLTLNMYEGQVTVLLGHNGAGKSTTLSMLTGLSPPSSGECYIGGYEITRDTALI 621

  Fly   611 RESLGICPQNNILFKEMSVRDHIIFFSKLKGIRGTKAVENEVGKYMTMLKLQDKSYVAAKNLSGG 675
            |.|||:|||:::||:.::|.:|:.|::.|||.......| ||.|.:.:|:|::|....:..||||
Frog   622 RRSLGLCPQHDVLFQGLTVEEHLYFYAGLKGCPRWCCPE-EVEKILQILRLEEKRNALSTQLSGG 685

  Fly   676 MKRKLSLCCALCGNAKVVLCDEPSSGIDAAGRRSLWDLLQSEKDGRTILLTTHYMDEADVLGDRI 740
            ..||||:..||.|.:|||:.|||:||:|.|.||..|:||:..|..||:|||||:|||||:|||||
Frog   686 TCRKLSIGIALIGGSKVVMLDEPTSGMDPASRRDTWELLRQHKHDRTLLLTTHFMDEADILGDRI 750

  Fly   741 AILSEGKLQCQGTSFYLKKRFGTGYLLVCIMQSGCDVGAVTQLIRKYVPPIKPERVLGTELTYRL 805
            |||::|:|||.|:..:||.::|.||.:|.:.:..|.|..:|.||..|||....|...|.||:|.|
Frog   751 AILAQGQLQCCGSPLFLKCKYGAGYHMVMVKEPHCQVEDITHLITSYVPNATLESNAGAELSYIL 815

  Fly   806 PTEYSKKFAELLQDLDEKCAQLQLVGYGLSGATLEDVFM----AVNTDKRVQGGAEGPPV----- 861
            |.|.:.:|..|..:|:.:..:|.:..||.|..|:|:||:    .|:|...:| ..:.||:
Frog   816 PKESTHRFEPLFSELELRREELGIASYGASVTTMEEVFLRVGKLVDTSLDIQ-AIQLPPLQYQHE 879

  Fly   862 --------DGSIDFKELVFDSK---TREKRRIR---RCFMFWQ---ALFLKKFYTTTRNYWLLGI 909
                    :.|....:...||.   |.:...|:   :|.::.|   |||:|:...:.||:.::..
Frog   880 RRANDWGTEESCSMSDCTEDSGTLITEDCSNIKLNGKCTLWCQQFYALFVKRAAYSWRNWKMVVG 944

  Fly   910 QLVLPIAVMALTILNSRGGRIYYELPAMPISINQYSSAYVV----LEDNTTDKTSSLADAYSKH- 969
            |.::|:....|.::..:......:.|.:.:|:..|  .|.|    |..|.:....||||.:...
Frog   945 QFLVPLVFTTLALVVGKTFPGPQDSPPLDLSLVPY--GYTVVPYSLPPNASTLLQSLADNFRDQF 1007

  Fly   970 -------------LEHYARRCTLLRTGD---LKFEDYILSHDVNH--SR-RIDFHFLAGLTVSEN 1015
                         |::|    .|.|..|   |..|..:.:.|:.:  || ::...|
Frog  1008 SGQQMEPQEVLDDLDNY----LLTRASDEGALFAERCLCAADIQNLGSRIKVTARF--------- 1059

  Fly  1016 NFIVWLNNKPLHTAPLTLNLLHNALAIKLLGQDASTYVTNEPLP-YSDDTRTLRLNKGQVLGAEI 1079
                  ||:..|.....|.|:.|||...:.|.:||..|||.|.| .:.:|...:|.:||. |..|
Frog  1060 ------NNQAYHAVASALALVDNALFKLIAGPEASISVTNYPQPRNTTETAQDQLLEGQA-GFAI 1117

  Fly  1080 SINLSLTMCFITAFYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVWDYLVFVLSALSSILTIA 1144
            :|||...|..:.:.:::.::.||..::|.:||:||....:||.|.:.||.|.|::.....:....
Frog  1118 AINLLYGMASLASTFSLLLVGERAVKSKHVQFVSGASALSYWLSALTWDLLNFLIPCTFMLAVFQ 1182

  Fly  1145 AFKEIGYITPLDLSRYFYMLLIFGFPGIMLSYAASGCFSDAATGFTRISIINTLMGTGLFLMFMT 1209
            ||....|.....|.....|||::|:..|.|.|..|..|:..||.:||::|.|.|.||..||....
Frog  1183 AFDVRAYTEEHHLVDVILMLLLYGWAVIPLMYLFSFLFTSTATAYTRLTIFNILSGTASFLSVTI 1247

  Fly  1210 LNFEAFQLKDVAEKLAWYFRLSPHYSLASSTHSIHIGYNIRRGCSIGGIRKLPKQ-LRCRNVPIC 1273
            ::..|..|.|::..|...|.:.|:|.|..|....:..|::.:.|     |..|:. :.|:...|.
Frog  1248 MSIPALGLVDLSHILDQVFLVLPNYCLGRSFSDFYQNYHLLKFC-----RSSPRSAIICQAFNIT 1307

  Fly  1274 CDIPGYYGWRKPGVLVEITYMIMLGST-LFLLIVMHDAKVCNLIAEKLGNCFSKRKR-----VEG 1332
            |. ..|:.|..|||...:|.|.:.||. |.||.::.....|.|    ...|.|.::.     .|.
Frog  1308 CQ-DNYFSWSSPGVGRYLTAMAVQGSAFLCLLFIIESQIFCRL----YNLCRSYKEHRWASLPES 1367

  Fly  1333 GTSIENDSVVAEQRVVREMINSGRKDV-----PLLVYKISKRYRSK---LAVKAISFHVPHAECF 1389
            ..|...|..||::|  ::::.|..:.:     ||::.::||.|..:   |||..||..|...|||
Frog  1368 PVSPPEDRDVADER--KKVLESPLEQLSALSSPLVIRELSKVYGRRALVLAVDRISLAVGRGECF 1430

  Fly  1390 GLLGINGAGKTSTFKMLAGDEKITSGEAYIDGTNISTH--KVYRKIGYCPQFDALFEDLTGRETL 1452
            ||||.||||||:||:||.|||.::||:|||||.:|..|  ||.::||||||||.|.:.:||||||
Frog  1431 GLLGFNGAGKTTTFRMLTGDETVSSGDAYIDGYSILRHIKKVQQRIGYCPQFDPLLDHMTGRETL 1495

  Fly  1453 NIYCLLRGVQRRHVTPICWGLAISFGFAKHMDKQTKHYSGGNRRKLSTAISVLGNPSVLYLDEPT 1517
            .:|..||||...::......:........|.:|..:.|||||:||||..|:::|.|||:::|||:
Frog  1496 CMYARLRGVPEGYINSCVENMLRGLLLEAHANKLVRTYSGGNKRKLSAGIALIGGPSVIFMDEPS 1560

  Fly  1518 SGMDPAARRQLWQIIGLIRTAGKSIVLTSHSMDECEALCSRLAIMVDGEFKCLGSVQSLKNQFSK 1582
            :||||.|||.||..:...|..||::::|||||:||||||:||||||:|:.|||||.|.|||:|..
Frog  1561 TGMDPVARRLLWDAVTRTRENGKAVIITSHSMEECEALCTRLAIMVNGQLKCLGSPQHLKNKFGS 1625

  Fly  1583 GLILKVKVKHKKKTFQRVVEDSSSSNDKKSISETDLKFLQMASVMESSQADRILKVNRFISKEIP 1647
            |..|..|.                                      |..|:.::....|:....|
Frog  1626 GYTLLAKT--------------------------------------SRGAEELMAFKDFVETIFP 1652

  Fly  1648 DAELKEEYNGLITYYIPHSKTLS--KIFQLLETNSHKLNIEDYLIMQTRLEEIFLDFASKRDS 1708
            .:.||.|:.|::.|:|. |:.||  ::|..||....|.::|||.:.|..||::||.|:..:.|
Frog  1653 GSVLKHEHQGMVHYHIT-SQELSWAQVFGTLEKAKEKFDLEDYCVSQISLEQVFLSFSHFQQS 1714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324	16/32 (50%)
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	575/1673 (34%)
abca3	XP_004918068.1	ABC2_membrane_3	<279..485	CDD:289468	72/208 (35%)
		CcmA	547..830	CDD:224054	131/283 (46%)
		ABC_subfamily_A	547..768	CDD:213230	107/221 (48%)
		ABC2_membrane_3	939..1287	CDD:289468	99/369 (27%)
		NatA	1399..1625	CDD:226927	120/225 (53%)
		ABC_subfamily_A	1399..1620	CDD:213230	116/220 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	162	1.000	Domainoid score	I3951
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1123	1.000	Inparanoid score	I228
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	1	1.000	-	-		FOG0000051
OrthoInspector	1	1.000	-	-		otm47667
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X215
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060