DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Crtc and Crtc3

DIOPT Version :9

Sequence 1:	NP_001261997.1	Gene:	Crtc / 39970	FlyBaseID:	FBgn0036746	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_776288.2	Gene:	Crtc3 / 70461	MGIID:	1917711	Length:	619	Species:	Mus musculus

Alignment Length:	860	Identity:	187/860 - (21%)
Similarity:	263/860 - (30%)	Gaps:	318/860 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ANPRKFSEKIALQKQKQAEGTAEFERIMKEVYATKRDEPPANQKILDGLVGGQ--EVSQ---SSP 61
            ||||||||||||..|:|||.|..||::|.::..::.......|..|....||.  .|||   |:|
Mouse    10 ANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSRVQFQKLQQLRLTQYHGGSLPNVSQLRNSAP 74

  Fly    62 -------GAGNGTGGGGSGSGSGASGGGASPDGLGGGGGSPTAYRESRGRSVGVGPMRRPS---- 115
                   .|.|..|....|                      ...|.:|.|   ..|:.|.|
Mouse    75 EFQPSLHQADNVRGTRHHG----------------------LVERPARNR---FHPLHRRSGDKP 114

  Fly   116 ERKQDRSPYGSSSTQQTLDNGQLNPHLLGPPTAE---------SLWRRSSSDSALHQSALVAGFN 171
            .|:.|.:.:.:|.:.|.||.......   ||..|         |...|::||||||.|||
Mouse   115 GRQFDGNAFAASYSSQHLDESWPRQQ---PPWKEEKHPGFRLTSALNRTNSDSALHTSAL----- 171

  Fly   172 SDVNSMGANYQQQQHQQQQQP----GQPRSHSPHHGI---NRTMSPQAQRRKSPLLQPHQLQLQQ 229
                          ..:.|.|    ||....:|:.|.   ......:......||.:.:.|.:.
Mouse   172 --------------STKPQDPYGGGGQSAWPAPYMGFCDGENDGHAEVAAFPGPLKEENLLNVP- 221

  Fly   230 LQQQQQQMQHQHQLHQQLQMQQLQQHQQQHQQQQQQQNTPYN------NAKFTNPVFRPLQDQVN 288
                                :.|.:|..:.::.|.....|.:      ||...|.....|...:.
Mouse   222 --------------------KPLPKHLWESKEIQSLSGRPRSCDVGGGNAFPHNGQNTGLSPFLG 266

  Fly   289 FANT-GSLPDLTALQNYGPQQQQQQSQQQPSQQQQQLQQTLSPVMSPHNHRRERDQSPSPFSPAG 352
            ..|| |||||||.|....|                 |..:|             |.|...|....
Mouse   267 TLNTGGSLPDLTNLHYSAP-----------------LPASL-------------DTSDHLFGSMS 301

  Fly   353 GGGGAGPGSPYQQQQHSPTGNTQQQQQQHQQPSNSPHLSFTNLATTQAAVTTFNPLPTLGPHNAT 417
            .|...|                           |.|      .|.|...:.|.:.|
Mouse   302 VGNSVG---------------------------NLP------AAMTHLGIRTSSGL--------- 324

  Fly   418 DYRQPPNPPSPRSSPGLLSSVSATDLHSSAPASPIRQQQQAHQQQQQQQQAQQQQQQFDNSYNSL 482
                    .|.||:|.:.:::|...|.||....|                    |....|:
Mouse   325 --------QSSRSNPSIQATLSKMALSSSLKCHP--------------------QPSVANA---- 357

  Fly   483 NTSFHNQFEIFSLGDSNSSPEQQGFANNFVALDFDDLSGGGGGGPSGGGGSNGGGLTNGYNKPEM 547
             ::.|....:|||    |:|          :|...:||     |||.........||
Mouse   358 -SALHPSLRLFSL----SNP----------SLSTTNLS-----GPSRRRQPPVSPLT-------- 394

  Fly   548 LDFSELSGSPEASGNNNHMRRGVSNLNNNGLSNGVVGSTHNGSTNLNGAGNNNSSSGGGTAQDPL 612
                 ||..|||....:......|.||....|..|.                       :.|.||
Mouse   395 -----LSPGPEAHQGFSRQLSATSPLNPYPASQMVT-----------------------SEQSPL 431

  Fly   613 GITTSPVPSPLGCPSSPLPIPIPMSAQSSPQQQHHHHQQQQQQHHQQQHHQQQQLSLSLHHSPHH 677
            ....:...:.:   |.|.|.|.|   |..||      ...||.|.|:...||.|.:.||..|...
Mouse   432 SFLPTDAQAQV---SPPPPYPTP---QELPQ------PLLQQPHAQEPPTQQPQAAPSLPQSDFQ 484

  Fly   678 ------SPMHS----------PHHGNSPLSSSSPVSHNACSNSNVVMNHQQQQQQHHHQQHHHQG 726
                  |.:.|          |...:.......|:         |..:|::.|...|.:.:.:..
Mouse   485 LLTAQGSALTSFFPDVRFDQQPMRPSPAFPQQVPL---------VQQSHREPQDSFHLRPNPYSS 540

  Fly   727 -SSQSHTPTTANIPSIIFSDYSSNADYTREIFDSLDLD----------LGQMDVAGLQMLSDQNP 780
             .|...|..|.:..|.:|...|.......|:  |||:|          :..:.:.||.||||.:
Mouse   541 CGSFPGTILTEDTNSNLFKGLSGGLSGMPEV--SLDMDTPFPLEEELQIEPLSLDGLNMLSDSS- 602

  Fly   781 IMIADPNIEDSFRRD 795
            :.:.||::|::||.|
Mouse   603 MGLLDPSVEETFRAD 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Crtc	NP_001261997.1	TORC_N	3..61	CDD:289639	27/62 (44%)
Crtc	NP_001261997.1	TORC_C	739..795	CDD:289641	19/65 (29%)
Crtc3	NP_776288.2	TORC_N	11..64	CDD:289639	23/52 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..148		6/21 (29%)
		TORC_M	159..321	CDD:289640	49/264 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	375..478		35/155 (23%)
		Required for interaction with PPP2CA and PPP2R1A. /evidence=ECO:0000269\|PubMed:30611118	380..401		9/38 (24%)
		TORC_C	545..619	CDD:289641	22/76 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849903
Domainoid	1	1.000	51	1.000	Domainoid score	I11491
eggNOG	1	0.900	-	-		E1_28MKB
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	93	1.000	Inparanoid score	I5063
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001294
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13589
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1320
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.980