DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG6052 and abcg8

DIOPT Version :9

Sequence 1:	NP_649002.3	Gene:	CG6052 / 39971	FlyBaseID:	FBgn0036747	Length:	1725	Species:	Drosophila melanogaster
Sequence 2:	NP_001108041.2	Gene:	abcg8 / 100136850	ZFINID:	ZDB-GENE-050517-41	Length:	684	Species:	Danio rerio

Alignment Length:	738	Identity:	149/738 - (20%)
Similarity:	267/738 - (36%)	Gaps:	213/738 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   551 KLKAVKGISLKMHRNEITVLLGHNGAGKTTTINMIT-----GIVKPTSGTAIVNGYDIRTHLAKA 610
            |...:|.::|.:|..::..::|.:|.|||:.:::||     |.:  .||..::||......|.|
Zfish    90 KQTVIKDLNLHVHSGQMLAVIGSSGCGKTSLLDIITCRDEGGSM--NSGEILINGKPSTRSLVK- 151

  Fly   611 RESLGICPQNNILFKEMSVRDHIIFFSKLK--GIRGTKAVENEVGKYMTMLKLQDKSYVAAKN-- 671
             :|:....|::.|...::||:.:.|.:||:  .....|..:..|...:..|:|:..::....|
Zfish   152 -KSIAHVRQDDRLLPHLTVRETLAFVAKLRLPANFSQKQRDQRVDDVIAELRLRQCAHTRVGNEY 215

  Fly   672 ---LSGGMKRKLSLCCALCGNAKVVLCDEPSSGIDAAGRRSL-WDLLQSEKDGRTILLTTHYMDE 732
               :|||.:|::|:...|..|..:::.|||:||:|:....:| ..|.:..:..|.:||:.| ...
Zfish   216 VRGVSGGERRRVSIAVQLLWNPGILILDEPTSGLDSFTAHNLVITLYRLARGNRLVLLSVH-QPR 279

  Fly   733 ADV--LGDRIAILSEGKLQCQGTSFYLKKRFGT-GYLLVCIMQSGCDVGAVTQLIRKYVPPIKPE 794
            :|:  |.|.:.:||.|.....|.:..:...|.| ||        .|.
Zfish   280 SDIFQLFDLVVLLSSGSAVYCGQAKDMVSYFTTLGY--------PCP------------------ 318

  Fly   795 RVLGTELTYRLPTEYSKKFAELLQDLDEKCAQLQLVGYGLSGATLEDVFMAVNTDKRVQGGAEGP 859
                   .|..|::|......:.:...||.||.......|:...||.|  ..|.|...:....||
Zfish   319 -------RYCNPSDYYVDLISIDRRTPEKEAQCLEKASMLAAQFLEKV--KNNEDFMWKSEVCGP 374

  Fly   860 PV-------DGSIDFKELVFDSKTREKRRIRRCFMFWQALFLKKFYTTTRNYWLL---GIQLVLP 914
            |.       ..|:..||.|. :.:::|.::......:..|..::.:...|:...|   |::.:|
Zfish   375 PALEAPQSSVPSVSMKESVI-TVSKQKDQLPGKVHQFTTLIRRQVFNDYRDLVTLVVHGLEALL- 437

  Fly   915 IAVMALTILNSRGGRIYYELPAMPISI---------------------------NQYSSAYVVLE 952
               |:|.|     |.:|:......:||                           ::.:..|..||
Zfish   438 ---MSLLI-----GFLYFGCTEEGLSIQDTVALLYMIGALTPFAVVLDVIAKCHSERAMLYHELE 494

  Fly   953 DNTTDKTSSLADAYSKHLEHYARRCTLLRTGDLKFEDYILSHDVNHSRRIDFHFLAGLTVSENNF 1017
            |.....|...   ::|.|......|.           :.|.:.|      ..::||||.|:.:.|
Zfish   495 DGMYSVTPYF---FAKVLGELPEHCA-----------FTLVYGV------PIYWLAGLNVAPDRF 539

  Fly  1018 -----IVWLNNKPLHTAPLTLNLLHNALAIKLLGQDASTYVTNEPLPYSDDTRTLRLNKGQVLGA 1077
                 :|||.             ::.:.::.|....|        ||        .|.....:|
Zfish   540 LLNFLLVWLT-------------VYCSRSMALFVAAA--------LP--------TLQTSSFMG- 574

  Fly  1078 EISINLSLTMCFITAFYAIPIIRERETRAKLLQFLSGVDVCAYWTSHIVWDYLVFVLSALSSILT 1142
                |...|:.::||.:.|.              |..:.:.|.|.|     |:.|:......:|.
Zfish   575 ----NALFTVFYLTAGFVIS--------------LENMWMVASWFS-----YISFMRWGFEGMLQ 616

  Fly  1143 IAAFKEIGYITPLDLSRYFYMLLIFGFPGI-------MLSYAASGCFSDAATGFTRISIINTLMG 1200
            : .|:  |...|:.:..     |...|.||       |..|....|:               |:.
Zfish   617 V-QFR--GTRIPITIGN-----LTVEFDGIKVVEMMKMNQYPLFSCY---------------LVL 658

  Fly  1201 TGLFLMFMTLNFEAFQLKDVAEK 1223
            ..:.|:|:.|.:  ..||.:.:|
Zfish   659 IAVSLVFILLYY--LSLKFIKQK 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6052	NP_649002.3	rim_protein	21..>54	CDD:130324
CG6052	NP_649002.3	rim_protein	<149..1709	CDD:130324	149/738 (20%)
abcg8	NP_001108041.2	3a01204	47..674	CDD:273361	146/731 (20%)
		ABCG_White	72..301	CDD:213201	56/215 (26%)
		ABC2_membrane	413..617	CDD:279410	49/285 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000